BE905890A - Anticorps monoclonaux a reaction croisee et protection croisee vis-a-vis des serotypes de p.aeruginosa. - Google Patents

Anticorps monoclonaux a reaction croisee et protection croisee vis-a-vis des serotypes de p.aeruginosa.

Info

Publication number
BE905890A
BE905890A BE0/217509A BE217509A BE905890A BE 905890 A BE905890 A BE 905890A BE 0/217509 A BE0/217509 A BE 0/217509A BE 217509 A BE217509 A BE 217509A BE 905890 A BE905890 A BE 905890A
Authority
BE
Belgium
Prior art keywords
monoclonal antibodies
cross
protection against
aeruginosa serotypes
reaction
Prior art date
Application number
BE0/217509A
Other languages
English (en)
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of BE905890A publication Critical patent/BE905890A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1214—Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

On a produit des lignées de cellules secrétant des anticorps monoclonaux humains capables de se lier aux molécules de lipopolysaccharide de sérotypes IATS choisis de Pseudomanas aeruginosa. Sont aussi comprises des compositions pharmaceutiques contenant ces anticorps, en combinaison avec d'autres anticorps monoclonaux, des fractions de plasma sanguin et des agents antimicrobiens, ainsi que l'utilisation prophylactactique et thérapeutique de ces compositions dans le traitement des infections.
BE0/217509A 1985-12-10 1986-12-10 Anticorps monoclonaux a reaction croisee et protection croisee vis-a-vis des serotypes de p.aeruginosa. BE905890A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80739485A 1985-12-10 1985-12-10
US93117986A 1986-11-24 1986-11-24

Publications (1)

Publication Number Publication Date
BE905890A true BE905890A (fr) 1987-06-10

Family

ID=27123006

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217509A BE905890A (fr) 1985-12-10 1986-12-10 Anticorps monoclonaux a reaction croisee et protection croisee vis-a-vis des serotypes de p.aeruginosa.

Country Status (21)

Country Link
US (4) US5378812A (fr)
JP (1) JPH07116237B2 (fr)
KR (1) KR910008361B1 (fr)
CN (1) CN86108380A (fr)
AT (1) AT400441B (fr)
BE (1) BE905890A (fr)
CH (1) CH677362A5 (fr)
DE (1) DE3642095C2 (fr)
DK (1) DK594586A (fr)
FI (1) FI86377C (fr)
FR (1) FR2593826B1 (fr)
GB (1) GB2185266B (fr)
HU (1) HUT41836A (fr)
IE (1) IE59741B1 (fr)
IT (1) IT1199735B (fr)
LU (1) LU86711A1 (fr)
NL (1) NL8603132A (fr)
NO (1) NO178718C (fr)
NZ (1) NZ218499A (fr)
PT (1) PT83894B (fr)
SE (1) SE468831B (fr)

Families Citing this family (26)

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IL81370A (en) * 1986-02-07 1991-06-30 Genetic Systems Corp Pharmaceutical and diagnostic compositions comprising a plurality of human monoclonal antibodies for the treatment of bacterial diseases,methods for the preparation of the compositions and antibodies and kits containing said compositions
GB2192185B (en) * 1986-07-03 1991-01-16 Genetic Systems Corp Monoclonal antibodies to pseudomonas aeruginosa flagella
EP0256713A3 (fr) * 1986-08-06 1989-02-15 Merck & Co. Inc. Anticorps humains thérapeutiques anti-pseudomonas aeruginosa
JP2725041B2 (ja) * 1986-12-15 1998-03-09 三井東圧化学株式会社 ヒトモノクローナル抗体とそれを有効成分とする感染症の予防、治療剤
US5521085A (en) * 1986-12-15 1996-05-28 Mitsui Toatsu Chemicals, Inc. Transformed cell lines producing human monoclonal antibodies specific for Pseudomonas aeruginosa serotypes
JPH01197500A (ja) * 1988-01-29 1989-08-09 Sumitomo Chem Co Ltd ヒトモノクローナル抗体
GB2218703B (en) * 1988-05-10 1992-10-28 Sumitomo Chemical Co Human monoclonal antibody to p.aeruginosa: its production and use
CA1341375C (fr) * 1988-10-12 2002-07-09 Baxter International Inc. Compositions pour le traitement et la prevention d'infections dues a des bacteries gram negatif, ainsi que leurs methodes d'utilisation
EP0382031A3 (fr) * 1989-02-10 1991-06-26 Miles Inc. Anticorps monoclonaux dans une préparation de globuline d'immunsérum
US4994269A (en) * 1989-03-17 1991-02-19 Miles Inc. Topical use of antibodies for prevention or treatment of pseudomonas infections
AU619672B2 (en) * 1989-03-20 1992-01-30 Mitsui Toatsu Chemicals Inc. Human monoclonal antibody reactive with pseudomonas aeruginosa, cell which produces the antibody, method of production, and pharmaceutical preparation
JPH02283294A (ja) * 1989-04-24 1990-11-20 Sumitomo Chem Co Ltd ヒトモノクローナル抗体
JPH0329196A (ja) * 1989-05-09 1991-02-07 Advanced Micro Devicds Inc センス増幅器
US5858728A (en) * 1991-03-13 1999-01-12 Common Services Agency Monoclonal antibody against LPS core
US20030096315A1 (en) 2000-05-03 2003-05-22 Sanders Mitchell C. Device for detecting bacterial contamination and method of use
WO2003063693A2 (fr) * 2002-01-31 2003-08-07 Expressive Constructs, Inc. Methode de detection de micro-organismes
EP1506217A4 (fr) * 2002-05-29 2006-04-12 Jackson H M Found Military Med Methodes d'identification de biomarqueurs genomiques et proteomiques pour la mucoviscidose, jeux ordonnes d'echantillons comprenant ces biomarqueurs et methodes d'utilisation de ces jeux ordonnes d'echantillons
BR0215954A (pt) * 2002-11-26 2005-09-13 Uc Tech Métodos de redução da possibilidade de mortalidade em um animal, de expressão virulenta em um patógeno intestinal, e da expressão de adesina / lectina pa-i em uma célula bacteriana, de inibição de expressão de adesina / lectina pa-i em um patógeno intestinal, de ativação induzida por intestino de adesina / lectina pa-i, de mudança morfológica induzida por c4-hsl de um patógeno intestinal, e de aderência de célula bacteriana em um intestino de mamìfero, de melhoria de patogênese intestinal, de prevenção de uma doença ou condição anormal, de infecção de pele e respiratória, de uma doença sexualmente transmitida, de um distúrbio de trato digestivo, de perda de capacidade lactante em um animal, e de desenvolvimento de um distúrbio epitelial mediado por micróbio em uma animal de idade de amamentação, de irrigação de pelo menos uma porção do trato urinário, e para monitoração da administração de poli (etileno-glicol) (peg) a um animal, composição farmacêutica, kits para a prevenção ou tratamento terapêutico de sepsia derivada de intestino, e para a monitoração da administração de poli (etileno-glicol), e, preservativo
AU2004225575B2 (en) * 2003-01-31 2008-02-21 Ethicon, Inc. Method for detecting escherichia coli
CA2557612C (fr) 2003-11-03 2014-06-17 Ethicon, Inc. Methodes, peptides, et biocapteurs utiles pour detecter un large spectre de bacteries
EP1690875A1 (fr) * 2005-02-14 2006-08-16 Kenta Biotech AG Anticorps monoclonal humain specifique pour lipoplysaccharides (LPS) de la Pseudomonas aeruginosa serotype IATS O11
JP5324438B2 (ja) * 2006-05-01 2013-10-23 バイオネス ニューロモジュレイション リミテッド 改良型機能的電気刺激システム
WO2010091189A1 (fr) * 2009-02-04 2010-08-12 Kalobios Pharmaceuticals, Inc. Antibiotique en combinaison et thérapie antibiotique pour traiter une infection par pseudomonas aeruginosa
US20130022603A1 (en) * 2010-02-18 2013-01-24 Symphogen A/S Antibody against serotype i lipopolysaccharide of pseudomonas aeruginosa
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH652145A5 (de) * 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4464465A (en) * 1982-04-05 1984-08-07 Genetic Systems Corporation Cell-driven viral transfer in eukaryotes
JPS59137497A (ja) * 1983-01-20 1984-08-07 ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア 抗原特異的免疫グロブリン生産性ヒト／ヒトハイブリド−マ及びその生産する抗体
JPS58216125A (ja) * 1982-06-09 1983-12-15 Asahi Chem Ind Co Ltd ヒト抗体の産生方法
JPS5929622A (ja) * 1982-08-10 1984-02-16 Meiji Seika Kaisha Ltd モノクロ−ナル抗体、その製造法およびその用途
DE3484773D1 (de) * 1983-05-06 1991-08-08 Velos Group Mit endotoxinkern reaktionsfaehige monoklonale antikoerper.
US4587121A (en) * 1983-06-14 1986-05-06 Miles Laboratories, Inc. High titer Pseudomonas immune serum globulin
US5179018A (en) * 1983-10-14 1993-01-12 Centocor, Inc. Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria
US4683196A (en) * 1983-12-12 1987-07-28 Meru, Inc. Method and materials for the identification of lipopolysaccharide producing microorganisms
EP0168422A1 (fr) * 1983-12-12 1986-01-22 Meru, Inc. Procede et substances permettant l'identification de micro-organismes produisant du lipopolysaccharide
JPS60248625A (ja) * 1984-05-25 1985-12-09 Mitsui Toatsu Chem Inc 抗緑膿菌モノクロ−ナル抗体、その製法ならびに用途
US4834975A (en) * 1984-05-25 1989-05-30 Genetics Corporation Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production
JP2565303B2 (ja) * 1984-05-25 1996-12-18 三井東圧化学株式会社 緑膿菌感染症の予防治療剤
DE3426903A1 (de) * 1984-07-20 1986-01-23 Biotest Pharma GmbH, 6000 Frankfurt Eine immunglobulinpraeparation in kombination mit einer anderen pharmakologisch wirksamen praeparation zur verwendung bei der behandlung von krankheiten
AU597877B2 (en) * 1984-12-26 1990-06-14 Teijin Limited Anti-pseudomonas aeruginosa human monoclonal antibody
US4677070A (en) * 1985-04-26 1987-06-30 Cetus Corporation Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use
JPS6229175A (ja) * 1985-07-29 1987-02-07 Nippon Telegr & Teleph Corp <Ntt> 電界効果型トランジスタの製造方法
EP0211352B1 (fr) * 1985-08-01 1994-03-16 Miles Inc. Anticorps protecteurs contre des déterminants sérotypiques d'antigènes flagellaires
US4772464A (en) * 1985-08-01 1988-09-20 Miles Laboratories, Inc. Protective antibodies to serotypic determinants of flagellar antigens
US4777136A (en) * 1985-09-27 1988-10-11 The Regents Of The University Of California Monoclonal antibody reactive with Pseudomonas Aeruginosa
US4970070A (en) * 1986-02-07 1990-11-13 Genetic Systems Corporation Protective monoclonal antibody compositions for infections due to group B streptococcus
GB2192185B (en) * 1986-07-03 1991-01-16 Genetic Systems Corp Monoclonal antibodies to pseudomonas aeruginosa flagella
EP0256713A3 (fr) * 1986-08-06 1989-02-15 Merck & Co. Inc. Anticorps humains thérapeutiques anti-pseudomonas aeruginosa

Also Published As

Publication number Publication date
NO864971L (no) 1987-06-11
SE8605295D0 (sv) 1986-12-10
SE8605295L (sv) 1987-06-11
FI86377C (fi) 1992-08-25
GB2185266A (en) 1987-07-15
NO178718B (no) 1996-02-12
DE3642095A1 (de) 1987-07-02
IE59741B1 (en) 1994-03-23
NO864971D0 (no) 1986-12-10
GB2185266B (en) 1990-09-05
HUT41836A (en) 1987-05-28
DK594586A (da) 1987-06-11
SE468831B (sv) 1993-03-29
IE863230L (en) 1987-06-10
CN86108380A (zh) 1987-10-28
FI865027A7 (fi) 1987-06-11
JPH07116237B2 (ja) 1995-12-13
JPS62187417A (ja) 1987-08-15
FR2593826B1 (fr) 1990-11-16
US5662905A (en) 1997-09-02
NZ218499A (en) 1990-04-26
DE3642095C2 (de) 1998-10-01
LU86711A1 (fr) 1988-07-14
KR870005648A (ko) 1987-07-06
KR910008361B1 (ko) 1991-10-12
US5378812A (en) 1995-01-03
NL8603132A (nl) 1987-07-01
ATA328286A (de) 1995-05-15
FI865027A0 (fi) 1986-12-10
US5628996A (en) 1997-05-13
FI86377B (fi) 1992-05-15
GB8629540D0 (en) 1987-01-21
NO178718C (no) 1996-05-22
CH677362A5 (fr) 1991-05-15
DK594586D0 (da) 1986-12-10
IT8622630A0 (it) 1986-12-10
AT400441B (de) 1995-12-27
US5627067A (en) 1997-05-06
IT1199735B (it) 1988-12-30
PT83894A (en) 1987-01-01
PT83894B (pt) 1989-07-31
FR2593826A1 (fr) 1987-08-07

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GENETIC SYSTEMS CORP.

Effective date: 20001231