BG104105A - Алатрофлоксацинови парентерални състави - Google Patents

Алатрофлоксацинови парентерални състави Download PDF

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Publication number
BG104105A
BG104105A BG104105A BG10410500A BG104105A BG 104105 A BG104105 A BG 104105A BG 104105 A BG104105 A BG 104105A BG 10410500 A BG10410500 A BG 10410500A BG 104105 A BG104105 A BG 104105A
Authority
BG
Bulgaria
Prior art keywords
compound
formula
impurities
pharmaceutically acceptable
parenteral composition
Prior art date
Application number
BG104105A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Guinn
John Lambert
Subramanian GUHAN
Stanley WALINSKY
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG104105A publication Critical patent/BG104105A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG104105A 1997-08-01 2000-01-25 Алатрофлоксацинови парентерални състави BG104105A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5424697P 1997-08-01 1997-08-01
PCT/IB1998/001122 WO1999006430A1 (fr) 1997-08-01 1998-07-23 Compositions a base d'alatrofloxacine, administrables par voie parenterale

Publications (1)

Publication Number Publication Date
BG104105A true BG104105A (bg) 2000-08-31

Family

ID=21989735

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104105A BG104105A (bg) 1997-08-01 2000-01-25 Алатрофлоксацинови парентерални състави

Country Status (40)

Country Link
US (1) US6194429B1 (fr)
EP (1) EP1000086B1 (fr)
JP (1) JP3463928B2 (fr)
KR (1) KR20010022495A (fr)
CN (1) CN1265671A (fr)
AP (1) AP1031A (fr)
AR (1) AR015417A1 (fr)
AT (1) ATE259827T1 (fr)
AU (1) AU734863B2 (fr)
BG (1) BG104105A (fr)
BR (1) BR9811580A (fr)
CA (1) CA2296466C (fr)
CO (1) CO4970688A1 (fr)
DE (1) DE69821767T2 (fr)
DK (1) DK1000086T3 (fr)
DZ (1) DZ2576A1 (fr)
EA (1) EA002120B1 (fr)
ES (1) ES2214716T3 (fr)
GT (1) GT199800112A (fr)
HN (1) HN1998000106A (fr)
HR (1) HRP980417B1 (fr)
HU (1) HUP0004793A3 (fr)
ID (1) ID24374A (fr)
IL (1) IL134156A0 (fr)
IS (1) IS5339A (fr)
MA (1) MA24626A1 (fr)
NO (1) NO20000485L (fr)
NZ (1) NZ502249A (fr)
OA (1) OA11281A (fr)
PA (1) PA8456701A1 (fr)
PE (1) PE103799A1 (fr)
PL (1) PL338477A1 (fr)
PT (1) PT1000086E (fr)
SK (1) SK1012000A3 (fr)
TN (1) TNSN98146A1 (fr)
TW (1) TW538043B (fr)
UY (1) UY25113A1 (fr)
WO (1) WO1999006430A1 (fr)
YU (1) YU2500A (fr)
ZA (1) ZA986874B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ECSP003699A (es) * 1999-10-08 2002-04-23 Smithkline Beecham Corp Inhibidores de fab i
EP1121933A1 (fr) * 2000-02-02 2001-08-08 Pfizer Products Inc. Compositions prémélangées injectables d'alatrofloxacin
DE60230934D1 (de) 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
EP1575951B1 (fr) 2002-12-06 2014-06-25 Debiopharm International SA Composes heterocycliques, procedes de production de ceux-ci et utilisation de ceux-ci dans un traitement
WO2004082586A2 (fr) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Compositions comportant plusieurs agents antibiotiques, et leurs procedes de mise en oeuvre
CA2467321A1 (fr) * 2004-05-14 2005-11-14 Paul J. Santerre Agents de couplage polymeres et polymeres ayant une activite pharmaceutique produits a partir de ceux-ci
US8450307B2 (en) 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
CA2632476A1 (fr) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Agents therapeutiques et ses procedes de fabrication et d'utilisation
EP2687533B1 (fr) 2006-07-20 2017-07-19 Debiopharm International SA Dérivés d'acrylamide en tant qu'inhibiteurs de FAB I
WO2008098374A1 (fr) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Sels, promédicaments et polymorphes d'inhibiteurs de fab 1
KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
RU2716164C2 (ru) * 2014-04-25 2020-03-06 Наурекс, Инк. Стабильные композиции нейроактивных пептидов
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
CA3087898A1 (fr) 2018-02-02 2019-08-08 Ripple Therapeutics Corporation Formulations de verre comprenant des dimeres steroidiens et utilisations associees
WO2020154815A1 (fr) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Formes cristallines de dimères de dexaméthasone et leurs utilisations
MY203711A (en) 2019-02-14 2024-07-15 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
JP7418475B2 (ja) 2019-06-14 2024-01-19 デバイオファーム インターナショナル エス．エー． バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用
US12509469B2 (en) 2019-08-07 2025-12-30 Ripple Therapeutics Corporation Compositions and methods for the treatment of pain and dependence disorders
JP2023524494A (ja) 2020-05-01 2023-06-12 リップル セラピューティクス コーポレーション 眼障害を処置するためのヘテロ二量体組成物と方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3713672A1 (de) 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
US5256791A (en) 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
RU2147303C1 (ru) 1994-01-18 2000-04-10 Пфайзер Инк. Промежуточные продукты и способ получения солей нафтиридонкарбоновой кислоты
TW420610B (en) 1994-04-07 2001-02-01 Pfizer A pharmaceutical composition for treating a H. pylori infection or gastric or duodenal ulcers
US5475116A (en) 1994-04-29 1995-12-12 Pfizer Inc. Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones
CA2223404C (fr) 1995-06-06 2001-01-16 Thomas A. Morris Nouvelle forme de cristal de sel anhydre d'acide methane-sulfonique et d'acide 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphtyridine-3 carboxylique
US5939550A (en) * 1995-06-15 1999-08-17 Pfizer Inc. Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide
IL122652A (en) * 1995-08-29 2000-01-31 Pfizer Polymorphs of the pro drug 6-n-(l-ala-l-ala)- trovafloxacin their preparation and pharmaceutical compositions containing them
PL325170A1 (en) 1995-08-29 1998-07-06 Pfizer Bipolar forms of throwaflocacin
GB9524466D0 (en) 1995-11-30 1996-01-31 Pfizer Ltd Process
JPH1087617A (ja) 1996-07-09 1998-04-07 Pfizer Inc キノリン系抗生物質の合成に有用な中間体の製法

Also Published As

Publication number Publication date
JP2001512133A (ja) 2001-08-21
PE103799A1 (es) 1999-10-25
HUP0004793A2 (hu) 2001-04-28
DE69821767T2 (de) 2005-01-13
PL338477A1 (en) 2000-11-06
TW538043B (en) 2003-06-21
KR20010022495A (ko) 2001-03-15
NO20000485L (no) 2000-03-27
TNSN98146A1 (fr) 2005-03-15
CA2296466A1 (fr) 1999-02-11
PT1000086E (pt) 2004-05-31
AU8236898A (en) 1999-02-22
IL134156A0 (en) 2001-04-30
NZ502249A (en) 2001-11-30
EP1000086A1 (fr) 2000-05-17
DE69821767D1 (de) 2004-03-25
CA2296466C (fr) 2003-04-15
SK1012000A3 (en) 2000-09-12
IS5339A (is) 2000-01-14
JP3463928B2 (ja) 2003-11-05
GT199800112A (es) 2000-01-15
DK1000086T3 (da) 2004-05-17
ID24374A (id) 2000-07-13
HN1998000106A (es) 1999-01-08
WO1999006430A1 (fr) 1999-02-11
AU734863B2 (en) 2001-06-21
MA24626A1 (fr) 1999-04-01
CN1265671A (zh) 2000-09-06
YU2500A (sh) 2002-09-19
AP1031A (en) 2001-12-21
HRP980417A2 (en) 1999-08-31
EA002120B1 (ru) 2001-12-24
AR015417A1 (es) 2001-05-02
US6194429B1 (en) 2001-02-27
UY25113A1 (es) 2000-12-29
NO20000485D0 (no) 2000-01-31
CO4970688A1 (es) 2000-11-07
HRP980417B1 (en) 2002-10-31
ZA986874B (en) 2000-01-31
AP9801310A0 (en) 1998-09-30
HUP0004793A3 (en) 2001-10-29
ATE259827T1 (de) 2004-03-15
EP1000086B1 (fr) 2004-02-18
ES2214716T3 (es) 2004-09-16
EA200000086A1 (ru) 2000-08-28
BR9811580A (pt) 2000-08-22
PA8456701A1 (es) 2000-05-24
OA11281A (en) 2002-11-19
DZ2576A1 (fr) 2003-02-22

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