BG107329A - 3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity - Google Patents

3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity

Info

Publication number: BG107329A
Authority: BG; Bulgaria
Prior art keywords: opiate; azabicyclo; pharmaceutically; opioid receptor; receptors
Prior art date: 2000-06-23

Application number

BG107329A

Other languages

Bulgarian (bg)

English (en)

Inventor

Bernard BANKS

Douglas CRITCHER

Ashley FENWICK

David GETHIN

Stephen GIBSON

Graham Lunn

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2002-11-28

Publication date

2003-07-31

2002-11-28 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2003-07-31 Publication of BG107329A publication Critical patent/BG107329A/xx

Links

108090000137 Opioid Receptors Proteins 0.000 title abstract 3
102000003840 Opioid Receptors Human genes 0.000 title abstract 3
150000005228 3‐azabicyclo[3.1.0]hexanes Chemical class 0.000 title 1
208000007848 Alcoholism Diseases 0.000 abstract 1
206010003645 Atopy Diseases 0.000 abstract 1
206010010774 Constipation Diseases 0.000 abstract 1
206010012434 Dermatitis allergic Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
206010019196 Head injury Diseases 0.000 abstract 1
206010028813 Nausea Diseases 0.000 abstract 1
208000012488 Opiate Overdose Diseases 0.000 abstract 1
101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108700023159 delta Opioid Receptors Proteins 0.000 abstract 1
102000048124 delta Opioid Receptors Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
230000008693 nausea Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
230000001823 pruritic effect Effects 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
230000035939 shock Effects 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
230000000391 smoking effect Effects 0.000 abstract 1
230000008673 vomiting Effects 0.000 abstract 1
108020001588 κ-opioid receptors Proteins 0.000 abstract 1
108020001612 μ-opioid receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BG107329A 2000-06-23 2002-11-28 3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity BG107329A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en)	2000-06-23	2001-06-07	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (1)

Publication Number	Publication Date
BG107329A true BG107329A (en)	2003-07-31

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107329A BG107329A (en)	2000-06-23	2002-11-28	3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (pl)
JP (1)	JP2004512263A (pl)
KR (1)	KR20040002386A (pl)
CN (1)	CN1639121A (pl)
AP (1)	AP2002002698A0 (pl)
AR (1)	AR028969A1 (pl)
AU (1)	AU781837B2 (pl)
BG (1)	BG107329A (pl)
BR (1)	BR0111867A (pl)
CA (1)	CA2412188A1 (pl)
CZ (1)	CZ20023967A3 (pl)
DO (1)	DOP2001000187A (pl)
DZ (1)	DZ3368A1 (pl)
EA (1)	EA005117B1 (pl)
GB (1)	GB0015562D0 (pl)
HR (1)	HRP20020998A2 (pl)
HU (1)	HUP0301228A3 (pl)
IL (1)	IL153427A0 (pl)
IS (1)	IS6637A (pl)
MA (1)	MA26915A1 (pl)
MX (1)	MXPA02012878A (pl)
NO (1)	NO20026168L (pl)
NZ (1)	NZ523141A (pl)
OA (1)	OA12293A (pl)
PA (1)	PA8519401A1 (pl)
PE (1)	PE20020253A1 (pl)
PL (1)	PL365956A1 (pl)
SK (1)	SK17172002A3 (pl)
TN (1)	TNSN01094A1 (pl)
UA (1)	UA73176C2 (pl)
UY (1)	UY26787A1 (pl)
WO (1)	WO2001098267A1 (pl)
YU (1)	YU91802A (pl)
ZA (1)	ZA200210278B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1440059B1 (en) *	2001-10-22	2008-04-16	Pfizer Products Inc.	3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists
US20050176746A1 (en) *	2002-05-17	2005-08-11	Frank Weber	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (de)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivate des Asimadolins mit kovalent gebundenen Säuren
PE20051173A1 (es)	2004-02-23	2006-02-14	Glaxo Group Ltd	Compuestos azabiciclico (3.1.0) hexanos como moduladores de receptores de dopamina d3
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
WO2006133945A1 (en) *	2005-06-14	2006-12-21	Glaxo Group Limited	Novel compounds
US8163927B2 (en)	2006-04-03	2012-04-24	Glaxo Group Limited	Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors
CN101677997B (zh)	2007-03-30	2012-05-09	泰奥加制药公司	用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
CA2802295C (en)	2010-06-11	2016-09-20	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013542929A (ja)	2010-09-28	2013-11-28	パナセアバイオテックリミテッド	新規ビシクロ環化合物
US9663463B2 (en) *	2013-11-20	2017-05-30	Sanwa Kagaku Kenkyusho Co., Ltd.	3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose
KR20180004734A (ko)	2015-05-20	2018-01-12	가부시키가이샤산와카가쿠켄큐쇼	신규 3-아자비시클로［3.1.0］헥산 유도체의 염의 결정 및 그의 의약 용도
BR112019016827A2 (pt)	2017-02-17	2020-04-07	Trevena Inc	compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
US11225487B2 (en)	2017-02-17	2022-01-18	Trevena, Inc.	7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same
CN110352055A (zh)	2017-03-02	2019-10-18	株式会社三和化学研究所	酒精使用障碍的治疗药物
CN108250088B (zh) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) *	2022-10-21	2024-09-20	昆明理工大学	一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
CA1321792C (en) *	1987-04-16	1993-08-31	Eli Lilly And Company	Piperidine opioid antagonists
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/pl not_active Application Discontinuation
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/xx active
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
2002
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20026168D0 (no)	2002-12-20
EA005117B1 (ru)	2004-10-28
ZA200210278B (en)	2003-12-19
PA8519401A1 (es)	2002-12-30
UA73176C2 (en)	2005-06-15
MXPA02012878A (es)	2003-05-14
IS6637A (is)	2002-11-28
DOP2001000187A (es)	2002-03-30
CZ20023967A3 (cs)	2004-02-18
JP2004512263A (ja)	2004-04-22
CN1639121A (zh)	2005-07-13
KR20040002386A (ko)	2004-01-07
PE20020253A1 (es)	2002-04-08
HUP0301228A3 (en)	2005-08-29
IL153427A0 (en)	2003-07-06
AU6259101A (en)	2002-01-02
BR0111867A (pt)	2003-07-01
SK17172002A3 (sk)	2004-09-08
GB0015562D0 (en)	2000-08-16
AP2002002698A0 (en)	2002-12-31
NZ523141A (en)	2005-06-24
AR028969A1 (es)	2003-05-28
EP1292574A1 (en)	2003-03-19
PL365956A1 (pl)	2005-01-24
TNSN01094A1 (fr)	2005-11-10
HRP20020998A2 (en)	2004-02-29
DZ3368A1 (fr)	2001-12-27
NO20026168L (no)	2003-02-18
AU781837B2 (en)	2005-06-16
WO2001098267A8 (en)	2003-02-27
UY26787A1 (es)	2002-01-31
OA12293A (en)	2004-03-18
WO2001098267A1 (en)	2001-12-27
CA2412188A1 (en)	2001-12-27
YU91802A (sh)	2006-05-25
MA26915A1 (fr)	2004-12-20
EA200201269A1 (ru)	2003-06-26
HUP0301228A2 (hu)	2003-08-28

Publication	Publication Date	Title
BG107329A (en)	2003-07-31	3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity
WO2005080343A3 (en)	2006-01-12	3-substituted 1,5-diphenylpyrazole derivatives useful as cb1 modulators
TW200503713A (en)	2005-02-01	Novel compounds
HK1049333A1 (zh)	2003-05-09	以环状琥珀酸酯代替内酰胺，作为制造Aβ蛋白质的抑制剂
WO2007095223A3 (en)	2010-06-24	Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases
WO2005028475A3 (en)	2005-06-09	Compositions useful as inhibitors of protein kinases
UA84930C2 (ru)	2008-12-10	Пиррольные соединения как ингибиторы протеинкиназ erk, их синтез и соответствующие промежуточные соединения
WO2002036596A3 (en)	2002-10-24	CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2007120647A3 (en)	2007-11-29	Compositions useful as inhibitors of voltage-gated sodium channels
WO2004087698A3 (en)	2004-12-09	Thiazoles useful as inhibitors of protein kinases
MY138478A (en)	2009-06-30	Benzazepine derivatives for the treatment of neurological disorders
TW200505921A (en)	2005-02-16	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
GEP20043366B (en)	2004-04-13	Benzothiophene Derivative Compounds Process of Preparation and Use Thereof
TW200503710A (en)	2005-02-01	Novel compounds
WO2009125923A3 (en)	2009-12-03	Novel indol carboxylic acid bispyridyl carboxamide derivatives, pharmaceutically acceptable salt thereof, preparation method and composition containing the same as an active ingredient
TW200514781A (en)	2005-05-01	Novel compounds
DE602004024188D1 (de)	2009-12-31	Des opioid-rezeptors
CY1110711T1 (el)	2015-06-10	Παραγωγα πυραζολο [3,4-d]αζεπινης ως ανταγωνιστες ισταμινης η3
WO2006067428A3 (en)	2007-12-06	1, 2-diphenyl-imidazole derivatives and their use as cb1 receptor ligands
WO2002011732A8 (en)	2002-06-20	Novel bicyclic and tricyclic pyrrolidine derivatives as gnrh antagonists
WO2004089908A3 (en)	2004-12-23	3-azabicyclo[3.2.1]octane derivatives
MX2007006754A (es)	2007-07-09	Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
AU2007288444A8 (en)	2013-05-09	Process for the synthesis of (+) and (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
WO2005035504A3 (en)	2005-06-30	5-h -benzo [d] naphth [2, 1-b] azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders
UA81464C2 (en)	2008-01-10	NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS