BG62875B1 - Циклоспоринови състави за орално приемане - Google Patents

Циклоспоринови състави за орално приемане Download PDF

Info

Publication number: BG62875B1
Authority: BG; Bulgaria
Prior art keywords: composition; cyclosporine; cyclosporin; carbon atoms; solvent
Prior art date: 1995-08-25

Application number

BG101443A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG101443A (en

Inventor

Moo Cho

Ralph Levy

Philippe Pouletty

Robert Floch

Christian Merle

Original Assignee

Sangstat Medical Corporation

University Of North Carolina At Chapel Hill

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-25

Filing date

1997-04-25

Publication date

2000-10-31

1995-08-25 Priority claimed from US08/519,689 external-priority patent/US5834017A/en

1996-03-21 Priority claimed from US08/620,021 external-priority patent/US5766629A/en

1996-03-25 Priority claimed from US08/622,516 external-priority patent/US5827822A/en

1997-04-25 Application filed by Sangstat Medical Corporation, University Of North Carolina At Chapel Hill filed Critical Sangstat Medical Corporation

1998-03-31 Publication of BG101443A publication Critical patent/BG101443A/xx

2000-10-31 Publication of BG62875B1 publication Critical patent/BG62875B1/bg

Links

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229920001477 hydrophilic polymer Polymers 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
208000016036 idiopathic nephrotic syndrome Diseases 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
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239000003018 immunosuppressive agent Substances 0.000 description 1
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235000010445 lecithin Nutrition 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
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238000012417 linear regression Methods 0.000 description 1
229940049918 linoleate Drugs 0.000 description 1
DTOSIQBPPRVQHS-PDBXOOCHSA-M linolenate Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC([O-])=O DTOSIQBPPRVQHS-PDBXOOCHSA-M 0.000 description 1
229940040452 linolenate Drugs 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
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229920000609 methyl cellulose Polymers 0.000 description 1
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235000010981 methylcellulose Nutrition 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229940113115 polyethylene glycol 200 Drugs 0.000 description 1
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239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
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102000004169 proteins and genes Human genes 0.000 description 1
230000001185 psoriatic effect Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
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230000004044 response Effects 0.000 description 1
239000004576 sand Substances 0.000 description 1
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239000004945 silicone rubber Substances 0.000 description 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
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210000003491 skin Anatomy 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
238000009987 spinning Methods 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
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230000004083 survival effect Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
229960001967 tacrolimus Drugs 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
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235000013311 vegetables Nutrition 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
Dispersion Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

BG101443A 1995-08-25 1997-04-25 Циклоспоринови състави за орално приемане BG62875B1 (bg)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/519,689 US5834017A (en)	1995-08-25	1995-08-25	Oral cyclopsporin formulations
US08/620,021 US5766629A (en)	1995-08-25	1996-03-21	Oral cyclosporin formulations
US08/622,516 US5827822A (en)	1996-03-25	1996-03-25	Cyclosporin a formulations as nanoparticles
PCT/US1996/012569 WO1997007787A1 (en)	1995-08-25	1996-07-31	Oral cyclosporin formulations

Publications (2)

Publication Number	Publication Date
BG101443A BG101443A (en)	1998-03-31
BG62875B1 true BG62875B1 (bg)	2000-10-31

Family

ID=27414735

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG101443A BG62875B1 (bg)	1995-08-25	1997-04-25	Циклоспоринови състави за орално приемане

Country Status (26)

Country	Link
EP (1)	EP0789561B1 (es)
JP (1)	JP3009742B2 (es)
KR (1)	KR100294935B1 (es)
CN (1)	CN1164828A (es)
AR (1)	AR001985A1 (es)
AT (1)	ATE263550T1 (es)
AU (1)	AU709548B2 (es)
BG (1)	BG62875B1 (es)
BR (1)	BR9606603A (es)
CA (1)	CA2202887A1 (es)
CZ (1)	CZ124897A3 (es)
DE (2)	DE789561T1 (es)
ES (1)	ES2129381T1 (es)
GE (1)	GEP20012547B (es)
HU (1)	HUP9801052A3 (es)
IL (1)	IL120673A0 (es)
IS (1)	IS4460A (es)
MX (1)	MX9702809A (es)
NO (1)	NO971890L (es)
NZ (1)	NZ313899A (es)
PL (1)	PL319898A1 (es)
RO (1)	RO119815B1 (es)
SI (1)	SI9620014A (es)
SK (1)	SK53697A3 (es)
TW (1)	TW460287B (es)
WO (1)	WO1997007787A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
WO1998040094A1 (en) *	1997-03-12	1998-09-17	Abbott Laboratories	Hydrophilic binary systems for the administration of cyclosporine
WO1999019471A1 (en)	1997-10-16	1999-04-22	Board Of Regents, The University Of Texas System	Models and treatments for cardiac hypertrophy in relation with nf-at3 function
EP1154759B1 (en)	1998-12-30	2008-08-13	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosporin
US6656504B1 (en) *	1999-09-09	2003-12-02	Elan Pharma International Ltd.	Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
HRP20040354B1 (en) *	2001-10-19	2012-10-31	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates
EP2079456B1 (en)	2007-04-04	2012-12-05	Sigmoid Pharma Limited	Pharmaceutical cyclosporin compositions
EP2586428B1 (en)	2007-04-26	2023-11-08	Sublimity Therapeutics Limited	Manufacture of multiple minicapsules
US20090130198A1 (en) *	2007-11-21	2009-05-21	Innopharmax Inc.	Pharmaceutical composition with enhanced bioavailability
ES2649112T3 (es)	2009-05-18	2018-01-10	Sigmoid Pharma Limited	Composición que comprende gotas de aceite
CN107582526A (zh)	2009-08-12	2018-01-16	希格默伊德药业有限公司	包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en)	2010-11-25	2011-01-12	Sigmoid Pharma Ltd	Composition
GB201212010D0 (en)	2012-07-05	2012-08-22	Sigmoid Pharma Ltd	Formulations
GB201304662D0 (en)	2013-03-14	2013-05-01	Sigmoid Pharma Ltd	Compositions
GB201319791D0 (en)	2013-11-08	2013-12-25	Sigmoid Pharma Ltd	Formulations
EP3881829A1 (en)	2014-11-07	2021-09-22	Sublimity Therapeutics Limited	Compositions comprising cyclosporin
CN104940132B (zh) *	2015-06-05	2018-02-27	河南牧翔动物药业有限公司	一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
HU201567B (en) *	1988-07-21	1990-11-28	Gyogyszerkutato Intezet	Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) *	1988-09-16	1994-08-30	Sandoz Ltd.	Pharmaceutical compositions comprising cyclosporins
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
EP1142568A1 (en) *	1992-09-25	2001-10-10	Novartis AG	Pharmaceutical compositions containing cyclosporins
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
AU715165B2 (en) *	1994-11-03	2000-01-20	Novartis Ag	Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them

1996
- 1996-07-31 EP EP96926214A patent/EP0789561B1/en not_active Expired - Lifetime
- 1996-07-31 AT AT96926214T patent/ATE263550T1/de not_active IP Right Cessation
- 1996-07-31 JP JP9510271A patent/JP3009742B2/ja not_active Expired - Fee Related
- 1996-07-31 BR BR9606603A patent/BR9606603A/pt not_active IP Right Cessation
- 1996-07-31 CZ CZ971248A patent/CZ124897A3/cs unknown
- 1996-07-31 ES ES96926214T patent/ES2129381T1/es active Pending
- 1996-07-31 CN CN96190962A patent/CN1164828A/zh active Pending
- 1996-07-31 HU HU9801052A patent/HUP9801052A3/hu unknown
- 1996-07-31 KR KR1019970702717A patent/KR100294935B1/ko not_active Expired - Fee Related
- 1996-07-31 SI SI9620014A patent/SI9620014A/sl unknown
- 1996-07-31 IL IL12067396A patent/IL120673A0/xx unknown
- 1996-07-31 RO RO97-00765A patent/RO119815B1/ro unknown
- 1996-07-31 PL PL96319898A patent/PL319898A1/xx unknown
- 1996-07-31 WO PCT/US1996/012569 patent/WO1997007787A1/en not_active Ceased
- 1996-07-31 NZ NZ313899A patent/NZ313899A/xx unknown
- 1996-07-31 DE DE0789561T patent/DE789561T1/de active Pending
- 1996-07-31 MX MX9702809A patent/MX9702809A/es unknown
- 1996-07-31 DE DE69632125T patent/DE69632125T2/de not_active Expired - Fee Related
- 1996-07-31 CA CA002202887A patent/CA2202887A1/en not_active Abandoned
- 1996-07-31 AU AU66441/96A patent/AU709548B2/en not_active Withdrawn - After Issue
- 1996-07-31 SK SK536-97A patent/SK53697A3/sk unknown
- 1996-07-31 GE GEAP19963706A patent/GEP20012547B/en unknown
- 1996-08-23 AR ARP960104092A patent/AR001985A1/es unknown
- 1996-09-23 TW TW085111622A patent/TW460287B/zh not_active IP Right Cessation
1997
- 1997-04-08 IS IS4460A patent/IS4460A/is unknown
- 1997-04-24 NO NO971890A patent/NO971890L/no not_active Application Discontinuation
- 1997-04-25 BG BG101443A patent/BG62875B1/bg unknown

Also Published As

Publication number	Publication date
IL120673A0 (en)	1997-08-14
DE69632125D1 (de)	2004-05-13
NZ313899A (en)	2000-03-27
SK53697A3 (en)	1997-10-08
EP0789561A1 (en)	1997-08-20
DE69632125T2 (de)	2004-09-16
AU709548B2 (en)	1999-09-02
MX9702809A (es)	1998-02-28
BR9606603A (pt)	1997-09-30
JPH10509462A (ja)	1998-09-14
HUP9801052A3 (en)	1998-12-28
ES2129381T1 (es)	1999-06-16
NO971890D0 (no)	1997-04-24
EP0789561A4 (en)	1998-12-02
PL319898A1 (en)	1997-09-01
GEP20012547B (en)	2001-10-25
RO119815B1 (ro)	2005-04-29
CA2202887A1 (en)	1997-03-06
HK1001956A1 (en)	1998-07-24
JP3009742B2 (ja)	2000-02-14
SI9620014A (sl)	1998-04-30
AR001985A1 (es)	1998-01-07
HUP9801052A2 (hu)	1998-09-28
IS4460A (is)	1997-04-08
WO1997007787A1 (en)	1997-03-06
AU6644196A (en)	1997-03-19
CZ124897A3 (en)	1997-09-17
ATE263550T1 (de)	2004-04-15
DE789561T1 (de)	1999-06-10
KR100294935B1 (ko)	2001-07-12
TW460287B (en)	2001-10-21
KR970706803A (ko)	1997-12-01
BG101443A (en)	1998-03-31
CN1164828A (zh)	1997-11-12
NO971890L (no)	1997-04-24
EP0789561B1 (en)	2004-04-07

Publication	Publication Date	Title
US6254885B1 (en)	2001-07-03	Oral cyclosphorin formulations
RU2174405C2 (ru)	2001-10-10	Композиция циклоспорина для перорального введения (варианты) и способ достижения иммуносупрессии в организме реципиента
BG62875B1 (bg)	2000-10-31	Циклоспоринови състави за орално приемане
KR0170769B1 (ko)	1999-02-01	신규한 사이클로스포린 갈렌 제제
US5834017A (en)	1998-11-10	Oral cyclopsporin formulations
HUT70947A (en)	1995-11-28	Injectable rapamycin solutions and process for producing them
MXPA97002809A (es)	1998-02-01	Formulaciones orales de ciclosporina
RU2178293C2 (ru)	2002-01-20	Фармацевтическая композиция, содержащая циклоспорин, способ получения мягких желатиновых капсул
SG11202110546UA (en)	2021-10-28	Formulation for oral delivery of proteins, peptides and small molecules with poor permeability
KR100308779B1 (ko)	2001-11-15	사이클로스포린을함유한신규조성물
RU2172183C2 (ru)	2001-08-20	Оральные циклоспориновые составы
AU762963B2 (en)	2003-07-10	Cyclosporin solution
AU764599B2 (en)	2003-08-21	Oral cyclosporin formulations
NZ502344A (en)	2001-09-28	Oral cyclosporin compositions wherein it is a suspension of less than 1 micrometer, non-ionic polyoxyalkylene surfactant and one alkanol solvent
HK1001956B (en)	2005-02-08	Oral cyclosporin formulations
CZ233799A3 (cs)	2000-01-12	Perorální farmaceutické přípravky cyklosporinu
RU2207870C2 (ru)	2003-07-10	Фармацевтическая композиция, включающая циклоспорин в качестве активного ингредиента
KR0173349B1 (ko)	1999-02-01	사이클로스포린-함유 고체 분산체 조성물
HK1025916A (en)	2000-12-01	Oral cyclosporin formulations
AU2026202738A1 (en)	2026-04-30	Formulation for oral delivery of proteins, peptides and small molecules with poor permeability