BG64337B1 - Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа - Google Patents

Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа Download PDF

Info

Publication number
BG64337B1
BG64337B1 BG104133A BG10413300A BG64337B1 BG 64337 B1 BG64337 B1 BG 64337B1 BG 104133 A BG104133 A BG 104133A BG 10413300 A BG10413300 A BG 10413300A BG 64337 B1 BG64337 B1 BG 64337B1
Authority
BG
Bulgaria
Prior art keywords
hemihydrate
nevirapine
solution
nevirapine hemihydrate
water
Prior art date
Application number
BG104133A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104133A (bg
Inventor
Karl Grozinger
Amale Hawi
Original Assignee
Boehringer Ingelheim Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22006658&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64337(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharmaceuticals, Inc. filed Critical Boehringer Ingelheim Pharmaceuticals, Inc.
Publication of BG104133A publication Critical patent/BG104133A/xx
Publication of BG64337B1 publication Critical patent/BG64337B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG104133A 1997-08-25 2000-02-07 Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа BG64337B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5680397P 1997-08-25 1997-08-25

Publications (2)

Publication Number Publication Date
BG104133A BG104133A (bg) 2000-08-31
BG64337B1 true BG64337B1 (bg) 2004-10-29

Family

ID=22006658

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104133A BG64337B1 (bg) 1997-08-25 2000-02-07 Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа

Country Status (37)

Country Link
US (2) US6172059B1 (cs)
EP (1) EP1019058B1 (cs)
JP (1) JP3472261B2 (cs)
KR (1) KR100426516B1 (cs)
CN (1) CN1197578C (cs)
AR (2) AR016869A1 (cs)
AT (1) ATE326971T1 (cs)
AU (1) AU742761B2 (cs)
BG (1) BG64337B1 (cs)
BR (1) BR9811994B1 (cs)
CA (1) CA2301646C (cs)
CL (1) CL2008003111A1 (cs)
CO (1) CO4970742A1 (cs)
CY (1) CY1105228T1 (cs)
CZ (1) CZ290667B6 (cs)
DE (1) DE69834655T2 (cs)
DK (1) DK1019058T3 (cs)
EG (1) EG24075A (cs)
ES (1) ES2265666T3 (cs)
HR (1) HRP980461B1 (cs)
HU (1) HU226063B1 (cs)
ID (1) ID21650A (cs)
IL (1) IL134185A (cs)
MY (1) MY122272A (cs)
NO (1) NO326226B1 (cs)
NZ (1) NZ503414A (cs)
PE (1) PE105799A1 (cs)
PL (1) PL192361B1 (cs)
PT (1) PT1019058E (cs)
RS (1) RS49808B (cs)
RU (1) RU2196584C2 (cs)
SA (1) SA98190680B1 (cs)
TR (1) TR200000490T2 (cs)
TW (1) TW450812B (cs)
UA (1) UA44370C2 (cs)
WO (1) WO1999009990A1 (cs)
ZA (1) ZA987623B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092095A1 (en) * 2001-05-11 2002-11-21 Boehringer Ingelheim International Gmbh Use of nevirapine to treat or prevent lipid pathology in patients with hiv that is resistant to nevirapine
EP1504040A1 (en) * 2002-04-23 2005-02-09 Boehringer Ingelheim Pharmaceuticals Inc. Method for reduction of residual organic solvent in carbomer
KR20080053317A (ko) * 2005-08-31 2008-06-12 씨아이피엘에이 엘티디. 라미부딘, 스타부딘 및 네비라핀을 포함하는 약학적 조합물
EP2306980A2 (en) * 2008-06-30 2011-04-13 Tibotec Pharmaceuticals Powders for reconstitution
CA2949127C (en) * 2009-11-10 2019-04-09 North-West University Method for increasing the solubility of a transcriptase inhibitor composition
CN102725293A (zh) * 2009-12-17 2012-10-10 西北大学 奈韦拉平的多晶型形式及其制备

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429987A2 (en) * 1989-11-17 1991-06-05 Boehringer Ingelheim Pharmaceuticals Inc. 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5569760A (en) * 1994-02-03 1996-10-29 Boehringer Ingelheim Kg Process for preparing nevirapine
US5571912A (en) * 1990-10-19 1996-11-05 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE103918T1 (de) * 1989-06-28 1994-04-15 Boehringer Ingelheim Pharma 5,11-dihydro-6h-dipyrido(3,2-b:2',3'e>(1,4>diazepin-6-one und -thione und ihre verwendung bei der aids-vorbeugung oder behandlung.
GB9215178D0 (en) * 1992-07-16 1992-08-26 Glaxo Group Ltd Antiviral combinations
JP3000564B2 (ja) * 1993-12-15 2000-01-17 メルク エンド カンパニー インコーポレーテッド Ｈｉｖプロテアーゼ阻害剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
EP0429987A2 (en) * 1989-11-17 1991-06-05 Boehringer Ingelheim Pharmaceuticals Inc. 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
US5571912A (en) * 1990-10-19 1996-11-05 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines
US5569760A (en) * 1994-02-03 1996-10-29 Boehringer Ingelheim Kg Process for preparing nevirapine

Also Published As

Publication number Publication date
BG104133A (bg) 2000-08-31
HRP980461B1 (en) 2002-08-31
SA98190680B1 (ar) 2006-04-04
CY1105228T1 (el) 2010-03-03
JP3472261B2 (ja) 2003-12-02
TW450812B (en) 2001-08-21
HUP0003093A2 (hu) 2001-08-28
KR20010023257A (ko) 2001-03-26
MY122272A (en) 2006-04-29
DE69834655T2 (de) 2006-12-14
CN1197578C (zh) 2005-04-20
ES2265666T3 (es) 2007-02-16
US6255481B1 (en) 2001-07-03
RS49808B (sr) 2008-08-07
CA2301646A1 (en) 1999-03-04
EG24075A (en) 2008-05-11
NO326226B1 (no) 2008-10-20
ZA987623B (en) 2000-03-22
CZ2000694A3 (cs) 2000-09-13
ATE326971T1 (de) 2006-06-15
AR016869A1 (es) 2001-08-01
AU8777198A (en) 1999-03-16
EP1019058B1 (en) 2006-05-24
DK1019058T3 (da) 2006-06-12
HK1027975A1 (en) 2001-02-02
HU226063B1 (hu) 2008-04-28
NZ503414A (en) 2002-11-26
IL134185A (en) 2005-11-20
PE105799A1 (es) 1999-11-16
KR100426516B1 (ko) 2004-04-13
JP2001513564A (ja) 2001-09-04
CZ290667B6 (cs) 2002-09-11
US6172059B1 (en) 2001-01-09
WO1999009990A1 (en) 1999-03-04
ID21650A (id) 1999-07-08
AR083451A2 (es) 2013-02-27
CO4970742A1 (es) 2000-11-07
PL338828A1 (en) 2000-11-20
NO20000906D0 (no) 2000-02-24
EP1019058A1 (en) 2000-07-19
NO20000906L (no) 2000-02-24
CN1268055A (zh) 2000-09-27
EP1019058A4 (en) 2004-11-10
TR200000490T2 (tr) 2000-08-21
CA2301646C (en) 2008-11-18
IL134185A0 (en) 2001-04-30
YU9800A (sh) 2001-12-26
PL192361B1 (pl) 2006-10-31
BR9811994A (pt) 2000-09-05
CL2008003111A1 (es) 2009-09-11
UA44370C2 (uk) 2002-02-15
PT1019058E (pt) 2006-08-31
RU2196584C2 (ru) 2003-01-20
HRP980461A2 (en) 1999-06-30
AU742761B2 (en) 2002-01-10
BR9811994B1 (pt) 2013-11-19
DE69834655D1 (de) 2006-06-29

Similar Documents

Publication Publication Date Title
US6169084B1 (en) 2-methyl-thieno-benzodiazepine formulation
JPH04234817A (ja) オメプラゾールの直腸投与組成物
KR880002087B1 (ko) 항균성 나프티리딘 또는 퀴놀린 화합물의 염 및 그의 제조방법
JP4551988B2 (ja) ２−メチル−チエノ−ベンゾジアゼピン製剤
KR101468153B1 (ko) 5α-안드로스테인-3β,5,6β-트리올 주사제 및 제조방법
BG64337B1 (bg) Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа
SK14152003A3 (sk) Pediatrický prípravok gatifloxacínu
US7303764B2 (en) 2-methyl-thieno-benzodiazepine formulation
KR20000069376A (ko) 데스페리옥사민의 제제 및 다형 형태, 및 이의 제조 방법
CA2617000C (en) Methods for preparing nevirapine hemihydrate and an aqueous suspension thereof
MXPA00001392A (en) Pharmaceutical suspension comprising nevirapine hemihydrate
EP0733368A1 (en) Granule fomulation for olanzapine
JPH09323934A (ja) 保存安定性の改善された坐剤
HK1027975B (en) Pharmaceutical suspension comprising nevirapine hemihydrate
JP3281872B2 (ja) ７−イソインドリン−３−キノリンカルボン酸の塩、その水和物およびそれらを活性成分とする組成物
CN110279664A (zh) 一种氟苯尼考包合物冻干粉针剂及其制备方法
JPH09323933A (ja) 安定性の改善された坐剤
KR20050034298A (ko) 암로디핀을 함유하는 연질캡슐제 조성물 및 그 제조방법