BG64337B1 - Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа - Google Patents

Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа Download PDF

Info

Publication number: BG64337B1
Authority: BG; Bulgaria
Prior art keywords: hemihydrate; nevirapine; solution; nevirapine hemihydrate; water
Prior art date: 1997-08-25

Application number

BG104133A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG104133A (bg

Inventor

Karl Grozinger

Amale Hawi

Original Assignee

Boehringer Ingelheim Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-25

Filing date

2000-02-07

Publication date

2004-10-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22006658&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64337(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-02-07 Application filed by Boehringer Ingelheim Pharmaceuticals, Inc. filed Critical Boehringer Ingelheim Pharmaceuticals, Inc.

2000-08-31 Publication of BG104133A publication Critical patent/BG104133A/xx

2004-10-29 Publication of BG64337B1 publication Critical patent/BG64337B1/bg

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG104133A 1997-08-25 2000-02-07 Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа BG64337B1 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5680397P	1997-08-25	1997-08-25

Publications (2)

Publication Number	Publication Date
BG104133A BG104133A (bg)	2000-08-31
BG64337B1 true BG64337B1 (bg)	2004-10-29

Family

ID=22006658

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104133A BG64337B1 (bg)	1997-08-25	2000-02-07	Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа

Country Status (37)

Country	Link
US (2)	US6172059B1 (cs)
EP (1)	EP1019058B1 (cs)
JP (1)	JP3472261B2 (cs)
KR (1)	KR100426516B1 (cs)
CN (1)	CN1197578C (cs)
AR (2)	AR016869A1 (cs)
AT (1)	ATE326971T1 (cs)
AU (1)	AU742761B2 (cs)
BG (1)	BG64337B1 (cs)
BR (1)	BR9811994B1 (cs)
CA (1)	CA2301646C (cs)
CL (1)	CL2008003111A1 (cs)
CO (1)	CO4970742A1 (cs)
CY (1)	CY1105228T1 (cs)
CZ (1)	CZ290667B6 (cs)
DE (1)	DE69834655T2 (cs)
DK (1)	DK1019058T3 (cs)
EG (1)	EG24075A (cs)
ES (1)	ES2265666T3 (cs)
HR (1)	HRP980461B1 (cs)
HU (1)	HU226063B1 (cs)
ID (1)	ID21650A (cs)
IL (1)	IL134185A (cs)
MY (1)	MY122272A (cs)
NO (1)	NO326226B1 (cs)
NZ (1)	NZ503414A (cs)
PE (1)	PE105799A1 (cs)
PL (1)	PL192361B1 (cs)
PT (1)	PT1019058E (cs)
RS (1)	RS49808B (cs)
RU (1)	RU2196584C2 (cs)
SA (1)	SA98190680B1 (cs)
TR (1)	TR200000490T2 (cs)
TW (1)	TW450812B (cs)
UA (1)	UA44370C2 (cs)
WO (1)	WO1999009990A1 (cs)
ZA (1)	ZA987623B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002092095A1 (en) *	2001-05-11	2002-11-21	Boehringer Ingelheim International Gmbh	Use of nevirapine to treat or prevent lipid pathology in patients with hiv that is resistant to nevirapine
CA2479943A1 (en) *	2002-04-23	2003-11-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for reduction of residual organic solvent in carbomer
KR20080053317A (ko) *	2005-08-31	2008-06-12	씨아이피엘에이 엘티디.	라미부딘, 스타부딘 및 네비라핀을 포함하는 약학적 조합물
EP2306980A2 (en) *	2008-06-30	2011-04-13	Tibotec Pharmaceuticals	Powders for reconstitution
US9273049B2 (en) *	2009-11-10	2016-03-01	North-West University	Method for increasing the solubility of nevirapine
CN102725293A (zh) *	2009-12-17	2012-10-10	西北大学	奈韦拉平的多晶型形式及其制备

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0429987A2 (en) *	1989-11-17	1991-06-05	Boehringer Ingelheim Pharmaceuticals Inc.	5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
US5366972A (en) *	1989-04-20	1994-11-22	Boehringer Ingelheim Pharmaceuticals, Inc.	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5569760A (en) *	1994-02-03	1996-10-29	Boehringer Ingelheim Kg	Process for preparing nevirapine
US5571912A (en) *	1990-10-19	1996-11-05	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2063202T3 (es) *	1989-06-28	1995-01-01	Boehringer Ingelheim Pharma	Nuevas 5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepin-6-onas y -tionas y su uso en la prevencion o tratamiento del sida.
GB9215178D0 (en) *	1992-07-16	1992-08-26	Glaxo Group Ltd	Antiviral combinations
HUT74681A (en) *	1993-12-15	1997-01-28	Merck & Co Inc	N-(2-hydroxy-1-indenyl)-2-phenylmethyl-4-hydroxy-5-(2-carboxamido-piperazinyl)-pentaneamide derivatives of hiv protease inhibitor activity and phrmaceutical compositions contining them

1998
- 1998-08-11 IL IL13418598A patent/IL134185A/xx not_active IP Right Cessation
- 1998-08-11 EP EP98939312A patent/EP1019058B1/en not_active Expired - Lifetime
- 1998-08-11 AU AU87771/98A patent/AU742761B2/en not_active Ceased
- 1998-08-11 DK DK98939312T patent/DK1019058T3/da active
- 1998-08-11 WO PCT/US1998/016581 patent/WO1999009990A1/en not_active Ceased
- 1998-08-11 DE DE69834655T patent/DE69834655T2/de not_active Expired - Lifetime
- 1998-08-11 ES ES98939312T patent/ES2265666T3/es not_active Expired - Lifetime
- 1998-08-11 AT AT98939312T patent/ATE326971T1/de active
- 1998-08-11 PL PL338828A patent/PL192361B1/pl unknown
- 1998-08-11 RU RU2000107825/14A patent/RU2196584C2/ru not_active IP Right Cessation
- 1998-08-11 CN CNB988084899A patent/CN1197578C/zh not_active Expired - Fee Related
- 1998-08-11 PE PE1998000718A patent/PE105799A1/es not_active Application Discontinuation
- 1998-08-11 UA UA2000031668A patent/UA44370C2/uk unknown
- 1998-08-11 PT PT98939312T patent/PT1019058E/pt unknown
- 1998-08-11 TR TR2000/00490T patent/TR200000490T2/xx unknown
- 1998-08-11 JP JP2000507380A patent/JP3472261B2/ja not_active Expired - Fee Related
- 1998-08-11 KR KR10-2000-7001889A patent/KR100426516B1/ko not_active Expired - Fee Related
- 1998-08-11 NZ NZ503414A patent/NZ503414A/xx not_active IP Right Cessation
- 1998-08-11 RS YUP-98/00A patent/RS49808B/sr unknown
- 1998-08-11 BR BRPI9811994-0B1A patent/BR9811994B1/pt not_active IP Right Cessation
- 1998-08-11 CZ CZ2000694A patent/CZ290667B6/cs not_active IP Right Cessation
- 1998-08-11 HU HU0003093A patent/HU226063B1/hu not_active IP Right Cessation
- 1998-08-11 US US09/131,829 patent/US6172059B1/en not_active Expired - Lifetime
- 1998-08-11 CA CA002301646A patent/CA2301646C/en not_active Expired - Fee Related
- 1998-08-21 MY MYPI98003819A patent/MY122272A/en unknown
- 1998-08-23 EG EG98398A patent/EG24075A/xx active
- 1998-08-24 CO CO98048247A patent/CO4970742A1/es unknown
- 1998-08-24 ID IDP981156A patent/ID21650A/id unknown
- 1998-08-24 HR HR980461A patent/HRP980461B1/xx not_active IP Right Cessation
- 1998-08-24 ZA ZA9807623A patent/ZA987623B/xx unknown
- 1998-08-24 TW TW087113878A patent/TW450812B/zh not_active IP Right Cessation
- 1998-08-25 AR ARP980104200A patent/AR016869A1/es not_active Application Discontinuation
- 1998-11-01 SA SA98190680A patent/SA98190680B1/ar unknown
2000
- 2000-02-07 BG BG104133A patent/BG64337B1/bg unknown
- 2000-02-24 NO NO20000906A patent/NO326226B1/no not_active IP Right Cessation
- 2000-03-02 US US09/517,564 patent/US6255481B1/en not_active Expired - Lifetime
2006
- 2006-08-11 CY CY20061101147T patent/CY1105228T1/el unknown
2008
- 2008-10-21 CL CL2008003111A patent/CL2008003111A1/es unknown
2011
- 2011-10-14 AR ARP110103815A patent/AR083451A2/es unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5366972A (en) *	1989-04-20	1994-11-22	Boehringer Ingelheim Pharmaceuticals, Inc.	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
EP0429987A2 (en) *	1989-11-17	1991-06-05	Boehringer Ingelheim Pharmaceuticals Inc.	5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
US5571912A (en) *	1990-10-19	1996-11-05	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines
US5569760A (en) *	1994-02-03	1996-10-29	Boehringer Ingelheim Kg	Process for preparing nevirapine

Also Published As

Publication number	Publication date
AU742761B2 (en)	2002-01-10
KR20010023257A (ko)	2001-03-26
NZ503414A (en)	2002-11-26
US6172059B1 (en)	2001-01-09
NO20000906D0 (no)	2000-02-24
RS49808B (sr)	2008-08-07
MY122272A (en)	2006-04-29
CN1197578C (zh)	2005-04-20
AU8777198A (en)	1999-03-16
HK1027975A1 (en)	2001-02-02
JP2001513564A (ja)	2001-09-04
IL134185A (en)	2005-11-20
TW450812B (en)	2001-08-21
PT1019058E (pt)	2006-08-31
EP1019058B1 (en)	2006-05-24
PL338828A1 (en)	2000-11-20
HU226063B1 (hu)	2008-04-28
ES2265666T3 (es)	2007-02-16
CZ2000694A3 (cs)	2000-09-13
JP3472261B2 (ja)	2003-12-02
YU9800A (sh)	2001-12-26
ZA987623B (en)	2000-03-22
SA98190680B1 (ar)	2006-04-04
DE69834655D1 (de)	2006-06-29
KR100426516B1 (ko)	2004-04-13
NO326226B1 (no)	2008-10-20
HUP0003093A2 (hu)	2001-08-28
EP1019058A1 (en)	2000-07-19
ID21650A (id)	1999-07-08
HRP980461A2 (en)	1999-06-30
DK1019058T3 (da)	2006-06-12
CA2301646C (en)	2008-11-18
US6255481B1 (en)	2001-07-03
PE105799A1 (es)	1999-11-16
DE69834655T2 (de)	2006-12-14
CL2008003111A1 (es)	2009-09-11
BR9811994B1 (pt)	2013-11-19
NO20000906L (no)	2000-02-24
BR9811994A (pt)	2000-09-05
AR016869A1 (es)	2001-08-01
CY1105228T1 (el)	2010-03-03
AR083451A2 (es)	2013-02-27
UA44370C2 (uk)	2002-02-15
ATE326971T1 (de)	2006-06-15
CZ290667B6 (cs)	2002-09-11
BG104133A (bg)	2000-08-31
EG24075A (en)	2008-05-11
RU2196584C2 (ru)	2003-01-20
TR200000490T2 (tr)	2000-08-21
CA2301646A1 (en)	1999-03-04
PL192361B1 (pl)	2006-10-31
WO1999009990A1 (en)	1999-03-04
HRP980461B1 (en)	2002-08-31
IL134185A0 (en)	2001-04-30
EP1019058A4 (en)	2004-11-10
CO4970742A1 (es)	2000-11-07
CN1268055A (zh)	2000-09-27

Publication	Publication Date	Title
US6169084B1 (en)	2001-01-02	2-methyl-thieno-benzodiazepine formulation
JPH04234817A (ja)	1992-08-24	オメプラゾールの直腸投与組成物
KR880002087B1 (ko)	1988-10-15	항균성 나프티리딘 또는 퀴놀린 화합물의 염 및 그의 제조방법
JP4551988B2 (ja)	2010-09-29	２−メチル−チエノ−ベンゾジアゼピン製剤
KR101468153B1 (ko)	2014-12-01	5α-안드로스테인-3β,5,6β-트리올 주사제 및 제조방법
KR100426516B1 (ko)	2004-04-13	네비라핀 반수화물의 수성 현탁액의 제조방법 및 네비라핀 반수화물을 함유하는 약제학적 조성물
SK14152003A3 (sk)	2004-06-08	Pediatrický prípravok gatifloxacínu
US7303764B2 (en)	2007-12-04	2-methyl-thieno-benzodiazepine formulation
JP2001519390A (ja)	2001-10-23	安定剤としてグリシンを含む製薬学的製剤
KR20000069376A (ko)	2000-11-25	데스페리옥사민의 제제 및 다형 형태, 및 이의 제조 방법
CA2617000C (en)	2011-02-15	Methods for preparing nevirapine hemihydrate and an aqueous suspension thereof
MXPA00001392A (en)	2001-03-05	Pharmaceutical suspension comprising nevirapine hemihydrate
EP0733368A1 (en)	1996-09-25	Granule fomulation for olanzapine
JPH09323934A (ja)	1997-12-16	保存安定性の改善された坐剤
HK1027975B (en)	2005-08-05	Pharmaceutical suspension comprising nevirapine hemihydrate
CN1589795A (zh)	2005-03-09	尼莫地平冻干组合物及其制备方法
JP3281872B2 (ja)	2002-05-13	７−イソインドリン−３−キノリンカルボン酸の塩、その水和物およびそれらを活性成分とする組成物
CN110279664A (zh)	2019-09-27	一种氟苯尼考包合物冻干粉针剂及其制备方法
JPH09323933A (ja)	1997-12-16	安定性の改善された坐剤
KR20050034298A (ko)	2005-04-14	암로디핀을 함유하는 연질캡슐제 조성물 및 그 제조방법