BR0013156A - Hidroxilação de compactina em pravastatina através de micromonospora - Google Patents

Hidroxilação de compactina em pravastatina através de micromonospora

Info

Publication number
BR0013156A
BR0013156A BR0013156-3A BR0013156A BR0013156A BR 0013156 A BR0013156 A BR 0013156A BR 0013156 A BR0013156 A BR 0013156A BR 0013156 A BR0013156 A BR 0013156A
Authority
BR
Brazil
Prior art keywords
formula
compound
micromonospora
hydroxylation
culture
Prior art date
Application number
BR0013156-3A
Other languages
English (en)
Inventor
Antonia Jekkel
Gabor Ambrus
Eva Ilkpoy
Ildiko Horvath
Attila Konya
Istvan Mihaly Szabo
Zsuzsanna Nagy
Gyula Horvath
Julia Mozes
Istvan Barta
Gyorgy Somogyi
Janos Salat
Sandor Boros
Original Assignee
Ivax Drug Res Inst Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Drug Res Inst Ltd filed Critical Ivax Drug Res Inst Ltd
Publication of BR0013156A publication Critical patent/BR0013156A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: "HIDROXILAçãO DE COMPACTINA EM PRAVASTATINA ATRAVéS DE MICROMONOSPORA". A presente invenção de refere a um novo processo microbiano para o preparo de um composto da fórmula (I) a partir de um composto da fórmula geral (II) em que R significa um íon de metal alcalino ou amónio, através da cultura submersa de um gênero o qual é capaz de 6<225>-hidroxilar o composto da fórmula (II) em fermentação aeróbica e através de separação e purificação do produto da fórmula (I) formado no curso da bioconversão. A última compreende a cultura de um gênero de Micromonospora o qual é capaz de 6<225>-hidroxilar o composto da fórmula (II) - em que R é conforme definido acima - a 25-32<198>C sobre um meio nutriente contendo fontes disponíveis de carbono e nitrogênio e sais minerais, após o que, alimentação do substrato a ser transformado na cultura em desenvolvimento, então, hidroxilação do substrato até finalização da bioconversão, então, separação do composto da fórmula (I) do caldo de cultura e, se desejado, purificação do mesmo.
BR0013156-3A 1999-07-12 2000-06-29 Hidroxilação de compactina em pravastatina através de micromonospora BR0013156A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására
PCT/HU2000/000066 WO2001004340A1 (en) 1999-07-12 2000-06-29 Hydroxylation of compactin to pravastatin by micromonospora

Publications (1)

Publication Number Publication Date
BR0013156A true BR0013156A (pt) 2002-04-02

Family

ID=89998701

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013156-3A BR0013156A (pt) 1999-07-12 2000-06-29 Hidroxilação de compactina em pravastatina através de micromonospora

Country Status (32)

Country Link
US (2) US6905851B1 (pt)
EP (3) EP1327689A1 (pt)
JP (2) JP4531315B2 (pt)
KR (2) KR100479837B1 (pt)
CN (2) CN1399686A (pt)
AP (1) AP1405A (pt)
AT (1) ATE243262T1 (pt)
AU (2) AU773633B2 (pt)
BG (1) BG65109B1 (pt)
BR (1) BR0013156A (pt)
CA (2) CA2379015A1 (pt)
CZ (2) CZ297009B6 (pt)
DE (1) DE60003424T2 (pt)
DK (1) DK1190087T3 (pt)
ES (1) ES2200891T3 (pt)
HR (1) HRP20020028B1 (pt)
HU (1) HUP9902352A1 (pt)
IL (2) IL147583A0 (pt)
IS (1) IS2138B (pt)
MX (1) MXPA02000356A (pt)
NO (1) NO20020119L (pt)
NZ (1) NZ516563A (pt)
OA (1) OA12150A (pt)
PL (2) PL353493A1 (pt)
PT (1) PT1190087E (pt)
RU (2) RU2235780C2 (pt)
SK (2) SK285726B6 (pt)
TR (1) TR200200726T2 (pt)
UA (1) UA67854C2 (pt)
WO (2) WO2001004340A1 (pt)
YU (1) YU2002A (pt)
ZA (1) ZA200200273B (pt)

Families Citing this family (20)

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SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
WO2001039768A1 (en) 1999-11-30 2001-06-07 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth
HK1049441A1 (zh) 1999-12-14 2003-05-16 Biogal Gyogyszergyar Rt 普伐他丁钠的崭新形式
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
CN100456962C (zh) * 2001-02-09 2009-02-04 荷兰联合利华有限公司 含大豆蛋白和抑制素的食物制品
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
PL1641447T3 (pl) 2003-11-24 2009-04-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania prawastatyny
SG188126A1 (en) * 2008-02-06 2013-03-28 Biocon Ltd Fermentation media comprising urea-like nitrogen sources and its use for the production of secondary metabolits, enzymes and recombinant proteias
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
CN114031496B (zh) * 2021-11-30 2024-09-27 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法
CN119330849B (zh) * 2022-12-25 2026-07-03 塔里木大学 一种化合物abagg及其用途

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (pt) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
JP2003504071A (ja) 2003-02-04
NO20020119D0 (no) 2002-01-10
YU2002A (sh) 2004-12-31
WO2001003647A2 (en) 2001-01-18
IS6227A (is) 2002-01-11
KR100479837B1 (ko) 2005-03-31
DK1190087T3 (da) 2003-10-13
KR20020048927A (ko) 2002-06-24
ATE243262T1 (de) 2003-07-15
NO20020119L (no) 2002-02-21
EP1190087B1 (en) 2003-06-18
UA67854C2 (en) 2004-07-15
IL147588A0 (en) 2002-08-14
KR20020060150A (ko) 2002-07-16
ZA200200273B (en) 2003-06-25
US20050124051A1 (en) 2005-06-09
EP1198448A2 (en) 2002-04-24
AU773633B2 (en) 2004-05-27
JP2003528576A (ja) 2003-09-30
EP1190087A1 (en) 2002-03-27
CZ2002119A3 (cs) 2003-02-12
JP4531315B2 (ja) 2010-08-25
RU2235780C2 (ru) 2004-09-10
PL364872A1 (en) 2004-12-27
DE60003424D1 (de) 2003-07-24
TR200200726T2 (tr) 2002-06-21
DE60003424T2 (de) 2004-05-19
AU5835500A (en) 2001-01-30
CA2379015A1 (en) 2001-01-18
CZ2002127A3 (cs) 2003-06-18
HU9902352D0 (en) 1999-09-28
CN1590555A (zh) 2005-03-09
HRP20020028A2 (en) 2003-06-30
NZ516563A (en) 2002-11-26
CA2373544A1 (en) 2001-01-18
CN1399686A (zh) 2003-02-26
WO2001003647A3 (en) 2001-06-28
SK285726B6 (sk) 2007-07-06
HUP9902352A1 (hu) 2000-09-28
RU2004114667A (ru) 2005-10-27
WO2001004340A1 (en) 2001-01-18
ES2200891T3 (es) 2004-03-16
EP1327689A1 (en) 2003-07-16
US6905851B1 (en) 2005-06-14
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31
IS2138B (is) 2006-08-15
IL147583A0 (en) 2002-08-14
EP1198448A4 (en) 2003-05-28
CZ297009B6 (cs) 2006-08-16
AP1405A (en) 2005-04-28
BG65109B1 (bg) 2007-02-28
BG106302A (en) 2002-10-31
SK612002A3 (en) 2002-12-03
AU6349200A (en) 2001-01-30
SK492002A3 (sk) 2005-03-04
PL353493A1 (en) 2003-11-17
OA12150A (en) 2006-05-05
HRP20020028B1 (en) 2005-04-30
AP2002002404A0 (en) 2002-03-31

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B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements