BR0312068A - Sequência de dna e preparação de alérgeno de pólen de gramìneas phl p 4 por métodos recombinantes - Google Patents

Sequência de dna e preparação de alérgeno de pólen de gramìneas phl p 4 por métodos recombinantes

Info

Publication number
BR0312068A
BR0312068A BR0312068-6A BR0312068A BR0312068A BR 0312068 A BR0312068 A BR 0312068A BR 0312068 A BR0312068 A BR 0312068A BR 0312068 A BR0312068 A BR 0312068A
Authority
BR
Brazil
Prior art keywords
dna
phl
encoding
poaceae
polypeptide
Prior art date
Application number
BR0312068-6A
Other languages
English (en)
Inventor
Helmut Fiebig
Andreas Nandy
Roland Suck
Oliver Cromwell
Arnd Petersen
Wolf-Meinhard Becker
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29797135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0312068(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BR0312068A publication Critical patent/BR0312068A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"SEQuêNCIA DE DNA E PREPARAçãO DE ALéRGENO DE PóLEN DE GRAMìNEAS PHL P 4 POR MéTODOS RECOMBINANTES". A presente invenção refere-se à provisão da seq³ência genética do principal alérgeno de pólen de gramínea Phl p 4. A invenção também abrange fragmentos, novas combinações de seq³ências parciais e mutantes do ponto que têm uma ação hipoalergência. As moléculas de DNA recombinante e os polipeptídeos derivados, fragmentos, novas combinações de seq³ências parciais e variantes podem ser utilizados para a terapia de doenças alérgicas a pólen. As proteínas preparadas por métodos recombinates podem ser empregadas para o diagnóstico in vitro e in vivo de alergias a pólen.
BR0312068-6A 2002-06-25 2003-06-11 Sequência de dna e preparação de alérgeno de pólen de gramìneas phl p 4 por métodos recombinantes BR0312068A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02013953 2002-06-25
PCT/EP2003/006092 WO2004000881A1 (de) 2002-06-25 2003-06-11 Dna-sequenz und rekombinante herstellung des graspollen-allergens phl p4

Publications (1)

Publication Number Publication Date
BR0312068A true BR0312068A (pt) 2005-03-29

Family

ID=29797135

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312068-6A BR0312068A (pt) 2002-06-25 2003-06-11 Sequência de dna e preparação de alérgeno de pólen de gramìneas phl p 4 por métodos recombinantes

Country Status (13)

Country Link
US (3) US8128935B2 (pt)
EP (2) EP2392591B1 (pt)
JP (1) JP2006510346A (pt)
CN (1) CN100391970C (pt)
AT (1) ATE550349T1 (pt)
AU (1) AU2003279352B2 (pt)
BR (1) BR0312068A (pt)
CA (1) CA2491038C (pt)
ES (2) ES2670573T3 (pt)
PL (2) PL219272B1 (pt)
PT (2) PT2392591T (pt)
RU (1) RU2327739C2 (pt)
WO (1) WO2004000881A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10359352A1 (de) 2003-12-16 2005-07-21 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung des Graspollen-Allergens Lol p 4
AU2013204574B2 (en) * 2003-12-16 2015-02-26 Merck Patent Gmbh DNA-sequence and recombinant production of group 4 major allergens from cereals
DE10359351A1 (de) 2003-12-16 2005-07-21 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden
AU2011202726B2 (en) * 2003-12-16 2012-04-26 Merck Patent Gmbh DNA-sequence and recombinant production of group 4 major allergens from cereals
AU2010342532B2 (en) * 2010-01-14 2016-07-21 Merck Patent Gmbh Variants of the group-6 allergens of the Poaceae with reduced allergenicity by mutagenesis of proline residues
CN104203277A (zh) * 2012-02-07 2014-12-10 拉霍拉敏感及免疫学研究所 梯牧草变应原和用于调节免疫反应的方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030135888A1 (en) * 2001-09-26 2003-07-17 Tong Zhu Genes that are modulated by posttranscriptional gene silencing

Also Published As

Publication number Publication date
PL215097B1 (pl) 2013-10-31
PL219272B1 (pl) 2015-04-30
PL372423A1 (en) 2005-07-25
JP2006510346A (ja) 2006-03-30
WO2004000881A9 (de) 2004-02-26
RU2005101744A (ru) 2005-06-27
CA2491038C (en) 2017-04-25
CN1665835A (zh) 2005-09-07
RU2327739C2 (ru) 2008-06-27
AU2003279352A1 (en) 2004-01-06
US9120866B2 (en) 2015-09-01
ES2670573T3 (es) 2018-05-31
ATE550349T1 (de) 2012-04-15
WO2004000881A1 (de) 2003-12-31
EP2392591A1 (de) 2011-12-07
AU2003279352B2 (en) 2009-09-10
US9556241B2 (en) 2017-01-31
US20060177470A1 (en) 2006-08-10
ES2384045T3 (es) 2012-06-28
CN100391970C (zh) 2008-06-04
EP2392591B1 (de) 2018-02-21
EP1515988B1 (de) 2012-03-21
PT1515988E (pt) 2012-06-25
US8128935B2 (en) 2012-03-06
PT2392591T (pt) 2018-05-23
US20150079120A1 (en) 2015-03-19
PL400683A1 (pl) 2013-02-04
US20120288526A1 (en) 2012-11-15
CA2491038A1 (en) 2003-12-31
EP1515988A1 (de) 2005-03-23

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL.: C07K 14/415, C12N 15/11, C12N 15/63, A61K 38/16, A61K 39/36, A61K 48/00.

Ipc: C12N 15/29 (2006.01), C12N 15/63 (2006.01), A61K 3

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements