BRPI0410870A - compostos trieterocìclicos, composições, e métodos para tratar cáncer ou doenças virais - Google Patents

compostos trieterocìclicos, composições, e métodos para tratar cáncer ou doenças virais

Info

Publication number
BRPI0410870A
BRPI0410870A BRPI0410870-1A BRPI0410870A BRPI0410870A BR PI0410870 A BRPI0410870 A BR PI0410870A BR PI0410870 A BRPI0410870 A BR PI0410870A BR PI0410870 A BRPI0410870 A BR PI0410870A
Authority
BR
Brazil
Prior art keywords
compositions
compounds
methods
trieterocyclic
treating cancer
Prior art date
Application number
BRPI0410870-1A
Other languages
English (en)
Inventor
Giorgio Attardo
Kenza Dairi
Jean-Francois Lavallee
Elise Rioux
Sasmita Tripathy
Xavier Billot
Terrence W Doyle
Original Assignee
Gemin X Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemin X Biotechnologies Inc filed Critical Gemin X Biotechnologies Inc
Publication of BRPI0410870A publication Critical patent/BRPI0410870A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

"COMPOSTOS TRIHETEROCìCLICOS, COMPOSIçõES, E MéTODOS PARA TRATAR CáNCER OU DOENçAS VIRAIS". A presente invenção refere-se a novos Compostos Triheterocíclicos, fórmula (1): e sais farmaceuticamente aceitáveis destes, em que: Q~ 1~ é -0-, -S- ou -N(R~ 1~)-; Q~ z~ é -C(R~ 3~)- OU -N-; Q~ 3~ é -C (R~ 5~)- OU -N-; Q~ 4~ é -C (R~ 9~)- ou -N-; composições que compreendem um Composto Triheterocíclico, e métodos úteis para tratar ou prevenir câncer ou um distúrbio neoplásico que compreende administrar um Composto Triheterocíclico. Os compostos, composições, e métodos da invenção são também úteis para inibir o crescimento de uma célula de câncer ou célula neoplásica, tratar ou prevenir uma infecção viral, ou inibir a replicação e/ou infectividade de um vírus.
BRPI0410870-1A 2003-05-30 2004-05-28 compostos trieterocìclicos, composições, e métodos para tratar cáncer ou doenças virais BRPI0410870A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47474103P 2003-05-30 2003-05-30
PCT/CA2004/000793 WO2004106328A1 (en) 2003-05-30 2004-05-28 Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases

Publications (1)

Publication Number Publication Date
BRPI0410870A true BRPI0410870A (pt) 2006-07-04

Family

ID=33490730

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410870-1A BRPI0410870A (pt) 2003-05-30 2004-05-28 compostos trieterocìclicos, composições, e métodos para tratar cáncer ou doenças virais

Country Status (23)

Country Link
US (4) US7425553B2 (pt)
EP (1) EP1644363B1 (pt)
JP (1) JP4980715B2 (pt)
KR (1) KR101168441B1 (pt)
CN (1) CN1832939B (pt)
AT (1) ATE546456T1 (pt)
AU (1) AU2004242928B2 (pt)
BR (1) BRPI0410870A (pt)
CA (1) CA2527583C (pt)
CY (1) CY1113038T1 (pt)
DK (1) DK1644363T3 (pt)
ES (1) ES2382377T3 (pt)
HR (1) HRP20120379T1 (pt)
IL (1) IL172189A (pt)
MX (1) MXPA05012799A (pt)
NO (1) NO333006B1 (pt)
NZ (1) NZ543897A (pt)
PL (1) PL1644363T3 (pt)
PT (1) PT1644363E (pt)
RU (1) RU2360913C2 (pt)
SI (1) SI1644363T1 (pt)
WO (1) WO2004106328A1 (pt)
ZA (1) ZA200509718B (pt)

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