DK1594885T3 - Lægemiddel til vækstinhibering af tumorer - Google Patents

Lægemiddel til vækstinhibering af tumorer

Info

Publication number: DK1594885T3
Authority: DK; Denmark
Prior art keywords: tumors; drug; growth inhibition; acid derivatives; betulinic acid
Prior art date: 2003-02-11

Application number

DK04709952T

Other languages

English (en)

Inventor

Edgar Selzer

Burkhard Jansen

Reinhard Paschke

Original Assignee

Novelix Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-11

Filing date

2004-02-11

Publication date

2009-04-20

2004-02-11 Application filed by Novelix Pharmaceuticals Inc filed Critical Novelix Pharmaceuticals Inc

2009-04-20 Application granted granted Critical

2009-04-20 Publication of DK1594885T3 publication Critical patent/DK1594885T3/da

Links

239000003814 drug Substances 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
229940079593 drug Drugs 0.000 title 1
230000009036 growth inhibition Effects 0.000 title 1
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 abstract 2
201000009030 Carcinoma Diseases 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
AIDS & HIV (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Pyrane Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK04709952T 2003-02-11 2004-02-11 Lægemiddel til vækstinhibering af tumorer DK1594885T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT2002003		2003-02-11
PCT/AT2004/000045 WO2004072092A1 (de)	2003-02-11	2004-02-11	Medikament zur wachstumsinhibierung von tumoren

Publications (1)

Publication Number	Publication Date
DK1594885T3 true DK1594885T3 (da)	2009-04-20

Family

ID=32854879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04709952T DK1594885T3 (da)	2003-02-11	2004-02-11	Lægemiddel til vækstinhibering af tumorer

Country Status (13)

Country	Link
US (2)	US7312205B2 (da)
EP (1)	EP1594885B8 (da)
JP (1)	JP4722031B2 (da)
CN (1)	CN100432094C (da)
AT (1)	ATE420099T1 (da)
AU (1)	AU2004210714C1 (da)
CA (1)	CA2515384C (da)
DE (1)	DE502004008819D1 (da)
DK (1)	DK1594885T3 (da)
ES (1)	ES2319653T3 (da)
PT (1)	PT1594885E (da)
SI (1)	SI1594885T1 (da)
WO (1)	WO2004072092A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200628161A (en) *	2004-11-12	2006-08-16	Panacos Pharmaceuticals Inc	Novel betulin derivatives, preparation thereof and use thereof
EP1893629A4 (en) *	2005-06-22	2008-12-17	Myriad Genetics Inc	ANTIVIRAL CONNECTIONS
WO2007112043A2 (en) *	2006-03-23	2007-10-04	Advanced Life Sciences Inc.	Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
US20080039428A1 (en) *	2006-06-29	2008-02-14	Panacos Pharmaceuticals, Inc.	Antiretroviral combination therapy
CZ300722B6 (cs) *	2006-09-27	2009-07-22	Univerzita Karlova v Praze, Prírodovedecká fakulta	Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující
WO2008115281A2 (en) *	2006-10-16	2008-09-25	Myriad Genetics, Inc.	Compounds for treating viral infections
WO2009090063A1 (en) *	2008-01-16	2009-07-23	Jado Technologies Gmbh	Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases
US20110077297A1 (en) *	2008-05-30	2011-03-31	Novelix Pharmaceuticals, Inc.	Compositions and methods for treatment of inflammation and hyperkeratotic lesions
KR100941595B1 (ko) *	2008-06-05	2010-02-11	주식회사 알앤엘바이오	바이러스 억제제로서 유용한 트리테르페노이드계 화합물
US9067966B2 (en) *	2009-07-14	2015-06-30	Hetero Research Foundation, Hetero Drugs Ltd.	Lupeol-type triterpene derivatives as antivirals
DE102009034367A1 (de) *	2009-07-20	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
CN103038245B (zh) *	2010-06-04	2015-03-25	百时美施贵宝公司	作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
US9637516B2 (en)	2012-12-31	2017-05-02	Hetero Research Foundation	Betulinic acid proline derivatives as HIV inhibitors
US20170129916A1 (en)	2014-06-26	2017-05-11	Hetero Research Foundation	Novel betulinic proline imidazole derivatives as hiv inhibitors
US9808011B2 (en)	2014-12-15	2017-11-07	Biovectra Inc.	Pentacyclic triterpene compounds and uses thereof
MA40886B1 (fr)	2015-02-09	2020-03-31	Hetero Research Foundation	Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en)	2015-03-16	2019-08-06	Hetero Labs Limited	C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
CN107501380B (zh) *	2016-11-16	2020-09-29	中国药科大学	23-羟基白桦酸23位修饰衍生物、其制备方法及用途
KR101909885B1 (ko) *	2018-05-25	2018-10-19	김예원	살리드로사이드 또는 베툴린을 이용한 뇌수막종 개선용 조성물
SI3924361T1 (sl) *	2019-02-11	2024-02-29	Hetero Labs Limited	Novi derivati triterpena kot zaviralci virusa hiv

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658947A (en) *	1995-03-21	1997-08-19	Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma using betalinic acid
US5962527A (en) *	1995-03-21	1999-10-05	The Board Of Trustees Of The University Of Illinois	Method and composition for treating cancers
US5962537A (en) *	1997-05-06	1999-10-05	Exxon Research And Engineering Co	Multizone downcomer for slurry hydrocarbon syntheses process
DE69832363D1 (de)	1998-03-18	2005-12-22	Dabur Pharma Ltd	Betulinsauer Derivate zur Hemmung von Krebswachstum
US6369109B1 (en)	1998-10-28	2002-04-09	Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts	Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
AU766599B2 (en)	1998-11-18	2003-10-16	Dabur Pharma Ltd.	Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors
EP1218402B1 (en)	1999-09-09	2004-05-26	Dabur Research Foundation	Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
WO2002016395A1 (en) *	2000-08-18	2002-02-28	The Board Of Trustees Of The University Of Illinois	Prodrugs of betulinic acid derivatives for the treatment of cancer and hiv
EP1476031A1 (en)	2001-05-11	2004-11-17	University of Ottawa	Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods

2004
- 2004-02-11 JP JP2006501337A patent/JP4722031B2/ja not_active Expired - Fee Related
- 2004-02-11 WO PCT/AT2004/000045 patent/WO2004072092A1/de not_active Ceased
- 2004-02-11 AU AU2004210714A patent/AU2004210714C1/en not_active Ceased
- 2004-02-11 CA CA2515384A patent/CA2515384C/en not_active Expired - Fee Related
- 2004-02-11 PT PT04709952T patent/PT1594885E/pt unknown
- 2004-02-11 DK DK04709952T patent/DK1594885T3/da active
- 2004-02-11 CN CNB2004800039078A patent/CN100432094C/zh not_active Expired - Fee Related
- 2004-02-11 ES ES04709952T patent/ES2319653T3/es not_active Expired - Lifetime
- 2004-02-11 US US10/545,143 patent/US7312205B2/en not_active Expired - Lifetime
- 2004-02-11 EP EP04709952A patent/EP1594885B8/de not_active Expired - Lifetime
- 2004-02-11 SI SI200431051T patent/SI1594885T1/sl unknown
- 2004-02-11 DE DE502004008819T patent/DE502004008819D1/de not_active Expired - Lifetime
- 2004-02-11 AT AT04709952T patent/ATE420099T1/de active
2007
- 2007-12-21 US US11/963,505 patent/US7851462B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4722031B2 (ja)	2011-07-13
US7851462B2 (en)	2010-12-14
ATE420099T1 (de)	2009-01-15
CN1747964A (zh)	2006-03-15
SI1594885T1 (sl)	2009-06-30
AU2004210714C1 (en)	2011-01-20
DE502004008819D1 (de)	2009-02-26
AU2004210714B2 (en)	2010-01-21
EP1594885B8 (de)	2009-03-25
CA2515384A1 (en)	2004-08-26
EP1594885A1 (de)	2005-11-16
ES2319653T3 (es)	2009-05-11
AU2004210714A1 (en)	2004-08-26
PT1594885E (pt)	2009-03-13
US7312205B2 (en)	2007-12-25
WO2004072092A1 (de)	2004-08-26
EP1594885B1 (de)	2009-01-07
US20060194774A1 (en)	2006-08-31
CN100432094C (zh)	2008-11-12
JP2006517208A (ja)	2006-07-20
US20080214516A1 (en)	2008-09-04
CA2515384C (en)	2012-04-17

Publication	Publication Date	Title
DK1594885T3 (da)	2009-04-20	Lægemiddel til vækstinhibering af tumorer
BG108318A (en)	2005-01-31	Carboxamide-substituted phenylurea derivatives and method for the production and use thereof as medicaments
DK1519724T3 (da)	2010-01-04	Fredericamycin-derivater som lægemidler til behandling af tumorer
NL300933I2 (nl)	2018-04-26	Letermovir
DE50310516D1 (de)	2008-10-30	Fredericamycin-derivate
NO20092033L (no)	2009-08-06	Nye forbindelser
EA200700096A1 (ru)	2007-06-29	Производные 2-карбамид-4-фенилтиазола, способ их получения и их применение в терапии
EA200801580A1 (ru)	2009-02-27	Новые производные пирониндола и способ их получения
CY1111327T1 (el)	2015-08-05	Υποκατεστημενα παραγωγα κυκλοεξυλοξεικου οξεος
CY1109569T1 (el)	2014-08-13	Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης
DE502005008057D1 (de)	2009-10-15	Substituierte cyclopenten-verbindungen
UY26133A1 (es)	2000-12-29	Derivado sustituido de pirazol.
EA200401319A1 (ru)	2005-04-28	Новые гетероциклические соединения, способы их получения и фармацевтические композиции, содержащие эти соединения, и их использование в медицине
SE0200198D0 (sv)	2002-01-23	New use
UY27733A1 (es)	2003-10-31	Derivados de ciclopenteno.
TW200621703A (en)	2006-07-01	Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
EA200600115A1 (ru)	2008-06-30	Производные 2-аминобензойной кислоты
ATE496899T1 (de)	2011-02-15	Tetrahydro- und dihydrochinazolinone
ATE373658T1 (de)	2007-10-15	Pyrazoloisoquinolinenderivaten zur inhibierung von nfkappab-induzierende kinase
ATE505193T1 (de)	2011-04-15	Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
DE60315597D1 (de)	2007-09-27	Haloacetamidobenzoesäure derivate und deren verwendung zur behandlung von parasitären erkrankungen
DK1553938T3 (da)	2007-03-26	Anvendelse af epothilonderivater til behandling af hyperparathyroidisme
DE60216090D1 (de)	2006-12-28	Verwendung von l-acetylcarnitin zur herstellung eines medikaments zur behandlung von anhedonia
CY1107483T1 (el)	2013-03-13	Παραγωγα πυριδαζινης, η χρηση τους ως φαρμακευτικα σκευασματα και η διαδικασια παρασκευης τους
SE0202287D0 (sv)	2002-07-19	New compounds