BRPI0413413A - feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada - Google Patents

feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada

Info

Publication number
BRPI0413413A
BRPI0413413A BRPI0413413-3A BRPI0413413A BRPI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A BR PI0413413 A BRPI0413413 A BR PI0413413A
Authority
BR
Brazil
Prior art keywords
piperidine
improved
vivo efficacy
antimicrobial activity
derivatives
Prior art date
Application number
BRPI0413413-3A
Other languages
English (en)
Inventor
Prasad Keshav Deshpande
Sachin Subhash Bhagwat
Milind Chintaman Shukla
Noel John De Souza
Mahesh Vithalbhai Patel
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of BRPI0413413A publication Critical patent/BRPI0413413A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"FENILOXAZOLIDINONAS DE PIPERIDINO SUBSTITUìDO TENDO ATIVIDADE ANTIMICROBIANA COM EFICáCIA IN VIVO MELHORADA". A presente invenção fornece agentes tendo atividade antimicrobiana para prevenir e tratar doenças infecciosas. Desse modo, a presente invenção fornece novos derivados de feniloxazolidinona de piperidino substituído, processos para preparar compostos, bem como composições antimicrobianas contendo os referidos derivados como ingredientes ativos e métodos de tratar infecções bacterianas com os referidos derivados.
BRPI0413413-3A 2003-09-08 2004-09-08 feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada BRPI0413413A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN924MU2003 2003-09-08
PCT/IN2004/000276 WO2005054234A2 (en) 2003-09-08 2004-09-08 Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy

Publications (1)

Publication Number Publication Date
BRPI0413413A true BRPI0413413A (pt) 2007-01-09

Family

ID=34640331

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413413-3A BRPI0413413A (pt) 2003-09-08 2004-09-08 feniloxazolidinonas de piperidino substituìdo tendo atividade antimicrobiana com eficácia in vivo melhorada

Country Status (8)

Country Link
US (2) US7687627B2 (pt)
EP (1) EP1664038A2 (pt)
JP (1) JP4917432B2 (pt)
AU (1) AU2004295208A1 (pt)
BR (1) BRPI0413413A (pt)
CA (1) CA2537559C (pt)
EA (1) EA200600374A1 (pt)
WO (1) WO2005054234A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
WO2007004049A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidinones containing azetidine as antibacterial agents
ES2556183T3 (es) * 2006-05-09 2016-01-13 Wockhardt Limited Piperidinofeniloxazolidinonas sustituidas
KR101336510B1 (ko) * 2006-09-25 2013-12-03 욱크하르트 리미티드 치환된 피페리디노페닐 옥사졸리디논
WO2009037542A2 (en) * 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Spirocyclic compounds as stearoyl coa desaturase inhibitors
EP2072513A1 (en) * 2007-12-17 2009-06-24 Ferrer Internacional, S.A. A cyano piperidinyl-phenil-oxazolidinone and use thereof
CA2712613C (en) 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
EP2141161A1 (en) * 2008-07-01 2010-01-06 Ferrer Internacional, S.A. 3-cyanopyrrolidinyl-phenyl-oxazolidinones as antibacterial agents
AU2010227195B2 (en) * 2009-03-27 2016-04-14 Council Of Scientific And Industrial Research Substituted 1, 4-dioxa-8-azaspiro [4,5] decanes useful as fungicides and a process for the preparation thereof
WO2012059823A1 (en) 2010-11-03 2012-05-10 Wockhardt Limited Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl] - 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester
WO2013044845A1 (zh) * 2011-09-29 2013-04-04 山东轩竹医药科技有限公司 联芳基杂环取代的噁唑烷酮抗菌药
WO2015066413A1 (en) * 2013-11-01 2015-05-07 Novartis Ag Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
CA3075364A1 (en) * 2017-10-27 2019-05-02 Huntsman International Llc Catalysts for making oxazolidinone materials
US12109203B2 (en) * 2018-07-25 2024-10-08 Zydus Lifesciences Limited Substituted oxazolidinones for the treatment of mammalian infections
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3344145A (en) * 1963-10-21 1967-09-26 Geschickter Fund Med Res N-substituted phenoxyalkyl or phenylthioalkyl-mono azaspiroalkanes
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
JP3933198B2 (ja) * 1994-10-26 2007-06-20 ファルマシア・アンド・アップジョン・カンパニー フェニルオキサゾリジノン抗菌剤
PT1019385E (pt) * 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
CN1138765C (zh) * 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂
TR200003595T2 (tr) * 1998-06-05 2001-07-23 Astrazeneca Ab Kimyasal bileşikler
GB9821938D0 (en) * 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
US6441005B1 (en) * 1999-07-28 2002-08-27 Pharmacia & Upjohn Company Oxazolidinone compounds and compositions, and methods of using the same
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB2356389B (en) * 1999-09-02 2003-07-16 Bruce Stanley Gunton Loading bay dock control
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
AU2002230665A1 (en) * 2000-12-06 2002-06-18 Sepracor, Inc. 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands
ES2248633T3 (es) * 2001-04-17 2006-03-16 MERCK & CO., INC. Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos.
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
EP1565461A2 (en) * 2002-07-11 2005-08-24 Mahesh V. Patel Antibacterial substituted cyanomethyl(ene)piperidinophenyl oxazolidinones, process for their preparation, and pharmaceutical compositions containing them
AU2003274676A1 (en) * 2002-07-11 2004-02-02 Yati Chugh Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
US7405228B2 (en) * 2002-07-11 2008-07-29 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites
KR100490643B1 (ko) * 2002-10-29 2005-05-19 한국과학기술연구원 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
ES2556183T3 (es) * 2006-05-09 2016-01-13 Wockhardt Limited Piperidinofeniloxazolidinonas sustituidas

Also Published As

Publication number Publication date
WO2005054234A3 (en) 2005-09-29
JP2007505102A (ja) 2007-03-08
US8729269B2 (en) 2014-05-20
CA2537559A1 (en) 2005-06-16
EA200600374A1 (ru) 2006-08-25
AU2004295208A1 (en) 2005-06-16
JP4917432B2 (ja) 2012-04-18
US7687627B2 (en) 2010-03-30
US20100144735A1 (en) 2010-06-10
WO2005054234A2 (en) 2005-06-16
CA2537559C (en) 2012-11-20
EP1664038A2 (en) 2006-06-07
WO2005054234A8 (en) 2006-11-23
US20050143421A1 (en) 2005-06-30

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 3A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.