BRPI0506607A - métodos para produzir morfinonas protegidas por 3-o e carboxilatos de morfinona dienol protegidas por 3-o - Google Patents

métodos para produzir morfinonas protegidas por 3-o e carboxilatos de morfinona dienol protegidas por 3-o

Info

Publication number
BRPI0506607A
BRPI0506607A BRPI0506607-7A BRPI0506607A BRPI0506607A BR PI0506607 A BRPI0506607 A BR PI0506607A BR PI0506607 A BRPI0506607 A BR PI0506607A BR PI0506607 A BRPI0506607 A BR PI0506607A
Authority
BR
Brazil
Prior art keywords
protected
methods
producing
compound
formula
Prior art date
Application number
BRPI0506607-7A
Other languages
English (en)
Inventor
Andreas Stumpf
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0506607(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of BRPI0506607A publication Critical patent/BRPI0506607A/pt
Publication of BRPI0506607B1 publication Critical patent/BRPI0506607B1/pt
Publication of BRPI0506607B8 publication Critical patent/BRPI0506607B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

MéTODOS PARA PRODUZIR MORFINONAS PROTEGIDAS POR 3-0 E CARBOXILATOS DE MORFINONA DIENOL PROTEGIDAS POR 3-0. São apresentados métodos para produzir aldeídos e cetonas que compreendem permitir que o álcool primário ou secundário correspondente reaja na presença de ácido tricloroisocianúrico, um composto de fórmula R~ 1~Sr~ 2~ e uma base. Em uma configuração, o álcool é um composto de fórmula (I) onde R~ 3~ é um grupo protetor. São também apresentados métodos para produzir carboxilatos de morfina dienol protegidos por 3 - 0 que compreendem permitir que um composto de fórmula (I) oxide na presença de um composto contendo cloro e um composto de fórmula R~ 1~SR~ 2~; e permitir que o produto da etapa de oxidação reaja com um agente de acilação.
BRPI0506607A 2004-02-06 2005-02-04 métodos para produzir morfinonas protegidas por 3-o e carboxilatos de morfinona doenol protegidas por 3-o e composição BRPI0506607B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06
US60/542,711 2004-02-06
PCT/US2005/003390 WO2005077957A2 (en) 2004-02-06 2005-02-04 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Publications (3)

Publication Number Publication Date
BRPI0506607A true BRPI0506607A (pt) 2007-05-02
BRPI0506607B1 BRPI0506607B1 (pt) 2018-01-16
BRPI0506607B8 BRPI0506607B8 (pt) 2021-05-25

Family

ID=34860329

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506607A BRPI0506607B8 (pt) 2004-02-06 2005-02-04 métodos para produzir morfinonas protegidas por 3-o e carboxilatos de morfinona doenol protegidas por 3-o e composição

Country Status (33)

Country Link
US (6) US8003793B2 (pt)
EP (3) EP1711502B1 (pt)
JP (1) JP4963968B2 (pt)
KR (4) KR101011460B1 (pt)
CN (1) CN1918168B (pt)
AP (1) AP2006003716A0 (pt)
AT (2) ATE406372T1 (pt)
AU (1) AU2005212258B2 (pt)
BR (1) BRPI0506607B8 (pt)
CA (2) CA2808199C (pt)
CR (1) CR8590A (pt)
CY (2) CY1108506T1 (pt)
DE (2) DE602005018265D1 (pt)
DK (2) DK1711502T3 (pt)
EA (2) EA012905B1 (pt)
EC (1) ECSP066824A (pt)
ES (2) ES2313299T3 (pt)
GE (1) GEP20084454B (pt)
HR (2) HRP20080618T3 (pt)
IL (2) IL177281A (pt)
MA (1) MA28346A1 (pt)
MX (1) MXPA06008931A (pt)
NO (2) NO20063989L (pt)
NZ (2) NZ565355A (pt)
PL (2) PL1711502T3 (pt)
PT (2) PT1711502E (pt)
RS (2) RS50663B (pt)
SG (1) SG150500A1 (pt)
SI (2) SI1711502T1 (pt)
TN (1) TNSN06248A1 (pt)
UA (2) UA88646C2 (pt)
WO (1) WO2005077957A2 (pt)
ZA (1) ZA200606252B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1711502T3 (pl) 2004-02-06 2009-02-27 Euro Celtique Sa Sposoby wytwarzania 3-o-zabezpieczonych morfinonów i karboksylanów 3-o-zabezpieczonych dienoli morfinonu
US8115002B2 (en) * 2006-09-20 2012-02-14 Mallinckrodt Llc Preparation of substituted morphinan-6-ones and salts and intermediates thereof
NZ579469A (en) * 2007-03-06 2011-02-25 Mallinckrodt Inc Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2285780B1 (en) * 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
US9458109B2 (en) * 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
CA2798884C (en) 2010-05-10 2016-09-13 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
AU2011252039B2 (en) 2010-05-10 2014-06-12 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
CN103002881B (zh) 2010-05-10 2015-09-02 欧洲凯尔特公司 载有活性剂的颗粒与额外活性剂的组合
WO2015071380A1 (en) 2013-11-13 2015-05-21 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
US10351512B2 (en) 2015-09-30 2019-07-16 Fujifilm Wako Pure Chemical Corporation Method of producing organic compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) * 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) * 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) * 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
PL1711502T3 (pl) 2004-02-06 2009-02-27 Euro Celtique Sa Sposoby wytwarzania 3-o-zabezpieczonych morfinonów i karboksylanów 3-o-zabezpieczonych dienoli morfinonu

Also Published As

Publication number Publication date
MA28346A1 (fr) 2006-12-01
NZ565355A (en) 2008-09-26
EA200601394A1 (ru) 2006-12-29
US20120022259A1 (en) 2012-01-26
US20140171643A1 (en) 2014-06-19
US20170233400A1 (en) 2017-08-17
MXPA06008931A (es) 2007-01-26
IL205596A (en) 2011-11-30
DK1711502T3 (da) 2008-12-01
EP2194059A2 (en) 2010-06-09
AU2005212258A1 (en) 2005-08-25
US20150239898A1 (en) 2015-08-27
CA2555215A1 (en) 2005-08-25
CA2808199A1 (en) 2005-08-25
WO2005077957A3 (en) 2006-05-04
EA200801811A1 (ru) 2008-12-30
GEP20084454B (en) 2008-08-10
CN1918168A (zh) 2007-02-21
HK1119160A1 (en) 2009-02-27
CY1109838T1 (el) 2014-09-10
DE602005009321D1 (de) 2008-10-09
SI1864987T1 (sl) 2010-04-30
HK1103071A1 (en) 2007-12-14
US9670218B2 (en) 2017-06-06
US8003793B2 (en) 2011-08-23
EA016062B1 (ru) 2012-01-30
RS51317B (sr) 2010-12-31
KR20070026401A (ko) 2007-03-08
RS50663B (sr) 2010-06-30
PT1711502E (pt) 2008-11-20
DK1864987T3 (da) 2010-04-12
EP2194059A3 (en) 2010-09-22
ZA200606252B (en) 2007-11-28
TNSN06248A1 (fr) 2007-12-03
KR100921696B1 (ko) 2009-10-15
PL1864987T3 (pl) 2010-05-31
IL177281A (en) 2012-02-29
NO20063989L (no) 2006-10-31
IL177281A0 (en) 2006-12-10
PL1711502T3 (pl) 2009-02-27
WO2005077957A2 (en) 2005-08-25
EP1864987B1 (en) 2009-12-09
SI1711502T1 (sl) 2009-02-28
EP1864987A3 (en) 2008-02-20
ECSP066824A (es) 2006-12-29
UA87833C2 (uk) 2009-08-25
BRPI0506607B1 (pt) 2018-01-16
CR8590A (es) 2007-07-19
DE602005018265D1 (de) 2010-01-21
NZ548786A (en) 2008-08-29
EP1711502A2 (en) 2006-10-18
ES2313299T3 (es) 2009-03-01
EP1864987A2 (en) 2007-12-12
AP2006003716A0 (en) 2006-08-31
KR20070108956A (ko) 2007-11-13
CA2808199C (en) 2015-10-27
NO20150276L (no) 2006-10-31
ATE451374T1 (de) 2009-12-15
EA012905B1 (ru) 2010-02-26
KR101011460B1 (ko) 2011-01-28
JP2007520563A (ja) 2007-07-26
ES2338054T3 (es) 2010-05-03
AU2005212258B2 (en) 2008-05-22
US20120225902A1 (en) 2012-09-06
NO339083B1 (no) 2016-11-14
CN1918168B (zh) 2011-04-27
CY1108506T1 (el) 2014-04-09
HRP20080618T3 (hr) 2009-01-31
PT1864987E (pt) 2010-03-09
US8685996B2 (en) 2014-04-01
ATE406372T1 (de) 2008-09-15
KR20090089486A (ko) 2009-08-21
HRP20100123T1 (hr) 2010-04-30
KR100921695B1 (ko) 2009-10-15
JP4963968B2 (ja) 2012-06-27
UA88646C2 (uk) 2009-11-10
SG150500A1 (en) 2009-03-30
CA2555215C (en) 2013-05-21
KR20070117701A (ko) 2007-12-12
BRPI0506607B8 (pt) 2021-05-25
US20080146804A1 (en) 2008-06-19
EP1711502B1 (en) 2008-08-27
US8198444B2 (en) 2012-06-12
US8975257B2 (en) 2015-03-10

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL. C07D 489/02.

Ipc: C07D 489/02 (2006.01), A61P 25/04 (2006.01)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25G Requested change of headquarter approved

Owner name: EURO-CELTIQUE S.A (LU)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/02/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2865 DE 02-12-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.