BRPI0517894A - derivados de 5-hidróxi-benzo tiazol possuindo atividade agonista de adrenorreceptor beta-2 - Google Patents

derivados de 5-hidróxi-benzo tiazol possuindo atividade agonista de adrenorreceptor beta-2

Info

Publication number
BRPI0517894A
BRPI0517894A BRPI0517894-0A BRPI0517894A BRPI0517894A BR PI0517894 A BRPI0517894 A BR PI0517894A BR PI0517894 A BRPI0517894 A BR PI0517894A BR PI0517894 A BRPI0517894 A BR PI0517894A
Authority
BR
Brazil
Prior art keywords
beta
agonist activity
adrenoreceptor agonist
hydroxybenzothiazole
derivatives
Prior art date
Application number
BRPI0517894-0A
Other languages
English (en)
Inventor
Robin Alec Fairhurst
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0517894A publication Critical patent/BRPI0517894A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS DE 5-HIDRóXI-BENZO TIAZOL POSSUINDO ATIVIDADE AGONISTA DE ADRENORRECEPTOR BETA-2. A presente invenção refere-se a compostos da fórmula (I) na forma livre, de sal ou solvato, onde T possui o significado conforme indicado no relatório descritivo, são úteis para tratamento de condições que são prevenidas ou aliviadas por ativação do adrenoreceptor <225>2. São também descritas composições farmacêuticas que contêm os compostos e um processo para preparação dos compostos.
BRPI0517894-0A 2004-11-29 2005-11-28 derivados de 5-hidróxi-benzo tiazol possuindo atividade agonista de adrenorreceptor beta-2 BRPI0517894A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0426164.0A GB0426164D0 (en) 2004-11-29 2004-11-29 Organic compounds
PCT/EP2005/012686 WO2006056471A1 (en) 2004-11-29 2005-11-28 5-hydroxy-benzothiazole derivatives having beta-2-adrenorecptor agonist activity

Publications (1)

Publication Number Publication Date
BRPI0517894A true BRPI0517894A (pt) 2008-10-21

Family

ID=33561510

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517894-0A BRPI0517894A (pt) 2004-11-29 2005-11-28 derivados de 5-hidróxi-benzo tiazol possuindo atividade agonista de adrenorreceptor beta-2

Country Status (19)

Country Link
US (2) US8076489B2 (pt)
EP (2) EP2305659A1 (pt)
JP (1) JP4648950B2 (pt)
KR (1) KR100891415B1 (pt)
CN (1) CN101065370B (pt)
AT (1) ATE520676T1 (pt)
AU (1) AU2005308909C1 (pt)
BR (1) BRPI0517894A (pt)
CA (1) CA2586443C (pt)
CY (1) CY1112237T1 (pt)
DK (1) DK1819686T3 (pt)
ES (1) ES2370833T3 (pt)
GB (1) GB0426164D0 (pt)
MX (1) MX2007006374A (pt)
PL (1) PL1819686T3 (pt)
PT (1) PT1819686E (pt)
RU (1) RU2402540C2 (pt)
SI (1) SI1819686T1 (pt)
WO (1) WO2006056471A1 (pt)

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WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
AU2012220572A1 (en) 2011-02-25 2013-08-29 Irm Llc Compounds and compositions as trk inhibitors
RU2452964C1 (ru) * 2011-04-15 2012-06-10 Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития (ФГУ "РКНПК" Минздравсоцразвития России) СПОСОБ ИММУНОФЕРМЕНТНОГО АНАЛИЗА ДЛЯ ОПРЕДЕЛЕНИЯ АУТОАНТИТЕЛ К β1-АДРЕНОРЕЦЕПТОРУ В ПЛАЗМЕ И СЫВОРОТКЕ КРОВИ ЧЕЛОВЕКА
JO3192B1 (ar) * 2011-09-06 2018-03-08 Novartis Ag مركب بنزوثيازولون
HRP20171362T1 (hr) * 2012-08-30 2017-11-03 Novartis Ag Soli benzotiazolonskog spoja koje služe kao agonist beta-2-adrenoceptora
MA38354B1 (fr) * 2013-02-28 2016-09-30 Novartis Ag Préparation contenant un composé de benzothiazolone
ITUB20153978A1 (it) * 2015-09-28 2017-03-28 Laboratorio Chimico Int S P A Procedimento per la preparazione di derivati di indanammina e di nuovi intermedi di sintesi.

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AU2005308909C1 (en) 2014-11-27
SI1819686T1 (sl) 2011-12-30
RU2402540C2 (ru) 2010-10-27
WO2006056471A1 (en) 2006-06-01
US20120041041A1 (en) 2012-02-16
CN101065370B (zh) 2012-11-14
AU2005308909B2 (en) 2009-08-27
RU2007124329A (ru) 2009-01-10
US20080096940A1 (en) 2008-04-24
ES2370833T3 (es) 2011-12-23
US8076489B2 (en) 2011-12-13
PT1819686E (pt) 2011-10-11
EP2305659A1 (en) 2011-04-06
CA2586443C (en) 2014-09-02
CN101065370A (zh) 2007-10-31
JP2008520618A (ja) 2008-06-19
JP4648950B2 (ja) 2011-03-09
MX2007006374A (es) 2007-06-20
KR20070067733A (ko) 2007-06-28
AU2005308909A1 (en) 2006-06-01
GB0426164D0 (en) 2004-12-29
ATE520676T1 (de) 2011-09-15
DK1819686T3 (da) 2011-12-05
CY1112237T1 (el) 2015-12-09
PL1819686T3 (pl) 2012-01-31
KR100891415B1 (ko) 2009-04-02
EP1819686A1 (en) 2007-08-22
CA2586443A1 (en) 2006-06-01

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