BRPI0520579B8 - composto, processo para a preparação de um composto e composição farmacêutica - Google Patents
composto, processo para a preparação de um composto e composição farmacêuticaInfo
- Publication number
- BRPI0520579B8 BRPI0520579B8 BRPI0520579A BRPI0520579A BRPI0520579B8 BR PI0520579 B8 BRPI0520579 B8 BR PI0520579B8 BR PI0520579 A BRPI0520579 A BR PI0520579A BR PI0520579 A BRPI0520579 A BR PI0520579A BR PI0520579 B8 BRPI0520579 B8 BR PI0520579B8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- pharmaceutical composition
- receptor
- present
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 2
- -1 aminoaryl sulphonamide derivatives Chemical class 0.000 abstract 2
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Semiconductor Integrated Circuits (AREA)
- Insulated Gate Type Field-Effect Transistor (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Abstract
composto, processo para a preparação de um composto, método para o tratamento de uma desordem do sistema nervoso central relacionada a ou afetada pelo receptor 5-ht6, composição farmacêutica, uso do composto e método para testar antagonistas e antagonistas com eletividade para o receptor 5-ht6. a presente invenção proporciona derivados de aminoaril sulfonamida de fórmula (i), úteis no tratamento de uma desordem do snc relacionada a ou afetada pelo receptor 5-ht6, o perfil farmacológico los referidos compostos incluem alta afinidade de ligação com o receptor 5-ht6 aliada a uma boa seletividade em relação ao referido receptor. a presente invenção inclui também os estereoisômeros, os sais, os métodos de preparação e um medicamento contendo os referidos derivados de aminoaril sulfonamida.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1127CH2005 | 2005-08-12 | ||
| IN1127/CHE/2005 | 2005-08-12 | ||
| PCT/IN2005/000345 WO2007020652A1 (en) | 2005-08-12 | 2005-10-26 | Aminoaryl sulphonamide derivatives as functional 5-ht6 ligands. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0520579A2 BRPI0520579A2 (pt) | 2009-11-10 |
| BRPI0520579B1 BRPI0520579B1 (pt) | 2019-08-06 |
| BRPI0520579B8 true BRPI0520579B8 (pt) | 2021-05-25 |
Family
ID=36130030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0520579A BRPI0520579B8 (pt) | 2005-08-12 | 2005-10-26 | composto, processo para a preparação de um composto e composição farmacêutica |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7998981B2 (pt) |
| EP (1) | EP1919896B1 (pt) |
| JP (1) | JP5091138B2 (pt) |
| KR (1) | KR101016972B1 (pt) |
| CN (1) | CN101258144B (pt) |
| AT (1) | ATE452885T1 (pt) |
| AU (1) | AU2005335620B2 (pt) |
| BR (1) | BRPI0520579B8 (pt) |
| CA (1) | CA2618636C (pt) |
| CY (1) | CY1110276T1 (pt) |
| DE (1) | DE602005018554D1 (pt) |
| DK (1) | DK1919896T3 (pt) |
| EA (1) | EA013875B1 (pt) |
| ES (1) | ES2337167T3 (pt) |
| MX (1) | MX2008002018A (pt) |
| NO (1) | NO340511B1 (pt) |
| NZ (1) | NZ566495A (pt) |
| PL (1) | PL1919896T3 (pt) |
| PT (1) | PT1919896E (pt) |
| SI (1) | SI1919896T1 (pt) |
| WO (1) | WO2007020652A1 (pt) |
| ZA (1) | ZA200801276B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009006077A (es) | 2007-01-08 | 2009-06-17 | Suven Life Sciences Ltd | Compuestos de 5-(heterociclil)alquil-n-(arilsulfonil)indol y su uso como ligandos de la 5-hidroxitriptamina6. |
| KR101162482B1 (ko) * | 2007-05-03 | 2012-07-03 | 수벤 라이프 사이언시스 리미티드 | 아미노알콕시 아릴술폰아미드 화합물 및 ５-ｈｔ６ 리간드로서의 그의 용도 |
| DK2200980T3 (da) * | 2007-10-26 | 2011-11-21 | Suven Life Sciences Ltd | Aminoarylsulfonamidforbindelser og deres anvendelse som 5-HT6-ligander |
| US8318725B2 (en) | 2008-09-17 | 2012-11-27 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands |
| AU2010340745B2 (en) * | 2010-01-05 | 2014-11-20 | Suven Life Sciences Limited | Sulfone compounds as 5-HT6 receptor ligands |
| CN102153884B (zh) * | 2011-02-16 | 2013-06-19 | 连云港清泰化工有限公司 | 一种墨水型染料及其制备方法与用途 |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| EP3166924B1 (en) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69230803T2 (de) * | 1991-11-25 | 2000-12-07 | Pfizer Inc., New York | 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| HUP0003073A3 (en) | 1997-07-11 | 2002-10-28 | Smithkline Beecham Plc | Benzenesulfonamide derivatives, process for producing them and their use as medicines |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| MXPA03005433A (es) * | 2000-12-22 | 2003-09-10 | Wyeth Corp | Compuestos de heterociclilalquilindol o-azaindol como ligandos de 5-hidroxitriptamina-6. |
| EP1383767A1 (en) | 2001-02-08 | 2004-01-28 | Memory Pharmaceutical Corporation | Trifluoromethylpurines as phosphodiesterase 4 inhibitors |
| EP1411925A1 (en) * | 2001-08-03 | 2004-04-28 | PHARMACIA & UPJOHN COMPANY | 5-arylsulfonyl indoles having 5-ht6 receptor affinity |
| AU2003238339A1 (en) | 2002-02-01 | 2003-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor |
| EP1471912A1 (en) | 2002-02-05 | 2004-11-03 | Glaxo Group Limited | Method of promoting neuronal growth |
| JP4467307B2 (ja) * | 2002-02-22 | 2010-05-26 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | ５−ｈｔ受容体アンタゴニストとしてのピリジルスルホン誘導体 |
| AU2003237705B2 (en) * | 2002-06-05 | 2009-07-30 | F. Hoffmann-La Roche Ag | 1-sulfonyl-4-aminoalkoxy indole derivatives as 5-HT6-receptor modulators for the treatment of CNS-disorders |
| DE60309498T2 (de) * | 2002-10-18 | 2007-08-30 | F. Hoffmann-La Roche Ag | 4-piperazinylbenzolsulfonyl-indole mit 5-ht6 rezeptor-affinität |
| AU2003292508A1 (en) | 2002-11-28 | 2004-06-18 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| PT1567492E (pt) | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| US7875605B2 (en) | 2002-11-28 | 2011-01-25 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| SI1581538T1 (sl) | 2002-12-18 | 2007-08-31 | Suven Life Sciences Ltd | Tetraciklični 3-substituirani indoli z afiniteto za receptor serotonina |
| US7705052B2 (en) * | 2003-09-12 | 2010-04-27 | Merck Serono Sa | Sulfonamide derivatives for the treatment of diabetes |
-
2005
- 2005-10-26 PT PT05813800T patent/PT1919896E/pt unknown
- 2005-10-26 AT AT05813800T patent/ATE452885T1/de active
- 2005-10-26 JP JP2008525723A patent/JP5091138B2/ja not_active Expired - Fee Related
- 2005-10-26 NZ NZ566495A patent/NZ566495A/en not_active IP Right Cessation
- 2005-10-26 DE DE602005018554T patent/DE602005018554D1/de not_active Expired - Lifetime
- 2005-10-26 SI SI200530928T patent/SI1919896T1/sl unknown
- 2005-10-26 MX MX2008002018A patent/MX2008002018A/es active IP Right Grant
- 2005-10-26 CA CA2618636A patent/CA2618636C/en not_active Expired - Fee Related
- 2005-10-26 EA EA200800573A patent/EA013875B1/ru not_active IP Right Cessation
- 2005-10-26 DK DK05813800.9T patent/DK1919896T3/da active
- 2005-10-26 KR KR1020087005968A patent/KR101016972B1/ko not_active Expired - Fee Related
- 2005-10-26 CN CN2005800515505A patent/CN101258144B/zh not_active Expired - Fee Related
- 2005-10-26 EP EP05813800A patent/EP1919896B1/en not_active Expired - Lifetime
- 2005-10-26 ES ES05813800T patent/ES2337167T3/es not_active Expired - Lifetime
- 2005-10-26 AU AU2005335620A patent/AU2005335620B2/en not_active Ceased
- 2005-10-26 US US11/990,383 patent/US7998981B2/en not_active Expired - Fee Related
- 2005-10-26 PL PL05813800T patent/PL1919896T3/pl unknown
- 2005-10-26 BR BRPI0520579A patent/BRPI0520579B8/pt not_active IP Right Cessation
- 2005-10-26 WO PCT/IN2005/000345 patent/WO2007020652A1/en not_active Ceased
-
2008
- 2008-02-06 ZA ZA200801276A patent/ZA200801276B/xx unknown
- 2008-02-08 NO NO20080705A patent/NO340511B1/no not_active IP Right Cessation
-
2010
- 2010-02-04 CY CY20101100110T patent/CY1110276T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2618636A1 (en) | 2007-02-22 |
| CA2618636C (en) | 2011-01-18 |
| JP2009504633A (ja) | 2009-02-05 |
| AU2005335620A1 (en) | 2007-02-22 |
| WO2007020652A1 (en) | 2007-02-22 |
| ES2337167T3 (es) | 2010-04-21 |
| BRPI0520579B1 (pt) | 2019-08-06 |
| CN101258144B (zh) | 2012-05-30 |
| DK1919896T3 (da) | 2010-04-19 |
| ATE452885T1 (de) | 2010-01-15 |
| BRPI0520579A2 (pt) | 2009-11-10 |
| NZ566495A (en) | 2010-06-25 |
| NO340511B1 (no) | 2017-05-02 |
| CY1110276T1 (el) | 2015-01-14 |
| CN101258144A (zh) | 2008-09-03 |
| HK1116796A1 (en) | 2009-01-02 |
| AU2005335620B2 (en) | 2009-12-10 |
| DE602005018554D1 (de) | 2010-02-04 |
| PL1919896T3 (pl) | 2010-05-31 |
| EA013875B1 (ru) | 2010-08-30 |
| KR101016972B1 (ko) | 2011-02-25 |
| US20100168168A1 (en) | 2010-07-01 |
| EA200800573A1 (ru) | 2008-08-29 |
| ZA200801276B (en) | 2009-02-25 |
| US7998981B2 (en) | 2011-08-16 |
| KR20080039984A (ko) | 2008-05-07 |
| SI1919896T1 (sl) | 2010-04-30 |
| NO20080705L (no) | 2008-05-06 |
| JP5091138B2 (ja) | 2012-12-05 |
| EP1919896A1 (en) | 2008-05-14 |
| MX2008002018A (es) | 2008-03-27 |
| PT1919896E (pt) | 2010-02-26 |
| EP1919896B1 (en) | 2009-12-23 |
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Legal Events
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO O PARECER DA PROCURADORIA NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012. |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2019, OBSERVADAS AS CONDICOES LEGAIS |
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