BRPI0613403A2 - tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina - Google Patents

tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina

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Publication number
BRPI0613403A2
BRPI0613403A2 BRPI0613403-3A BRPI0613403A BRPI0613403A2 BR PI0613403 A2 BRPI0613403 A2 BR PI0613403A2 BR PI0613403 A BRPI0613403 A BR PI0613403A BR PI0613403 A2 BRPI0613403 A2 BR PI0613403A2
Authority
BR
Brazil
Prior art keywords
serotonin
dopamine
norepinephrine
aryl
tetrahydrobenzodiazepines
Prior art date
Application number
BRPI0613403-3A
Other languages
English (en)
Inventor
Aruna Sambandam
Peter R Guzzo
Min Hu
Congxiang Zha
Kassoum Nacro
David D Manning
Matthew L Isherwood
Kristen N Fleming
Weng Cui
Richard E Olson
Bruce F Molino
Bristol-Myers Squibb Company
Shuang Liu
Original Assignee
Amr Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc filed Critical Amr Technology Inc
Publication of BRPI0613403A2 publication Critical patent/BRPI0613403A2/pt

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Abstract

TETRAHIDROBENZODIAZEPINAS ARIL- E HETE- ROARILA-SUBSTITUÍDAS E USO DAS MESMAS PARA BLOQUEAR A RECAPTAÇçO DE NOREPINEFRINA, DOPAMINA E SEROTONINA. A presente invenção refere-se aos compostos da presente invenção que são representados pelos seguintes derivados de tetrahidroben-zodiazepina e dihidrobenzodiazepina aril- e heteroarila-substítuídos tendo as fórmulas l(A-E) e a fórmula (II): onde o átomo de carbono designado * está na configuração R ou S e os substituintes X e R1-R9 são conforme definido aqui.
BRPI0613403-3A 2005-07-15 2006-07-17 tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina BRPI0613403A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70005705P 2005-07-15 2005-07-15
PCT/US2006/027574 WO2007011820A2 (en) 2005-07-15 2006-07-17 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Publications (1)

Publication Number Publication Date
BRPI0613403A2 true BRPI0613403A2 (pt) 2009-02-10

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BRPI0613403-3A BRPI0613403A2 (pt) 2005-07-15 2006-07-17 tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina

Country Status (17)

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US (4) US7956050B2 (pt)
EP (1) EP1904069B1 (pt)
JP (2) JP5258561B2 (pt)
KR (3) KR101594898B1 (pt)
CN (1) CN101495184A (pt)
AU (1) AU2006270071B2 (pt)
BR (1) BRPI0613403A2 (pt)
CA (1) CA2615403C (pt)
EA (1) EA019115B1 (pt)
GE (1) GEP20125566B (pt)
IL (3) IL188758A (pt)
MX (1) MX2008000717A (pt)
NZ (1) NZ565111A (pt)
PH (1) PH12014501033A1 (pt)
UA (1) UA95454C2 (pt)
WO (1) WO2007011820A2 (pt)
ZA (1) ZA200800440B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101389246B1 (ko) * 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
ZA200800440B (en) 2005-07-15 2009-12-30 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
KR20090040259A (ko) 2006-05-29 2009-04-23 하이 포인트 파마슈티칼스, 엘엘씨 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 ｈ3 수용체 안타고니스트로서의 용도
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