BRPI0617880B8 - composto derivado de piridina substituído por heterociclo, composição farmacêutica, medicamento e agente antifúngico que compreende o dito composto e uso do mesmo para prevenir e/ou tratar infecção fúngica - Google Patents

composto derivado de piridina substituído por heterociclo, composição farmacêutica, medicamento e agente antifúngico que compreende o dito composto e uso do mesmo para prevenir e/ou tratar infecção fúngica

Info

Publication number
BRPI0617880B8
BRPI0617880B8 BRPI0617880A BRPI0617880A BRPI0617880B8 BR PI0617880 B8 BRPI0617880 B8 BR PI0617880B8 BR PI0617880 A BRPI0617880 A BR PI0617880A BR PI0617880 A BRPI0617880 A BR PI0617880A BR PI0617880 B8 BRPI0617880 B8 BR PI0617880B8
Authority
BR
Brazil
Prior art keywords
group
atom
compound
antifungal agent
alkyl
Prior art date
Application number
BRPI0617880A
Other languages
English (en)
Inventor
Nakamoto Kazutaka
Tanaka Keigo
Matsukura Masayuki
Murai Norio
Inoue Satoshi
Abe Shinya
Shirotori Shuji
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Priority claimed from PCT/JP2006/321678 external-priority patent/WO2007052615A1/ja
Publication of BRPI0617880A2 publication Critical patent/BRPI0617880A2/pt
Publication of BRPI0617880B1 publication Critical patent/BRPI0617880B1/pt
Publication of BRPI0617880B8 publication Critical patent/BRPI0617880B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

derivados de piridina substituídos heterocíclicos e agente antifúngico que os contém. um objetivo da presente invenção é proporcionar um agente antifúngico que tenha excelentes efeitos antifúngicos e seja superior em termos de suas propriedades físicas, segurança e estabilidade metabólica. de acordo com a presente invenção, divulga-se um composto representado pela fórmula (i) a seguir, ou um seu sal: onde r^ 1^ representa um átomo de hidrogênio, um átomo de halogênio, um grupo amino, um grupo alquila de c~ 1-6~, um grupo alcóxi de c~ 1-6~ ou um grupo alcóxi de c~ 1-6~ alquila de c~1-6~; r^ 2^ representa um átomo de hidrogênio, um grupo alquila de c~ 1-6~, um grupo amino ou um grupo di alquilamino de c~ 1-6~; um de x e y é um átomo de nitrogênio, enquanto o outro é um átomo de nitrogênio ou um átomo de oxigênio; o anel a representa um anel de heteroarila de 5 ou 6 elementos ou um anel de benzeno que pode ter um átomo de halogênio, ou 1 ou 2 grupos alquila de c~ 1-6~; z representa uma ligação simples, um grupo metileno, um grupo etileno, um átomo de oxigênio, um átomo de enxofre, -ch~ 2~o-, -och~ 2~-, -nh-, -ch~ 2~nh-, -nrch~ 2~-, -ch~ 2~s-, ou -sch~ 2~-; r^ 3^ representa um átomo de hidrogênio, um átomo de halogênio, um grupo alquila de c~ 1-6~, um grupo cicloalquila de c~ 3-8~, um grupo arila de c~ 6-10~, um grupo heteroarila de 5 ou 6 elementos, ou um grupo heterocíclico não-aromático de 5 ou 6 elementos, o qual pode ter 1 ou 2 substituintes; e r^ 4^ representa um átomo de hidrogênio ou um átomo de halogênio.
BRPI0617880A 2005-10-31 2006-10-30 composto derivado de piridina substituído por heterociclo, composição farmacêutica, medicamento e agente antifúngico que compreende o dito composto e uso do mesmo para prevenir e/ou tratar infecção fúngica BRPI0617880B8 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US73126705P 2005-10-31 2005-10-31
JP2005-317680 2005-10-31
JP2005317680 2005-10-31
US60/731.267 2005-10-31
US75339105P 2005-12-27 2005-12-27
US60/753.391 2005-12-27
JP2005-374395 2005-12-27
JP2005374395 2005-12-27
PCT/JP2006/321678 WO2007052615A1 (ja) 2005-10-31 2006-10-30 ヘテロ環置換ピリジン誘導体およびそれらを含有する抗真菌剤

Publications (3)

Publication Number Publication Date
BRPI0617880A2 BRPI0617880A2 (pt) 2011-08-09
BRPI0617880B1 BRPI0617880B1 (pt) 2021-01-19
BRPI0617880B8 true BRPI0617880B8 (pt) 2021-05-25

Family

ID=44351887

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0617880A BRPI0617880B8 (pt) 2005-10-31 2006-10-30 composto derivado de piridina substituído por heterociclo, composição farmacêutica, medicamento e agente antifúngico que compreende o dito composto e uso do mesmo para prevenir e/ou tratar infecção fúngica

Country Status (8)

Country Link
US (4) US7691882B2 (pt)
EP (1) EP2628738B1 (pt)
JP (1) JP5107721B2 (pt)
BR (1) BRPI0617880B8 (pt)
ES (1) ES2517521T3 (pt)
MY (1) MY145746A (pt)
SA (1) SA06270396B1 (pt)
TW (1) TWI385169B (pt)

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US7691882B2 (en) 2010-04-06
US20100168173A1 (en) 2010-07-01
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