BRPI0916668A2 - composições e métodos para anticorpos direcionados à proteína do complemento c5 - Google Patents

composições e métodos para anticorpos direcionados à proteína do complemento c5

Info

Publication number
BRPI0916668A2
BRPI0916668A2 BRPI0916668-8A BRPI0916668A BRPI0916668A2 BR PI0916668 A2 BRPI0916668 A2 BR PI0916668A2 BR PI0916668 A BRPI0916668 A BR PI0916668A BR PI0916668 A2 BRPI0916668 A2 BR PI0916668A2
Authority
BR
Brazil
Prior art keywords
methods
antibody compositions
targeting antibody
complement protein
protein targeting
Prior art date
Application number
BRPI0916668-8A
Other languages
English (en)
Inventor
Diefenbach-Streiber Beate
Eberth Adina
Charles Guild Braydon
Kim Yong-In
Roguska Michael
Splawski Igor
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0916668A2 publication Critical patent/BRPI0916668A2/pt
Publication of BRPI0916668B1 publication Critical patent/BRPI0916668B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

inibidor de dpp-4 e seu uso em cicatrização de ferida, composição farmacêutica, comprimido para uso oral, e preparação tópica. a presente invenção refere-se a descoberto que certos inibidores de dpp-4 são particulamente adequados para cura de ferida preferívelmente em pacientes diabéticos.
BRPI0916668-8A 2008-08-05 2009-08-03 Anticorpo monoclonal isolado, composição farmacêutica, ácido nucleico isolado e vetor BRPI0916668B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8635508P 2008-08-05 2008-08-05
US61/086,355 2008-08-05
PCT/EP2009/060052 WO2010015608A1 (en) 2008-08-05 2009-08-03 Compositions and methods for antibodies targeting complement protein c5

Publications (2)

Publication Number Publication Date
BRPI0916668A2 true BRPI0916668A2 (pt) 2019-10-15
BRPI0916668B1 BRPI0916668B1 (pt) 2021-12-28

Family

ID=41227252

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916668-8A BRPI0916668B1 (pt) 2008-08-05 2009-08-03 Anticorpo monoclonal isolado, composição farmacêutica, ácido nucleico isolado e vetor

Country Status (39)

Country Link
US (5) US8241628B2 (pt)
EP (3) EP2328616B1 (pt)
JP (2) JP5815403B2 (pt)
KR (1) KR101463296B1 (pt)
CN (2) CN104177495B (pt)
AR (1) AR072897A1 (pt)
AU (1) AU2009279197B2 (pt)
BR (1) BRPI0916668B1 (pt)
CA (1) CA2732782C (pt)
CL (1) CL2011000233A1 (pt)
CO (1) CO6351750A2 (pt)
CR (2) CR20110035A (pt)
CU (1) CU23978B1 (pt)
DK (1) DK2328616T3 (pt)
EA (1) EA027575B1 (pt)
EC (1) ECSP11010805A (pt)
ES (2) ES2541142T3 (pt)
HK (1) HK1203156A1 (pt)
HN (1) HN2011000357A (pt)
HR (1) HRP20150799T1 (pt)
HU (1) HUE026179T2 (pt)
IL (1) IL210768B (pt)
JO (1) JO3118B1 (pt)
MA (1) MA32535B1 (pt)
MX (2) MX356218B (pt)
MY (1) MY159396A (pt)
NZ (2) NZ600622A (pt)
PE (1) PE20110225A1 (pt)
PL (1) PL2328616T3 (pt)
PT (1) PT2328616E (pt)
PY (1) PY09026846A (pt)
RS (1) RS54113B1 (pt)
SG (1) SG10201405377XA (pt)
SI (1) SI2328616T1 (pt)
SV (1) SV2011003834A (pt)
TW (2) TW201350130A (pt)
UA (1) UA105009C2 (pt)
WO (1) WO2010015608A1 (pt)
ZA (1) ZA201100375B (pt)

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