BRPI1011439B8 - composição de alta penetração, composição farmacêutica, sistemas de aplicação terapêutico transdérmico e uso da referida composição - Google Patents

composição de alta penetração, composição farmacêutica, sistemas de aplicação terapêutico transdérmico e uso da referida composição

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Publication number
BRPI1011439B8
BRPI1011439B8 BRPI1011439A BRPI1011439A BRPI1011439B8 BR PI1011439 B8 BRPI1011439 B8 BR PI1011439B8 BR PI1011439 A BRPI1011439 A BR PI1011439A BR PI1011439 A BRPI1011439 A BR PI1011439A BR PI1011439 B8 BRPI1011439 B8 BR PI1011439B8
Authority
BR
Brazil
Prior art keywords
composition
high penetration
peptide
transdermal therapeutic
therapeutic application
Prior art date
Application number
BRPI1011439A
Other languages
English (en)
Inventor
Yan Binbing
Yu Chongxi
Xu Lina
Tu Shiqian
Chen Yuhua
Original Assignee
Yu Chongxi
Techfields Biochem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/463,374 external-priority patent/US9376381B2/en
Application filed by Yu Chongxi, Techfields Biochem Co Ltd filed Critical Yu Chongxi
Publication of BRPI1011439A2 publication Critical patent/BRPI1011439A2/pt
Publication of BRPI1011439B1 publication Critical patent/BRPI1011439B1/pt
Publication of BRPI1011439B8 publication Critical patent/BRPI1011439B8/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
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Abstract

composição de alta penetração, composição farmacêutica, sistema de aplicação terapêutico transdérmico e uso da referida composição. a presente invenção refere-se a uma composição de alta penetração ou profármacos de alta penetração do peptídeo ou composto relacionado ao peptídeo compreendendo uma unidade funcional, ligante e unidade de transporte. a unidade funcional é ligada covalentemente à unidade de transporte através do ligante e compreende uma fração de peptídeo ou o composto relacionado ao peptídeo. a unidade de transporte compreende grupo amida protonável. o ligante compreende ligação química que é capaz de ser clivada após a composição penetrar através da barreira biológica.
BRPI1011439A 2009-05-08 2010-05-10 composição de alta penetração, composição farmacêutica, sistemas de aplicação terapêutico transdérmico e uso da referida composição BRPI1011439B8 (pt)

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CN200910135997 2009-05-08
CN200910135997.0 2009-05-08
US12/463,374 US9376381B2 (en) 2006-11-08 2009-05-08 High penetration prodrug compositions of peptides and peptide-related compounds
US12/463,374 2009-05-08
PCT/CN2010/072561 WO2010127640A1 (en) 2009-05-08 2010-05-10 High penetration prodrug compositions of peptides and peptide-related compounds

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JP6352587B2 (ja) 2018-07-11
RU2627065C2 (ru) 2017-08-03
WO2010127640A1 (en) 2010-11-11
EP2427475A1 (en) 2012-03-14
US9248109B2 (en) 2016-02-02
JP2012526055A (ja) 2012-10-25
CN108084246A (zh) 2018-05-29
MX2011011876A (es) 2012-02-29
JP7194530B2 (ja) 2022-12-22
EP2660247A2 (en) 2013-11-06
JP2017036325A (ja) 2017-02-16
KR20120034642A (ko) 2012-04-12
RU2016139056A (ru) 2018-12-13
EP2660247A3 (en) 2014-09-03
JP2019001797A (ja) 2019-01-10
CN109232716A (zh) 2019-01-18
TW201106975A (en) 2011-03-01
RU2016139056A3 (pt) 2020-07-21
JP2020189847A (ja) 2020-11-26
EP2427475A4 (en) 2012-12-05
BRPI1011439A2 (pt) 2016-03-15
KR101903768B1 (ko) 2018-10-04
CN102459313A (zh) 2012-05-16
AU2016247145A1 (en) 2016-11-10
MX2018005737A (es) 2021-11-16
CA2761489A1 (en) 2010-11-11
US20120156279A1 (en) 2012-06-21

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