BRPI9912819B8 - vetor de expressão, micro-organismo transgênico, usos de uma molécula de ácido nucléico e de um fator de crescimento neurotrófico, bem como composições farmacêuticas compreendendo os mesmos - Google Patents

vetor de expressão, micro-organismo transgênico, usos de uma molécula de ácido nucléico e de um fator de crescimento neurotrófico, bem como composições farmacêuticas compreendendo os mesmos

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Publication number
BRPI9912819B8
BRPI9912819B8 BRPI9912819A BRPI9912819A BRPI9912819B8 BR PI9912819 B8 BRPI9912819 B8 BR PI9912819B8 BR PI9912819 A BRPI9912819 A BR PI9912819A BR PI9912819 A BRPI9912819 A BR PI9912819A BR PI9912819 B8 BRPI9912819 B8 BR PI9912819B8
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BR
Brazil
Prior art keywords
growth factor
nucleic acid
acid molecule
well
pharmaceutical compositions
Prior art date
Application number
BRPI9912819A
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English (en)
Inventor
Alfons Gabriel Geerts Hugo
August Laurentius Ver Donck Luc
Cik Miroslav
Leo Jozef Masure Stefan
Frans Meert Theo
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27269394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9912819(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9815283.8A external-priority patent/GB9815283D0/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI9912819B1 publication Critical patent/BRPI9912819B1/pt
Publication of BRPI9912819B8 publication Critical patent/BRPI9912819B8/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)

Abstract

patente de invenção: <b>"fator de crescimento neurotrófico"<d>. a esse respeito é revelado uma molécula de ácido nucléico isolada codificando uma enovin designada de fator de crescimento neurotrófico humano e tendo a seqüência de aminoácido ilustrada na figura 1, 21, 23 ou 24 ou codificando um equivalente, derivado ou bioprecusor funcional do dito fator de crescimento. o fator de crescimento preferivelmente compreende a seqüência de aminoácio de posição 27 a 139 da seqüência ilustrada na figura 1, ou um equivalente, derivado ou bioprecusor funcional disso. a molécula de ácido nucléico codificando enovin pode ser usada para transformar uma célula, tecido ou organismo hospedeiro incluindo-o em um vetor apropriado. a célula, tecido ou organismo hospedeiro e o vetor também formam parte da invenção.
BRPI9912819A 1998-07-14 1999-07-14 vetor de expressão, micro-organismo transgênico, usos de uma molécula de ácido nucléico e de um fator de crescimento neurotrófico, bem como composições farmacêuticas compreendendo os mesmos BRPI9912819B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9815283.8A GB9815283D0 (en) 1998-07-14 1998-07-14 Neurotrophic growth factor
US24877299A 1999-02-12 1999-02-12
US32766899A 1999-06-08 1999-06-08
PCT/EP1999/005031 WO2000004050A2 (en) 1998-07-14 1999-07-14 Neurotrophic growth factor

Publications (2)

Publication Number Publication Date
BRPI9912819B1 BRPI9912819B1 (pt) 2018-09-18
BRPI9912819B8 true BRPI9912819B8 (pt) 2021-05-25

Family

ID=27269394

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9912819A BRPI9912819B8 (pt) 1998-07-14 1999-07-14 vetor de expressão, micro-organismo transgênico, usos de uma molécula de ácido nucléico e de um fator de crescimento neurotrófico, bem como composições farmacêuticas compreendendo os mesmos
BR9912819-5A BR9912819A (pt) 1998-07-14 1999-07-14 Fator de crescimento neurotrófico

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR9912819-5A BR9912819A (pt) 1998-07-14 1999-07-14 Fator de crescimento neurotrófico

Country Status (28)

Country Link
US (1) US7544788B2 (pt)
EP (2) EP1640381B1 (pt)
JP (2) JP4469500B2 (pt)
KR (2) KR100773776B1 (pt)
CN (1) CN1243770C (pt)
AT (1) ATE343594T1 (pt)
AU (1) AU768472B2 (pt)
BG (1) BG65518B1 (pt)
BR (2) BRPI9912819B8 (pt)
CA (1) CA2333910C (pt)
CY (2) CY1105949T1 (pt)
CZ (1) CZ303868B6 (pt)
DE (1) DE69933771T2 (pt)
DK (2) DK1097167T3 (pt)
ES (2) ES2479067T3 (pt)
HK (1) HK1045528B (pt)
HR (1) HRP20010036B1 (pt)
HU (1) HU226073B1 (pt)
ID (1) ID27024A (pt)
IL (1) IL140877A0 (pt)
NO (1) NO331809B1 (pt)
NZ (1) NZ509723A (pt)
PL (1) PL209952B1 (pt)
PT (2) PT1640381E (pt)
SI (1) SI1640381T1 (pt)
SK (1) SK287361B6 (pt)
TR (1) TR200100074T2 (pt)
WO (1) WO2000004050A2 (pt)

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BR9911908A (pt) * 1998-07-06 2001-03-27 Nsgene As ácido nucléico, sequência de ácido nucléico, processos de usar um ácido nucléico, de usar o vetor, de fabricar o polipeptìdeo, de administrar o polipeptìdeo, de tratar uma doença ou distúrbio neurodegenerativos em um animal, de determinar se uma doença ou distúrbio neurodegenerativos em um animal, de produzir qualquer um polipeptìdeo, processo para identificar, isolar ou amplificar uma sequência de ácido nucléico de neublastina, de diagnosticar ou avaliar quanto a presença de uma doença ou distúrbio ou uma predisposiçãopara desnvolvê-los, para avaliar um polipeptìdeo de neublastina purificado ou um derivado ou fragmento deste ou um modulador da atividade dos precedentes quanto a atividade em tratar ou prevenir uma doença, de tratar um distúbio neurológico, de usar a sequência de um ou mais ácidos nucléicos, e para identificar um composto candidato que induza um efeito biológico mediado pela neuroblastina, vetor, célula transformada com ácido nucléico, polipeptìdeo, cmposição, anticorpo, gene sintético, e, conjunto.
US7067473B1 (en) * 1998-07-14 2006-06-27 Janssen Pharmaceutica N.V. Neurotrophic growth factor
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JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
WO2004094592A2 (en) 2003-04-18 2004-11-04 Biogen Idec Ma Inc. Polymer-conjugated glycosylated neublastin
ATE423134T1 (de) 2003-06-10 2009-03-15 Nsgene As Verbesserte sezernierung von neublastin
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KR101241551B1 (ko) * 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
KR101215697B1 (ko) * 2004-08-19 2012-12-28 바이오겐 아이덱 엠에이 인코포레이티드 뉴블라스틴 변형체
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
CA2677273A1 (en) 2007-02-06 2008-08-14 Tai-June Yoo Use of a composition comprising a cytokine encoding nucleic acid for treating alzheimer's disease
ES2476253T3 (es) 2007-05-01 2014-07-14 Biogen Idec Ma Inc. P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
AU2008269689A1 (en) * 2007-06-27 2008-12-31 Auckland Uniservices Limited Polypeptides and polynucleotides for artemin and related ligands, and methods of use thereof
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JO3462B1 (ar) * 2012-08-22 2020-07-05 Regeneron Pharma أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها
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DE69933771T2 (de) * 1998-07-14 2007-09-13 Janssen Pharmaceutica N.V. Neurotrophischer wachstumsfaktor
US7067473B1 (en) 1998-07-14 2006-06-27 Janssen Pharmaceutica N.V. Neurotrophic growth factor
US20020002269A1 (en) 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
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IL140877A0 (en) 2002-02-10
TR200100074T2 (tr) 2001-11-21
JP2010158241A (ja) 2010-07-22
AU768472B2 (en) 2003-12-11
EP1640381B1 (en) 2014-05-14
CN1243770C (zh) 2006-03-01
JP2002520042A (ja) 2002-07-09
NO20010212L (no) 2001-03-14
HK1092477A1 (en) 2007-02-09
EP1097167B1 (en) 2006-10-25
HUP0102821A3 (en) 2003-09-29
NO331809B1 (no) 2012-04-10
CA2333910A1 (en) 2000-01-27
EP1097167B2 (en) 2018-12-12
DK1097167T3 (da) 2007-03-12
WO2000004050A3 (en) 2000-11-09
SK142001A3 (en) 2002-02-05
PT1640381E (pt) 2014-07-17
HK1045528A1 (en) 2002-11-29
BRPI9912819B1 (pt) 2018-09-18
ATE343594T1 (de) 2006-11-15
PL209952B1 (pl) 2011-11-30
HRP20010036A2 (en) 2001-12-31
HRP20010036B1 (hr) 2010-06-30
BG105107A (en) 2001-10-31
BR9912819A (pt) 2001-05-02
ES2479067T3 (es) 2014-07-23
HU226073B1 (en) 2008-04-28
NO20010212D0 (no) 2001-01-12
EP1097167A2 (en) 2001-05-09
CZ200128A3 (cs) 2001-08-15
JP4624476B2 (ja) 2011-02-02
CY1105949T1 (el) 2011-04-06
HK1045528B (zh) 2006-10-27
SI1640381T1 (sl) 2014-07-31
CA2333910C (en) 2016-11-15
KR20060061408A (ko) 2006-06-07
EP1640381A3 (en) 2007-01-31
AU5283299A (en) 2000-02-07
DE69933771D1 (de) 2006-12-07
DK1640381T3 (da) 2014-07-14
KR100712223B1 (ko) 2007-04-27
PL348431A1 (en) 2002-05-20
ES2275349T3 (es) 2007-06-01
KR20010083108A (ko) 2001-08-31
BG65518B1 (bg) 2008-10-31
WO2000004050A2 (en) 2000-01-27
EP1640381A2 (en) 2006-03-29
DE69933771T2 (de) 2007-09-13
HUP0102821A2 (hu) 2001-11-28
KR100773776B1 (ko) 2007-11-12
CZ303868B6 (cs) 2013-06-05
US7544788B2 (en) 2009-06-09
US20050233359A1 (en) 2005-10-20
JP4469500B2 (ja) 2010-05-26
SK287361B6 (sk) 2010-08-09
CY1115496T1 (el) 2017-01-04
NZ509723A (en) 2004-01-30
PT1097167E (pt) 2007-02-28
CN1342165A (zh) 2002-03-27
ID27024A (id) 2001-02-22

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