CA1039632A - Substrat pour epreuves immunologiques et methode de fabrication - Google Patents

Substrat pour epreuves immunologiques et methode de fabrication

Info

Publication number: CA1039632A
Authority: CA; Canada
Prior art keywords: coating; set forth; device set; substrate; indium
Prior art date: 1974-02-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA218,333A

Other languages

English (en)

Other versions

CA218333S (en

Inventor

Ivar Giaever

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

General Electric Co

Original Assignee

General Electric Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-02-25

Filing date

1975-01-21

Publication date

1978-10-03

1975-01-21 Application filed by General Electric Co filed Critical General Electric Co

1978-10-03 Application granted granted Critical

1978-10-03 Publication of CA1039632A publication Critical patent/CA1039632A/fr

Status Expired legal-status Critical Current

Links

239000000758 substrate Substances 0.000 title claims abstract description 79
238000012360 testing method Methods 0.000 title abstract description 25
230000001900 immune effect Effects 0.000 title abstract description 7
238000004519 manufacturing process Methods 0.000 title abstract description 6
239000002245 particle Substances 0.000 claims abstract description 53
APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims abstract description 40
229910052738 indium Inorganic materials 0.000 claims abstract description 39
239000010931 gold Substances 0.000 claims abstract description 31
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 26
239000011521 glass Substances 0.000 claims abstract description 13
102000004169 proteins and genes Human genes 0.000 claims description 36
108090000623 proteins and genes Proteins 0.000 claims description 36
229910052737 gold Inorganic materials 0.000 claims description 30
239000000427 antigen Substances 0.000 claims description 23
239000011248 coating agent Substances 0.000 claims description 22
238000000576 coating method Methods 0.000 claims description 22
102000036639 antigens Human genes 0.000 claims description 21
108091007433 antigens Proteins 0.000 claims description 21
229910003437 indium oxide Inorganic materials 0.000 claims description 11
PJXISJQVUVHSOJ-UHFFFAOYSA-N indium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[In+3].[In+3] PJXISJQVUVHSOJ-UHFFFAOYSA-N 0.000 claims description 11
229910000510 noble metal Inorganic materials 0.000 claims description 9
230000001788 irregular Effects 0.000 claims description 6
229910000906 Bronze Inorganic materials 0.000 claims description 5
239000010974 bronze Substances 0.000 claims description 5
KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 claims description 5
239000000463 material Substances 0.000 claims description 5
229910045601 alloy Inorganic materials 0.000 claims description 4
239000000956 alloy Substances 0.000 claims description 4
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical group [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 2
229910052709 silver Inorganic materials 0.000 claims description 2
239000004332 silver Substances 0.000 claims description 2
239000000470 constituent Substances 0.000 claims 14
239000002131 composite material Substances 0.000 claims 2
230000003647 oxidation Effects 0.000 abstract description 15
238000007254 oxidation reaction Methods 0.000 abstract description 15
238000010438 heat treatment Methods 0.000 abstract description 7
230000035945 sensitivity Effects 0.000 abstract description 6
238000000151 deposition Methods 0.000 abstract description 5
229910001020 Au alloy Inorganic materials 0.000 abstract description 3
229910000846 In alloy Inorganic materials 0.000 abstract description 2
239000010410 layer Substances 0.000 description 63
239000000243 solution Substances 0.000 description 34
239000010408 film Substances 0.000 description 23
229910052751 metal Inorganic materials 0.000 description 15
239000002184 metal Substances 0.000 description 15
238000001514 detection method Methods 0.000 description 14
238000001704 evaporation Methods 0.000 description 14
241000282414 Homo sapiens Species 0.000 description 13
238000000034 method Methods 0.000 description 11
210000002966 serum Anatomy 0.000 description 11
230000008020 evaporation Effects 0.000 description 8
150000002739 metals Chemical class 0.000 description 8
101100070137 Seriola quinqueradiata hbab gene Proteins 0.000 description 7
230000008105 immune reaction Effects 0.000 description 7
208000002672 hepatitis B Diseases 0.000 description 6
230000005764 inhibitory process Effects 0.000 description 6
238000005275 alloying Methods 0.000 description 5
208000006454 hepatitis Diseases 0.000 description 5
231100000283 hepatitis Toxicity 0.000 description 5
230000008569 process Effects 0.000 description 5
230000000007 visual effect Effects 0.000 description 5
241001465754 Metazoa Species 0.000 description 4
101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 4
GPYPVKIFOKLUGD-UHFFFAOYSA-N gold indium Chemical compound [In].[Au] GPYPVKIFOKLUGD-UHFFFAOYSA-N 0.000 description 4
239000002356 single layer Substances 0.000 description 4
241000251539 Vertebrata <Metazoa> Species 0.000 description 3
239000010953 base metal Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
230000008021 deposition Effects 0.000 description 3
-1 for example Inorganic materials 0.000 description 3
239000000126 substance Substances 0.000 description 3
229910052715 tantalum Inorganic materials 0.000 description 3
GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
229940098773 bovine serum albumin Drugs 0.000 description 2
238000005520 cutting process Methods 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000001035 drying Methods 0.000 description 2
239000003353 gold alloy Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
229910052753 mercury Inorganic materials 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
238000000746 purification Methods 0.000 description 2
239000012266 salt solution Substances 0.000 description 2
239000004065 semiconductor Substances 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
108010017384 Blood Proteins Proteins 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
241000283707 Capra Species 0.000 description 1
206010018612 Gonorrhoea Diseases 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229910002064 alloy oxide Inorganic materials 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
230000002494 anti-cea effect Effects 0.000 description 1
238000005842 biochemical reaction Methods 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
238000007664 blowing Methods 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
239000006059 cover glass Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
229910003460 diamond Inorganic materials 0.000 description 1
239000010432 diamond Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
208000001786 gonorrhea Diseases 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000009545 invasion Effects 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000008520 organization Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
208000006379 syphilis Diseases 0.000 description 1
239000010409 thin film Substances 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/26—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
- Y10T428/263—Coating layer not in excess of 5 mils thick or equivalent
- Y10T428/264—Up to 3 mils
- Y10T428/265—1 mil or less
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
- Y10T428/31768—Natural source-type polyamide [e.g., casein, gelatin, etc.]

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Inorganic Chemistry (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)

CA218,333A 1974-02-25 1975-01-21 Substrat pour epreuves immunologiques et methode de fabrication Expired CA1039632A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US445204A US3926564A (en)	1974-02-25	1974-02-25	Substrate for immunological tests and method of fabrication thereof

Publications (1)

Publication Number	Publication Date
CA1039632A true CA1039632A (fr)	1978-10-03

Family

ID=23767988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA218,333A Expired CA1039632A (fr)	1974-02-25	1975-01-21	Substrat pour epreuves immunologiques et methode de fabrication

Country Status (2)

Country	Link
US (1)	US3926564A (fr)
CA (1)	CA1039632A (fr)

Families Citing this family (49)

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US3979184A (en) *	1975-05-27	1976-09-07	General Electric Company	Diagnostic device for visually detecting presence of biological particles
US4112925A (en) *	1976-04-22	1978-09-12	Corning Glass Works	Blood sample container having an anticoagulant coating of polyvinyl pyrrolidone and a salt of ethylene diamine tetracetate
US4090849A (en) *	1976-12-20	1978-05-23	General Electric Company	Diagnostic device and manufacture thereof
US4219335A (en) *	1978-09-18	1980-08-26	E. I. Du Pont De Nemours And Company	Immunochemical testing using tagged reagents
US4247589A (en) *	1977-12-16	1981-01-27	Greenspan Donald J	Decorative oxidation process and article
US4181501A (en) *	1979-03-26	1980-01-01	General Electric Company	Method and apparatus for measuring antibody levels
DE3215484A1 (de) *	1982-04-26	1983-11-03	Sagax Instrument AB, 18302 Täby	Aus mehreren schichten bestehender schichtkoerper und verfahren zum nachweis und/oder messen der konzentration einer chemischen substanz, insbesondere biologischer herkunft
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US5041373A (en) *	1984-01-31	1991-08-20	The Board Of Trustees Of The University Of Illinois	Method for determining periodontal disease
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US6060237A (en)	1985-02-26	2000-05-09	Biostar, Inc.	Devices and methods for optical detection of nucleic acid hybridization
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US4727024A (en) *	1986-05-12	1988-02-23	Martin Koocher	Binding assays involving formation and detection of light scattering crystals
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CA1317206C (fr) *	1986-09-22	1993-05-04	Takeyuki Kawaguchi	Methode pour la detection d'un composant d'un systeme biologique, et dispositif et trousse de detection utilises a cette fin
US5089387A (en) *	1988-07-07	1992-02-18	Adeza Biomedical Corporation	Dna probe diffraction assay and reagents
CA1337173C (fr) *	1989-04-28	1995-10-03	Westaim Biomedical Corp.	Dispositif a pellicule mince de detection de substances
US5541057A (en) *	1989-09-18	1996-07-30	Biostar, Inc.	Methods for detection of an analyte
US5639671A (en) *	1989-09-18	1997-06-17	Biostar, Inc.	Methods for optimizing of an optical assay device
US5955377A (en) *	1991-02-11	1999-09-21	Biostar, Inc.	Methods and kits for the amplification of thin film based assays
US5550063A (en) *	1991-02-11	1996-08-27	Biostar, Inc.	Methods for production of an optical assay device
US5998220A (en) *	1991-05-29	1999-12-07	Beckman Coulter, Inc.	Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en)	1991-05-29	2001-01-02	Beckman Coulter, Inc.	Multiple component chromatographic assay device
US5877028A (en) *	1991-05-29	1999-03-02	Smithkline Diagnostics, Inc.	Immunochromatographic assay device
US5837552A (en) *	1991-07-22	1998-11-17	Medifor, Ltd.	Surface-enhanced analytical procedures and substrates
EP0598003B1 (fr) *	1991-07-22	1999-02-10	Kloehn Instruments, Ltd.	Substrat pour procedes analytiques a surface amelioree, et substrats prepares pour des procedes specifiques
US5418136A (en) *	1991-10-01	1995-05-23	Biostar, Inc.	Devices for detection of an analyte based upon light interference
US5494829A (en) *	1992-07-31	1996-02-27	Biostar, Inc.	Devices and methods for detection of an analyte based upon light interference
US5552272A (en) *	1993-06-10	1996-09-03	Biostar, Inc.	Detection of an analyte by fluorescence using a thin film optical device
US5413939A (en) *	1993-06-29	1995-05-09	First Medical, Inc.	Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
CA2228970A1 (fr) *	1995-08-18	1997-02-27	Donald W. Landry	Detection de composes organiques par regulation de reactions catalysees par des anticorps
DE19601488C1 (de)	1996-01-17	1997-05-28	Itt Ind Gmbh Deutsche	Verfahren zum Herstellen einer Meßeinrichtung sowie danach hergestellte Meßeinrichtung
US5679579A (en) *	1996-01-29	1997-10-21	First Medical, Inc.	Immunofluorescence measurement of analytes bound to a substrate and apparatus therefor
US5958704A (en) *	1997-03-12	1999-09-28	Ddx, Inc.	Sensing system for specific substance and molecule detection
DE19753848A1 (de)	1997-12-04	1999-06-10	Roche Diagnostics Gmbh	Modifikation von Oberflächen zur Steigerung der Oberflächenspannung
US6376619B1 (en) *	1998-04-13	2002-04-23	3M Innovative Properties Company	High density, miniaturized arrays and methods of manufacturing same
US6395483B1 (en)	1999-09-02	2002-05-28	3M Innovative Properties Company	Arrays with mask layers
US7167615B1 (en)	1999-11-05	2007-01-23	Board Of Regents, The University Of Texas System	Resonant waveguide-grating filters and sensors and methods for making and using same
US6482638B1 (en)	1999-12-09	2002-11-19	3M Innovative Properties Company	Heat-relaxable substrates and arrays
US6492133B1 (en) *	2000-05-01	2002-12-10	3M Innovative Properties Company	Reflective disc assay devices, systems and methods
US20120077206A1 (en)	2003-07-12	2012-03-29	Accelr8 Technology Corporation	Rapid Microbial Detection and Antimicrobial Susceptibility Testing
ES2661168T3 (es)	2003-07-12	2018-03-27	Accelerate Diagnostics, Inc.	Biodetección sensible y rápida
WO2012122314A2 (fr)	2011-03-07	2012-09-13	Accelr8 Technology Corporation	Systèmes de purification rapide de cellules
US10254204B2 (en)	2011-03-07	2019-04-09	Accelerate Diagnostics, Inc.	Membrane-assisted purification
US9677109B2 (en)	2013-03-15	2017-06-13	Accelerate Diagnostics, Inc.	Rapid determination of microbial growth and antimicrobial susceptibility
US10253355B2 (en)	2015-03-30	2019-04-09	Accelerate Diagnostics, Inc.	Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
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US3271179A (en) *	1962-09-24	1966-09-06	Temescal Metallurgical Corp	Method for the manufacture of an optical filter
US3530055A (en) *	1968-08-26	1970-09-22	Ibm	Formation of layers of solids on substrates
US3694337A (en) *	1971-01-04	1972-09-26	Nippon Sheet Glass Co Ltd	Sputtering method for manufacturing transparent,heat ray reflecting glass
US3691045A (en) *	1971-03-15	1972-09-12	Corning Glass Works	Method of making photochromic films on glass substrates
US3717563A (en) *	1971-06-09	1973-02-20	Ibm	Method of adhering gold to an insulating layer on a semiconductor substrate

1974
- 1974-02-25 US US445204A patent/US3926564A/en not_active Expired - Lifetime
1975
- 1975-01-21 CA CA218,333A patent/CA1039632A/fr not_active Expired

Also Published As

Publication number	Publication date
US3926564A (en)	1975-12-16

Publication	Publication Date	Title
CA1039632A (fr)	1978-10-03	Substrat pour epreuves immunologiques et methode de fabrication
US3960490A (en)	1976-06-01	Method and apparatus for detecting immunologic reactions by diffusion in gel
US4054646A (en)	1977-10-18	Method and apparatus for detection of antibodies and antigens
US3979509A (en)	1976-09-07	Opaque layer method for detecting biological particles
CA1039649A (fr)	1978-10-03	Methode pour former des films d'un complexe immunologique en plusieurs couches
US3960488A (en)	1976-06-01	Method and apparatus for quantitative surface inhibition test
US3979184A (en)	1976-09-07	Diagnostic device for visually detecting presence of biological particles
EP0598003B1 (fr)	1999-02-10	Substrat pour procedes analytiques a surface amelioree, et substrats prepares pour des procedes specifiques
US4172827A (en)	1979-10-30	Method for concentration and purification of antigens and antibodies
US5837552A (en)	1998-11-17	Surface-enhanced analytical procedures and substrates
JP2528134B2 (ja)	1996-08-28	光学構造体の表面を処理する方法
US4794089A (en)	1988-12-27	Method for electronic detection of a binding reaction
DE69030004T2 (de)	1997-06-12	Verfahren und vorrichtung zum nachweis eines analyten
JPH0224548A (ja)	1990-01-26	免疫反応の電気的検出
JPH04501605A (ja)	1992-03-19	バイオセンサーシステムに使用する選択的生体分子相互作用の可能な検出表面
US4791069A (en)	1988-12-13	Methods for attaching ligands or anti-ligands to a solid phase
CA1047918A (fr)	1979-02-06	Methode et appareil pour le depistage et la purification des proteines et des anticorps
DK151240B (da)	1987-11-16	Fremgangsmaade til fremstilling af multimolekylaere lag af immunologisk reaktive proteiner paa et egnet substrat
WO1993025910A1 (fr)	1993-12-23	Dosage de plusieurs analytes a l'aide de ligands co-immobilises
CA1049398A (fr)	1979-02-27	Methode et appareil pour detecter les particules biologiques ayant des proprietes immunologiques
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