CA1113096A - Agents de blocage neuromusculaire - Google Patents

Agents de blocage neuromusculaire

Info

Publication number
CA1113096A
CA1113096A CA308,434A CA308434A CA1113096A CA 1113096 A CA1113096 A CA 1113096A CA 308434 A CA308434 A CA 308434A CA 1113096 A CA1113096 A CA 1113096A
Authority
CA
Canada
Prior art keywords
formula
hydrogen
methoxy
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA308,434A
Other languages
English (en)
Inventor
John J. Savarese
Richard J. Kitz
Sara Ginsburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of CA1113096A publication Critical patent/CA1113096A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA308,434A 1977-08-01 1978-07-31 Agents de blocage neuromusculaire Expired CA1113096A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82079477A 1977-08-01 1977-08-01
US820,794 1977-08-01

Publications (1)

Publication Number Publication Date
CA1113096A true CA1113096A (fr) 1981-11-24

Family

ID=25231743

Family Applications (1)

Application Number Title Priority Date Filing Date
CA308,434A Expired CA1113096A (fr) 1977-08-01 1978-07-31 Agents de blocage neuromusculaire

Country Status (21)

Country Link
JP (1) JPS5455577A (fr)
AT (1) AT368496B (fr)
AU (1) AU523706B2 (fr)
BE (1) BE869415A (fr)
CA (1) CA1113096A (fr)
DD (1) DD143254A5 (fr)
DE (1) DE2833505A1 (fr)
DK (1) DK339078A (fr)
ES (1) ES472229A1 (fr)
FI (1) FI782363A7 (fr)
FR (1) FR2399429A1 (fr)
GB (1) GB2002758B (fr)
IE (1) IE47014B1 (fr)
IL (1) IL55254A (fr)
LU (1) LU80062A1 (fr)
MC (1) MC1197A1 (fr)
NL (1) NL7808067A (fr)
PL (1) PL121492B1 (fr)
SE (1) SE7808267L (fr)
SU (1) SU862820A3 (fr)
ZA (1) ZA784331B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125287A (fr) * 1978-07-21 1982-06-08 John J. Savarese Modes d'emploi de substances a base de bis-isoquinolinium
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
JPS5645459A (en) * 1979-09-20 1981-04-25 Otsuka Pharmaceut Co Ltd Cyclic amine
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
JPH0555438A (ja) * 1991-08-26 1993-03-05 Rohm Co Ltd 電子部品のリード端子構造
CN1203061C (zh) * 1997-03-25 2005-05-25 艾弗拉药品公司 取代异喹啉类，其制备方法，药物组合物及其制药用途
AU2007328210B2 (en) * 2006-12-06 2012-11-22 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
CN114057642B (zh) * 2021-12-10 2023-03-28 广东嘉博制药有限公司 一种米库氯铵中间体的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5156762U (fr) * 1974-10-28 1976-05-04

Also Published As

Publication number Publication date
BE869415A (fr) 1979-01-31
GB2002758A (en) 1979-02-28
PL121492B1 (en) 1982-05-31
GB2002758B (en) 1982-02-03
AU523706B2 (en) 1982-08-12
LU80062A1 (fr) 1979-05-15
IE47014B1 (en) 1983-11-30
ZA784331B (en) 1979-12-27
FR2399429B1 (fr) 1981-07-17
ES472229A1 (es) 1979-03-16
ATA555478A (de) 1982-02-15
AT368496B (de) 1982-10-11
DD143254A5 (de) 1980-08-13
DE2833505A1 (de) 1979-04-05
NL7808067A (nl) 1979-02-05
MC1197A1 (fr) 1979-03-19
SE7808267L (sv) 1979-02-02
FR2399429A1 (fr) 1979-03-02
JPS5455577A (en) 1979-05-02
SU862820A3 (ru) 1981-09-07
IL55254A (en) 1983-03-31
DK339078A (da) 1979-02-02
IL55254A0 (en) 1978-09-29
PL208757A1 (pl) 1979-06-04
IE781550L (en) 1979-02-01
FI782363A7 (fi) 1979-02-02
AU3847678A (en) 1980-02-07

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