CA2041074A1 - Gels viscoelastiques biocompatibles, leur preparation et leur utilisation - Google Patents

Gels viscoelastiques biocompatibles, leur preparation et leur utilisation

Info

Publication number
CA2041074A1
CA2041074A1 CA2041074A CA2041074A CA2041074A1 CA 2041074 A1 CA2041074 A1 CA 2041074A1 CA 2041074 A CA2041074 A CA 2041074A CA 2041074 A CA2041074 A CA 2041074A CA 2041074 A1 CA2041074 A1 CA 2041074A1
Authority
CA
Canada
Prior art keywords
preparation
viscoelastic gel
slurries
biocompatible viscoelastic
gel slurries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2041074A
Other languages
English (en)
Other versions
CA2041074C (fr
Inventor
Edward Leshchiner
Endre A. Balazs
Nancy E. Larsen
Adelya Leshchiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Biosurgery Inc
Original Assignee
Biomatrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24196529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2041074(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomatrix Inc filed Critical Biomatrix Inc
Publication of CA2041074A1 publication Critical patent/CA2041074A1/fr
Application granted granted Critical
Publication of CA2041074C publication Critical patent/CA2041074C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B10/00—Transmission systems employing electromagnetic waves other than radio-waves, e.g. infrared, visible or ultraviolet light, or employing corpuscular radiation, e.g. quantum communication
    • H04B10/50—Transmitters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Electromagnetism (AREA)
  • Signal Processing (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
CA002041074A 1990-07-09 1991-04-24 Gels viscoelastiques biocompatibles, leur preparation et leur utilisation Expired - Lifetime CA2041074C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/550,287 US5143724A (en) 1990-07-09 1990-07-09 Biocompatible viscoelastic gel slurries, their preparation and use
US07/550,287 1990-07-09

Publications (2)

Publication Number Publication Date
CA2041074A1 true CA2041074A1 (fr) 1992-01-10
CA2041074C CA2041074C (fr) 1996-10-15

Family

ID=24196529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002041074A Expired - Lifetime CA2041074C (fr) 1990-07-09 1991-04-24 Gels viscoelastiques biocompatibles, leur preparation et leur utilisation

Country Status (9)

Country Link
US (1) US5143724A (fr)
EP (1) EP0466300B1 (fr)
JP (1) JPH0793943B2 (fr)
AT (1) ATE165979T1 (fr)
AU (1) AU629467B2 (fr)
CA (1) CA2041074C (fr)
DE (1) DE69129391T2 (fr)
DK (1) DK0466300T3 (fr)
ES (1) ES2117634T3 (fr)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5246698A (en) * 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5575995A (en) * 1991-08-15 1996-11-19 Giovanoni; Richard L. Ferric subsulfate gel and methods of using same
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
US7060287B1 (en) 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
DE4328329C2 (de) * 1992-08-26 1998-02-12 Suwelack Nachf Dr Otto Gefriergetrocknete Biomatrix
JP3390477B2 (ja) * 1993-01-25 2003-03-24 生化学工業株式会社 薬剤組成物及びその製造法
US5681825A (en) * 1993-03-15 1997-10-28 Lindqvist; Bengt Surgical method
JP2995090B2 (ja) * 1993-03-19 1999-12-27 キユー・メド・アクチエボラーグ 組織増大のための組成物および方法
FR2704431B1 (fr) * 1993-04-30 1995-07-21 Sebbin Laboratoires Utilisation d'hydrogels à base d'acide hyaluronique et/ou de polydésoxyribonucléotides comme matériaux de remplissage de prothèses et prothèses en résultant.
JPH0733682A (ja) * 1993-07-26 1995-02-03 Shiseido Co Ltd 新規複合体、それを担体として利用する徐放性製剤
WO1995003789A1 (fr) * 1993-07-28 1995-02-09 The Johns Hopkins University School Of Medicine Liberation regulee de substances pharmaceutiquement actives provenant de microcapsules de coacervat
CA2130295A1 (fr) * 1993-08-26 1995-02-27 Richard A. Berg Gels a glycosaminoglycanes reticulees a liaisons ioniques utilises pour l'augmentation des tissus mous et la liberation des principes actifs
FR2733427B1 (fr) * 1995-04-25 2001-05-25 W K Et Associes Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique
FR2733426B1 (fr) * 1995-04-25 1997-07-18 Debacker Yves Dispositif medical pour le comblement des deformations du volume de la peau telles que rides et cicatrices par injection de 2 formes physico-chimiques differentes d'un polymere biologique
US5827937A (en) * 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
US5662708A (en) * 1995-08-08 1997-09-02 Novamed Medical Products Manufacturing, Inc. Rheologically modified and osmotically balanced fill material for implant
US6387407B1 (en) 1995-09-29 2002-05-14 L.A.M. Pharmaceutical Corporation Topical drug preparations
US5897880A (en) * 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
CA2233280A1 (fr) * 1995-09-29 1997-04-03 Peter Rothbart Systeme d'administration a liberation prolongee et antagonistes et analgesiques narcotiques a effet de longue duree
US6036977A (en) * 1995-09-29 2000-03-14 L.A.M. Pharmaceutical Corp. Drug preparations for treating sexual dysfunction
US6007843A (en) 1995-09-29 1999-12-28 Lam Pharmaceuticals Corp. Sustained release delivery system
US5716631A (en) * 1995-09-29 1998-02-10 Rdn Therapeutics Inc. Long acting narcotic analgesics and antagonists
US6251436B1 (en) 1995-09-29 2001-06-26 L.A.M. Pharmaceutical Corporation Drug preparations for treating sexual dysfunction
US5861175A (en) 1996-03-15 1999-01-19 Alliance Pharmaceutical Corp. Use of fluorocarbons for diagnosis and treatment of articular disorders
US8603511B2 (en) * 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
FR2758334B1 (fr) * 1997-01-14 1999-05-21 Oreal Composition aqueuse epaissie comprenant un polymere amphiphile et une silicone polyoxyalkylenee et utilisation en cosmetique
DE19712708A1 (de) * 1997-03-26 1998-10-01 Thueringisches Inst Textil Getrocknete kontaminationsarme Hydrokolloide und Hydrogele
WO1999010385A1 (fr) * 1997-08-22 1999-03-04 Denki Kagaku Kogyo Kabushiki Kaisha Gel d'acide hyaluronique, son procede de production et substance therapeutique le contenant
ITFI980104A1 (it) * 1998-05-04 1999-11-04 Hibiscus S R L Composizioni stabilizzate contenenti acido ialuronico,loro preparazione ed uso
US6521223B1 (en) 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
CA2430130A1 (fr) * 2000-11-28 2002-06-06 Focal, Inc. Formulations polymeres ameliorant la viscosite du polyalkylene glycol
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
FR2819722B1 (fr) * 2001-01-19 2006-11-24 Corneal Ind Utilisation de l'acide hyaluronique ou d'au moins l'un de ses sels dans le cadre d'un traitemnet chirurgical de la presbytie
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
ITMO20010086A1 (it) * 2001-05-08 2002-11-08 Worgas Bruciatori Srl Metodo ed apparato per ridurre le emissioni di biossido di azoto (no2)in un apparecchio da riscaldamento senza canna fumaria
US20030138494A1 (en) * 2001-05-15 2003-07-24 L.A.M. Pharmaceutical Corporation Drug preparations for treating sexual dysfunction
MXPA01011542A (es) * 2001-11-13 2003-05-22 Alcon Inc Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel.
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
ITPD20020003A1 (it) 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
TW200307011A (en) 2002-04-18 2003-12-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modifier
CN101134119A (zh) 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
US7811298B2 (en) 2002-08-28 2010-10-12 Allergan, Inc. Fatigue-resistant gastric banding device
FR2849602B1 (fr) * 2003-01-06 2008-09-05 Assist Publ Hopitaux De Paris Solutions injectables gelifiantes a base de polymeres reticules et non reticules, et leurs applications
US20040167480A1 (en) * 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
JP4854299B2 (ja) * 2003-03-10 2012-01-18 川澄化学工業株式会社 癒着防止材
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050158356A1 (en) * 2003-11-20 2005-07-21 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
BRPI0418309B8 (pt) * 2003-12-30 2021-05-25 Genzyme Corp "géis coesos de hialuronado e/ou hilano reticulados, processo para a preparação dos mesmos, bem como composições e dispositivos compreendendo os referidos géis".
US8524213B2 (en) * 2003-12-30 2013-09-03 Genzyme Corporation Polymeric materials, their preparation and use
CN1909844B (zh) 2004-01-23 2011-02-16 阿勒根公司 可松脱式固定的一体式可调胃带
EP2145610A1 (fr) 2004-03-08 2010-01-20 Allergan Medical S.A. Système de fermeture pour organes tubulaires
EP1732635B1 (fr) 2004-03-18 2011-07-27 Allergan, Inc. Appareil de reglage du volume de ballons intragastriques
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
ATE503465T1 (de) * 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20060140988A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Visco-supplement composition and methods
CN103860582A (zh) 2004-12-30 2014-06-18 建新公司 用于关节内粘弹性补充的方案
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US8251888B2 (en) 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
WO2007070547A2 (fr) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Traitements de l'arthrite et d'autres troubles musculo-squelettiques avec de l'acide hyaluronique réticulé
US20070202084A1 (en) 2005-12-14 2007-08-30 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
CN100400580C (zh) * 2005-12-20 2008-07-09 武汉大学 一种聚电解质多糖纳米粒子及其制备方法
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US7798954B2 (en) 2006-01-04 2010-09-21 Allergan, Inc. Hydraulic gastric band with collapsible reservoir
US20070184087A1 (en) 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
FR2897775B1 (fr) * 2006-02-24 2013-05-03 Elisabeth Laugier Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations
KR20090006153A (ko) 2006-03-31 2009-01-14 큐엘티 플러그 딜리버리, 인코포레이티드 비루관계에 대한 약물 전달 방법, 구조, 및 조성물
FR2909560B1 (fr) * 2006-12-06 2012-12-28 Fabre Pierre Dermo Cosmetique Gel d'acide hyaluronique pour injection intradermique
US8383586B2 (en) * 2007-01-18 2013-02-26 Warsaw Orthopedic, Inc. Compositions and methods for soft tissue repair
WO2008143680A1 (fr) * 2007-05-16 2008-11-27 Medicis Pharmaceutical Corporation Méthodes pour identifier des surfaces de la peau d'un sujet qui semblent manquer de volume
CA2687990A1 (fr) 2007-05-23 2008-12-04 Allergan, Inc. Collagene reticule et utilisations de ce dernier
FR2918377B1 (fr) 2007-07-05 2010-10-08 Estelle Piron Gel co-reticule de polysaccharides
CA2658681A1 (fr) * 2007-07-25 2009-02-19 S & V Technologies Ag Dispersion d'acide hyaluronique, sa preparation et son application
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
WO2009018546A1 (fr) * 2007-08-02 2009-02-05 Medicis Pharmaceutical Corporation Procédé d'application d'un produit de comblement des rides injectable
US20090204101A1 (en) * 2007-08-20 2009-08-13 Wortzman Mitchell S Method of applying an injectable filler
US9011361B2 (en) 2007-09-07 2015-04-21 Mati Therapeutics Inc. Lacrimal implant detection
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
PT2818184T (pt) 2007-11-16 2019-01-28 Aclaris Therapeutics Inc Composições e métodos para o tratamento de púrpura
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
FR2924615B1 (fr) 2007-12-07 2010-01-22 Vivacy Lab Hydrogel cohesif biodegradable.
US9161970B2 (en) 2007-12-12 2015-10-20 Allergan, Inc. Dermal filler
US9044477B2 (en) 2007-12-12 2015-06-02 Allergan, Inc. Botulinum toxin formulation
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
CA2735173C (fr) 2008-09-02 2017-01-10 Tautona Group Lp Fils d'acide hyaluronique et/ou derives de ceux-ci, procedes de fabrication de ceux-ci et utilisations de ceux-ci
WO2010042493A1 (fr) 2008-10-06 2010-04-15 Allergan, Inc. Bande gastrique mécanique avec coussins
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
US8679470B2 (en) 2008-11-28 2014-03-25 Luromed Llc Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications
DK2413894T3 (en) * 2009-04-02 2017-04-03 Allergan Inc HIGHLY FORMED HYDROGLES FOR SOFTWARE STRENGTH
US8273725B2 (en) 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
US8247390B2 (en) * 2009-09-28 2012-08-21 Luromed Llc Modified hydrophilic polymers containing hydrophobic groups
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
FR2955258A1 (fr) * 2010-01-20 2011-07-22 Biopharmex Holding Ltd Composition injectable
US8758221B2 (en) 2010-02-24 2014-06-24 Apollo Endosurgery, Inc. Source reservoir with potential energy for remotely adjustable gastric banding system
US8840541B2 (en) * 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
US8586562B2 (en) 2010-03-12 2013-11-19 Allergan Industrie, Sas Fluid compositions for improving skin conditions
EP4062950A1 (fr) 2010-03-22 2022-09-28 Allergan, Inc. Seringue comprenant un agent de remplissage dermique pour l'augmentation des tissus mous
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
FR2962040B3 (fr) * 2010-07-05 2012-08-10 Alain Villette Composition injectable comprenant un medicament injectable et un gel
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
ITUD20100233A1 (it) 2010-12-22 2012-06-23 Lima Lto S P A Materiale composito per uso biomedico e procedimento per la sua realizzazione
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
RU2624239C2 (ru) 2011-06-03 2017-07-03 Аллерган, Инк. Составы кожного наполнителя, включая антиоксиданты
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
EP2581079B1 (fr) * 2011-10-11 2016-12-07 BioPolymer GmbH & Co. KG Combinaison d'acide hyaluronique et de prilocaïne
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
IN2014DN10147A (fr) * 2012-06-15 2015-08-21 Merz Pharma Gmbh & Co Kgaa
HK1214618A1 (zh) 2013-01-11 2016-07-29 Carbylan Therapeutics, Inc. 含有透明質酸的穩定化組合物
AR099900A1 (es) 2014-04-01 2016-08-24 Merz Pharma Gmbh & Co Kgaa Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso
WO2016051219A1 (fr) 2014-09-30 2016-04-07 Allergan Industrie, Sas Compositions d'hydrogel stables pourvues d'additifs
SG11201704494SA (en) 2014-12-02 2017-06-29 Silk Therapeutics Inc Silk performance apparel and products and methods of preparing the same
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
WO2016128783A1 (fr) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions et méthodes pour améliorer l'apparence de la peau
RU2715234C2 (ru) 2015-02-13 2020-02-26 Аллерган Эндюстри, Сас Имплантаты для моделирования, увеличения или коррекции частей лица, например подбородка
US10004824B2 (en) 2015-05-11 2018-06-26 Laboratoires Vivacy Compositions comprising at least one polyol and at least one anesthetic
US20180177707A1 (en) 2015-06-30 2018-06-28 Merz Pharma Gmbh & Co. Kgaa Method of preparing a composition based on hyaluronic acid
CN108135975A (zh) 2015-07-14 2018-06-08 丝绸医疗公司 丝性能服装和产品及其制备方法
KR20170090965A (ko) * 2016-01-29 2017-08-08 한미약품 주식회사 복합 히알루론산 가교물 및 그 제조방법
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
US11969526B2 (en) 2017-04-03 2024-04-30 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US11975123B2 (en) 2018-04-02 2024-05-07 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US12599706B2 (en) 2017-04-03 2026-04-14 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US11390988B2 (en) 2017-09-27 2022-07-19 Evolved By Nature, Inc. Silk coated fabrics and products and methods of preparing the same
JP7309716B2 (ja) 2017-12-22 2023-07-18 ガルデルマ ホールディング ソシエテ アノニム 注入可能なゲル製品
WO2020030629A1 (fr) 2018-08-07 2020-02-13 Merz Pharma Gmbh & Co. Kgaa Procédé de filtration dynamique d'un hydrogel réticulé
BR112021004771A2 (pt) 2018-09-13 2021-11-09 Allergan Inc Composições de ácido hialurônico-toxina clostridial
EP3860613B1 (fr) 2018-10-01 2025-09-10 The Board of Trustees of the Leland Stanford Junior University Hydrogels injectables pour libération contrôlée de composés immunomodulateurs
TW202025994A (zh) * 2018-10-04 2020-07-16 美商米拉齊創新智囊團有限公司 漿料及溶液組合物
JP2023522079A (ja) * 2020-04-17 2023-05-26 ブレンダン パトリック パーセル ヒアルロン酸組成物の制御放出

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57167919A (en) * 1981-04-07 1982-10-16 Hirozo Ohira Preventing agent for intraperitoneal adhesion
US4544516A (en) * 1982-07-28 1985-10-01 Battelle Development Corporation Collagen orientation
US4783448A (en) * 1983-06-07 1988-11-08 Perstorp Ab Method for cleansing an infected sore
JPS61210034A (ja) * 1985-03-15 1986-09-18 Seikagaku Kogyo Co Ltd 関節症治療剤
SE456346B (sv) * 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
EP0224987B1 (fr) * 1985-11-29 1992-04-15 Biomatrix, Inc. Systèmes à base de l'hyaluronanne, de ses dérivés et de ses sels pour la libération de médicaments et leur procédé de fabrication
CA1305069C (fr) * 1987-03-11 1992-07-14 John Cornell Pansement en feuille ou en gelee
IT1214505B (it) * 1987-03-12 1990-01-18 Gentili Ist Spa Procedimento per la preparazione di collageno e prodotti cosi'ottenuto.
US4994277A (en) * 1989-10-31 1991-02-19 Pfizer Hospital Products Group, Inc. Use of xanthan gum for preventing adhesions
HU227563B1 (en) * 1989-10-31 2011-08-29 Columbia Lab Bermuda Ltd Process for production of composition for moisturizing of tissue

Also Published As

Publication number Publication date
EP0466300A2 (fr) 1992-01-15
HK1011502A1 (en) 1999-07-09
DK0466300T3 (da) 1998-10-07
ATE165979T1 (de) 1998-05-15
CA2041074C (fr) 1996-10-15
DE69129391T2 (de) 1998-10-08
EP0466300B1 (fr) 1998-05-13
DE69129391D1 (de) 1998-06-18
JPH0793943B2 (ja) 1995-10-11
ES2117634T3 (es) 1998-08-16
JPH04261664A (ja) 1992-09-17
AU7405591A (en) 1992-01-09
AU629467B2 (en) 1992-10-01
US5143724A (en) 1992-09-01
EP0466300A3 (en) 1993-03-03

Similar Documents

Publication Publication Date Title
AU7405591A (en) Biocompatible viscoelastic gel slurries, their preparation and use
EP1607429A3 (fr) Procédé de préparation de dispersions aqueuses de particules polymères solubles dans l'eau
CA2159055A1 (fr) Compositions contenant des polysaccharides polyanioniques et des polymeres bioabsorbables hydrophobes
CA2226488A1 (fr) Composition de gel a base de polysaccharide
WO2000049084A8 (fr) Composition gelifiee a base d'acide hyaluronique, procede de production associe et matiere medicale contenant ladite composition
CA2230530A1 (fr) Biomateriaux destines a prevenir les adherences post-chirurgicales et constitues de derives d'acide hyaluronique
CA2356849A1 (fr) Polysaccharides superabsorbants acides
CA2237192A1 (fr) Gel d'acide hyaluronique reticule photopolymerisable et procede de preparation
NO924875L (no) Vannuloeselige derivater av hyaluronsyre
CS5939290A2 (en) Cross-linked hydrogels, method of their production and their application as wound tegmentum
CA2019422A1 (fr) Macromeres pour polyols de greffe; polyols ainsi obtenus
CA2362233A1 (fr) Procede de reticulation d'acide hyaluronique avec des polymeres
CA2209060A1 (fr) Polymeres hydrosolubles ou gonflables dans l'eau
CA2288793A1 (fr) Cryogel d'alcool polyvinylique
CA2183263A1 (fr) Procede ameliore de fixation d'un tissu biologique resistant a la calcification
CA2270599A1 (fr) Modification chimique de materiaux biomedicaux par la genipine
IE881150L (en) Low molecular weight heparins of regular structure, their¹preparation and their biological uses
NO863135L (no) Polysakkaridpolymer fremstilt ved hjelp av en mikroorganisme av slekten xanthomonas.
CA2253833A1 (fr) Derives de polysaccharide k5 ayant une activite anticoagulante elevee
CA2022478A1 (fr) Compose cosmetique solide
CA2009065A1 (fr) Utilisation de solutions d'atelocollagene et de polyholosides, par exemple des glycosaminoglycanes, pour la fabrication de microcapsules, microcapsules ainsi produites, procedes pour la fabrication de ces microcapsules et compositions cosmetiques, pharmaceutiques ou alimentaires dans lesquelles ces microcapsules sont presentes
CA2019481A1 (fr) Encollage a la gamme gelifiante
AU1754997A (en) Absorbent gelling materials of cross-linked polyaspartate
CA2265465A1 (fr) Compositions de solutions aqueuses contenant des compositions d'hydrogel polymere
EP0939086B1 (fr) Procédé pour préparer un acide hyaluronique réticulé

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry