CA2127381A1 - Procede d'isolement et de purification de la mevinoline - Google Patents

Procede d'isolement et de purification de la mevinoline

Info

Publication number: CA2127381A1
Authority: CA; Canada
Prior art keywords: mevinolin; fermentation liquor; isolation; purification; biomass
Prior art date: 1992-11-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2127381A

Other languages

English (en)

Other versions

CA2127381C (fr

Inventor

Vilmos Keri

Eva Ilkoy

Irma Hogye

Ilona Bagdi

Gabor Ambrus

Attila Jakab

Istvan Szabo

Janos Balint

Zsuzsanna Scheidl

Etelka Deli

Gyula Horvath

Csaba Szabo

Ildiko Lang

Imre Szekely

Imre Moravcsik

Vera Kovacs

Szabolcs Matyas

Zsuzsanna Sztaray

Laszlo Eszenyi

Antonia Jekkel

Attila Andor

Lajos Deak

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teva Pharmaceutical Works PLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-04

Filing date

1993-09-08

Publication date

1994-05-11

1993-09-08 Application filed by Individual filed Critical Individual

1994-05-11 Publication of CA2127381A1 publication Critical patent/CA2127381A1/fr

1997-12-23 Application granted granted Critical

1997-12-23 Publication of CA2127381C publication Critical patent/CA2127381C/fr

2013-09-08 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title abstract 5
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title abstract 5
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title abstract 5
238000002955 isolation Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1
238000000855 fermentation Methods 0.000 abstract 6
230000004151 fermentation Effects 0.000 abstract 6
239000002028 Biomass Substances 0.000 abstract 3
239000007795 chemical reaction product Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA002127381A 1992-11-04 1993-09-08 Procede d'isolement et de purification de la mevinoline Expired - Fee Related CA2127381C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HUP9203458		1992-11-04
HU9203458A HU210867B (en)	1992-11-04	1992-11-04	Method for extraction and purification of mevinolin from culture medium

Publications (2)

Publication Number	Publication Date
CA2127381A1 true CA2127381A1 (fr)	1994-05-11
CA2127381C CA2127381C (fr)	1997-12-23

Family

ID=10982513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002127381A Expired - Fee Related CA2127381C (fr)	1992-11-04	1993-09-08	Procede d'isolement et de purification de la mevinoline

Country Status (8)

Country	Link
AT (1)	AT401060B (fr)
CA (1)	CA2127381C (fr)
DE (2)	DE4395515C2 (fr)
ES (1)	ES2081776B1 (fr)
GR (1)	GR930100408A (fr)
HU (1)	HU210867B (fr)
IT (1)	IT1266672B1 (fr)
WO (1)	WO1994010328A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI9300303A (en) *	1993-06-08	1994-12-31	Krka Tovarna Zdravil	Process for isolation of hypolipemic effective substance
EA000954B1 (ru) *	1995-12-06	2000-08-28	Балканфарма - Разград Ад	Способ получения ловастатина
SK282679B6 (sk) *	1999-04-16	2002-11-06	Biotika, A. S.	Spôsob izolácie lovastatínu z vyfermentovanej pôdy
RU2265665C2 (ru) *	2000-02-24	2005-12-10	Тева Джиоджисзерджиар Ресзвенитаршашаг	Способ очистки ферментационного бульона
TR200403001T3 (tr) *	2000-03-03	2005-02-21	Plus Chemical, S.A.	Lovastatin ve simvastatinin, azaltılmış dimerik katışkı seviyelerine sahip olacak şekilde arıtılması için bir işlem
ES2204285B1 (es) *	2002-05-20	2005-03-01	Ercros Industrial, S.A.	Procedimiento para el aislamiento y purificacion de lovastatina.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) *	1979-05-11	1980-11-25	Sankyo Co Ltd	Preparation of a new physiologically active substance mb-530b
GR69216B (fr) *	1979-06-15	1982-05-07	Merck & Co Inc
HU208997B (en) *	1992-06-17	1994-02-28	Gyogyszerkutato Intezet	Microbiological method for producing mevinoline

1992
- 1992-11-04 HU HU9203458A patent/HU210867B/hu not_active IP Right Cessation
1993
- 1993-09-08 WO PCT/HU1993/000051 patent/WO1994010328A1/fr not_active Ceased
- 1993-09-08 AT AT0901593A patent/AT401060B/de not_active IP Right Cessation
- 1993-09-08 CA CA002127381A patent/CA2127381C/fr not_active Expired - Fee Related
- 1993-09-08 DE DE4395515A patent/DE4395515C2/de not_active Expired - Fee Related
- 1993-09-08 ES ES09450018A patent/ES2081776B1/es not_active Expired - Fee Related
- 1993-09-08 DE DE4395515T patent/DE4395515T1/de active Pending
- 1993-10-18 GR GR930100408A patent/GR930100408A/el not_active IP Right Cessation
- 1993-11-04 IT IT93MI002343A patent/IT1266672B1/it active IP Right Grant

Also Published As

Publication number	Publication date
DE4395515T1 (de)	1994-12-01
ES2081776A1 (es)	1996-03-01
ITMI932343A1 (it)	1995-05-04
ITMI932343A0 (it)	1993-11-04
GR930100408A (el)	1994-07-29
AT401060B (de)	1996-06-25
IT1266672B1 (it)	1997-01-09
HU210867B (en)	1995-10-30
DE4395515C2 (de)	1999-06-17
WO1994010328A1 (fr)	1994-05-11
ES2081776B1 (es)	1996-10-16
CA2127381C (fr)	1997-12-23
ATA901593A (de)	1995-10-15

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Legal Events

Date	Code	Title	Description
1994-11-15	EEER	Examination request
2006-09-08	MKLA	Lapsed