GR930100408A - Μέ?οδος απομόνωσης και κα?αρισμού μεβινολίνης. - Google Patents

Μέ?οδος απομόνωσης και κα?αρισμού μεβινολίνης.

Info

Publication number: GR930100408A
Authority: GR; Greece
Prior art keywords: separating; mevinolin; isolation; purification; active ingredient
Prior art date: 1992-11-04

Application number

GR930100408A

Other languages

Greek (el)

English (en)

Inventor

Gabor Ambrus

Attila Andor

Ilona Bagdi

Janos Balint

Lajos Deak

Etelka Deli

Laszlo Eszenyi

Irma Hogye

Gyula Horvath

Eva Ilkoy

Attila Jakab

Antonia Jekkel

Vilmos Keri

Vera Kovacs

Ildiko Lang

Szabolcs Matyas

Imre Moravcsik

Original Assignee

Biogal Gyogyszergyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-04

Filing date

1993-10-18

Publication date

1994-07-29

1993-10-18 Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar

1994-07-29 Publication of GR930100408A publication Critical patent/GR930100408A/el

Links

238000000034 method Methods 0.000 title abstract 3
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title 1
238000002955 isolation Methods 0.000 title 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title 1
238000000746 purification Methods 0.000 title 1
239000007788 liquid Substances 0.000 abstract 3
239000004480 active ingredient Substances 0.000 abstract 2
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
239000002028 Biomass Substances 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
238000001953 recrystallisation Methods 0.000 abstract 1
230000007928 solubilization Effects 0.000 abstract 1
238000005063 solubilization Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR930100408A 1992-11-04 1993-10-18 Μέ?οδος απομόνωσης και κα?αρισμού μεβινολίνης. GR930100408A (el)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU9203458A HU210867B (en)	1992-11-04	1992-11-04	Method for extraction and purification of mevinolin from culture medium

Publications (1)

Publication Number	Publication Date
GR930100408A true GR930100408A (el)	1994-07-29

Family

ID=10982513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR930100408A GR930100408A (el)	1992-11-04	1993-10-18	Μέ?οδος απομόνωσης και κα?αρισμού μεβινολίνης.

Country Status (8)

Country	Link
AT (1)	AT401060B (fr)
CA (1)	CA2127381C (fr)
DE (2)	DE4395515C2 (fr)
ES (1)	ES2081776B1 (fr)
GR (1)	GR930100408A (fr)
HU (1)	HU210867B (fr)
IT (1)	IT1266672B1 (fr)
WO (1)	WO1994010328A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI9300303A (en) *	1993-06-08	1994-12-31	Krka Tovarna Zdravil	Process for isolation of hypolipemic effective substance
EA000954B1 (ru) *	1995-12-06	2000-08-28	Балканфарма - Разград Ад	Способ получения ловастатина
SK282679B6 (sk) *	1999-04-16	2002-11-06	Biotika, A. S.	Spôsob izolácie lovastatínu z vyfermentovanej pôdy
HRP20020683A2 (en) *	2000-02-24	2004-12-31	Biogal Gyogyszergyar	Method of purifying a fermentation broth
CA2402061A1 (fr) *	2000-03-03	2001-09-13	Vilmos Keri	Procede de purification de lovastatine et de simvastatine pour la reduction de la teneur en impuretes dimeres
ES2204285B1 (es) *	2002-05-20	2005-03-01	Ercros Industrial, S.A.	Procedimiento para el aislamiento y purificacion de lovastatina.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5925599B2 (ja) *	1979-02-20	1984-06-19	三共株式会社	新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) *	1979-05-11	1980-11-25	Sankyo Co Ltd	Preparation of a new physiologically active substance mb-530b
IL60219A (en) *	1979-06-15	1985-05-31	Merck & Co Inc	Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
HU208997B (en) *	1992-06-17	1994-02-28	Gyogyszerkutato Intezet	Microbiological method for producing mevinoline

1992
- 1992-11-04 HU HU9203458A patent/HU210867B/hu not_active IP Right Cessation
1993
- 1993-09-08 DE DE4395515A patent/DE4395515C2/de not_active Expired - Fee Related
- 1993-09-08 WO PCT/HU1993/000051 patent/WO1994010328A1/fr not_active Ceased
- 1993-09-08 DE DE4395515T patent/DE4395515T1/de active Pending
- 1993-09-08 AT AT0901593A patent/AT401060B/de not_active IP Right Cessation
- 1993-09-08 ES ES09450018A patent/ES2081776B1/es not_active Expired - Fee Related
- 1993-09-08 CA CA002127381A patent/CA2127381C/fr not_active Expired - Fee Related
- 1993-10-18 GR GR930100408A patent/GR930100408A/el not_active IP Right Cessation
- 1993-11-04 IT IT93MI002343A patent/IT1266672B1/it active IP Right Grant

Also Published As

Publication number	Publication date
AT401060B (de)	1996-06-25
CA2127381C (fr)	1997-12-23
ES2081776B1 (es)	1996-10-16
ITMI932343A1 (it)	1995-05-04
ATA901593A (de)	1995-10-15
WO1994010328A1 (fr)	1994-05-11
HU210867B (en)	1995-10-30
ITMI932343A0 (it)	1993-11-04
DE4395515T1 (de)	1994-12-01
CA2127381A1 (fr)	1994-05-11
IT1266672B1 (it)	1997-01-09
ES2081776A1 (es)	1996-03-01
DE4395515C2 (de)	1999-06-17

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Legal Events

Date	Code	Title	Description
2006-05-04	ML	Lapse due to non-payment of fees