CA2268143C - Production of a multimeric protein by cell fusion method - Google Patents

Production of a multimeric protein by cell fusion method Download PDF

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Publication number
CA2268143C
CA2268143C CA002268143A CA2268143A CA2268143C CA 2268143 C CA2268143 C CA 2268143C CA 002268143 A CA002268143 A CA 002268143A CA 2268143 A CA2268143 A CA 2268143A CA 2268143 C CA2268143 C CA 2268143C
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CA
Canada
Prior art keywords
cell
cells
antibody
light chain
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002268143A
Other languages
English (en)
French (fr)
Other versions
CA2268143A1 (en
Inventor
Nobuaki Hori
Claude Geoffrey Davis
Krisztina M. Zsebo
Aya Jakobovits
Larry Green
Richard F. Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Amgen Fremont Inc
Original Assignee
Japan Tobacco Inc
Abgenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc, Abgenix Inc filed Critical Japan Tobacco Inc
Publication of CA2268143A1 publication Critical patent/CA2268143A1/en
Application granted granted Critical
Publication of CA2268143C publication Critical patent/CA2268143C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/166—Animal cells resulting from interspecies fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002268143A 1996-10-11 1997-10-10 Production of a multimeric protein by cell fusion method Expired - Lifetime CA2268143C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/730,639 US5916771A (en) 1996-10-11 1996-10-11 Production of a multimeric protein by cell fusion method
US08/730,639 1996-10-11
PCT/US1997/018910 WO1998016654A1 (en) 1996-10-11 1997-10-10 Production of a multimeric protein by cell fusion method

Publications (2)

Publication Number Publication Date
CA2268143A1 CA2268143A1 (en) 1998-04-23
CA2268143C true CA2268143C (en) 2009-12-08

Family

ID=24936175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268143A Expired - Lifetime CA2268143C (en) 1996-10-11 1997-10-10 Production of a multimeric protein by cell fusion method

Country Status (8)

Country Link
US (2) US5916771A (de)
EP (1) EP0931162B1 (de)
JP (1) JP2001505049A (de)
KR (1) KR100416680B1 (de)
AT (1) ATE553125T1 (de)
AU (1) AU734800B2 (de)
CA (1) CA2268143C (de)
WO (1) WO1998016654A1 (de)

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ATE553125T1 (de) 2012-04-15
US6207418B1 (en) 2001-03-27
EP0931162B1 (de) 2012-04-11
EP0931162A1 (de) 1999-07-28
JP2001505049A (ja) 2001-04-17
WO1998016654A1 (en) 1998-04-23
AU734800B2 (en) 2001-06-21
US5916771A (en) 1999-06-29
EP0931162A4 (de) 2002-07-10
KR100416680B1 (ko) 2004-01-31
CA2268143A1 (en) 1998-04-23
AU4989897A (en) 1998-05-11

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