CA2306985A1 - Novel use of compounds for anti-pruritic activity - Google Patents

Novel use of compounds for anti-pruritic activity Download PDF

Info

Publication number: CA2306985A1
Authority: CA; Canada
Prior art keywords: xanthine; compound; cyclopropylmethyl; butyl; nitro
Prior art date: 1997-10-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002306985A

Other languages

English (en)

French (fr)

Inventor

Siegfried Benjamin Christensen Iv

Don E. Griswold

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-17

Filing date

1998-10-16

Publication date

1999-04-29

1998-10-16 Application filed by Individual filed Critical Individual

1999-04-29 Publication of CA2306985A1 publication Critical patent/CA2306985A1/en

Status Abandoned legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims description 72
230000001139 anti-pruritic effect Effects 0.000 title claims description 8
238000000034 method Methods 0.000 claims description 35
150000003839 salts Chemical class 0.000 claims description 19
208000003251 Pruritus Diseases 0.000 claims description 13
241000124008 Mammalia Species 0.000 claims description 10
229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims description 8
125000000217 alkyl group Chemical group 0.000 claims description 8
239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims description 8
KSPYMJJKQMWWNB-UHFFFAOYSA-N cipamfylline Chemical compound O=C1N(CC2CC2)C(=O)C=2NC(N)=NC=2N1CC1CC1 KSPYMJJKQMWWNB-UHFFFAOYSA-N 0.000 claims description 7
239000001257 hydrogen Substances 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 5
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 5
125000000623 heterocyclic group Chemical group 0.000 claims description 5
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 5
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
125000005843 halogen group Chemical group 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
DAHOPKGGXGFYEW-UHFFFAOYSA-N 1,3-bis(cyclohexylmethyl)-8-piperidin-1-yl-7h-purine-2,6-dione Chemical compound C1=2N=C(N3CCCCC3)NC=2C(=O)N(CC2CCCCC2)C(=O)N1CC1CCCCC1 DAHOPKGGXGFYEW-UHFFFAOYSA-N 0.000 claims description 2
INEZLVVKMUWARI-UHFFFAOYSA-N 1,3-bis(cyclopropylmethyl)-8-morpholin-4-yl-7h-purine-2,6-dione Chemical compound C1=2N=C(N3CCOCC3)NC=2C(=O)N(CC2CC2)C(=O)N1CC1CC1 INEZLVVKMUWARI-UHFFFAOYSA-N 0.000 claims description 2
UFAQFYMNIFOKGO-UHFFFAOYSA-N 1,3-bis(cyclopropylmethyl)-8-piperidin-1-yl-7h-purine-2,6-dione Chemical compound C1=2N=C(N3CCCCC3)NC=2C(=O)N(CC2CC2)C(=O)N1CC1CC1 UFAQFYMNIFOKGO-UHFFFAOYSA-N 0.000 claims description 2
AGCQOIRZOOICOR-UHFFFAOYSA-N 1,3-bis(cyclopropylmethyl)-8-pyrrolidin-1-yl-7h-purine-2,6-dione Chemical compound C1=2N=C(N3CCCC3)NC=2C(=O)N(CC2CC2)C(=O)N1CC1CC1 AGCQOIRZOOICOR-UHFFFAOYSA-N 0.000 claims description 2
NODRXLCGHIPPNV-UHFFFAOYSA-N 1,3-dibutyl-8-chloro-7h-purine-2,6-dione Chemical compound O=C1N(CCCC)C(=O)N(CCCC)C2=C1NC(Cl)=N2 NODRXLCGHIPPNV-UHFFFAOYSA-N 0.000 claims description 2
IWJJMAURPLFEJI-UHFFFAOYSA-N 1,3-dibutyl-8-piperidin-1-yl-7h-purine-2,6-dione Chemical compound N1C=2C(=O)N(CCCC)C(=O)N(CCCC)C=2N=C1N1CCCCC1 IWJJMAURPLFEJI-UHFFFAOYSA-N 0.000 claims description 2
ZIBJHVUQUMZJBQ-UHFFFAOYSA-N 1,3-dibutyl-8-pyrrolidin-1-yl-7h-purine-2,6-dione Chemical compound N1C=2C(=O)N(CCCC)C(=O)N(CCCC)C=2N=C1N1CCCC1 ZIBJHVUQUMZJBQ-UHFFFAOYSA-N 0.000 claims description 2
WQBKKJIJEGGRNX-UHFFFAOYSA-N 8-amino-1,3-bis(cyclobutylmethyl)-7h-purine-2,6-dione Chemical compound O=C1N(CC2CCC2)C(=O)C=2NC(N)=NC=2N1CC1CCC1 WQBKKJIJEGGRNX-UHFFFAOYSA-N 0.000 claims description 2
FZMLHPFGNMRBNM-UHFFFAOYSA-N 8-amino-1,3-bis(cyclohexylmethyl)-7h-purine-2,6-dione Chemical compound O=C1N(CC2CCCCC2)C(=O)C=2NC(N)=NC=2N1CC1CCCCC1 FZMLHPFGNMRBNM-UHFFFAOYSA-N 0.000 claims description 2
MVILGRWJMAJOGO-UHFFFAOYSA-N 8-amino-1,3-bis(cyclopentylmethyl)-7h-purine-2,6-dione Chemical compound O=C1N(CC2CCCC2)C(=O)C=2NC(N)=NC=2N1CC1CCCC1 MVILGRWJMAJOGO-UHFFFAOYSA-N 0.000 claims description 2
LCPGQPIZMXWYDE-UHFFFAOYSA-N 8-amino-1,3-dibutyl-7h-purine-2,6-dione Chemical compound O=C1N(CCCC)C(=O)N(CCCC)C2=C1NC(N)=N2 LCPGQPIZMXWYDE-UHFFFAOYSA-N 0.000 claims description 2
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QZMLAWVVWTZRLF-UHFFFAOYSA-N 8-chloro-1,3-bis(cyclopropylmethyl)-7h-purine-2,6-dione Chemical compound O=C1N(CC2CC2)C(=O)C=2NC(Cl)=NC=2N1CC1CC1 QZMLAWVVWTZRLF-UHFFFAOYSA-N 0.000 claims description 2
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IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 2
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150000003431 steroids Chemical class 0.000 claims description 2
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CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
229910052794 bromium Inorganic materials 0.000 description 1
125000001246 bromo group Chemical group Br* 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
229960002152 chlorhexidine acetate Drugs 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
125000001309 chloro group Chemical group Cl* 0.000 description 1
235000020415 coconut juice Nutrition 0.000 description 1
238000004040 coloring Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000006196 drop Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
150000002066 eicosanoids Chemical class 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
210000003979 eosinophil Anatomy 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000012530 fluid Substances 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
229940074045 glyceryl distearate Drugs 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
210000003630 histaminocyte Anatomy 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
239000011147 inorganic material Substances 0.000 description 1
125000002346 iodo group Chemical group I* 0.000 description 1
208000001875 irritant dermatitis Diseases 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000008101 lactose Substances 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000007726 management method Methods 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
229940071648 metered dose inhaler Drugs 0.000 description 1
201000002266 mite infestation Diseases 0.000 description 1
230000001333 moisturizer Effects 0.000 description 1
125000002757 morpholinyl group Chemical group 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
229940127293 prostanoid Drugs 0.000 description 1
150000003814 prostanoids Chemical class 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
MHOZZUICEDXVGD-UHFFFAOYSA-N pyrrolo[2,3-d]imidazole Chemical compound C1=NC2=CC=NC2=N1 MHOZZUICEDXVGD-UHFFFAOYSA-N 0.000 description 1
230000004044 response Effects 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000000344 soap Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
108060008037 tachykinin Proteins 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002306985A 1997-10-17 1998-10-16 Novel use of compounds for anti-pruritic activity Abandoned CA2306985A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6374697P	1997-10-17	1997-10-17
US60/063,746		1997-10-17
PCT/US1998/021886 WO1999020280A1 (en)	1997-10-17	1998-10-16	Novel use of compounds for anti-pruritic activity

Publications (1)

Publication Number	Publication Date
CA2306985A1 true CA2306985A1 (en)	1999-04-29

Family

ID=22051225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002306985A Abandoned CA2306985A1 (en)	1997-10-17	1998-10-16	Novel use of compounds for anti-pruritic activity

Country Status (18)

Country	Link
EP (1)	EP1030666A4 (tr)
JP (1)	JP2001520196A (tr)
KR (1)	KR20010031149A (tr)
CN (1)	CN1306426A (tr)
AR (1)	AR015966A1 (tr)
AU (1)	AU740875B2 (tr)
BR (1)	BR9814080A (tr)
CA (1)	CA2306985A1 (tr)
CO (1)	CO4810374A1 (tr)
CZ (1)	CZ20001376A3 (tr)
HU (1)	HUP0003792A3 (tr)
IL (1)	IL135581A0 (tr)
NO (1)	NO20001847L (tr)
NZ (1)	NZ503551A (tr)
PL (1)	PL341062A1 (tr)
TR (1)	TR200001040T2 (tr)
WO (1)	WO1999020280A1 (tr)
ZA (1)	ZA989450B (tr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8492543B2 (en)	2007-08-17	2013-07-23	Eisai R&D Management Co., Ltd.	Method for producing quinazoline derivative
TWI404709B (zh) *	2006-02-21	2013-08-11	Eisai R&D Man Co Ltd	4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives
US8530654B2 (en)	2007-02-16	2013-09-10	Eisai R&D Management Co., Ltd.	Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2248231T3 (es)	2001-01-31	2006-03-16	Pfizer Products Inc.	Derivados de eteres utiles como inhibidores de las isozimas pde4.
US7250518B2 (en)	2001-01-31	2007-07-31	Pfizer Inc.	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN1489588A (zh)	2001-01-31	2004-04-14	�Ʒ�	用作pde4同功酶抑制剂的噻唑基,噁唑基,吡咯基,和咪唑基羧酸酰胺衍生物
EE200300360A (et)	2001-01-31	2003-12-15	Pfizer Products Inc.	PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
US20030175314A1 (en) *	2001-11-19	2003-09-18	Didriksen Erik Johannes	Pharmaceutical composition for dermal application
US20060258703A1 (en) *	2003-07-17	2006-11-16	Ono Pharmaceutical Co., Ltd.	Remedy for pruritus comprising piperidine derivative as the active ingredient
WO2005053672A1 (ja) *	2003-12-04	2005-06-16	Santen Pharmaceutical Co., Ltd.	シロミラストまたはその塩を有効成分とする掻痒治療剤
JP2005187458A (ja) *	2003-12-04	2005-07-14	Santen Pharmaceut Co Ltd	シロミラストまたはその塩を有効成分とする掻痒治療剤
PL1781657T3 (pl)	2004-02-14	2013-08-30	Glaxosmithkline Ip Dev Ltd	Leki o aktywności wobec receptora HM74A
JP2008137892A (ja) *	2005-03-04	2008-06-19	Eisai Co Ltd	止痒剤
ES2401128T3 (es)	2005-08-10	2013-04-17	Glaxosmithkline Llc	Derivados de xantina como agonistas selectivos de HM74A
AU2007218725B2 (en) *	2006-02-21	2011-12-01	Eisai R & D Management Co., Ltd.	4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative
CA2696793A1 (en)	2007-08-17	2009-02-26	Eisai R&D Management Co., Ltd.	Novel preparation for external use
ES2659458T3 (es) *	2011-06-28	2018-03-15	Mitsubishi Tanabe Pharma Corporation	Compuestos de naftaleno para tratar el prurito
EP3251675B1 (en)	2015-01-30	2021-04-21	Shanton Pharma Pte. Ltd.	Prevention or treatment of uric acid or gout disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2148170T3 (es) *	1990-12-21	2000-10-16	Beecham Group Plc	Derivados de xantina.
SI0889886T1 (en) *	1996-03-26	2003-02-28	Altana Pharma Ag	Novel phenanthridines substituted in the 6 position
ES2187775T3 (es) *	1996-05-15	2003-06-16	Altana Pharma Ag	Imidazopiridinas.
SI0968211T1 (en) *	1997-03-07	2004-02-29	Altana Pharma Ag	Tetrazole derivatives
SK122199A3 (en) *	1997-03-18	2000-12-11	Basf Ag	Methods and compositions for modulating responsiveness to corticosteroids
ES2193539T3 (es) *	1997-06-03	2003-11-01	Altana Pharma Ag	Benzonaftiridinas.

1998
- 1998-10-15 AR ARP980105131A patent/AR015966A1/es not_active Application Discontinuation
- 1998-10-16 CO CO98060225A patent/CO4810374A1/es unknown
- 1998-10-16 KR KR1020007004053A patent/KR20010031149A/ko not_active Withdrawn
- 1998-10-16 WO PCT/US1998/021886 patent/WO1999020280A1/en not_active Ceased
- 1998-10-16 CZ CZ20001376A patent/CZ20001376A3/cs unknown
- 1998-10-16 CA CA002306985A patent/CA2306985A1/en not_active Abandoned
- 1998-10-16 HU HU0003792A patent/HUP0003792A3/hu unknown
- 1998-10-16 BR BR9814080-9A patent/BR9814080A/pt not_active IP Right Cessation
- 1998-10-16 PL PL98341062A patent/PL341062A1/xx unknown
- 1998-10-16 JP JP2000516677A patent/JP2001520196A/ja not_active Withdrawn
- 1998-10-16 AU AU10938/99A patent/AU740875B2/en not_active Ceased
- 1998-10-16 NZ NZ503551A patent/NZ503551A/en unknown
- 1998-10-16 ZA ZA989450A patent/ZA989450B/xx unknown
- 1998-10-16 EP EP98953608A patent/EP1030666A4/en not_active Withdrawn
- 1998-10-16 TR TR2000/01040T patent/TR200001040T2/tr unknown
- 1998-10-16 IL IL13558198A patent/IL135581A0/xx unknown
- 1998-10-16 CN CN98810066A patent/CN1306426A/zh active Pending
2000
- 2000-04-10 NO NO20001847A patent/NO20001847L/no not_active Application Discontinuation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI404709B (zh) *	2006-02-21	2013-08-11	Eisai R&D Man Co Ltd	4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives
US8530654B2 (en)	2007-02-16	2013-09-10	Eisai R&D Management Co., Ltd.	Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid
US8492543B2 (en)	2007-08-17	2013-07-23	Eisai R&D Management Co., Ltd.	Method for producing quinazoline derivative

Also Published As

Publication number	Publication date
HUP0003792A2 (hu)	2001-10-28
CN1306426A (zh)	2001-08-01
EP1030666A1 (en)	2000-08-30
NO20001847D0 (no)	2000-04-10
CO4810374A1 (es)	1999-06-30
ZA989450B (en)	1999-04-19
EP1030666A4 (en)	2002-10-16
JP2001520196A (ja)	2001-10-30
IL135581A0 (en)	2001-05-20
WO1999020280A1 (en)	1999-04-29
KR20010031149A (ko)	2001-04-16
TR200001040T2 (tr)	2001-01-22
BR9814080A (pt)	2000-09-26
AU1093899A (en)	1999-05-10
CZ20001376A3 (cs)	2002-06-12
HUP0003792A3 (en)	2001-12-28
AU740875B2 (en)	2001-11-15
NZ503551A (en)	2002-05-31
AR015966A1 (es)	2001-05-30
NO20001847L (no)	2000-04-10
PL341062A1 (en)	2001-03-26

Legal Events

Date	Code	Title	Description
2002-11-19	EEER	Examination request
2004-10-18	FZDE	Discontinued

Publication	Publication Date	Title
AU740875B2 (en)	2001-11-15	Novel use of compounds for anti-pruritic activity
Golightly et al.	1988	Pharmaceutical excipients: adverse effects associated with inactive ingredients in drug products (Part I)
JPS62249923A (ja)	1987-10-30	パ−キンソン病、うつ病、ナルコレプシ−および脳器官精神症候群の抑制用薬剤およびその製造方法
JP2002527392A (ja)	2002-08-27	末梢的に作用する抗掻痒アヘン剤
ITMI20080395A1 (it)	2009-09-11	Formulazioni per il trattamento delle verruche e delle placche psoriatiche
WO2008091704A2 (en)	2008-07-31	Treatment of cushing's syndrome and autism
JPS62185014A (ja)	1987-08-13	複合調剤薬
JPWO2006041121A1 (ja)	2008-05-15	慢性皮膚疾患の治療および／または予防剤
US20030050329A1 (en)	2003-03-13	Synergistic combination comprising roflumilast and a PDE-3 inhibitor
JPS625913A (ja)	1987-01-12	ジヒドロピリジン含有製剤
JPH02160720A (ja)	1990-06-20	医薬組成物
UA123780C2 (uk)	2021-06-02	Лікування екземи кистей
JPH03204815A (ja)	1991-09-06	皮膚炎に対する治療用組成物
JP2016517419A (ja)	2016-06-16	障害組織の全身および局所組合わせ処置
EP0402422A1 (en)	1990-12-19	Certain paf antagonist antihistamine combinations and methods
MXPA00003775A (en)	2001-03-05	Novel use of compounds for anti-pruritic activity
JPH03215435A (ja)	1991-09-20	アルドース還元酵素阻害剤を主成分とする潰瘍治療剤
JPH06500129A (ja)	1994-01-06	ヌクレオシド誘導体
JP2004026810A (ja)	2004-01-29	鼻炎用組成物
JPS6245525A (ja)	1987-02-27	脂質低下剤
AU1563902A (en)	2002-03-28	Novel use of compounds for anti-pruritic activity
JPH0522687B2 (tr)	1993-03-30
AU5010193A (en)	1994-03-15	Methods of treating psoriasis employing substituted azaspiranes
EP0760663A1 (fr)	1997-03-12	Utilisation des derives de 2- 4-(azolylbutyl)-piperazinyl-methyl]-benzimidazole pour le traitement de la conjonctivite allergique
JPH0259521A (ja)	1990-02-28	高尿酸血症治療用医薬組成物

CA2306985A1 - Novel use of compounds for anti-pruritic activity - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (3)

Publications (1)

Family

ID=22051225

Family Applications (1)

Country Status (18)

Cited By (3)

Families Citing this family (15)

Family Cites Families (6)

Cited By (3)

Also Published As

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