CA2423820C - Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
CA2423820C
CA2423820C CA 2423820 CA2423820A CA2423820C CA 2423820 C CA2423820 C CA 2423820C CA 2423820 CA2423820 CA 2423820 CA 2423820 A CA2423820 A CA 2423820A CA 2423820 C CA2423820 C CA 2423820C
Authority
CA
Canada
Prior art keywords
formula
compound
pharmaceutically acceptable
disorders
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 2423820
Other languages
English (en)
French (fr)
Other versions
CA2423820A1 (fr
Inventor
Gilbert Lavielle
Olivier Muller
Mark Millan
Alain Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of CA2423820A1 publication Critical patent/CA2423820A1/fr
Application granted granted Critical
Publication of CA2423820C publication Critical patent/CA2423820C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CA 2423820 2002-03-27 2003-03-26 Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related CA2423820C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02.03788 2002-03-27
FR0203788A FR2837823B1 (fr) 2002-03-27 2002-03-27 Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CA2423820A1 CA2423820A1 (fr) 2003-09-27
CA2423820C true CA2423820C (fr) 2008-08-05

Family

ID=8871507

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2423820 Expired - Fee Related CA2423820C (fr) 2002-03-27 2003-03-26 Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (23)

Country Link
US (2) US6759421B2 (de)
EP (1) EP1348704B1 (de)
JP (1) JP3926284B2 (de)
KR (1) KR100562207B1 (de)
CN (1) CN1209359C (de)
AR (1) AR039145A1 (de)
AT (1) ATE326457T1 (de)
AU (1) AU2003203287B2 (de)
BR (1) BR0300759A (de)
CA (1) CA2423820C (de)
CY (1) CY1105509T1 (de)
DE (1) DE60305229T2 (de)
DK (1) DK1348704T3 (de)
EA (1) EA005620B1 (de)
ES (1) ES2263927T3 (de)
FR (1) FR2837823B1 (de)
MX (1) MXPA03002532A (de)
NO (1) NO324761B1 (de)
NZ (1) NZ524958A (de)
PL (1) PL208281B1 (de)
PT (1) PT1348704E (de)
SI (1) SI1348704T1 (de)
ZA (1) ZA200302392B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101005534B1 (ko) * 2008-06-23 2011-01-04 (주)핼릭스케어 충격 흡수력이 우수한 인솔

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656003A1 (de) * 1992-08-20 1995-06-07 Smithkline Beecham Plc Kondensierte indol derivate als 5ht2c und 5ht2b antagonisten
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
EP0757687A1 (de) * 1994-04-23 1997-02-12 Smithkline Beecham Plc Tricyclische derivate als 5ht2c und 5ht2b antagonisten
US6221884B1 (en) * 1997-06-04 2001-04-24 Eli Lilly And Company Carboxamides useful as 5-HT1F agonists
FR2807754A1 (fr) * 2000-04-13 2001-10-19 Adir Nouveaux derives de cyclobuta-indole carboxamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AU2003203287B2 (en) 2008-08-28
DE60305229D1 (de) 2006-06-22
ZA200302392B (en) 2003-09-30
PT1348704E (pt) 2006-08-31
EA200300302A1 (ru) 2003-10-30
DE60305229T2 (de) 2007-05-24
EA005620B1 (ru) 2005-04-28
EP1348704A1 (de) 2003-10-01
US20030199555A1 (en) 2003-10-23
JP3926284B2 (ja) 2007-06-06
NO324761B1 (no) 2007-12-10
PL208281B1 (pl) 2011-04-29
CY1105509T1 (el) 2010-04-28
ATE326457T1 (de) 2006-06-15
AU2003203287A1 (en) 2003-10-23
NO20031371L (no) 2003-09-29
KR100562207B1 (ko) 2006-03-22
NZ524958A (en) 2004-03-26
CN1209359C (zh) 2005-07-06
CA2423820A1 (fr) 2003-09-27
US20040192736A1 (en) 2004-09-30
ES2263927T3 (es) 2006-12-16
FR2837823B1 (fr) 2005-04-08
MXPA03002532A (es) 2004-09-06
HK1057368A1 (en) 2004-04-02
AR039145A1 (es) 2005-02-09
KR20030078035A (ko) 2003-10-04
BR0300759A (pt) 2004-09-14
FR2837823A1 (fr) 2003-10-03
EP1348704B1 (de) 2006-05-17
US7053108B2 (en) 2006-05-30
NO20031371D0 (no) 2003-03-26
JP2004035541A (ja) 2004-02-05
PL359357A1 (en) 2003-10-06
US6759421B2 (en) 2004-07-06
DK1348704T3 (da) 2006-09-25
SI1348704T1 (sl) 2006-08-31
CN1446813A (zh) 2003-10-08

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Effective date: 20130326