CA2940772A1 - Composes aryle, heteroaryle et heterocycliques pour le traitement de troubles induits par un complement - Google Patents

Composes aryle, heteroaryle et heterocycliques pour le traitement de troubles induits par un complement Download PDF

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Publication number
CA2940772A1
CA2940772A1 CA2940772A CA2940772A CA2940772A1 CA 2940772 A1 CA2940772 A1 CA 2940772A1 CA 2940772 A CA2940772 A CA 2940772A CA 2940772 A CA2940772 A CA 2940772A CA 2940772 A1 CA2940772 A1 CA 2940772A1
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Prior art keywords
c4alkyl
independently chosen
c6alkyl
hydrogen
halogen
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CA2940772A
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CA2940772C (fr
Inventor
Venkat Rao GADHACHANDA
Qiuping Wang
Godwin Pais
Akihiro Hashimoto
Dawei Chen
Xiangzhu Wang
Atul Agarwal
Milind Deshpande
Jason Allan Wiles
Avinash S. Phadke
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Achillion Pharmaceuticals Inc
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Achillion Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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Abstract

L'invention concerne des composés, des procédés d'utilisation et des processus pour produire des inhibiteurs de complément de facteur D selon la formule générale I, ou un sel ou une composition pharmaceutiquement acceptables de ces derniers, où R12 ou R13sur le groupe A est un aryle, hétéroaryle ou hétérocycle (R32). Ces inhibiteurs ciblent le facteur D et inhibent ou régulent la cascade du complément au niveau à un point essentiel et précoce dans la voie alternative du complément, et réduisent la capacité du facteur D à moduler les voies du complément classique de lectine. Les inhibiteurs du facteur D décrits ici sont capables de réduire l'activation excessive du complément, qui a été associée à certaines maladies auto-immunes, inflammatoires et neurodégénératives, ainsi que les blessures par ischémie-reperfusion et le cancer.
CA2940772A 2014-02-25 2015-02-25 Composes aryle, heteroaryle et heterocycliques pour le traitement de troubles induits par un complement Active 2037-02-25 CA2940772C (fr)

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Application Number Priority Date Filing Date Title
US201461944189P 2014-02-25 2014-02-25
US61/944,189 2014-02-25
US201462022916P 2014-07-10 2014-07-10
US62/022,916 2014-07-10
US201462046783P 2014-09-05 2014-09-05
US62/046,783 2014-09-05
PCT/US2015/017593 WO2015130838A1 (fr) 2014-02-25 2015-02-25 Composés aryle, hétéroaryle et hétérocycliques pour le traitement de troubles induits par un complément

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CA2940645A Abandoned CA2940645A1 (fr) 2014-02-25 2015-02-25 Composes amide pour le traitement de troubles medies par le complement
CA2940777A Pending CA2940777A1 (fr) 2014-02-25 2015-02-25 Composes pour traiter les troubles a mediation par le complement
CA2940774A Abandoned CA2940774A1 (fr) 2014-02-25 2015-02-25 Composes d'ether pour le traitement de troubles dans lequel intervient le complement
CA2940769A Abandoned CA2940769A1 (fr) 2014-02-25 2015-02-25 Composes amines pour traiter les troubles a mediation par le complement
CA2940772A Active 2037-02-25 CA2940772C (fr) 2014-02-25 2015-02-25 Composes aryle, heteroaryle et heterocycliques pour le traitement de troubles induits par un complement
CA2940775A Abandoned CA2940775A1 (fr) 2014-02-25 2015-02-25 Phosphonates pour le traitement de troubles faisant intervenir le complement

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CA2940774A Abandoned CA2940774A1 (fr) 2014-02-25 2015-02-25 Composes d'ether pour le traitement de troubles dans lequel intervient le complement
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