CH367182A - Verfahren zur Herstellung von 3-(p-Amino-benzolsulfonamido)-6-oxy-pyridazin - Google Patents

Verfahren zur Herstellung von 3-(p-Amino-benzolsulfonamido)-6-oxy-pyridazin

Info

Publication number: CH367182A
Authority: CH; Switzerland
Prior art keywords: benzenesulfonamido; oxy; amino; pyridazine; preparation
Prior art date: 1958-04-28

Application number

CH5887658A

Other languages

German (de)

English (en)

Inventor

Jean Dr Druey

Emil Dr Merz

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-04-28

Filing date

1958-04-28

Publication date

1963-02-15

1958-04-28 Application filed by Ciba Geigy filed Critical Ciba Geigy

1958-04-28 Priority to CH5887658A priority Critical patent/CH367182A/de

1959-03-31 Priority to ES0248331A priority patent/ES248331A1/es

1963-02-15 Publication of CH367182A publication Critical patent/CH367182A/de

Links

238000000034 method Methods 0.000 title claims description 10
-1 p-Amino-benzenesulfonamido Chemical group 0.000 title claims description 9
238000002360 preparation method Methods 0.000 title claims description 5
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 9
150000001875 compounds Chemical class 0.000 claims description 4
230000007062 hydrolysis Effects 0.000 claims description 4
238000006460 hydrolysis reaction Methods 0.000 claims description 4
125000005843 halogen group Chemical group 0.000 claims description 3
239000007858 starting material Substances 0.000 claims description 3
XOXHILFPRYWFOD-UHFFFAOYSA-N sulfachloropyridazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=C(Cl)N=N1 XOXHILFPRYWFOD-UHFFFAOYSA-N 0.000 claims description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000000243 solution Substances 0.000 description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
229960000583 acetic acid Drugs 0.000 description 6
239000012362 glacial acetic acid Substances 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 4
238000001914 filtration Methods 0.000 description 4
239000003610 charcoal Substances 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000001816 cooling Methods 0.000 description 3
238000001035 drying Methods 0.000 description 3
239000000155 melt Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
238000005406 washing Methods 0.000 description 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
239000003513 alkali Substances 0.000 description 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
229910052794 bromium Inorganic materials 0.000 description 2
229910052801 chlorine Inorganic materials 0.000 description 2
239000000460 chlorine Substances 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
239000011777 magnesium Substances 0.000 description 2
229910052749 magnesium Inorganic materials 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
229940124530 sulfonamide Drugs 0.000 description 2
150000003456 sulfonamides Chemical class 0.000 description 2
125000003396 thiol group Chemical group [H]S* 0.000 description 2
241000894006 Bacteria Species 0.000 description 1
ZPPLGUJWNDBZBF-UHFFFAOYSA-N CSC1=CC=C(NS(C(C=C2)=CC=C2N)(=O)=O)N=N1 Chemical compound CSC1=CC=C(NS(C(C=C2)=CC=C2N)(=O)=O)N=N1 ZPPLGUJWNDBZBF-UHFFFAOYSA-N 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
150000003938 benzyl alcohols Chemical class 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
239000007788 liquid Substances 0.000 description 1
DQGCGYHKEFSCGC-UHFFFAOYSA-N n-[4-[(6-chloropyridazin-3-yl)sulfamoyl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1S(=O)(=O)NC1=CC=C(Cl)N=N1 DQGCGYHKEFSCGC-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CH5887658A 1958-04-28 1958-04-28 Verfahren zur Herstellung von 3-(p-Amino-benzolsulfonamido)-6-oxy-pyridazin CH367182A (de)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
CH5887658A CH367182A (de)	1958-04-28	1958-04-28	Verfahren zur Herstellung von 3-(p-Amino-benzolsulfonamido)-6-oxy-pyridazin
ES0248331A ES248331A1 (es)	1958-04-28	1959-03-31	Procedimiento para la obtenciën de una nueva sulfonomida de la serie piridacinica

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH5887658A CH367182A (de)	1958-04-28	1958-04-28	Verfahren zur Herstellung von 3-(p-Amino-benzolsulfonamido)-6-oxy-pyridazin

Publications (1)

Publication Number	Publication Date
CH367182A true CH367182A (de)	1963-02-15

Family

ID=4521992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH5887658A CH367182A (de)	1958-04-28	1958-04-28	Verfahren zur Herstellung von 3-(p-Amino-benzolsulfonamido)-6-oxy-pyridazin

Country Status (2)

Country	Link
CH (1)	CH367182A (es)
ES (1)	ES248331A1 (es)

1958
- 1958-04-28 CH CH5887658A patent/CH367182A/de unknown
1959
- 1959-03-31 ES ES0248331A patent/ES248331A1/es not_active Expired

Also Published As

Publication number	Publication date
ES248331A1 (es)	1960-01-01

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