CH649783A5 - Procede pour la production de prolactine humaine. - Google Patents

Procede pour la production de prolactine humaine. Download PDF

Info

Publication number: CH649783A5
Authority: CH; Switzerland
Prior art keywords: cells; human; prolactin; production; warm
Prior art date: 1980-08-22

Application number

CH5373/81A

Other languages

English (en)

French (fr)

Inventor

Kaname Sugimoto

Original Assignee

Hayashibara Biochem Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-08-22

Filing date

1981-08-20

Publication date

1985-06-14

1981-08-20 Application filed by Hayashibara Biochem Lab filed Critical Hayashibara Biochem Lab

1985-06-14 Publication of CH649783A5 publication Critical patent/CH649783A5/fr

Links

101000687438 Homo sapiens Prolactin Proteins 0.000 title claims description 53
238000004519 manufacturing process Methods 0.000 title claims description 41
238000000034 method Methods 0.000 title claims description 18
210000004027 cell Anatomy 0.000 claims description 71
241001465754 Metazoa Species 0.000 claims description 33
210000005260 human cell Anatomy 0.000 claims description 30
108010057464 Prolactin Proteins 0.000 claims description 13
102000003946 Prolactin Human genes 0.000 claims description 13
229940097325 prolactin Drugs 0.000 claims description 13
239000000411 inducer Substances 0.000 claims description 12
238000002054 transplantation Methods 0.000 claims description 11
239000007788 liquid Substances 0.000 claims description 8
241000700159 Rattus Species 0.000 claims description 6
229940088597 hormone Drugs 0.000 claims description 6
239000005556 hormone Substances 0.000 claims description 6
230000000050 nutritive effect Effects 0.000 claims description 6
241000699800 Cricetinae Species 0.000 claims description 5
102100032251 Pro-thyrotropin-releasing hormone Human genes 0.000 claims description 5
101800004623 Thyrotropin-releasing hormone Proteins 0.000 claims description 5
XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims description 5
229940034199 thyrotropin-releasing hormone Drugs 0.000 claims description 5
206010062767 Hypophysitis Diseases 0.000 claims description 4
XNSAINXGIQZQOO-UHFFFAOYSA-N L-pyroglutamyl-L-histidyl-L-proline amide Natural products NC(=O)C1CCCN1C(=O)C(NC(=O)C1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-UHFFFAOYSA-N 0.000 claims description 4
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
241000699666 Mus <mouse, genus> Species 0.000 claims description 4
239000000627 Thyrotropin-Releasing Hormone Substances 0.000 claims description 4
210000003635 pituitary gland Anatomy 0.000 claims description 4
235000002639 sodium chloride Nutrition 0.000 claims description 4
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical class [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
241000283973 Oryctolagus cuniculus Species 0.000 claims description 3
210000004198 anterior pituitary gland Anatomy 0.000 claims description 3
235000011148 calcium chloride Nutrition 0.000 claims description 3
230000007910 cell fusion Effects 0.000 claims description 3
210000004754 hybrid cell Anatomy 0.000 claims description 3
235000011164 potassium chloride Nutrition 0.000 claims description 3
DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 claims description 2
WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims description 2
239000004475 Arginine Substances 0.000 claims description 2
241000283690 Bos taurus Species 0.000 claims description 2
241000283707 Capra Species 0.000 claims description 2
241000700199 Cavia porcellus Species 0.000 claims description 2
241000282693 Cercopithecidae Species 0.000 claims description 2
241000272201 Columbiformes Species 0.000 claims description 2
241000283073 Equus caballus Species 0.000 claims description 2
241000282326 Felis catus Species 0.000 claims description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
239000004472 Lysine Substances 0.000 claims description 2
241000124008 Mammalia Species 0.000 claims description 2
241000009328 Perro Species 0.000 claims description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 claims description 2
QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 claims description 2
241000282898 Sus scrofa Species 0.000 claims description 2
241000700605 Viruses Species 0.000 claims description 2
235000001014 amino acid Nutrition 0.000 claims description 2
150000001413 amino acids Chemical class 0.000 claims description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 2
229960001076 chlorpromazine Drugs 0.000 claims description 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
235000018417 cysteine Nutrition 0.000 claims description 2
229940011871 estrogen Drugs 0.000 claims description 2
239000000262 estrogen Substances 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
201000005296 lung carcinoma Diseases 0.000 claims description 2
229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
235000019341 magnesium sulphate Nutrition 0.000 claims description 2
235000010755 mineral Nutrition 0.000 claims description 2
239000011707 mineral Substances 0.000 claims description 2
229950000688 phenothiazine Drugs 0.000 claims description 2
244000144977 poultry Species 0.000 claims description 2
BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical group O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 claims description 2
229960003147 reserpine Drugs 0.000 claims description 2
MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
208000003200 Adenoma Diseases 0.000 claims 1
206010001233 Adenoma benign Diseases 0.000 claims 1
239000011591 potassium Substances 0.000 claims 1
229910052700 potassium Inorganic materials 0.000 claims 1
239000011734 sodium Substances 0.000 claims 1
229910052708 sodium Inorganic materials 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
239000006285 cell suspension Substances 0.000 description 19
208000005310 acidophil adenoma Diseases 0.000 description 14
206010028980 Neoplasm Diseases 0.000 description 10
238000000338 in vitro Methods 0.000 description 10
238000002360 preparation method Methods 0.000 description 9
238000009792 diffusion process Methods 0.000 description 7
238000002474 experimental method Methods 0.000 description 6
239000002609 medium Substances 0.000 description 6
241000699670 Mus sp. Species 0.000 description 5
230000008105 immune reaction Effects 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
238000005303 weighing Methods 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 3
235000013601 eggs Nutrition 0.000 description 3
238000000605 extraction Methods 0.000 description 3
238000001914 filtration Methods 0.000 description 3
238000011534 incubation Methods 0.000 description 3
WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Inorganic materials [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
229930064664 L-arginine Natural products 0.000 description 2
235000014852 L-arginine Nutrition 0.000 description 2
241000711408 Murine respirovirus Species 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
230000028993 immune response Effects 0.000 description 2
239000007943 implant Substances 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000012528 membrane Substances 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
239000011148 porous material Substances 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
206010003445 Ascites Diseases 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
102000012410 DNA Ligases Human genes 0.000 description 1
108010061982 DNA Ligases Proteins 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
208000019395 Lactation disease Diseases 0.000 description 1
101710163270 Nuclease Proteins 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
206010042576 Suppressed lactation Diseases 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
235000009697 arginine Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
244000309466 calf Species 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000010367 cloning Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000012136 culture method Methods 0.000 description 1
238000003795 desorption Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
239000012510 hollow fiber Substances 0.000 description 1
210000004408 hybridoma Anatomy 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
229960003444 immunosuppressant agent Drugs 0.000 description 1
230000001861 immunosuppressant effect Effects 0.000 description 1
239000003018 immunosuppressive agent Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
235000018977 lysine Nutrition 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
210000001161 mammalian embryo Anatomy 0.000 description 1
210000005075 mammary gland Anatomy 0.000 description 1
239000000463 material Substances 0.000 description 1
210000004379 membrane Anatomy 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
210000004303 peritoneum Anatomy 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000047 product Substances 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000006798 recombination Effects 0.000 description 1
238000005185 salting out Methods 0.000 description 1
210000001625 seminal vesicle Anatomy 0.000 description 1
238000000926 separation method Methods 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000894007 species Species 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
201000010653 vesiculitis Diseases 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57554—Prolactin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CH5373/81A 1980-08-22 1981-08-20 Procede pour la production de prolactine humaine. CH649783A5 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP55114680A JPS5739795A (en)	1980-08-22	1980-08-22	Preparation of human prolactin

Publications (1)

Publication Number	Publication Date
CH649783A5 true CH649783A5 (fr)	1985-06-14

Family

ID=14643938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH5373/81A CH649783A5 (fr)	1980-08-22	1981-08-20	Procede pour la production de prolactine humaine.

Country Status (6)

Country	Link
JP (1)	JPS5739795A (ja)
KR (1)	KR860000896B1 (ja)
CH (1)	CH649783A5 (ja)
FR (1)	FR2488804B1 (ja)
GB (1)	GB2085891B (ja)
IT (1)	IT1143224B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE8516184U1 (de) *	1985-06-03	1985-07-18	Pfaff Industriemaschinen Gmbh, 6750 Kaiserslautern	Führungsvorrichtung für das Nähgut an Nähmaschinen
JPS62120881A (ja) *	1985-11-20	1987-06-02	ブラザー工業株式会社	ミシンの布送り装置
NZ234439A (en) *	1990-07-10	1997-08-22	Pharmacia & Upjohn Ab	Use of igf-1 to reduce fetal growth retardation in non human mammals
JPH0583089U (ja) *	1992-04-20	1993-11-09	不二グレート工業株式会社	コンクリ−ト製のｕ字溝

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2016015B (en) *	1978-01-22	1982-05-06	Hayashibara Co	Method of preparing interferon and preparations containing interferon

1980
- 1980-08-22 JP JP55114680A patent/JPS5739795A/ja active Granted
1981
- 1981-08-17 KR KR1019810002970A patent/KR860000896B1/ko not_active Expired
- 1981-08-17 IT IT49117/81A patent/IT1143224B/it active
- 1981-08-20 CH CH5373/81A patent/CH649783A5/fr not_active IP Right Cessation
- 1981-08-21 FR FR8116056A patent/FR2488804B1/fr not_active Expired
- 1981-08-21 GB GB8125630A patent/GB2085891B/en not_active Expired

Also Published As

Publication number	Publication date
FR2488804A1 (fr)	1982-02-26
FR2488804B1 (fr)	1986-05-09
JPS5739795A (en)	1982-03-05
KR830005867A (ko)	1983-09-14
IT1143224B (it)	1986-10-22
GB2085891B (en)	1984-02-08
IT8149117A0 (it)	1981-08-17
KR860000896B1 (ko)	1986-07-16
JPS5756876B2 (ja)	1982-12-01
GB2085891A (en)	1982-05-06

Legal Events

Date	Code	Title	Description
1994-04-29	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
CH650024A5 (fr)	1985-06-28	Procede pour la production d'erythropoietine humaine.
CH653364A5 (fr)	1985-12-31	Procede pour la production du facteur de croissance epidermique humain.
CH649786A5 (fr)	1985-06-14	Production de facteur leucopoietique humain.
CH650023A5 (fr)	1985-06-28	Production d'hormone humaine stimulant les follicules.
CH649784A5 (fr)	1985-06-14	Procede pour la production de gonadotrophine chorionique humaine.
CH649785A5 (fr)	1985-06-14	Production d'hormone luteinisante humaine.
FR2487851A1 (fr)	1982-02-05	Procede pour la production d'insuline humaine
FR2495635A1 (fr)	1982-06-11	Production d'urokinase humaine
FR2487852A1 (fr)	1982-02-05	Production d'hormone de croissance humaine
CH649783A5 (fr)	1985-06-14	Procede pour la production de prolactine humaine.
CH664969A5 (fr)	1988-04-15	Lymphokine humain, sa production et son utilisation pour obtenir un anticorps monoclonal specifique de ce lymphokine.
CH652748A5 (fr)	1985-11-29	Production d'hormone parathyroidienne humaine.
CH652749A5 (fr)	1985-11-29	Production de calcitonine humaine.
CH652745A5 (fr)	1985-11-29	Procede pour la production d'hormone adrenocorticotrope humaine.
CH652747A5 (fr)	1985-11-29	Production d'hormone de stimulation de la thyroide humaine.
CH652746A5 (fr)	1985-11-29	Production d'hormone lactogene, placentaire, humaine.
CH658668A5 (fr)	1986-11-28	Procede pour la production de kallikreine humaine.
GB2092158A (en)	1982-08-11	Process for the production of human multiplication stimulating activity
CH661745A5 (fr)	1987-08-14	Application d'un procede a la production de suppresseur de reponse immunitaire humain.
FR2523155A1 (fr)	1983-09-16	Preparation de facteur de croissance des cellules t humaines
CH651588A5 (en)	1985-09-30	Preparation of human T cell growth factor