CL2007001380A1 - Compuestos derivados de tiazolo-pirimidina-urea, antiparasitos activos del receptor de adenosina a2b; composicion farmaceutica que comprende a dichos compuestos; y su uso del compuesto en el tratamiento y profilaxis de diabetes, retinopatia asma y diarrea. - Google Patents
Compuestos derivados de tiazolo-pirimidina-urea, antiparasitos activos del receptor de adenosina a2b; composicion farmaceutica que comprende a dichos compuestos; y su uso del compuesto en el tratamiento y profilaxis de diabetes, retinopatia asma y diarrea.Info
- Publication number
- CL2007001380A1 CL2007001380A1 CL2007001380A CL2007001380A CL2007001380A1 CL 2007001380 A1 CL2007001380 A1 CL 2007001380A1 CL 2007001380 A CL2007001380 A CL 2007001380A CL 2007001380 A CL2007001380 A CL 2007001380A CL 2007001380 A1 CL2007001380 A1 CL 2007001380A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- antiparasites
- thiazolo
- diarrhea
- adenosine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000007470 Adenosine A2B Receptor Human genes 0.000 title abstract 2
- 108010085273 Adenosine A2B receptor Proteins 0.000 title abstract 2
- 206010012735 Diarrhoea Diseases 0.000 title abstract 2
- 230000002141 anti-parasite Effects 0.000 title abstract 2
- 208000006673 asthma Diseases 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 208000017442 Retinal disease Diseases 0.000 title 1
- 206010038923 Retinopathy Diseases 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- GAOJUAYPDKVFDO-UHFFFAOYSA-N pyridine;urea Chemical compound NC(N)=O.C1=CC=NC=C1 GAOJUAYPDKVFDO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de tiazolo/piridina urea, antiparásitos activos del receptor de adenosina a2b; composición farmacéutica que comprende a dichos compuestos; y su uso en el tratamiento y profilaxis de diabetes, retinopatía diabética, asma y diarrea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80148106P | 2006-05-18 | 2006-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001380A1 true CL2007001380A1 (es) | 2008-01-04 |
Family
ID=38308768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2007001380A CL2007001380A1 (es) | 2006-05-18 | 2007-05-15 | Compuestos derivados de tiazolo-pirimidina-urea, antiparasitos activos del receptor de adenosina a2b; composicion farmaceutica que comprende a dichos compuestos; y su uso del compuesto en el tratamiento y profilaxis de diabetes, retinopatia asma y diarrea. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7947692B2 (es) |
| EP (1) | EP2027132B1 (es) |
| JP (1) | JP5026511B2 (es) |
| KR (1) | KR101077295B1 (es) |
| CN (1) | CN101448844B (es) |
| AR (1) | AR060957A1 (es) |
| AT (1) | ATE481409T1 (es) |
| AU (1) | AU2007253485B2 (es) |
| BR (1) | BRPI0712516A2 (es) |
| CA (1) | CA2651769C (es) |
| CL (1) | CL2007001380A1 (es) |
| DE (1) | DE602007009221D1 (es) |
| ES (1) | ES2350013T3 (es) |
| IL (1) | IL195006A0 (es) |
| MX (1) | MX2008014690A (es) |
| TW (1) | TW200813073A (es) |
| WO (1) | WO2007134958A1 (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006074025A1 (en) | 2004-12-30 | 2006-07-13 | Janssen Pharmaceutica N.V. | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase |
| JP2010528114A (ja) * | 2007-05-25 | 2010-08-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 脂肪酸アミド加水分解酵素のヘテロアリール置換尿素モジュレータ |
| WO2009011872A1 (en) * | 2007-07-17 | 2009-01-22 | Merck & Co., Inc. | Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5562865B2 (ja) | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Trpv1のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
| WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| US8598356B2 (en) | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
| EP2923734B1 (en) | 2009-03-13 | 2018-01-10 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Purine analogues and their use as immunosuppressive agents |
| WO2010141809A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
| US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| RU2012106657A (ru) * | 2009-07-24 | 2013-08-27 | Вандербилт Юниверсити | Изоформы избирательного ингибитора фосфолипазы d |
| US20130029978A1 (en) * | 2009-12-25 | 2013-01-31 | Mochida Pharmaceutical Co., Ltd. | Novel aryl urea derivative |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US20120122924A1 (en) * | 2010-11-15 | 2012-05-17 | Abbott Laboratories | Nampt inhibitors |
| SG10202010119TA (en) | 2010-11-15 | 2020-11-27 | Abbvie Inc | NAMPT And Rock Inhibitors |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| DE102011083283A1 (de) * | 2011-09-23 | 2013-03-28 | Beiersdorf Ag | Heteroalkylamidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Heteroalkylamidothiazolen |
| US9453017B2 (en) | 2011-09-30 | 2016-09-27 | Vanderbilt University | Antiviral therapies with phospholipase D inhibitors |
| RU2475481C1 (ru) * | 2012-03-01 | 2013-02-20 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение |
| RU2504541C1 (ru) * | 2012-12-26 | 2014-01-20 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция для местного применения |
| EA201391552A1 (ru) * | 2012-03-01 | 2014-12-30 | Общество с ограниченной ответственностью "Метаген" | 2-нитрогетерилтиоцианаты для лечения грибковых инфекций, фармацевтическая композиция и их применение |
| EP2968303B1 (en) | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| US9938291B2 (en) * | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
| US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
| EA201600318A1 (ru) * | 2013-10-07 | 2016-09-30 | Байер Фарма Акциенгезельшафт | Циклические тиеноурацилкарбоксамиды и их применение |
| CN111393434B (zh) | 2014-04-30 | 2022-11-04 | 哥伦比亚大学董事会 | 取代的4-苯基哌啶及其制备和用途 |
| AR111295A1 (es) | 2017-03-20 | 2019-06-26 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr) |
| WO2019025099A1 (en) * | 2017-08-01 | 2019-02-07 | Merck Patent Gmbh | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| WO2020146795A1 (en) | 2019-01-11 | 2020-07-16 | Omeros Corporation | Methods and compositions for treating cancer |
| MX2022003025A (es) | 2019-09-19 | 2022-04-07 | Forma Therapeutics Inc | Activacion de la piruvato cinasa r. |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| EP4351640A1 (en) * | 2021-06-07 | 2024-04-17 | Ares Trading S.A. | Combination treatment of cancer |
| CN114591327B (zh) * | 2022-03-25 | 2023-02-07 | 河南大学 | 吲哚啉哌啶脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用 |
| AU2023252914A1 (en) | 2022-04-13 | 2024-10-17 | Arcus Biosciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| EP4651872A1 (en) * | 2023-01-17 | 2025-11-26 | Septerna, Inc. | Compounds, compositions and methods of use to treat hypoparathyroidism and osteoporosis |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2026019756A1 (en) * | 2024-07-16 | 2026-01-22 | Septerna, Inc. | Bicyclic heteroaromatic agonists of the parathyroid hormone 1 receptor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060481A (en) | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
| RU2251419C2 (ru) * | 2000-06-21 | 2005-05-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензотиазола |
| US6713499B2 (en) | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
| EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
| WO2005028484A1 (en) * | 2003-09-19 | 2005-03-31 | F. Hoffmann-La Roche Ag | Thiazolopyridine derivatives as adenosine receptor ligands |
| GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| ES2241496B1 (es) * | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
| WO2006013054A1 (en) * | 2004-08-05 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituted n-acyl-2-aminothiazoles |
-
2007
- 2007-05-08 KR KR1020087028022A patent/KR101077295B1/ko not_active Expired - Fee Related
- 2007-05-08 BR BRPI0712516A patent/BRPI0712516A2/pt not_active IP Right Cessation
- 2007-05-08 DE DE602007009221T patent/DE602007009221D1/de active Active
- 2007-05-08 AU AU2007253485A patent/AU2007253485B2/en not_active Ceased
- 2007-05-08 AT AT07728869T patent/ATE481409T1/de active
- 2007-05-08 WO PCT/EP2007/054416 patent/WO2007134958A1/en not_active Ceased
- 2007-05-08 JP JP2009510407A patent/JP5026511B2/ja not_active Expired - Fee Related
- 2007-05-08 MX MX2008014690A patent/MX2008014690A/es active IP Right Grant
- 2007-05-08 CA CA2651769A patent/CA2651769C/en not_active Expired - Fee Related
- 2007-05-08 ES ES07728869T patent/ES2350013T3/es active Active
- 2007-05-08 CN CN2007800180233A patent/CN101448844B/zh not_active Expired - Fee Related
- 2007-05-08 EP EP07728869A patent/EP2027132B1/en not_active Not-in-force
- 2007-05-11 US US11/801,972 patent/US7947692B2/en not_active Expired - Fee Related
- 2007-05-15 TW TW096117228A patent/TW200813073A/zh unknown
- 2007-05-15 CL CL2007001380A patent/CL2007001380A1/es unknown
- 2007-05-16 AR ARP070102114A patent/AR060957A1/es not_active Application Discontinuation
-
2008
- 2008-10-30 IL IL195006A patent/IL195006A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007253485A1 (en) | 2007-11-29 |
| CA2651769C (en) | 2013-12-17 |
| MX2008014690A (es) | 2008-11-27 |
| KR20080111141A (ko) | 2008-12-22 |
| BRPI0712516A2 (pt) | 2016-08-23 |
| JP2009537473A (ja) | 2009-10-29 |
| CA2651769A1 (en) | 2007-11-29 |
| JP5026511B2 (ja) | 2012-09-12 |
| IL195006A0 (en) | 2009-08-03 |
| DE602007009221D1 (de) | 2010-10-28 |
| US20070270433A1 (en) | 2007-11-22 |
| WO2007134958A1 (en) | 2007-11-29 |
| CN101448844B (zh) | 2012-07-25 |
| EP2027132B1 (en) | 2010-09-15 |
| ATE481409T1 (de) | 2010-10-15 |
| AU2007253485B2 (en) | 2010-07-08 |
| CN101448844A (zh) | 2009-06-03 |
| KR101077295B1 (ko) | 2011-10-26 |
| EP2027132A1 (en) | 2009-02-25 |
| AR060957A1 (es) | 2008-07-23 |
| US7947692B2 (en) | 2011-05-24 |
| TW200813073A (en) | 2008-03-16 |
| ES2350013T3 (es) | 2011-01-14 |
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