CL2012001007A1 - Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros. - Google Patents

Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros.

Info

Publication number: CL2012001007A1
Authority: CL; Chile
Prior art keywords: cfrt; trifluoromethyl; hcl; dihydroquinoline; heptan
Prior art date: 2009-10-23

Application number

CL2012001007A

Other languages

English (en)

Spanish (es)

Inventor

Beili Zhang

Mariusz Krawiec

Brian Luisi

Ales Medek

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-23

Filing date

2012-04-20

Publication date

2012-09-07

2012-04-20 Application filed by Vertex Pharma filed Critical Vertex Pharma

2012-09-07 Publication of CL2012001007A1 publication Critical patent/CL2012001007A1/es

Links

208000006673 asthma Diseases 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
201000003883 Cystic fibrosis Diseases 0.000 title 1
QYLPFQBPOBAQSP-UHFFFAOYSA-N n-[4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl]-4-oxo-5-(trifluoromethyl)-1h-quinoline-3-carboxamide Chemical compound C1=CC(C(F)(F)F)=C2C(=O)C(C(=O)NC3=CC=C(C=C3C(F)(F)F)N3C4CCC3CC4)=CNC2=C1 QYLPFQBPOBAQSP-UHFFFAOYSA-N 0.000 title 1
206010016654 Fibrosis Diseases 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
230000004761 fibrosis Effects 0.000 abstract 1

Classifications

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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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CL2012001007A 2009-10-23 2012-04-20 Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros. CL2012001007A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25461409P	2009-10-23	2009-10-23

Publications (1)

Publication Number	Publication Date
CL2012001007A1 true CL2012001007A1 (es)	2012-09-07

Family

ID=43334525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2012001007A CL2012001007A1 (es)	2009-10-23	2012-04-20	Formas cristalinas a-hcl, b-hci y b de n-(4-(7-azabiciclo [2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-carboxamida, modulador de cfrt; sus composiciones farmaceuticas; metodo para modular cfrt; y su uso para el tratamiento de la fibrosis quistica, asma, entre otros.

Country Status (18)

Country	Link
US (2)	US8389727B2 (2)
EP (1)	EP2491042A1 (2)
JP (1)	JP5877157B2 (2)
KR (1)	KR20120102645A (2)
CN (1)	CN102666546B (2)
AR (1)	AR078766A1 (2)
AU (1)	AU2010310617A1 (2)
BR (1)	BR112012009584A2 (2)
CA (1)	CA2778493A1 (2)
CL (1)	CL2012001007A1 (2)
IL (1)	IL219327A0 (2)
MX (1)	MX2012004791A (2)
NZ (1)	NZ599703A (2)
RU (1)	RU2568608C2 (2)
TW (1)	TWI507409B (2)
UA (1)	UA108087C2 (2)
WO (1)	WO2011050220A1 (2)
ZA (1)	ZA201202919B (2)

Families Citing this family (47)

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EP1945632B1 (en)	2005-11-08	2013-09-18	Vertex Pharmaceuticals Incorporated	Heterocyclic modulators of atp-binding cassette transporters
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WO2007079139A2 (en)	2005-12-28	2007-07-12	Vertex Pharmaceuticals, Inc.	Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
NZ571803A (en)	2006-04-07	2011-12-22	Vertex Pharma	Amide indole derivatives as modulators of ATP-binding cassette transporters
US8563573B2 (en) *	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
US8969386B2 (en)	2007-05-09	2015-03-03	Vertex Pharmaceuticals Incorporated	Modulators of CFTR
HUE028426T2 (en)	2007-08-24	2016-12-28	Vertex Pharma	Isothiazolopyridinones for (inter alia) treating cystic fibrosis
SI2217572T1 (sl)	2007-11-16	2014-05-30	Vertex Pharmaceuticals Incorporated	Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto
SI2225230T1 (sl)	2007-12-07	2017-03-31	Vertex Pharmaceuticals Incorporated	Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
EP2639224B1 (en)	2007-12-07	2016-08-24	Vertex Pharmaceuticals Incorporated	Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
WO2009076141A2 (en) *	2007-12-07	2009-06-18	Vertex Pharmaceuticals Incorporated	Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cycklopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
US20100036130A1 (en)	2007-12-07	2010-02-11	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
NZ720282A (en)	2008-02-28	2017-12-22	Vertex Pharma	Heteroaryl derivatives as cftr modulators
EP2271621B1 (en)	2008-03-31	2013-11-20	Vertex Pharmaceuticals Incorporated	Pyridyl derivatives as cftr modulators
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
JP2012504143A (ja) *	2008-09-29	2012-02-16	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の用量単位
NZ592685A (en) *	2008-10-23	2013-04-26	Vertex Pharma	Modulators of cystic fibrosis transmembrane conductance regulator
PT2358680E (pt) *	2008-10-23	2013-05-14	Vertex Pharma	Formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2- (trifluorometil)fenil)-4-oxo- 5-(trifluorometil)-1,4- dihidroquinolina-3-carboxamida
SI2408750T1 (sl)	2009-03-20	2015-11-30	Vertex Pharmaceuticals Incorporated	Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
BR112012006031A2 (pt) *	2009-09-17	2019-09-24	Vertex Pharma	processo para preparação de compostos azabicíclicos.
WO2011050220A1 (en) *	2009-10-23	2011-04-28	Vertex Pharmaceuticals Incorporated	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
CN102648182A (zh) *	2009-10-23	2012-08-22	沃泰克斯药物股份有限公司	用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
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HRP20211752T1 (hr)	2010-04-07	2022-02-18	Vertex Pharmaceuticals Incorporated	Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
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2010
- 2010-10-21 WO PCT/US2010/053633 patent/WO2011050220A1/en not_active Ceased
- 2010-10-21 CN CN201080053379.2A patent/CN102666546B/zh not_active Expired - Fee Related
- 2010-10-21 KR KR1020127013139A patent/KR20120102645A/ko not_active Withdrawn
- 2010-10-21 AU AU2010310617A patent/AU2010310617A1/en not_active Abandoned
- 2010-10-21 JP JP2012535394A patent/JP5877157B2/ja not_active Expired - Fee Related
- 2010-10-21 MX MX2012004791A patent/MX2012004791A/es active IP Right Grant
- 2010-10-21 UA UAA201206183A patent/UA108087C2/uk unknown
- 2010-10-21 EP EP10774360A patent/EP2491042A1/en not_active Withdrawn
- 2010-10-21 US US12/909,789 patent/US8389727B2/en active Active
- 2010-10-21 RU RU2012121168/04A patent/RU2568608C2/ru not_active IP Right Cessation
- 2010-10-21 CA CA2778493A patent/CA2778493A1/en not_active Abandoned
- 2010-10-21 BR BR112012009584A patent/BR112012009584A2/pt not_active IP Right Cessation
- 2010-10-21 NZ NZ599703A patent/NZ599703A/en not_active IP Right Cessation
- 2010-10-22 TW TW099136177A patent/TWI507409B/zh not_active IP Right Cessation
- 2010-10-25 AR ARP100103915A patent/AR078766A1/es unknown
2012
- 2012-04-20 CL CL2012001007A patent/CL2012001007A1/es unknown
- 2012-04-20 ZA ZA2012/02919A patent/ZA201202919B/en unknown
- 2012-04-22 IL IL219327A patent/IL219327A0/en unknown
2013
- 2013-01-28 US US13/751,656 patent/US8741922B2/en active Active

Also Published As

Publication number	Publication date
TWI507409B (zh)	2015-11-11
JP2013508407A (ja)	2013-03-07
CA2778493A1 (en)	2011-04-28
AR078766A1 (es)	2011-11-30
WO2011050220A1 (en)	2011-04-28
HK1173151A1 (zh)	2013-07-05
NZ599703A (en)	2014-06-27
BR112012009584A2 (pt)	2019-09-24
US8741922B2 (en)	2014-06-03
EP2491042A1 (en)	2012-08-29
US20110123449A1 (en)	2011-05-26
ZA201202919B (en)	2013-06-26
US20130137722A1 (en)	2013-05-30
KR20120102645A (ko)	2012-09-18
AU2010310617A1 (en)	2012-05-24
UA108087C2 (uk)	2015-03-25
CN102666546B (zh)	2015-09-09
US8389727B2 (en)	2013-03-05
TW201121976A (en)	2011-07-01
CN102666546A (zh)	2012-09-12
JP5877157B2 (ja)	2016-03-02
RU2012121168A (ru)	2013-11-27
RU2568608C2 (ru)	2015-11-20
IL219327A0 (en)	2012-06-28
MX2012004791A (es)	2013-02-01

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