JP5877157B2 - Ｎ−（４−（７−アザビシクロ［２．２．１］ヘプタン−７−イル）−２−（トリフルオロメチル）フェニル）−４−オキソ−５−（トリフルオロメチル）−１，４−ジヒドロキノリン−３−カルボキサミドの固体形態 - Google Patents

Ｎ−（４−（７−アザビシクロ［２．２．１］ヘプタン−７−イル）−２−（トリフルオロメチル）フェニル）−４−オキソ−５−（トリフルオロメチル）−１，４−ジヒドロキノリン−３−カルボキサミドの固体形態 Download PDF

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Publication number: JP5877157B2
Authority: JP; Japan
Prior art keywords: peak; degrees; disease; hcl; cftr
Prior art date: 2009-10-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2012535394A

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English (en)

Japanese (ja)

Other versions

JP2013508407A (ja

JP2013508407A5 (2

Inventor

ベイリーチャン，

マリウスクラウィーク，

ブライアンルイジ，

アレスメデク，

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Vertex Pharmaceuticals Inc

Original Assignee

Vertex Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-23

Filing date

2010-10-21

Publication date

2016-03-02

2010-10-21 Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc

2013-03-07 Publication of JP2013508407A publication Critical patent/JP2013508407A/ja

2013-12-05 Publication of JP2013508407A5 publication Critical patent/JP2013508407A5/ja

2016-03-02 Application granted granted Critical

2016-03-02 Publication of JP5877157B2 publication Critical patent/JP5877157B2/ja

Status Expired - Fee Related legal-status Critical Current

2030-10-21 Anticipated expiration legal-status Critical

Links

0 *c(ccc(C(F)(F)F)c1)c1N Chemical compound *c(ccc(C(F)(F)F)c1)c1N 0.000 description 3
SNZSSCZJMVIOCR-UHFFFAOYSA-N C(C1)C2NC1CC2 Chemical compound C(C1)C2NC1CC2 SNZSSCZJMVIOCR-UHFFFAOYSA-N 0.000 description 1
LCBYVSMPQYNZCN-UHFFFAOYSA-N NC(C(C(F)(F)F)=C1)=CCC1N1C2CCC1CC2 Chemical compound NC(C(C(F)(F)F)=C1)=CCC1N1C2CCC1CC2 LCBYVSMPQYNZCN-UHFFFAOYSA-N 0.000 description 1
QYLPFQBPOBAQSP-UHFFFAOYSA-N O=C(C1=CNc2cccc(C(F)(F)F)c2C1=O)Nc(cc1)c(C(F)(F)F)cc1N1C2CCC1CC2 Chemical compound O=C(C1=CNc2cccc(C(F)(F)F)c2C1=O)Nc(cc1)c(C(F)(F)F)cc1N1C2CCC1CC2 QYLPFQBPOBAQSP-UHFFFAOYSA-N 0.000 description 1
WAEYWIDTDWJDJA-UHFFFAOYSA-N OC(C1=CNc2cccc(C(F)(F)F)c2C1=O)=O Chemical compound OC(C1=CNc2cccc(C(F)(F)F)c2C1=O)=O WAEYWIDTDWJDJA-UHFFFAOYSA-N 0.000 description 1

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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
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Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
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Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Immunology (AREA)
Psychology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Otolaryngology (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)

JP2012535394A 2009-10-23 2010-10-21 Ｎ−（４−（７−アザビシクロ［２．２．１］ヘプタン−７−イル）−２−（トリフルオロメチル）フェニル）−４−オキソ−５−（トリフルオロメチル）−１，４−ジヒドロキノリン−３−カルボキサミドの固体形態 Expired - Fee Related JP5877157B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25461409P	2009-10-23	2009-10-23
US61/254,614		2009-10-23
PCT/US2010/053633 WO2011050220A1 (en)	2009-10-23	2010-10-21	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Publications (3)

Publication Number	Publication Date
JP2013508407A JP2013508407A (ja)	2013-03-07
JP2013508407A5 JP2013508407A5 (2)	2013-12-05
JP5877157B2 true JP5877157B2 (ja)	2016-03-02

Family

ID=43334525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2012535394A Expired - Fee Related JP5877157B2 (ja)	2009-10-23	2010-10-21	Ｎ−（４−（７−アザビシクロ［２．２．１］ヘプタン−７−イル）−２−（トリフルオロメチル）フェニル）−４−オキソ−５−（トリフルオロメチル）−１，４−ジヒドロキノリン−３−カルボキサミドの固体形態

Country Status (18)

Country	Link
US (2)	US8389727B2 (2)
EP (1)	EP2491042A1 (2)
JP (1)	JP5877157B2 (2)
KR (1)	KR20120102645A (2)
CN (1)	CN102666546B (2)
AR (1)	AR078766A1 (2)
AU (1)	AU2010310617A1 (2)
BR (1)	BR112012009584A2 (2)
CA (1)	CA2778493A1 (2)
CL (1)	CL2012001007A1 (2)
IL (1)	IL219327A0 (2)
MX (1)	MX2012004791A (2)
NZ (1)	NZ599703A (2)
RU (1)	RU2568608C2 (2)
TW (1)	TWI507409B (2)
UA (1)	UA108087C2 (2)
WO (1)	WO2011050220A1 (2)
ZA (1)	ZA201202919B (2)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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ZA200602755B (en)	2003-09-06	2007-06-27	Vertex Pharma	Modulators of ATP-binding cassette transporters
US7977322B2 (en)	2004-08-20	2011-07-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
LT2502911T (lt)	2004-06-24	2017-09-11	Vertex Pharmaceuticals Incorporated	Atp surišančios kasetės transporterių moduliatoriai
ATE512145T1 (de)	2005-08-11	2011-06-15	Vertex Pharma	Modulatoren des cystic fibrosis transmembrane conductance regulators
EP1945632B1 (en)	2005-11-08	2013-09-18	Vertex Pharmaceuticals Incorporated	Heterocyclic modulators of atp-binding cassette transporters
AU2006336504C9 (en)	2005-12-28	2015-05-14	Vertex Pharmaceuticals Incorporated	1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
WO2007079139A2 (en)	2005-12-28	2007-07-12	Vertex Pharmaceuticals, Inc.	Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
NZ571803A (en)	2006-04-07	2011-12-22	Vertex Pharma	Amide indole derivatives as modulators of ATP-binding cassette transporters
US8563573B2 (en) *	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
US8969386B2 (en)	2007-05-09	2015-03-03	Vertex Pharmaceuticals Incorporated	Modulators of CFTR
HUE028426T2 (en)	2007-08-24	2016-12-28	Vertex Pharma	Isothiazolopyridinones for (inter alia) treating cystic fibrosis
SI2217572T1 (sl)	2007-11-16	2014-05-30	Vertex Pharmaceuticals Incorporated	Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto
SI2225230T1 (sl)	2007-12-07	2017-03-31	Vertex Pharmaceuticals Incorporated	Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
EP2639224B1 (en)	2007-12-07	2016-08-24	Vertex Pharmaceuticals Incorporated	Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
WO2009076141A2 (en) *	2007-12-07	2009-06-18	Vertex Pharmaceuticals Incorporated	Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cycklopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
US20100036130A1 (en)	2007-12-07	2010-02-11	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
NZ720282A (en)	2008-02-28	2017-12-22	Vertex Pharma	Heteroaryl derivatives as cftr modulators
EP2271621B1 (en)	2008-03-31	2013-11-20	Vertex Pharmaceuticals Incorporated	Pyridyl derivatives as cftr modulators
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
JP2012504143A (ja) *	2008-09-29	2012-02-16	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の用量単位
NZ592685A (en) *	2008-10-23	2013-04-26	Vertex Pharma	Modulators of cystic fibrosis transmembrane conductance regulator
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2010
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TWI507409B (zh)	2015-11-11
JP2013508407A (ja)	2013-03-07
CA2778493A1 (en)	2011-04-28
AR078766A1 (es)	2011-11-30
WO2011050220A1 (en)	2011-04-28
HK1173151A1 (zh)	2013-07-05
NZ599703A (en)	2014-06-27
CL2012001007A1 (es)	2012-09-07
BR112012009584A2 (pt)	2019-09-24
US8741922B2 (en)	2014-06-03
EP2491042A1 (en)	2012-08-29
US20110123449A1 (en)	2011-05-26
ZA201202919B (en)	2013-06-26
US20130137722A1 (en)	2013-05-30
KR20120102645A (ko)	2012-09-18
AU2010310617A1 (en)	2012-05-24
UA108087C2 (uk)	2015-03-25
CN102666546B (zh)	2015-09-09
US8389727B2 (en)	2013-03-05
TW201121976A (en)	2011-07-01
CN102666546A (zh)	2012-09-12
RU2012121168A (ru)	2013-11-27
RU2568608C2 (ru)	2015-11-20
IL219327A0 (en)	2012-06-28
MX2012004791A (es)	2013-02-01

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