IL219327A0 - Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide and compositions comprising the same and uses thereof - Google Patents

Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide and compositions comprising the same and uses thereof

Info

Publication number: IL219327A0
Authority: IL; Israel
Prior art keywords: trifluoromethyl; dihydroquinoline; heptan; azabicyclo; carboxamide
Prior art date: 2009-10-23

Application number

IL219327A

Other languages

English (en)

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-23

Filing date

2012-04-22

Publication date

2012-06-28

2012-04-22 Application filed by Vertex Pharma filed Critical Vertex Pharma

2012-06-28 Publication of IL219327A0 publication Critical patent/IL219327A0/en

Links

239000000203 mixture Substances 0.000 title 1
239000007787 solid Substances 0.000 title 1

Classifications

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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
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IL219327A 2009-10-23 2012-04-22 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide and compositions comprising the same and uses thereof IL219327A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25461409P	2009-10-23	2009-10-23
PCT/US2010/053633 WO2011050220A1 (en)	2009-10-23	2010-10-21	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Publications (1)

Publication Number	Publication Date
IL219327A0 true IL219327A0 (en)	2012-06-28

Family

ID=43334525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL219327A IL219327A0 (en)	2009-10-23	2012-04-22	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide and compositions comprising the same and uses thereof

Country Status (18)

Country	Link
US (2)	US8389727B2 (2)
EP (1)	EP2491042A1 (2)
JP (1)	JP5877157B2 (2)
KR (1)	KR20120102645A (2)
CN (1)	CN102666546B (2)
AR (1)	AR078766A1 (2)
AU (1)	AU2010310617A1 (2)
BR (1)	BR112012009584A2 (2)
CA (1)	CA2778493A1 (2)
CL (1)	CL2012001007A1 (2)
IL (1)	IL219327A0 (2)
MX (1)	MX2012004791A (2)
NZ (1)	NZ599703A (2)
RU (1)	RU2568608C2 (2)
TW (1)	TWI507409B (2)
UA (1)	UA108087C2 (2)
WO (1)	WO2011050220A1 (2)
ZA (1)	ZA201202919B (2)

Families Citing this family (47)

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US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
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SI2225230T1 (sl)	2007-12-07	2017-03-31	Vertex Pharmaceuticals Incorporated	Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
EP2639224B1 (en)	2007-12-07	2016-08-24	Vertex Pharmaceuticals Incorporated	Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
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US20100036130A1 (en)	2007-12-07	2010-02-11	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
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EP2271621B1 (en)	2008-03-31	2013-11-20	Vertex Pharmaceuticals Incorporated	Pyridyl derivatives as cftr modulators
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US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
JP2012504143A (ja) *	2008-09-29	2012-02-16	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の用量単位
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CN102648182A (zh) *	2009-10-23	2012-08-22	沃泰克斯药物股份有限公司	用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
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HRP20211752T1 (hr)	2010-04-07	2022-02-18	Vertex Pharmaceuticals Incorporated	Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
HRP20160682T1 (hr)	2010-04-07	2016-07-29	Vertex Pharmaceuticals Incorporated	Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzojeve kiseline
ES2608474T3 (es)	2010-04-22	2017-04-11	Vertex Pharmaceuticals Incorporated	Proceso de producción de compuestos indol cycloalkylcarboxamido
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2010
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2012
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2013
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Also Published As

Publication number	Publication date
TWI507409B (zh)	2015-11-11
JP2013508407A (ja)	2013-03-07
CA2778493A1 (en)	2011-04-28
AR078766A1 (es)	2011-11-30
WO2011050220A1 (en)	2011-04-28
HK1173151A1 (zh)	2013-07-05
NZ599703A (en)	2014-06-27
CL2012001007A1 (es)	2012-09-07
BR112012009584A2 (pt)	2019-09-24
US8741922B2 (en)	2014-06-03
EP2491042A1 (en)	2012-08-29
US20110123449A1 (en)	2011-05-26
ZA201202919B (en)	2013-06-26
US20130137722A1 (en)	2013-05-30
KR20120102645A (ko)	2012-09-18
AU2010310617A1 (en)	2012-05-24
UA108087C2 (uk)	2015-03-25
CN102666546B (zh)	2015-09-09
US8389727B2 (en)	2013-03-05
TW201121976A (en)	2011-07-01
CN102666546A (zh)	2012-09-12
JP5877157B2 (ja)	2016-03-02
RU2012121168A (ru)	2013-11-27
RU2568608C2 (ru)	2015-11-20
MX2012004791A (es)	2013-02-01

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