UA108087C2 - Тверді форми n-(4-(7-азабіцикло[2.2.1]гептан-7-іл)-2-(трифторметил)феніл)-4-оксо-5-(трифторметил)-1,4-дигідрохінолін-3-карбоксаміду - Google Patents

Тверді форми n-(4-(7-азабіцикло[2.2.1]гептан-7-іл)-2-(трифторметил)феніл)-4-оксо-5-(трифторметил)-1,4-дигідрохінолін-3-карбоксаміду

Info

Publication number: UA108087C2
Authority: UA; Ukraine
Prior art keywords: trifluoromethyl; dihydroquinoline; azabicyclo; carboxamide; heptane
Prior art date: 2009-10-23

Application number

UAA201206183A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Бейлі Чжан

Маріуш Кравец

Брайан Луізі

Алес МЕДЕК

Original Assignee

Вертекс Фармасьютікалз Інкорпорейтед

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-23

Filing date

2010-10-21

Publication date

2015-03-25

2010-10-21 Application filed by Вертекс Фармасьютікалз Інкорпорейтед filed Critical Вертекс Фармасьютікалз Інкорпорейтед

2015-03-25 Publication of UA108087C2 publication Critical patent/UA108087C2/uk

Links

239000007787 solid Substances 0.000 title abstract 2
QYLPFQBPOBAQSP-UHFFFAOYSA-N n-[4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl]-4-oxo-5-(trifluoromethyl)-1h-quinoline-3-carboxamide Chemical compound C1=CC(C(F)(F)F)=C2C(=O)C(C(=O)NC3=CC=C(C=C3C(F)(F)F)N3C4CCC3CC4)=CNC2=C1 QYLPFQBPOBAQSP-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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UAA201206183A 2009-10-23 2010-10-21 Тверді форми n-(4-(7-азабіцикло[2.2.1]гептан-7-іл)-2-(трифторметил)феніл)-4-оксо-5-(трифторметил)-1,4-дигідрохінолін-3-карбоксаміду UA108087C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25461409P	2009-10-23	2009-10-23
PCT/US2010/053633 WO2011050220A1 (en)	2009-10-23	2010-10-21	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Publications (1)

Publication Number	Publication Date
UA108087C2 true UA108087C2 (uk)	2015-03-25

Family

ID=43334525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA201206183A UA108087C2 (uk)	2009-10-23	2010-10-21	Тверді форми n-(4-(7-азабіцикло[2.2.1]гептан-7-іл)-2-(трифторметил)феніл)-4-оксо-5-(трифторметил)-1,4-дигідрохінолін-3-карбоксаміду

Country Status (18)

Country	Link
US (2)	US8389727B2 (2)
EP (1)	EP2491042A1 (2)
JP (1)	JP5877157B2 (2)
KR (1)	KR20120102645A (2)
CN (1)	CN102666546B (2)
AR (1)	AR078766A1 (2)
AU (1)	AU2010310617A1 (2)
BR (1)	BR112012009584A2 (2)
CA (1)	CA2778493A1 (2)
CL (1)	CL2012001007A1 (2)
IL (1)	IL219327A0 (2)
MX (1)	MX2012004791A (2)
NZ (1)	NZ599703A (2)
RU (1)	RU2568608C2 (2)
TW (1)	TWI507409B (2)
UA (1)	UA108087C2 (2)
WO (1)	WO2011050220A1 (2)
ZA (1)	ZA201202919B (2)

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NZ720282A (en)	2008-02-28	2017-12-22	Vertex Pharma	Heteroaryl derivatives as cftr modulators
EP2271621B1 (en)	2008-03-31	2013-11-20	Vertex Pharmaceuticals Incorporated	Pyridyl derivatives as cftr modulators
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
JP2012504143A (ja) *	2008-09-29	2012-02-16	バーテックスファーマシューティカルズインコーポレイテッド	３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の用量単位
NZ592685A (en) *	2008-10-23	2013-04-26	Vertex Pharma	Modulators of cystic fibrosis transmembrane conductance regulator
PT2358680E (pt) *	2008-10-23	2013-05-14	Vertex Pharma	Formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2- (trifluorometil)fenil)-4-oxo- 5-(trifluorometil)-1,4- dihidroquinolina-3-carboxamida
SI2408750T1 (sl)	2009-03-20	2015-11-30	Vertex Pharmaceuticals Incorporated	Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
BR112012006031A2 (pt) *	2009-09-17	2019-09-24	Vertex Pharma	processo para preparação de compostos azabicíclicos.
WO2011050220A1 (en) *	2009-10-23	2011-04-28	Vertex Pharmaceuticals Incorporated	Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
CN102648182A (zh) *	2009-10-23	2012-08-22	沃泰克斯药物股份有限公司	用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
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2010
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- 2010-10-21 KR KR1020127013139A patent/KR20120102645A/ko not_active Withdrawn
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- 2010-10-25 AR ARP100103915A patent/AR078766A1/es unknown
2012
- 2012-04-20 CL CL2012001007A patent/CL2012001007A1/es unknown
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2013
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Publication number	Publication date
TWI507409B (zh)	2015-11-11
JP2013508407A (ja)	2013-03-07
CA2778493A1 (en)	2011-04-28
AR078766A1 (es)	2011-11-30
WO2011050220A1 (en)	2011-04-28
HK1173151A1 (zh)	2013-07-05
NZ599703A (en)	2014-06-27
CL2012001007A1 (es)	2012-09-07
BR112012009584A2 (pt)	2019-09-24
US8741922B2 (en)	2014-06-03
EP2491042A1 (en)	2012-08-29
US20110123449A1 (en)	2011-05-26
ZA201202919B (en)	2013-06-26
US20130137722A1 (en)	2013-05-30
KR20120102645A (ko)	2012-09-18
AU2010310617A1 (en)	2012-05-24
CN102666546B (zh)	2015-09-09
US8389727B2 (en)	2013-03-05
TW201121976A (en)	2011-07-01
CN102666546A (zh)	2012-09-12
JP5877157B2 (ja)	2016-03-02
RU2012121168A (ru)	2013-11-27
RU2568608C2 (ru)	2015-11-20
IL219327A0 (en)	2012-06-28
MX2012004791A (es)	2013-02-01

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