CL2017001729A1 - Anticuerpos anti-cd3, moleculas de union a antigeno biespecificas que se unen a cd3 y cd20; y usos de los mismos. - Google Patents

Anticuerpos anti-cd3, moleculas de union a antigeno biespecificas que se unen a cd3 y cd20; y usos de los mismos.

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Publication number
CL2017001729A1
CL2017001729A1 CL2017001729A CL2017001729A CL2017001729A1 CL 2017001729 A1 CL2017001729 A1 CL 2017001729A1 CL 2017001729 A CL2017001729 A CL 2017001729A CL 2017001729 A CL2017001729 A CL 2017001729A CL 2017001729 A1 CL2017001729 A1 CL 2017001729A1
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CL
Chile
Prior art keywords
antigen binding
antibodies
bind
bispecific antigen
present
Prior art date
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CL2017001729A
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English (en)
Inventor
Eric Smith
Nicolas J Papadopoulos
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Regeneron Pharma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49304338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017001729(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of CL2017001729A1 publication Critical patent/CL2017001729A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Secondary Cells (AREA)
  • Liquid Crystal Substances (AREA)
  • Prostheses (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<p>La presente invención proporciona anticuerpos que se unen a CD3 y métodos para el uso de los mismos. De acuerdo con ciertas modalidades, los anticuerpos de Ia invención se unen a CD3 humano con alta afinidad e inducen Ia proliferación de células T hurnanas. La presente invención incluye anticuerpos que se unen a CD3 e inducen la muerte de células tumorales mediada por células T. De acuerdo con ciertas modalidades. Ia presente invención proporciona moléculas de unión a antígeno biespecíficas que comprenden un primer dominio de unión a antígeno que se une específicamente a CD3 humano. y un segundo dominio de unión a antígeno que se une específicamente a CD20. En ciertas modalidades, las moléculas de unión a antígeno biespecíficas de Ia presente invención son capaces de inhibir el crecimiento de tumores de células B que expresan CD20. Los anticuerpos y moléculas de unión a antígeno biespecíficas de la invención son útiles para el tratamiento de enfermedades y trastornos en los que una respuesta inmunitaria dirigida regulada hacia arriba o inducida es deseable y/o terapéuticamente beneficiosa. Por ejemplo, los anticuerpos de Ia invención son útiles para el tratamiento de diferentes tipos de cancer asi como de otras enfermedades y trastornos relacionados con el CD20.</p>
CL2017001729A 2012-09-21 2017-06-29 Anticuerpos anti-cd3, moleculas de union a antigeno biespecificas que se unen a cd3 y cd20; y usos de los mismos. CL2017001729A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261704029P 2012-09-21 2012-09-21
US201361753461P 2013-01-17 2013-01-17
US201361763110P 2013-02-11 2013-02-11
US201361827098P 2013-05-24 2013-05-24

Publications (1)

Publication Number Publication Date
CL2017001729A1 true CL2017001729A1 (es) 2018-03-16

Family

ID=49304338

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2015000713A CL2015000713A1 (es) 2012-09-21 2015-03-20 Anticuerpos anti-cd3, moléculas de unión a antígeno biespecificas que se unen a cd3 y cd20 y usos de los mismos
CL2017001729A CL2017001729A1 (es) 2012-09-21 2017-06-29 Anticuerpos anti-cd3, moleculas de union a antigeno biespecificas que se unen a cd3 y cd20; y usos de los mismos.
CL2020003179A CL2020003179A1 (es) 2012-09-21 2020-12-04 (divisional de solicitud 713-2015) anticuerpos anti-cd3, moleculas de union a antígeno biespecificas que se unen a cd3 y cd20; y usos de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2015000713A CL2015000713A1 (es) 2012-09-21 2015-03-20 Anticuerpos anti-cd3, moléculas de unión a antígeno biespecificas que se unen a cd3 y cd20 y usos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2020003179A CL2020003179A1 (es) 2012-09-21 2020-12-04 (divisional de solicitud 713-2015) anticuerpos anti-cd3, moleculas de union a antígeno biespecificas que se unen a cd3 y cd20; y usos de los mismos.

Country Status (34)

Country Link
US (5) US9657102B2 (es)
EP (3) EP3778641B1 (es)
JP (7) JP6923292B2 (es)
KR (2) KR102470709B1 (es)
CN (3) CN104640881B (es)
AR (1) AR092612A1 (es)
AU (3) AU2013318059C1 (es)
BR (1) BR112015005380B1 (es)
CA (3) CA3253502A1 (es)
CL (3) CL2015000713A1 (es)
CO (1) CO7400860A2 (es)
DK (2) DK2897981T5 (es)
EA (1) EA033400B1 (es)
ES (2) ES2948807T3 (es)
FI (2) FI3778641T3 (es)
HR (2) HRP20230844T1 (es)
HU (2) HUE065481T2 (es)
IL (2) IL237301B (es)
JO (3) JOP20200236A1 (es)
LT (2) LT2897981T (es)
MX (2) MX373931B (es)
MY (1) MY179577A (es)
NZ (2) NZ742078A (es)
PH (2) PH12019502070B1 (es)
PL (2) PL2897981T3 (es)
PT (2) PT3778641T (es)
RS (2) RS64378B1 (es)
SG (3) SG10201704833WA (es)
SI (2) SI2897981T1 (es)
SM (2) SMT202300226T1 (es)
TW (4) TWI688573B (es)
UY (1) UY35042A (es)
WO (1) WO2014047231A1 (es)
ZA (2) ZA201501097B (es)

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