CN1067393C - 新的嘧啶并[1,2－a]吲哚类化合物 - Google Patents

新的嘧啶并[1,2－a]吲哚类化合物 Download PDF

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Publication number
CN1067393C
CN1067393C CN97110275A CN97110275A CN1067393C CN 1067393 C CN1067393 C CN 1067393C CN 97110275 A CN97110275 A CN 97110275A CN 97110275 A CN97110275 A CN 97110275A CN 1067393 C CN1067393 C CN 1067393C
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CN
China
Prior art keywords
chain
carbon atoms
branched
straight
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97110275A
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English (en)
Chinese (zh)
Other versions
CN1176965A (zh
Inventor
U·穆勒
P·埃肯伯格
R·格鲁兹曼
H·比肖夫
D·顿泽
S·沃尔费尔
S·洛马
U·尼尔彻
P·科克夫
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Bayer AG
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Bayer AG
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Publication date
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Publication of CN1176965A publication Critical patent/CN1176965A/zh
Application granted granted Critical
Publication of CN1067393C publication Critical patent/CN1067393C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN97110275A 1996-04-04 1997-04-04 新的嘧啶并[1,2－a]吲哚类化合物 Expired - Fee Related CN1067393C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19613550A DE19613550A1 (de) 1996-04-04 1996-04-04 Neue Pyrimido[1,2-a]indole
DE19613550.8 1996-04-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN00127092A Division CN1312246A (zh) 1996-04-04 2000-09-12 制备羧酸的方法

Publications (2)

Publication Number Publication Date
CN1176965A CN1176965A (zh) 1998-03-25
CN1067393C true CN1067393C (zh) 2001-06-20

Family

ID=7790502

Family Applications (2)

Application Number Title Priority Date Filing Date
CN97110275A Expired - Fee Related CN1067393C (zh) 1996-04-04 1997-04-04 新的嘧啶并[1,2－a]吲哚类化合物
CN00127092A Pending CN1312246A (zh) 1996-04-04 2000-09-12 制备羧酸的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN00127092A Pending CN1312246A (zh) 1996-04-04 2000-09-12 制备羧酸的方法

Country Status (33)

Country Link
US (1) US6114341A (fr)
EP (1) EP0799828A3 (fr)
JP (1) JPH1059972A (fr)
KR (1) KR970070008A (fr)
CN (2) CN1067393C (fr)
AR (1) AR006497A1 (fr)
AU (1) AU725786B2 (fr)
BG (1) BG62934B1 (fr)
BR (1) BR9701675A (fr)
CA (1) CA2201434A1 (fr)
CO (1) CO4520306A1 (fr)
CZ (1) CZ102297A3 (fr)
DE (1) DE19613550A1 (fr)
DZ (1) DZ2201A1 (fr)
EE (1) EE9700078A (fr)
HN (1) HN1997000045A (fr)
HR (1) HRP970154A2 (fr)
HU (1) HUP9700708A3 (fr)
ID (1) ID16520A (fr)
IL (3) IL131645A (fr)
MA (1) MA24131A1 (fr)
MY (1) MY126362A (fr)
NO (1) NO309092B1 (fr)
NZ (1) NZ314497A (fr)
PE (1) PE42398A1 (fr)
PL (1) PL319249A1 (fr)
SG (1) SG63698A1 (fr)
SK (1) SK42797A3 (fr)
SV (1) SV1997000025A (fr)
TN (1) TNSN97061A1 (fr)
TR (1) TR199700261A2 (fr)
YU (1) YU12397A (fr)
ZA (1) ZA972829B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826469A1 (de) * 1998-06-13 2000-05-25 Bayer Ag Verfahren zur Herstellung von 2,4-Dimethylcarbolin und 2,4-Dimethylpyrimido[1,2-a]indol
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
JP4254093B2 (ja) * 2001-10-17 2009-04-15 宇部興産株式会社 ５−ハロゲノインドールの製法
DE10349175A1 (de) * 2003-10-22 2005-05-19 Bayer Healthcare Ag Mittel zur Gewichtsreduktion
US7932268B2 (en) 2004-03-05 2011-04-26 The Trustees Of The University Of Pennsylvania Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US7967838B2 (en) 2005-05-12 2011-06-28 C. R. Bard, Inc. Removable embolus blood clot filter
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
CA2616818C (fr) 2005-08-09 2014-08-05 C.R. Bard, Inc. Filtre pour caillots de sang generateurs d'embolie et systeme de mise en place
EP1951220A2 (fr) * 2005-10-18 2008-08-06 Aegerion Pharmaceuticals Compositions destinees a l'abbaissement du cholesterol serique et/ou des triglycerides
US10188496B2 (en) 2006-05-02 2019-01-29 C. R. Bard, Inc. Vena cava filter formed from a sheet
CA2673290A1 (fr) * 2006-12-21 2008-07-03 Aegerion Pharmaceuticals, Inc. Procedes de traitement de l'obesite a l'aide d'une combinaison comprenant un inhibiteur de mtp et un inhibiteur de l'absorption du cholesterol
US20230285376A1 (en) 2020-07-29 2023-09-14 Amryt Pharmaceuticals Inc. Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066065A (zh) * 1991-04-26 1992-11-11 拜尔公司 杂环取代的苯乙酸衍生物及其制法和药物用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2200584A1 (de) * 1971-01-11 1972-07-27 Wyeth John & Brother Ltd Heterocyclische Verbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
ZA718536B (en) * 1971-01-11 1972-09-27 Wyeth John & Brother Ltd Heterocyclic compounds
GB8614246D0 (en) * 1986-06-11 1986-07-16 Wyeth John & Brother Ltd Substituted pyrimidoindoles
DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
US5576342A (en) * 1992-03-13 1996-11-19 Bayer Aktiengesellschaft Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives
DE4208051A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Substituierte phenylessigsaeureamide
DE4208052A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Imidazolyl substituierte phenylessigsaeureamide
DE4309968A1 (de) * 1993-03-26 1994-09-29 Bayer Ag Phenylglycinamide von heterocyclisch substituierten Phenylessigsäurederivaten
NZ257545A (en) * 1992-11-05 1997-01-29 Smithkline Beecham Plc Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
DE4302956A1 (de) * 1993-02-03 1994-08-04 Bayer Ag Substituierte Imidazo(4,5-b)pyridine und Benzimidazole

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066065A (zh) * 1991-04-26 1992-11-11 拜尔公司 杂环取代的苯乙酸衍生物及其制法和药物用途

Also Published As

Publication number Publication date
SV1997000025A (es) 1997-10-23
ZA972829B (en) 1997-10-31
IL131645A0 (en) 2001-01-28
SG63698A1 (en) 1999-03-30
CO4520306A1 (es) 1997-10-15
MX9702445A (es) 1997-10-31
NO971512L (no) 1997-10-06
NO309092B1 (no) 2000-12-11
NO971512D0 (no) 1997-04-03
HUP9700708A3 (en) 2000-01-28
DE19613550A1 (de) 1997-10-09
AR006497A1 (es) 1999-08-25
ID16520A (id) 1997-10-09
MA24131A1 (fr) 1997-10-01
BG62934B1 (bg) 2000-11-30
MY126362A (en) 2006-09-29
HRP970154A2 (en) 1998-04-30
HU9700708D0 (en) 1997-05-28
BG101379A (en) 1997-11-28
NZ314497A (en) 1999-10-28
IL131645A (en) 2000-12-06
CN1176965A (zh) 1998-03-25
BR9701675A (pt) 1998-11-03
CN1312246A (zh) 2001-09-12
KR970070008A (ko) 1997-11-07
HUP9700708A2 (hu) 1998-10-28
EP0799828A2 (fr) 1997-10-08
IL120590A0 (en) 1997-08-14
CZ102297A3 (en) 1997-10-15
AU1660397A (en) 1997-10-09
DZ2201A1 (fr) 2002-12-03
JPH1059972A (ja) 1998-03-03
SK42797A3 (en) 1997-11-05
EE9700078A (et) 1997-10-15
TR199700261A2 (xx) 1997-10-21
CA2201434A1 (fr) 1997-10-04
AU725786B2 (en) 2000-10-19
EP0799828A3 (fr) 1998-04-08
IL120590A (en) 2000-02-17
PE42398A1 (es) 1998-10-12
PL319249A1 (en) 1997-10-13
TNSN97061A1 (fr) 2005-03-15
YU12397A (en) 1999-11-22
US6114341A (en) 2000-09-05
HN1997000045A (es) 1997-06-26

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