CN1067393C - 新的嘧啶并[1,2－a]吲哚类化合物 - Google Patents

新的嘧啶并[1,2－a]吲哚类化合物 Download PDF

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Publication number
CN1067393C
CN1067393C CN97110275A CN97110275A CN1067393C CN 1067393 C CN1067393 C CN 1067393C CN 97110275 A CN97110275 A CN 97110275A CN 97110275 A CN97110275 A CN 97110275A CN 1067393 C CN1067393 C CN 1067393C
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CN
China
Prior art keywords
chain
carbon atoms
branched
straight
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97110275A
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English (en)
Chinese (zh)
Other versions
CN1176965A (zh
Inventor
U·穆勒
P·埃肯伯格
R·格鲁兹曼
H·比肖夫
D·顿泽
S·沃尔费尔
S·洛马
U·尼尔彻
P·科克夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
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Bayer AG
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Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN1176965A publication Critical patent/CN1176965A/zh
Application granted granted Critical
Publication of CN1067393C publication Critical patent/CN1067393C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CN97110275A 1996-04-04 1997-04-04 新的嘧啶并[1,2－a]吲哚类化合物 Expired - Fee Related CN1067393C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19613550A DE19613550A1 (de) 1996-04-04 1996-04-04 Neue Pyrimido[1,2-a]indole
DE19613550.8 1996-04-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN00127092A Division CN1312246A (zh) 1996-04-04 2000-09-12 制备羧酸的方法

Publications (2)

Publication Number Publication Date
CN1176965A CN1176965A (zh) 1998-03-25
CN1067393C true CN1067393C (zh) 2001-06-20

Family

ID=7790502

Family Applications (2)

Application Number Title Priority Date Filing Date
CN97110275A Expired - Fee Related CN1067393C (zh) 1996-04-04 1997-04-04 新的嘧啶并[1,2－a]吲哚类化合物
CN00127092A Pending CN1312246A (zh) 1996-04-04 2000-09-12 制备羧酸的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN00127092A Pending CN1312246A (zh) 1996-04-04 2000-09-12 制备羧酸的方法

Country Status (33)

Country Link
US (1) US6114341A (fr)
EP (1) EP0799828A3 (fr)
JP (1) JPH1059972A (fr)
KR (1) KR970070008A (fr)
CN (2) CN1067393C (fr)
AR (1) AR006497A1 (fr)
AU (1) AU725786B2 (fr)
BG (1) BG62934B1 (fr)
BR (1) BR9701675A (fr)
CA (1) CA2201434A1 (fr)
CO (1) CO4520306A1 (fr)
CZ (1) CZ102297A3 (fr)
DE (1) DE19613550A1 (fr)
DZ (1) DZ2201A1 (fr)
EE (1) EE9700078A (fr)
HN (1) HN1997000045A (fr)
HR (1) HRP970154A2 (fr)
HU (1) HUP9700708A3 (fr)
ID (1) ID16520A (fr)
IL (3) IL120590A (fr)
MA (1) MA24131A1 (fr)
MY (1) MY126362A (fr)
NO (1) NO309092B1 (fr)
NZ (1) NZ314497A (fr)
PE (1) PE42398A1 (fr)
PL (1) PL319249A1 (fr)
SG (1) SG63698A1 (fr)
SK (1) SK42797A3 (fr)
SV (1) SV1997000025A (fr)
TN (1) TNSN97061A1 (fr)
TR (1) TR199700261A2 (fr)
YU (1) YU12397A (fr)
ZA (1) ZA972829B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826469A1 (de) * 1998-06-13 2000-05-25 Bayer Ag Verfahren zur Herstellung von 2,4-Dimethylcarbolin und 2,4-Dimethylpyrimido[1,2-a]indol
AU2001244635A1 (en) * 2000-03-30 2001-10-15 Yamanouchi Pharmaceutical Co..Ltd. Hydrazide derivatives
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
JP4254093B2 (ja) * 2001-10-17 2009-04-15 宇部興産株式会社 ５−ハロゲノインドールの製法
DE10349175A1 (de) * 2003-10-22 2005-05-19 Bayer Healthcare Ag Mittel zur Gewichtsreduktion
KR101494067B1 (ko) 2004-03-05 2015-02-16 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과 연관된 질환 또는 질병의 치료 방법
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
CA3029306C (fr) 2005-05-12 2020-12-29 C.R. Bard Inc. Filtre amovible pour caillot sanguin ou embole
EP1890767A2 (fr) * 2005-05-27 2008-02-27 Pfizer Products Inc. Combinaison d'un antagoniste des recepteurs cannabinoides-1 et d'un inhibiteur des proteines microsomales de transfert de triglycerides pour traiter l'obesite ou maintenir une perte de poids
US8062327B2 (en) 2005-08-09 2011-11-22 C. R. Bard, Inc. Embolus blood clot filter and delivery system
AU2006304689A1 (en) * 2005-10-18 2007-04-26 Aegerion Pharmaceuticals Compositions for lowering serum cholesterol and/or triglycerides
WO2007133366A2 (fr) 2006-05-02 2007-11-22 C. R. Bard, Inc. Filtre à veine cave formé à partir d'une feuille
JP2010513534A (ja) * 2006-12-21 2010-04-30 エージェリオン ファーマシューティカルズ， インコーポレイテッド Ｍｔｐインヒビターおよびコレステロール吸収インヒビターを含む組み合わせを用いて肥満症を処置する方法
CA3186856A1 (fr) 2020-07-29 2022-02-03 Ruth NALLEN Lomitapide destine a etre utilise dans des methodes de traitement de l'hyperlipidemie et de l'hypercholesterolemie chez des patients pediatriques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066065A (zh) * 1991-04-26 1992-11-11 拜尔公司 杂环取代的苯乙酸衍生物及其制法和药物用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA718536B (en) * 1971-01-11 1972-09-27 Wyeth John & Brother Ltd Heterocyclic compounds
DE2200584A1 (de) * 1971-01-11 1972-07-27 Wyeth John & Brother Ltd Heterocyclische Verbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
GB8614246D0 (en) * 1986-06-11 1986-07-16 Wyeth John & Brother Ltd Substituted pyrimidoindoles
DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4309968A1 (de) * 1993-03-26 1994-09-29 Bayer Ag Phenylglycinamide von heterocyclisch substituierten Phenylessigsäurederivaten
DE4208051A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Substituierte phenylessigsaeureamide
DE4208052A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Imidazolyl substituierte phenylessigsaeureamide
US5576342A (en) * 1992-03-13 1996-11-19 Bayer Aktiengesellschaft Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives
EP0667867A1 (fr) * 1992-11-05 1995-08-23 Smithkline Beecham Plc Derives de piperidine utiles comme antagonistes de recepteur de 5-ht4
DE4302956A1 (de) * 1993-02-03 1994-08-04 Bayer Ag Substituierte Imidazo(4,5-b)pyridine und Benzimidazole

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066065A (zh) * 1991-04-26 1992-11-11 拜尔公司 杂环取代的苯乙酸衍生物及其制法和药物用途

Also Published As

Publication number Publication date
KR970070008A (ko) 1997-11-07
TNSN97061A1 (fr) 2005-03-15
SK42797A3 (en) 1997-11-05
NO971512L (no) 1997-10-06
BG101379A (en) 1997-11-28
SG63698A1 (en) 1999-03-30
MY126362A (en) 2006-09-29
EE9700078A (et) 1997-10-15
EP0799828A2 (fr) 1997-10-08
BG62934B1 (bg) 2000-11-30
PL319249A1 (en) 1997-10-13
MX9702445A (es) 1997-10-31
IL120590A (en) 2000-02-17
EP0799828A3 (fr) 1998-04-08
NZ314497A (en) 1999-10-28
HUP9700708A2 (hu) 1998-10-28
ZA972829B (en) 1997-10-31
HU9700708D0 (en) 1997-05-28
CO4520306A1 (es) 1997-10-15
DZ2201A1 (fr) 2002-12-03
CN1312246A (zh) 2001-09-12
AU1660397A (en) 1997-10-09
NO309092B1 (no) 2000-12-11
PE42398A1 (es) 1998-10-12
BR9701675A (pt) 1998-11-03
CN1176965A (zh) 1998-03-25
HUP9700708A3 (en) 2000-01-28
YU12397A (en) 1999-11-22
US6114341A (en) 2000-09-05
AU725786B2 (en) 2000-10-19
HRP970154A2 (en) 1998-04-30
HN1997000045A (es) 1997-06-26
IL131645A (en) 2000-12-06
IL120590A0 (en) 1997-08-14
IL131645A0 (en) 2001-01-28
SV1997000025A (es) 1997-10-23
DE19613550A1 (de) 1997-10-09
TR199700261A2 (xx) 1997-10-21
JPH1059972A (ja) 1998-03-03
CZ102297A3 (en) 1997-10-15
NO971512D0 (no) 1997-04-03
AR006497A1 (es) 1999-08-25
MA24131A1 (fr) 1997-10-01
ID16520A (id) 1997-10-09
CA2201434A1 (fr) 1997-10-04

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