CN1171742A - ε－氨基的选择性酰化 - Google Patents

ε－氨基的选择性酰化 Download PDF

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Publication number
CN1171742A
CN1171742A CN95197224A CN95197224A CN1171742A CN 1171742 A CN1171742 A CN 1171742A CN 95197224 A CN95197224 A CN 95197224A CN 95197224 A CN95197224 A CN 95197224A CN 1171742 A CN1171742 A CN 1171742A
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CN
China
Prior art keywords
insulin
amino groups
fatty acid
solution
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN95197224A
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English (en)
Chinese (zh)
Inventor
J·C·贝克
V·J·陈
J·M·汉奎尔
A·V·克里奥修纳斯
B·A·莫萨
R·T·舒曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1171742A publication Critical patent/CN1171742A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN95197224A 1994-11-17 1995-11-14 ε－氨基的选择性酰化 Pending CN1171742A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups
US08/341,231 1994-11-17

Publications (1)

Publication Number Publication Date
CN1171742A true CN1171742A (zh) 1998-01-28

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95197224A Pending CN1171742A (zh) 1994-11-17 1995-11-14 ε－氨基的选择性酰化

Country Status (27)

Country Link
US (2) US5646242A (2)
EP (2) EP1227107A1 (2)
JP (1) JP4312828B2 (2)
CN (1) CN1171742A (2)
AR (1) AR003915A1 (2)
AT (1) ATE328902T1 (2)
AU (2) AU691066B2 (2)
BR (1) BR9509652A (2)
CA (1) CA2205061A1 (2)
CO (1) CO4520285A1 (2)
CZ (1) CZ287731B6 (2)
DE (1) DE69535031T2 (2)
DK (1) DK0712862T3 (2)
ES (1) ES2264124T3 (2)
HU (2) HU217585B (2)
IL (1) IL115972A (2)
IN (1) IN179820B (2)
NO (1) NO972185D0 (2)
NZ (1) NZ297256A (2)
PL (1) PL320556A1 (2)
PT (1) PT712862E (2)
RU (1) RU2155773C2 (2)
SI (1) SI0712862T1 (2)
TR (1) TR199501421A2 (2)
WO (1) WO1996015803A1 (2)
YU (1) YU71495A (2)
ZA (1) ZA959680B (2)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305A (zh) * 2015-10-10 2015-12-02 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125A (zh) * 2015-11-25 2016-03-30 山东阿华生物药业有限公司 地特胰岛素或其类似物的制备方法
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法

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US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
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US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
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US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
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JP4468174B2 (ja) * 2002-09-25 2010-05-26 ノボ ノルディスク アクティーゼルスカブ ペプチドをアシル化するための方法
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CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
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WO2007121318A2 (en) * 2006-04-12 2007-10-25 Emisphere Technologies, Inc. Formulations for delivering insulin
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CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
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CN102149411A (zh) 2008-09-12 2011-08-10 诺沃—诺迪斯克有限公司 酰化肽或蛋白的方法
CN102202683A (zh) * 2008-10-30 2011-09-28 诺沃-诺迪斯克有限公司 用少于每日一次的注射频率注射胰岛素来治疗糖尿病
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CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305A (zh) * 2015-10-10 2015-12-02 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125A (zh) * 2015-11-25 2016-03-30 山东阿华生物药业有限公司 地特胰岛素或其类似物的制备方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法

Also Published As

Publication number Publication date
DE69535031D1 (de) 2006-07-20
HU217585B (hu) 2000-02-28
AU7885498A (en) 1998-11-05
AR003915A1 (es) 1998-09-30
IL115972A (en) 2000-09-28
NO972185L (no) 1997-05-13
IL115972A0 (en) 1996-01-31
DK0712862T3 (da) 2006-09-25
IN179820B (2) 1997-12-13
YU71495A (sh) 1998-09-18
HUT77737A (hu) 1998-07-28
ES2264124T3 (es) 2006-12-16
JP4312828B2 (ja) 2009-08-12
AU720820B2 (en) 2000-06-15
EP0712862A3 (en) 1998-03-04
PL320556A1 (en) 1997-10-13
DE69535031T2 (de) 2006-12-28
TR199501421A2 (tr) 1996-06-21
SI0712862T1 (sl) 2006-10-31
NZ297256A (en) 2000-01-28
EP1227107A1 (en) 2002-07-31
BR9509652A (pt) 1997-09-16
AU4237296A (en) 1996-06-17
CO4520285A1 (es) 1997-10-15
PT712862E (pt) 2006-08-31
EP0712862A2 (en) 1996-05-22
USRE37971E1 (en) 2003-01-28
AU691066B2 (en) 1998-05-07
WO1996015803A1 (en) 1996-05-30
HK1014007A1 (en) 1999-09-17
HU9903007D0 (en) 1999-11-29
CZ145697A3 (en) 1997-12-17
ZA959680B (en) 1997-05-14
NO972185D0 (no) 1997-05-13
US5646242A (en) 1997-07-08
JPH10509176A (ja) 1998-09-08
ATE328902T1 (de) 2006-06-15
CZ287731B6 (en) 2001-01-17
CA2205061A1 (en) 1996-05-30
MX9703506A (es) 1997-07-31
RU2155773C2 (ru) 2000-09-10
EP0712862B1 (en) 2006-06-07

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