CN87100927A - 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原 - Google Patents

人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原 Download PDF

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Publication number
CN87100927A
CN87100927A CN198787100927A CN87100927A CN87100927A CN 87100927 A CN87100927 A CN 87100927A CN 198787100927 A CN198787100927 A CN 198787100927A CN 87100927 A CN87100927 A CN 87100927A CN 87100927 A CN87100927 A CN 87100927A
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China
Prior art keywords
cells
antibody
monoclonal antibody
lung cancer
small cell
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Pending
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CN198787100927A
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English (en)
Chinese (zh)
Inventor
卡尔·埃里克·赫尔斯特罗姆
约瑟夫·P·布朗
英吉格·赫尔斯特罗姆
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ONKJIN CO
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ONKJIN CO
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Publication of CN87100927A publication Critical patent/CN87100927A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN198787100927A 1986-02-26 1987-03-14 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原 Pending CN87100927A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US834,172 1986-02-26
US06/834,172 US5185432A (en) 1986-02-26 1986-02-26 Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas

Publications (1)

Publication Number Publication Date
CN87100927A true CN87100927A (zh) 1988-10-05

Family

ID=25266276

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198787100927A Pending CN87100927A (zh) 1986-02-26 1987-03-14 人类非小细胞肺癌及其它几种癌症的单克隆抗和抗原

Country Status (28)

Country Link
US (1) US5185432A (2)
JP (1) JPS62220197A (2)
KR (2) KR870008026A (2)
CN (1) CN87100927A (2)
AT (1) AT400577B (2)
AU (1) AU612967B2 (2)
BE (1) BE1000611A5 (2)
CA (1) CA1312025C (2)
CH (1) CH675880A5 (2)
DD (2) DD276165A5 (2)
DE (1) DE3705276A1 (2)
DK (1) DK98187A (2)
ES (1) ES2004245A6 (2)
FI (1) FI870764A7 (2)
FR (1) FR2596062B1 (2)
GB (1) GB2186885B (2)
GR (1) GR870294B (2)
IE (1) IE60286B1 (2)
IT (1) IT1203511B (2)
LU (1) LU86786A1 (2)
NL (1) NL8700415A (2)
NO (1) NO174719C (2)
NZ (1) NZ219338A (2)
OA (1) OA08485A (2)
PT (1) PT84370B (2)
SE (2) SE467988B (2)
YU (1) YU46189B (2)
ZA (1) ZA869494B (2)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732333B (zh) * 2000-07-28 2012-08-15 大日本住友制药株式会社 癌症治疗药
CN102791736A (zh) * 2009-09-23 2012-11-21 艾斯可勒皮恩有限公司 用于癌症治疗的dsg2拮抗剂
WO2013063874A1 (zh) * 2011-11-03 2013-05-10 Pan Shiyang 抗人非小细胞肺癌单克隆抗体及其应用
CN103221419A (zh) * 2010-09-17 2013-07-24 独立行政法人产业技术综合研究所 肺癌鉴定标志物

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531301A1 (de) * 1985-09-02 1987-03-05 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte glykoproteine, verfahren zu ihrer herstellung sowie ihre verwendung
JPH0813840B2 (ja) * 1987-03-31 1996-02-14 協和醗酵工業株式会社 抗ヒト肺腺癌単クロ−ン性抗体
US5134075A (en) * 1989-02-17 1992-07-28 Oncogen Limited Partnership Monoclonal antibody to novel antigen associated with human tumors
US5171665A (en) * 1989-04-17 1992-12-15 Oncogen Monoclonal antibody to novel antigen associated with human tumors
US5342774A (en) * 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5589579A (en) * 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
EP0863402B1 (en) 1997-03-03 2005-09-14 Amersham Biosciences UK Limited In-situ cell extraction and assay method
DE19725133A1 (de) * 1997-06-13 1998-12-17 Micromet Ges Fuer Biomedizinis Nachweis von seltenen Zellen
US20050089918A1 (en) * 1998-02-23 2005-04-28 Amersham Biosciences Uk Limited In-situ cell extraction and assay method
US6117981A (en) * 1999-06-03 2000-09-12 Cytoclonal Pharmaceutics, Inc. Hybridomas for lung cancer marker and monoclonal antibodies thereof
CA2389916A1 (en) * 1999-09-03 2001-03-15 Human Genome Sciences, Inc. B7-like polynucleotides, polypeptides, and antibodies
CA2412377A1 (en) 2000-06-06 2001-12-13 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
CN101724072B (zh) * 2008-10-27 2013-10-09 谷为岳 一种抗肿瘤的单克隆抗体的序列及应用
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
JP5998060B2 (ja) 2010-03-04 2016-09-28 マクロジェニクス，インコーポレーテッド Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
TWI781098B (zh) 2016-04-15 2022-10-21 美商宏觀基因股份有限公司 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法
CN111662371B (zh) * 2020-04-30 2023-07-04 美康生物科技股份有限公司 细胞角蛋白19片段抗原及其制备方法和应用
CN112300284B (zh) * 2020-12-29 2021-04-06 慈达(广州)生物技术有限公司 核酸筛选结合抗体检测用于癌症检测中的用途及其制备的试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569788A (en) * 1983-05-18 1986-02-11 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies against non small cell lung cancer
IL76877A (en) * 1984-11-02 1991-11-21 Oncogen Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies
ZA858371B (en) * 1984-11-02 1987-03-25 Oncogen Monoclonal antibodies for human non-small cell lung carcinomas

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732333B (zh) * 2000-07-28 2012-08-15 大日本住友制药株式会社 癌症治疗药
CN102791736A (zh) * 2009-09-23 2012-11-21 艾斯可勒皮恩有限公司 用于癌症治疗的dsg2拮抗剂
CN103221419A (zh) * 2010-09-17 2013-07-24 独立行政法人产业技术综合研究所 肺癌鉴定标志物
CN103221419B (zh) * 2010-09-17 2015-12-09 独立行政法人产业技术综合研究所 肺癌鉴定标志物
WO2013063874A1 (zh) * 2011-11-03 2013-05-10 Pan Shiyang 抗人非小细胞肺癌单克隆抗体及其应用

Also Published As

Publication number Publication date
AU612967B2 (en) 1991-07-25
SE9201529D0 (sv) 1992-05-14
AT400577B (de) 1996-01-25
DK98187D0 (da) 1987-02-25
SE467988B (sv) 1992-10-12
IT8719491A0 (it) 1987-02-25
GB8703700D0 (en) 1987-03-25
FR2596062B1 (fr) 1990-06-08
DD266028A5 (de) 1989-03-22
IE60286B1 (en) 1994-06-29
IT1203511B (it) 1989-02-15
KR870008026A (ko) 1987-09-23
KR880010438A (ko) 1988-10-08
NL8700415A (nl) 1987-09-16
ATA43587A (de) 1995-06-15
SE9201529A0 (sv) 1992-05-14
NO870770D0 (no) 1987-02-25
GB2186885B (en) 1990-10-03
NO174719B (no) 1994-03-14
FI870764A0 (fi) 1987-02-23
YU46189B (sh) 1993-05-28
DD276165A5 (de) 1990-02-14
US5185432A (en) 1993-02-09
FR2596062A1 (fr) 1987-09-25
CH675880A5 (2) 1990-11-15
CA1312025C (en) 1992-12-29
SE8700805L (sv) 1987-10-22
NO870770L (no) 1987-08-27
KR900006338B1 (ko) 1990-08-28
DE3705276A1 (de) 1987-08-27
GR870294B (en) 1987-06-30
BE1000611A5 (fr) 1989-02-21
NZ219338A (en) 1991-11-26
IE870487L (en) 1987-08-26
LU86786A1 (fr) 1987-09-15
PT84370A (en) 1987-03-01
ES2004245A6 (es) 1988-12-16
SE8700805D0 (sv) 1987-02-25
DK98187A (da) 1987-08-27
FI870764A7 (fi) 1987-08-27
GB2186885A (en) 1987-08-26
YU25787A (en) 1990-12-31
PT84370B (pt) 1989-11-10
AU6927287A (en) 1987-08-27
JPS62220197A (ja) 1987-09-28
ZA869494B (en) 1987-10-28
OA08485A (fr) 1988-07-29
NO174719C (no) 1994-06-22

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