CO2020002959A2 - Moduladores de piruvato quinasas y uso de los mismos - Google Patents

Moduladores de piruvato quinasas y uso de los mismos

Info

Publication number
CO2020002959A2
CO2020002959A2 CONC2020/0002959A CO2020002959A CO2020002959A2 CO 2020002959 A2 CO2020002959 A2 CO 2020002959A2 CO 2020002959 A CO2020002959 A CO 2020002959A CO 2020002959 A2 CO2020002959 A2 CO 2020002959A2
Authority
CO
Colombia
Prior art keywords
pyruvate kinase
kinase modulators
compounds
formula
modulators
Prior art date
Application number
CONC2020/0002959A
Other languages
English (en)
Inventor
Giovanni Cianchetta
Charles Kung
Tao Liu
Anil Kumar Padyana
Zhihua Sui
Zhenwei Cai
Dawei Cui
Jingjing Ji
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of CO2020002959A2 publication Critical patent/CO2020002959A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Métodos para usar los compuestos de fórmula (I) para modular la actividad de la PKM2 en un sujeto. Estos compuestos están representados por la fórmula (I): (I) donde R1, R2, L1, y L2 son como se los define en la presente.
CONC2020/0002959A 2017-08-15 2020-03-12 Moduladores de piruvato quinasas y uso de los mismos CO2020002959A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2017097496 2017-08-15
US201862673526P 2018-05-18 2018-05-18
US201862673533P 2018-05-18 2018-05-18
PCT/US2018/000129 WO2019035865A1 (en) 2017-08-15 2018-08-15 MODULATORS OF PYRUVATE KINASE AND THEIR USE

Publications (1)

Publication Number Publication Date
CO2020002959A2 true CO2020002959A2 (es) 2020-04-13

Family

ID=63524352

Family Applications (2)

Application Number Title Priority Date Filing Date
CONC2020/0002959A CO2020002959A2 (es) 2017-08-15 2020-03-12 Moduladores de piruvato quinasas y uso de los mismos
CONC2020/0002961A CO2020002961A2 (es) 2017-08-15 2020-03-12 Activadores de piruvato quinasas para usar en el tratamiento de trastornos en la sangre

Family Applications After (1)

Application Number Title Priority Date Filing Date
CONC2020/0002961A CO2020002961A2 (es) 2017-08-15 2020-03-12 Activadores de piruvato quinasas para usar en el tratamiento de trastornos en la sangre

Country Status (34)

Country Link
US (8) US11464775B2 (es)
EP (4) EP3668513B1 (es)
JP (5) JP7301040B2 (es)
KR (3) KR102642408B1 (es)
CN (3) CN117186119B (es)
AU (4) AU2018316587B2 (es)
BR (1) BR112020003254A2 (es)
CA (1) CA3072455A1 (es)
CL (1) CL2020000375A1 (es)
CO (2) CO2020002959A2 (es)
CR (1) CR20200123A (es)
CY (1) CY1124953T1 (es)
DK (2) DK3668513T3 (es)
EC (1) ECSP20018487A (es)
ES (3) ES2966825T3 (es)
FI (1) FI3668512T3 (es)
HR (2) HRP20230452T1 (es)
HU (2) HUE061910T2 (es)
IL (3) IL272599B (es)
LT (2) LT3668512T (es)
MD (1) MD3668513T2 (es)
MX (2) MX2020001833A (es)
MY (1) MY204421A (es)
PE (1) PE20200724A1 (es)
PH (1) PH12020500343B1 (es)
PL (2) PL3668512T3 (es)
PT (2) PT3668512T (es)
RS (2) RS62871B1 (es)
SG (2) SG11202001353PA (es)
SI (2) SI3668513T1 (es)
SM (2) SMT202200023T1 (es)
TW (3) TWI790271B (es)
UA (1) UA126292C2 (es)
WO (3) WO2019035863A1 (es)

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LT3668512T (lt) 2023-06-12
PH12020500343A1 (en) 2021-02-08
US11957680B2 (en) 2024-04-16
JP7301040B2 (ja) 2023-06-30
PL3668512T3 (pl) 2023-06-19
WO2019035863A8 (en) 2019-03-28
PT3668512T (pt) 2023-05-22
HRP20220039T1 (hr) 2022-04-15
CO2020002961A2 (es) 2020-04-13
EP4026838A1 (en) 2022-07-13
IL272599B (en) 2022-08-01
EP3668513A1 (en) 2020-06-24
MD3668513T2 (ro) 2022-04-30
CY1124953T1 (el) 2023-01-05
WO2019035865A8 (en) 2019-03-28
US20230226055A1 (en) 2023-07-20
HUE061910T2 (hu) 2023-08-28
MX2020001832A (es) 2020-07-22
CN111032045B (zh) 2023-08-15
AU2018316587B2 (en) 2023-05-11
US20200207785A1 (en) 2020-07-02
PT3668513T (pt) 2022-01-21
TWI823580B (zh) 2023-11-21
KR102764124B1 (ko) 2025-02-05
IL272597A (en) 2020-03-31
JP2023027276A (ja) 2023-03-01
EP3668881B1 (en) 2023-10-04
JP7275107B2 (ja) 2023-05-17
AU2024205818A1 (en) 2024-09-05
WO2019035864A1 (en) 2019-02-21
CN117186119B (zh) 2026-04-28
CN117186119A (zh) 2023-12-08
CN111032046B (zh) 2023-09-26
SG11202001262QA (en) 2020-03-30
ES2966825T3 (es) 2024-04-24
AU2018316587A1 (en) 2020-02-20
JP2023052478A (ja) 2023-04-11
AU2018316588B2 (en) 2023-02-02
SI3668513T1 (sl) 2022-04-29
KR20200054200A (ko) 2020-05-19
IL292530A (en) 2022-06-01
CL2020000375A1 (es) 2020-12-11
SI3668512T1 (sl) 2023-06-30
AU2018316588A1 (en) 2020-02-20
WO2019035864A8 (en) 2019-03-28
PH12020500343B1 (en) 2024-02-21
US20220395503A1 (en) 2022-12-15
KR20230127364A (ko) 2023-08-31
RS62871B1 (sr) 2022-02-28
SMT202300146T1 (it) 2023-07-20
DK3668512T3 (da) 2023-05-22
US11364240B2 (en) 2022-06-21
WO2019035863A1 (en) 2019-02-21
KR102717594B1 (ko) 2024-10-14
RU2020110573A3 (es) 2021-12-24
US20220233541A1 (en) 2022-07-28
US11040036B2 (en) 2021-06-22
CA3071993A1 (en) 2019-02-21
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CN111032045A (zh) 2020-04-17
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TWI790271B (zh) 2023-01-21
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US20210077490A1 (en) 2021-03-18
BR112020003262A2 (pt) 2020-09-01
TW202323258A (zh) 2023-06-16
US20200206225A1 (en) 2020-07-02
LT3668513T (lt) 2022-03-25
US20250144093A1 (en) 2025-05-08
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US11590132B2 (en) 2023-02-28
DK3668513T3 (da) 2022-01-10
MX2020001833A (es) 2020-07-22
TW201919631A (zh) 2019-06-01
AU2023202772A1 (en) 2023-05-18
EP3668881A1 (en) 2020-06-24
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KR20200054199A (ko) 2020-05-19
US11464775B2 (en) 2022-10-11
US11872225B2 (en) 2024-01-16
ES2944545T3 (es) 2023-06-22
SG11202001353PA (en) 2020-03-30
HUE057178T2 (hu) 2022-04-28
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JP2020531432A (ja) 2020-11-05
BR112020003254A2 (pt) 2020-10-27
JP2020531443A (ja) 2020-11-05
EP3668513B1 (en) 2021-11-10
CA3072455A1 (en) 2019-02-21
JP7530453B2 (ja) 2024-08-07
EP3668512A1 (en) 2020-06-24
PE20200724A1 (es) 2020-07-21
IL292530B2 (en) 2023-06-01
TWI796353B (zh) 2023-03-21

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