CR20170420A - Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 - Google Patents

Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8

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Publication number
CR20170420A
CR20170420A CR20170420A CR20170420A CR20170420A CR 20170420 A CR20170420 A CR 20170420A CR 20170420 A CR20170420 A CR 20170420A CR 20170420 A CR20170420 A CR 20170420A CR 20170420 A CR20170420 A CR 20170420A
Authority
CR
Costa Rica
Prior art keywords
cinamide
alfa
compositions
compounds
hdac8 inhibitors
Prior art date
Application number
CR20170420A
Other languages
English (en)
Inventor
Pui Yee Ng
Bingsong; Han
Xiaozhang; Zheng
Kenneth W ; Bair
Nicholas; Barczak
Aleksandra; Rudnitskaya
Mary-Margaret; Zablocki
David R Jr ; Lancia
Cuixian; Lui
Matthew W ; Martin
Jennifer R ; Thomason
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of CR20170420A publication Critical patent/CR20170420A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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Abstract

La presente invención se refiere a inhibidores de histona deacetilasas, en particular HDAC8, que son útiles para el tratamiento de cáncer y otras enfermedades y trastornos, así como la síntesis y aplicaciones de dichos inhibidores.
CR20170420A 2015-03-13 2016-03-11 Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 CR20170420A (es)

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US201562184335P 2015-06-25 2015-06-25
US201562270371P 2015-12-21 2015-12-21
PCT/US2016/022029 WO2016149099A1 (en) 2015-03-13 2016-03-11 Alpha-cinnamide compounds and compositions as hdac8 inhibitors

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WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
AR105911A1 (es) 2015-09-03 2017-11-22 Forma Therapeutics Inc Inhibidores de hdac8 bicíclicos fusionados [6,6]
TWI659949B (zh) 2016-05-16 2019-05-21 臺北醫學大學 組蛋白去乙醯酶6抑制劑及其用途
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US11230524B2 (en) * 2017-08-17 2022-01-25 Standard Llc Myocyte enhancer factor 2 (MEF2) modulators
CN112292370A (zh) * 2018-04-20 2021-01-29 瓦洛早期发现股份有限公司 作为hdac抑制剂的异吲哚啉
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors
KR102055369B1 (ko) * 2018-08-09 2019-12-12 충북대학교 산학협력단 신규한 3/4-((치환된 벤즈아미도페녹시)메틸)-n-히드록시 벤즈아미드/프로펜아미드 화합물 및 이의 용도
CN113015735B (zh) * 2018-12-06 2024-06-21 诺华股份有限公司 用于诱导软骨发生以治疗关节损害的5-羟基-7-氧杂双环[2.2.1]庚烷-2-甲酰胺衍生物
CN113493407B (zh) * 2020-04-03 2025-01-28 中国医学科学院药物研究所 一种吡啶类化合物及其制法和药物用途
CN111728961B (zh) * 2020-08-05 2021-06-15 牡丹江医学院 一种用于治疗老年痴呆的药物组合物及其用途
CN114605304A (zh) * 2020-12-04 2022-06-10 杭州中美华东制药有限公司 一种(±)-2-(4-(1-氧代异吲哚-2-基)苯基)丁酸乙酯的合成方法
CN113192633B (zh) * 2021-05-24 2022-05-31 山西大学 基于注意力机制的胃癌细粒度分类方法
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