CR6938A - Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento. - Google Patents

Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento.

Info

Publication number
CR6938A
CR6938A CR6938A CR6938A CR6938A CR 6938 A CR6938 A CR 6938A CR 6938 A CR6938 A CR 6938A CR 6938 A CR6938 A CR 6938A CR 6938 A CR6938 A CR 6938A
Authority
CR
Costa Rica
Prior art keywords
crystalline
monohidrate
employment
manufacture
manufacturing
Prior art date
Application number
CR6938A
Other languages
English (en)
Inventor
Rolf Banholzer
Manfred Graulich
Christian Kulinna
Andreas Mathes
Helmut Meissner
Peter Sieger
Peter Specht
Michael Trunk
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR6938(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CR6938A publication Critical patent/CR6938A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se refiere a un monohidrato cristalino de bromuro de (1a,2b, 4b, 5a, 7b)-7-(hidroxidi-2-tienilacetil) oxi]-9-dimetil-3-oxa-9-azoniatrycyclo[3.3.1.0 24]nonane, al metodo para producirlo asi como su utilizacion para la produccion de un medicamento , en particular la produccion de un medicamento con efecto anticolinergico
CR6938A 2000-10-12 2003-03-26 Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento. CR6938A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (1)

Publication Number Publication Date
CR6938A true CR6938A (es) 2004-10-28

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6938A CR6938A (es) 2000-10-12 2003-03-26 Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento.

Country Status (46)

Country Link
EP (2) EP1326862B1 (es)
JP (1) JP3764422B2 (es)
KR (1) KR100823860B1 (es)
CN (2) CN100519558C (es)
AP (1) AP1572A (es)
AR (2) AR034389A1 (es)
AT (1) ATE276253T1 (es)
AU (2) AU1499602A (es)
BG (1) BG66161B1 (es)
BR (1) BR0114584A (es)
CA (1) CA2425539C (es)
CR (1) CR6938A (es)
CZ (1) CZ301841B6 (es)
DE (1) DE50103666D1 (es)
DK (1) DK1326862T3 (es)
DZ (1) DZ3478A1 (es)
EA (1) EA004381B1 (es)
EC (1) ECSP034540A (es)
EE (1) EE04567B1 (es)
EG (1) EG24142A (es)
ES (1) ES2228965T3 (es)
GE (1) GEP20063905B (es)
HR (1) HRP20030276B1 (es)
HU (1) HU226830B1 (es)
IL (2) IL155335A0 (es)
IS (1) IS2339B (es)
MA (1) MA25842A1 (es)
ME (2) MEP40008A (es)
MX (1) MXPA03003221A (es)
MY (1) MY126931A (es)
NO (1) NO328465B1 (es)
NZ (1) NZ525733A (es)
OA (1) OA12403A (es)
PE (1) PE20020422A1 (es)
PL (1) PL207870B1 (es)
PT (1) PT1326862E (es)
RS (1) RS50218B (es)
SA (1) SA01220412B1 (es)
SI (1) SI1326862T1 (es)
SK (1) SK287009B6 (es)
TR (1) TR200402579T4 (es)
TW (1) TW589313B (es)
UA (1) UA74215C2 (es)
UY (2) UY26962A1 (es)
WO (1) WO2002030928A1 (es)
ZA (1) ZA200302500B (es)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
CZ302786B6 (cs) * 2001-06-22 2011-11-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Krystalický bezvodý tiotropiumbromid, zpusob jeho výroby a jeho použití pro výrobu léciva pro lécbu asthmatu
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
MXPA06004697A (es) 2003-11-03 2006-07-05 Boehringer Ingelheim Int Procedimiento para la preparacion de sales de tiotropio, sles de tiotropio, asi como formulaciones medicamentosas que las contienen.
AU2004285685B2 (en) * 2003-11-03 2011-03-24 Boehringer Ingelheim International Gmbh Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
ES2338563T3 (es) * 2003-11-03 2010-05-10 Boehringer Ingelheim International Gmbh Nuevo anhidrato cristalino con efecto anticolinergico.
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
AU2005235419B2 (en) 2004-04-22 2010-11-04 Boehringer Ingelheim International Gmbh Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ES2322148T3 (es) 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
BRPI0517282A (pt) * 2004-10-21 2008-10-07 Boehringer Ingelheim Int blister para inaladores
WO2006094924A2 (en) * 2005-03-09 2006-09-14 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
NZ563448A (en) 2005-04-28 2011-01-28 Boehringer Ingelheim Int Benzofuranone derivatives for treating inflammatory diseases
BRPI0609295A2 (pt) 2005-05-02 2010-03-23 Boehringer Ingelheim Int formas cristalinas de brometo de tiotràpio, composiÇço farmacÊutica, uso e mÉtodo para preparar as mesmas
JP2008540367A (ja) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
AU2006277968A1 (en) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of severe persistant asthma
CN101208316B (zh) 2005-08-15 2012-05-09 贝林格尔·英格海姆国际有限公司 制备β-模拟物的方法
TWI396541B (zh) * 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
RS52663B2 (sr) 2005-12-19 2018-05-31 Sicor Inc Nova kristalna forma tiotropijum bromida i proces njene pripreme
EP1966196A2 (en) * 2005-12-19 2008-09-10 Sicor, Inc. Pure and stable tiotropium bromide
JP2009525950A (ja) * 2006-01-04 2009-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中等症持続型喘息の治療におけるチオトロピウム塩の使用
MX2007012313A (es) 2006-04-19 2007-11-21 Boehringer Ingelheim Int Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias.
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
JP2010500318A (ja) 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療用医薬組成物
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
AU2008313660B2 (en) 2007-10-19 2013-11-07 Boehringer Ingelheim International Gmbh Substituted piperidino-dihydrothienopyrimidines
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
US20100272811A1 (en) * 2008-07-23 2010-10-28 Alkermes,Inc. Complex of trospium and pharmaceutical compositions thereof
HUE025547T2 (en) 2008-12-19 2016-02-29 Boehringer Ingelheim Int Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
US20130143905A1 (en) 2009-12-17 2013-06-06 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
NZ600857A (en) 2010-01-29 2014-06-27 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011144501A1 (en) 2010-05-17 2011-11-24 Boehringer Ingelheim International Gmbh Ccr2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
JP5959537B2 (ja) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリジニル−ピリミジン及び医薬としてのその使用
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja) 2011-06-16 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の選択的ｃｃｒ２拮抗薬
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
CN103827090B (zh) 2011-07-26 2016-04-20 勃林格殷格翰国际有限公司 取代的喹啉及其作为药物的用途
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
UA115888C2 (uk) 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
CN106255689B (zh) 2014-03-19 2019-09-17 勃林格殷格翰国际有限公司 杂芳基syk抑制剂
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
WO2018084817A2 (en) * 2016-11-04 2018-05-11 Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ A new form of active agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SK280911B6 (sk) * 1992-12-09 2000-09-12 Boehringer Ingelheim Pharmaceuticals, Inc. Farmaceutický prostriedok
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
CN1150890C (zh) * 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂

Also Published As

Publication number Publication date
GEP20063905B (en) 2006-08-25
KR20030042008A (ko) 2003-05-27
AR034389A1 (es) 2004-02-25
NZ525733A (en) 2005-01-28
IL155335A0 (en) 2003-11-23
PL207870B1 (pl) 2011-02-28
IS6772A (is) 2003-04-09
EA004381B1 (ru) 2004-04-29
SK4362003A3 (en) 2003-08-05
PL366041A1 (en) 2005-01-24
NO328465B1 (no) 2010-02-22
HU226830B1 (en) 2009-11-30
WO2002030928A1 (de) 2002-04-18
HUP0301022A2 (hu) 2003-10-28
ATE276253T1 (de) 2004-10-15
JP3764422B2 (ja) 2006-04-05
TR200402579T4 (tr) 2004-12-21
CZ301841B6 (cs) 2010-07-07
NO20031694L (no) 2003-04-11
AU2002214996B2 (en) 2007-03-15
BG107687A (bg) 2003-09-30
JP2004526668A (ja) 2004-09-02
PE20020422A1 (es) 2002-06-28
IL155335A (en) 2009-02-11
NO20031694D0 (no) 2003-04-11
MEP40008A (en) 2011-02-10
CA2425539C (en) 2007-04-03
BG66161B1 (bg) 2011-09-30
CN1469877A (zh) 2004-01-21
HUP0301022A3 (en) 2005-12-28
MXPA03003221A (es) 2004-12-03
AU1499602A (en) 2002-04-22
MA25842A1 (fr) 2003-07-01
ME00243B (me) 2011-05-10
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
DE50103666D1 (de) 2004-10-21
AR068527A2 (es) 2009-11-18
TW589313B (en) 2004-06-01
EP1326862A1 (de) 2003-07-16
UY34901A (es) 2015-02-27
BR0114584A (pt) 2003-08-26
RS50218B (sr) 2009-07-15
EG24142A (en) 2008-08-06
CN100519558C (zh) 2009-07-29
ZA200302500B (en) 2004-04-22
MY126931A (en) 2006-10-31
SI1326862T1 (sl) 2005-02-28
HRP20030276A2 (en) 2005-02-28
ES2228965T3 (es) 2005-04-16
DK1326862T3 (da) 2004-11-22
EE04567B1 (et) 2005-12-15
IS2339B (is) 2008-02-15
HK1060567A1 (en) 2004-08-13
CN1733761A (zh) 2006-02-15
YU27303A (sh) 2006-05-25
KR100823860B1 (ko) 2008-04-21
UA74215C2 (uk) 2005-11-15
EP1326862B1 (de) 2004-09-15
UY26962A1 (es) 2002-06-20
SK287009B6 (sk) 2009-09-07
SA01220412B1 (ar) 2006-11-05
OA12403A (en) 2006-04-18
EP1468998A1 (de) 2004-10-20
AP2003002775A0 (en) 2003-03-31
AP1572A (en) 2006-02-13
HRP20030276B1 (en) 2006-02-28
PT1326862E (pt) 2004-11-30
DZ3478A1 (fr) 2002-04-18
CA2425539A1 (en) 2003-04-11
ECSP034540A (es) 2003-07-25
HK1086557A1 (zh) 2006-09-22
EA200300457A1 (ru) 2003-10-30

Similar Documents

Publication Publication Date Title
CR6938A (es) Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento.
UY27342A1 (es) Agente anticolinérgico cristalino, procedimiento para su preparación y su utilización para la preparación de un medicamento
AU2002214996A1 (en) Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
YU2003A (sh) Stabilne soli o-acetilsalicilne kiseline sa baznim amino-kiselinama
UY27725A1 (es) Material micronizado cristalino, procedimiento para su preparación y su utilización para la preparación de un medicamento.
UY26139A1 (es) Composiciones de medicamentos a base de compuestos anticolinérgicamente activos y beta- miméticos
YU174490A (sh) Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja
GT199900054A (es) Uso de dihidropirimidinas como medicamento y nuevas sustancis. as.
AU2002213977A1 (en) Novel anticholinergics, method for the production thereof and use thereof as medicaments
AU2001293802A1 (en) Substituted cinnamic acid guanidides, method for the production thereof, their use as a medicament, and to medicament containing these compounds
WO2002030467A3 (en) Pharmaceutical composition containing honey for the treatment of wounds
PE20070548A1 (es) Formas cristalinas de la sal de di-sodio del acido n-(5-clorosaliciloil)-8-aminocaprilico
DE60307358D1 (de) Zubereitung zur Verabreichung von Dithranol
AU2001258200A1 (en) Synthetic derivatives of lunularic acid, medicaments containing said compounds, method for producing the lunularic acid derivatives and the use thereof
AR029639A1 (es) Amidas sustituidas del acido fenilciclohexanocarboxilico, procedimiento para su preparacion, compuestos intermediarios, medicamentos, y el uso para la manufactura de un medicamento utiles como inhibidores de la incorporacion de adenosina
BRPI0509529B8 (pt) forma cristalina de ácido 8-ciano-1-ciclopropil-7-(1s,6s-2,8-diaza-biciclo[4.3.0]nonan-8-il)-6-flúor-1,4-dihidro-4-oxo-3-quinoli-nocarboxílico, seu uso, e medicamento
AR024100A1 (es) Amidas de acidos fenilciclohexanocarboxilicos sustituidos
FR2814369B1 (fr) Preparation medicamenteuse a base de vitamines d3 et son procede de fabrication
HUP0002147A3 (en) Hydroxybenzoic acid derivatives, process for producing them and pharmaceutical compositions having antiplasmid activity comprising the said compounds
ES2015770A6 (es) Procedimiento de preparacion de acido (5r,6s)-2-carbamoiloximetil-6- (1r-hidroxietil)-2-penem carboxilico y sus formulaciones farmaceuticas
UY26178A1 (es) Amidas de ácidos fenilciclohexanocarboxilicos sustituidos.
AU2002329270A1 (en) Salicylic acid salts, methods for the production and use thereof as medicaments
AU2002317182A1 (en) Use of 2,5-dihydroxybenzenesulphonic acid derivatives in the production of a medicament used to potentiate the effect of other drugs in the treatment of erectile dysfunction
ECSP003499A (es) Amidas de acidos fenilciclohexanocarboxilicos sustituidos
ECSP034921A (es) Anticolinérgico cristalino, metodo para su producción, y uso del mismo en la producción de una droga