CR6938A - Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento. - Google Patents

Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento.

Info

Publication number
CR6938A
CR6938A CR6938A CR6938A CR6938A CR 6938 A CR6938 A CR 6938A CR 6938 A CR6938 A CR 6938A CR 6938 A CR6938 A CR 6938A CR 6938 A CR6938 A CR 6938A
Authority
CR
Costa Rica
Prior art keywords
crystalline
monohidrate
employment
manufacture
manufacturing
Prior art date
Application number
CR6938A
Other languages
English (en)
Inventor
Rolf Banholzer
Manfred Graulich
Christian Kulinna
Andreas Mathes
Helmut Meissner
Peter Sieger
Peter Specht
Michael Trunk
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR6938(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CR6938A publication Critical patent/CR6938A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se refiere a un monohidrato cristalino de bromuro de (1a,2b, 4b, 5a, 7b)-7-(hidroxidi-2-tienilacetil) oxi]-9-dimetil-3-oxa-9-azoniatrycyclo[3.3.1.0 24]nonane, al metodo para producirlo asi como su utilizacion para la produccion de un medicamento , en particular la produccion de un medicamento con efecto anticolinergico
CR6938A 2000-10-12 2003-03-26 Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento. CR6938A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (1)

Publication Number Publication Date
CR6938A true CR6938A (es) 2004-10-28

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6938A CR6938A (es) 2000-10-12 2003-03-26 Monohidrato cristalino metodo para su fabricacion y su empleo en la fabricacion de un medicamento.

Country Status (46)

Country Link
EP (2) EP1468998A1 (es)
JP (1) JP3764422B2 (es)
KR (1) KR100823860B1 (es)
CN (2) CN1221549C (es)
AP (1) AP1572A (es)
AR (2) AR034389A1 (es)
AT (1) ATE276253T1 (es)
AU (2) AU2002214996B2 (es)
BG (1) BG66161B1 (es)
BR (1) BR0114584A (es)
CA (1) CA2425539C (es)
CR (1) CR6938A (es)
CZ (1) CZ301841B6 (es)
DE (1) DE50103666D1 (es)
DK (1) DK1326862T3 (es)
DZ (1) DZ3478A1 (es)
EA (1) EA004381B1 (es)
EC (1) ECSP034540A (es)
EE (1) EE04567B1 (es)
EG (1) EG24142A (es)
ES (1) ES2228965T3 (es)
GE (1) GEP20063905B (es)
HR (1) HRP20030276B1 (es)
HU (1) HU226830B1 (es)
IL (2) IL155335A0 (es)
IS (1) IS2339B (es)
MA (1) MA25842A1 (es)
ME (2) MEP40008A (es)
MX (1) MXPA03003221A (es)
MY (1) MY126931A (es)
NO (1) NO328465B1 (es)
NZ (1) NZ525733A (es)
OA (1) OA12403A (es)
PE (1) PE20020422A1 (es)
PL (1) PL207870B1 (es)
PT (1) PT1326862E (es)
RS (1) RS50218B (es)
SA (1) SA01220412B1 (es)
SI (1) SI1326862T1 (es)
SK (1) SK287009B6 (es)
TR (1) TR200402579T4 (es)
TW (1) TW589313B (es)
UA (1) UA74215C2 (es)
UY (2) UY26962A1 (es)
WO (1) WO2002030928A1 (es)
ZA (1) ZA200302500B (es)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
CA2450961C (en) * 2001-06-22 2010-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
WO2005042527A1 (de) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Neues kristallines anhydrat mit anticholinerger wirksamkeit
DK1682541T3 (da) * 2003-11-03 2010-06-28 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af tiotropiumsalte
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DK1682543T3 (da) * 2003-11-03 2010-12-13 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af nye tiotropiumsalte
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
EP1781298B1 (de) 2004-04-22 2012-01-04 Boehringer Ingelheim International GmbH Arzneinmittelkombinationen enthaltend benzoxazine zur behandlung von atemwegserkrankungen
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2322148T3 (es) 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
AU2005298780A1 (en) * 2004-10-21 2006-05-04 Boehringer Ingelheim International Gmbh Blister for inhalers
JP2008532973A (ja) * 2005-03-09 2008-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬とｐｄｅ５−阻害剤に基づく新規な医薬組成物
KR20080007645A (ko) 2005-04-28 2008-01-22 베링거 인겔하임 인터내셔날 게엠베하 염증성 질환 치료용 신규 화합물
EP1879888A2 (en) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
KR20080012932A (ko) 2005-05-02 2008-02-12 베링거 인겔하임 인터내셔날 게엠베하 티오트로퓸 브로마이드의 신규한 결정형
KR20080024532A (ko) * 2005-06-15 2008-03-18 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로퓸 염의 제조방법, 신규한 티오트로퓸 염및 이의 약제학적 조성물
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
KR20080039974A (ko) * 2005-08-06 2008-05-07 베링거 인겔하임 인터내셔날 게엠베하 중증 지속성 천식의 치료에서 티오트로퓸 염의 용도
EP1917253B1 (de) 2005-08-15 2015-01-07 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von betamimetika
US20070086957A1 (en) * 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
JP2008530251A (ja) * 2005-12-19 2008-08-07 シコール インコーポレイティド 純粋且つ安定な臭化チオトロピウム
PT1869035E (pt) 2005-12-19 2013-01-10 Sicor Inc Novas formas de brometo de tiotrópio e processos para sua preparação
KR20080083060A (ko) * 2006-01-04 2008-09-12 베링거 인겔하임 인터내셔날 게엠베하 중등 지속성 천식의 치료에서 티오트로퓸 염의 용도
HRP20090395T1 (hr) 2006-04-19 2009-08-31 Boehringer Ingelheim International Gmbh Dihidrotienpirimidini za liječenje upalnih bolesti
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
JP2010500318A (ja) 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療用医薬組成物
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
SI2610258T1 (sl) 2007-10-19 2014-12-31 Boehringer Ingelheim International Gmbh Substituirani piperidino-dihidrotienopirimidini
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
WO2010011813A1 (en) * 2008-07-23 2010-01-28 Alkermes, Inc. Complex of trospium and pharmaceutical compositions thereof
ES2551557T3 (es) 2008-12-19 2015-11-19 Boehringer Ingelheim International Gmbh Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
CA2768553C (en) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011073155A1 (en) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh Novel antagonists for ccr2 and uses thereof
PL2513093T3 (pl) 2009-12-17 2015-03-31 Centrexion Therapeutics Corp Nowi antagoniści receptora CCR2 i ich zastosowanie
CA2786245A1 (en) 2010-01-29 2011-08-04 Boehringer Ingelheim International Gmbh Substituted naphthyridines and their use as syk kinase inhibitors
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (en) 2010-05-17 2015-01-21 Boehringer Ingelheim International GmbH Ccr2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
JP5721242B2 (ja) 2010-06-01 2015-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２アンタゴニスト
EP2668177B1 (en) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
WO2012171863A1 (en) 2011-06-16 2012-12-20 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
PH12014500209A1 (en) 2011-07-26 2014-03-03 Boehringer Ingelheim Int Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
ES2620758T3 (es) 2012-11-05 2017-06-29 Zentiva K.S. Estabilización de solvatos de tiotropio
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
ES2738416T3 (es) 2014-03-19 2020-01-22 Boehringer Ingelheim Int Inhibidores heteroarílicos de SYK
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
EP3430011A4 (en) * 2016-11-04 2019-08-14 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI NOVEL ACTIVE SUBSTANCE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
ES2129117T3 (es) * 1992-12-09 1999-06-01 Boehringer Ingelheim Pharma Formulaciones en disolucion en forma de aerosol medicinales estabilizadas.
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
ATE234604T1 (de) * 1998-08-04 2003-04-15 Jago Res Ag Medizinische aerosolformulierungen

Also Published As

Publication number Publication date
CN1733761A (zh) 2006-02-15
EE04567B1 (et) 2005-12-15
AP1572A (en) 2006-02-13
HK1060567A1 (en) 2004-08-13
EA200300457A1 (ru) 2003-10-30
ATE276253T1 (de) 2004-10-15
CA2425539A1 (en) 2003-04-11
EP1326862B1 (de) 2004-09-15
UA74215C2 (uk) 2005-11-15
PT1326862E (pt) 2004-11-30
CZ301841B6 (cs) 2010-07-07
EP1468998A1 (de) 2004-10-20
ES2228965T3 (es) 2005-04-16
UY26962A1 (es) 2002-06-20
NO20031694L (no) 2003-04-11
NZ525733A (en) 2005-01-28
MA25842A1 (fr) 2003-07-01
IS6772A (is) 2003-04-09
OA12403A (en) 2006-04-18
NO328465B1 (no) 2010-02-22
EG24142A (en) 2008-08-06
HRP20030276A2 (en) 2005-02-28
AU1499602A (en) 2002-04-22
TW589313B (en) 2004-06-01
HU226830B1 (en) 2009-11-30
BR0114584A (pt) 2003-08-26
KR100823860B1 (ko) 2008-04-21
HUP0301022A2 (hu) 2003-10-28
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
HUP0301022A3 (en) 2005-12-28
AP2003002775A0 (en) 2003-03-31
AR068527A2 (es) 2009-11-18
CA2425539C (en) 2007-04-03
PE20020422A1 (es) 2002-06-28
UY34901A (es) 2015-02-27
MY126931A (en) 2006-10-31
HK1086557A1 (zh) 2006-09-22
DK1326862T3 (da) 2004-11-22
DE50103666D1 (de) 2004-10-21
YU27303A (sh) 2006-05-25
IS2339B (is) 2008-02-15
SK4362003A3 (en) 2003-08-05
ZA200302500B (en) 2004-04-22
ECSP034540A (es) 2003-07-25
AR034389A1 (es) 2004-02-25
MEP40008A (en) 2011-02-10
TR200402579T4 (tr) 2004-12-21
SI1326862T1 (sl) 2005-02-28
EP1326862A1 (de) 2003-07-16
IL155335A (en) 2009-02-11
BG66161B1 (bg) 2011-09-30
GEP20063905B (en) 2006-08-25
JP3764422B2 (ja) 2006-04-05
EA004381B1 (ru) 2004-04-29
ME00243B (me) 2011-05-10
NO20031694D0 (no) 2003-04-11
KR20030042008A (ko) 2003-05-27
DZ3478A1 (fr) 2002-04-18
SK287009B6 (sk) 2009-09-07
WO2002030928A1 (de) 2002-04-18
HRP20030276B1 (en) 2006-02-28
RS50218B (sr) 2009-07-15
PL366041A1 (en) 2005-01-24
PL207870B1 (pl) 2011-02-28
AU2002214996B2 (en) 2007-03-15
CN1469877A (zh) 2004-01-21
IL155335A0 (en) 2003-11-23
MXPA03003221A (es) 2004-12-03
BG107687A (bg) 2003-09-30
JP2004526668A (ja) 2004-09-02
CN100519558C (zh) 2009-07-29
SA01220412B1 (ar) 2006-11-05

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