NO20073099L - Amino-imidazoloner for inhibering av beta-sekretase - Google Patents
Amino-imidazoloner for inhibering av beta-sekretaseInfo
- Publication number
- NO20073099L NO20073099L NO20073099A NO20073099A NO20073099L NO 20073099 L NO20073099 L NO 20073099L NO 20073099 A NO20073099 A NO 20073099A NO 20073099 A NO20073099 A NO 20073099A NO 20073099 L NO20073099 L NO 20073099L
- Authority
- NO
- Norway
- Prior art keywords
- secretase
- imidazolones
- inhibition
- beta
- amino
- Prior art date
Links
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 2
- ZMLJHXQHPNGPJP-UHFFFAOYSA-N 4-aminoimidazol-2-one Chemical class NC1=NC(=O)N=C1 ZMLJHXQHPNGPJP-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 102100021257 Beta-secretase 1 Human genes 0.000 abstract 1
- 206010019909 Hernia Diseases 0.000 abstract 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 abstract 1
- -1 aminoimidazolone compound Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64380505P | 2005-01-14 | 2005-01-14 | |
| PCT/US2006/000656 WO2006076284A2 (en) | 2005-01-14 | 2006-01-09 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073099L true NO20073099L (no) | 2007-07-31 |
Family
ID=36581776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073099A NO20073099L (no) | 2005-01-14 | 2007-06-18 | Amino-imidazoloner for inhibering av beta-sekretase |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7563796B2 (es) |
| EP (2) | EP1836208A2 (es) |
| JP (1) | JP2008526966A (es) |
| KR (1) | KR20070095948A (es) |
| CN (1) | CN101103034A (es) |
| AR (1) | AR052458A1 (es) |
| AU (1) | AU2006205127A1 (es) |
| BR (1) | BRPI0606690A2 (es) |
| CA (1) | CA2593515A1 (es) |
| CR (1) | CR9244A (es) |
| GT (1) | GT200600009A (es) |
| IL (1) | IL183938A0 (es) |
| MX (1) | MX2007008555A (es) |
| NO (1) | NO20073099L (es) |
| PA (1) | PA8660001A1 (es) |
| PE (1) | PE20060842A1 (es) |
| RU (1) | RU2007126570A (es) |
| TW (1) | TW200637866A (es) |
| WO (1) | WO2006076284A2 (es) |
| ZA (1) | ZA200705783B (es) |
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| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| ES2332659T3 (es) * | 2004-06-16 | 2010-02-10 | Wyeth | Derivados de amino-5,5-difenilimidazolona para la inhibicion de beta-secretasa. |
| ATE423121T1 (de) | 2004-06-16 | 2009-03-15 | Wyeth Corp | Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren |
| MX2007009313A (es) * | 2005-02-01 | 2007-09-12 | Wyeth Corp | Amino-piridinas como inhibidores de ????-secretasa. |
| BRPI0606902A2 (pt) | 2005-02-14 | 2009-07-28 | Wyeth Corp | composto; método para o tratamento de uma doença ou distúrbio associado a atividade excessiva de bace em um paciente que dele necessite; método para modular a atividade de bace; composição farmacêutica |
| CN101228163A (zh) | 2005-06-14 | 2008-07-23 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
| CA2610828A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Heterocyclic aspartyl protease inhibitors, preparation and use thereof |
| EP1896448A1 (en) * | 2005-06-30 | 2008-03-12 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
| TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| KR20080050430A (ko) * | 2005-09-26 | 2008-06-05 | 와이어쓰 | 베타-세크레타제 (ｂａｃｅ) 억제제로서아미노-5-[4-(디플루오로메톡시)페닐]-5-페닐이미다졸론화합물 |
| EP2612854B1 (en) | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
| CN101360737A (zh) * | 2005-12-19 | 2009-02-04 | 惠氏公司 | 2-氨基-5-哌啶咪唑酮化合物和其用于β分泌酶调节的用途 |
| WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| EP2032542A2 (en) | 2006-06-12 | 2009-03-11 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
| TW200815449A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
| TW200815443A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
| TW200808796A (en) * | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| TW200817406A (en) * | 2006-08-17 | 2008-04-16 | Wyeth Corp | Imidazole amines as inhibitors of β-secretase |
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| EP2064201A2 (en) * | 2006-09-21 | 2009-06-03 | Wyeth | Indolylalkylpyridin-2-amines for the inhibition of beta-secretase |
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| WO2008133273A1 (ja) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | アルツハイマー症治療用医薬組成物 |
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| WO2009151098A1 (ja) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
| JP5417860B2 (ja) * | 2008-08-26 | 2014-02-19 | 住友化学株式会社 | α−ヒドロキシエステル類の製造方法 |
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| CA2911693C (en) | 2013-06-12 | 2021-08-24 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace) |
| CA2912156C (en) | 2013-06-12 | 2021-07-20 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace) |
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| TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| EP1896448A1 (en) | 2005-06-30 | 2008-03-12 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
| TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| KR20080050430A (ko) | 2005-09-26 | 2008-06-05 | 와이어쓰 | 베타-세크레타제 (ｂａｃｅ) 억제제로서아미노-5-[4-(디플루오로메톡시)페닐]-5-페닐이미다졸론화합물 |
| CN101360737A (zh) | 2005-12-19 | 2009-02-04 | 惠氏公司 | 2-氨基-5-哌啶咪唑酮化合物和其用于β分泌酶调节的用途 |
| WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| US7700606B2 (en) | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
-
2006
- 2006-01-09 CN CNA2006800021783A patent/CN101103034A/zh active Pending
- 2006-01-09 CA CA002593515A patent/CA2593515A1/en not_active Abandoned
- 2006-01-09 KR KR1020077016053A patent/KR20070095948A/ko not_active Withdrawn
- 2006-01-09 BR BRPI0606690-9A patent/BRPI0606690A2/pt not_active IP Right Cessation
- 2006-01-09 MX MX2007008555A patent/MX2007008555A/es unknown
- 2006-01-09 AU AU2006205127A patent/AU2006205127A1/en not_active Abandoned
- 2006-01-09 WO PCT/US2006/000656 patent/WO2006076284A2/en not_active Ceased
- 2006-01-09 EP EP06717815A patent/EP1836208A2/en not_active Withdrawn
- 2006-01-09 JP JP2007551307A patent/JP2008526966A/ja not_active Withdrawn
- 2006-01-09 RU RU2007126570/04A patent/RU2007126570A/ru unknown
- 2006-01-09 EP EP10173563A patent/EP2264036A1/en not_active Withdrawn
- 2006-01-10 PE PE2006000052A patent/PE20060842A1/es not_active Application Discontinuation
- 2006-01-11 GT GT200600009A patent/GT200600009A/es unknown
- 2006-01-13 AR ARP060100150A patent/AR052458A1/es not_active Application Discontinuation
- 2006-01-13 US US11/332,732 patent/US7563796B2/en not_active Expired - Fee Related
- 2006-01-13 PA PA20068660001A patent/PA8660001A1/es unknown
- 2006-01-13 TW TW095101509A patent/TW200637866A/zh unknown
-
2007
- 2007-06-14 IL IL183938A patent/IL183938A0/en unknown
- 2007-06-18 NO NO20073099A patent/NO20073099L/no not_active Application Discontinuation
- 2007-07-12 CR CR9244A patent/CR9244A/es not_active Application Discontinuation
- 2007-07-13 ZA ZA200705783A patent/ZA200705783B/xx unknown
-
2009
- 2009-06-18 US US12/487,395 patent/US20090253716A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006076284A3 (en) | 2007-04-19 |
| ZA200705783B (en) | 2008-09-25 |
| WO2006076284A2 (en) | 2006-07-20 |
| EP1836208A2 (en) | 2007-09-26 |
| CN101103034A (zh) | 2008-01-09 |
| US20060160828A1 (en) | 2006-07-20 |
| KR20070095948A (ko) | 2007-10-01 |
| US20090253716A1 (en) | 2009-10-08 |
| MX2007008555A (es) | 2007-11-21 |
| CA2593515A1 (en) | 2006-07-20 |
| PA8660001A1 (es) | 2006-09-08 |
| PE20060842A1 (es) | 2006-10-12 |
| BRPI0606690A2 (pt) | 2009-07-14 |
| AR052458A1 (es) | 2007-03-21 |
| CR9244A (es) | 2007-09-07 |
| GT200600009A (es) | 2006-08-17 |
| EP2264036A1 (en) | 2010-12-22 |
| TW200637866A (en) | 2006-11-01 |
| IL183938A0 (en) | 2007-10-31 |
| RU2007126570A (ru) | 2009-02-20 |
| JP2008526966A (ja) | 2008-07-24 |
| US7563796B2 (en) | 2009-07-21 |
| AU2006205127A1 (en) | 2006-07-20 |
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