CU20120169A7 - Compuestos pirimidinílicos como inhibidores de la cinasa atr - Google Patents

Compuestos pirimidinílicos como inhibidores de la cinasa atr

Info

Publication number
CU20120169A7
CU20120169A7 CU2012000169A CU20120169A CU20120169A7 CU 20120169 A7 CU20120169 A7 CU 20120169A7 CU 2012000169 A CU2012000169 A CU 2012000169A CU 20120169 A CU20120169 A CU 20120169A CU 20120169 A7 CU20120169 A7 CU 20120169A7
Authority
CU
Cuba
Prior art keywords
atr
inhibitors
cinasa
pyrimidinyl compounds
pyrimidinyl
Prior art date
Application number
CU2012000169A
Other languages
English (en)
Other versions
CU24109B1 (es
Inventor
Kevin Michael Foote
Johannes Wilhelmus María Nissink
Paul Turner
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CU20120169A7 publication Critical patent/CU20120169A7/es
Publication of CU24109B1 publication Critical patent/CU24109B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporcionan compuestos pirimidinílicos de fórmula(I), o sales farmacéuticamente aceptables de estos, procesos para su preparación,composiciones farmacéuticas que los contienen útiles en el tratamiento de una enfermedad proliferativa, tal como el cáncer, y particularmente en en una enfermedad mediada por ataxia-telangiectasia mutada e inhibidores de la proteína cinasa relacionada con RAD-3, denominada habitualmente ATR.
CU20120169A 2010-06-11 2011-09-06 Compuestos pirimidinílicos como inhibidores de la cinasa atr CU24109B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35371310P 2010-06-11 2010-06-11
PCT/GB2011/051074 WO2011154737A1 (en) 2010-06-11 2011-06-09 Morpholino pyrimidines and their use in therapy

Publications (2)

Publication Number Publication Date
CU20120169A7 true CU20120169A7 (es) 2014-02-28
CU24109B1 CU24109B1 (es) 2015-07-30

Family

ID=44168987

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20120169A CU24109B1 (es) 2010-06-11 2011-09-06 Compuestos pirimidinílicos como inhibidores de la cinasa atr

Country Status (38)

Country Link
US (5) US8252802B2 (es)
EP (1) EP2579877B1 (es)
JP (1) JP5721821B2 (es)
KR (1) KR101820996B1 (es)
CN (1) CN103068391B (es)
AR (1) AR081859A1 (es)
AU (1) AU2011263491B2 (es)
BR (1) BR112012031561B1 (es)
CA (1) CA2800203C (es)
CL (1) CL2012003503A1 (es)
CO (1) CO6640270A2 (es)
CR (1) CR20120628A (es)
CU (1) CU24109B1 (es)
DK (1) DK2579877T3 (es)
DO (1) DOP2012000310A (es)
EA (1) EA022087B1 (es)
EC (1) ECSP12012334A (es)
ES (1) ES2514325T3 (es)
GT (1) GT201200334A (es)
HR (1) HRP20140953T1 (es)
MX (1) MX2012014477A (es)
MY (1) MY158193A (es)
NI (1) NI201200184A (es)
NZ (1) NZ604480A (es)
PE (1) PE20130306A1 (es)
PH (1) PH12012502438A1 (es)
PL (1) PL2579877T3 (es)
PT (1) PT2579877E (es)
RS (1) RS53566B1 (es)
SA (1) SA111320519B1 (es)
SG (1) SG185711A1 (es)
SI (1) SI2579877T1 (es)
SM (1) SMT201400146B (es)
TW (1) TWI526208B (es)
UA (1) UA109010C2 (es)
UY (1) UY33440A (es)
WO (1) WO2011154737A1 (es)
ZA (1) ZA201300255B (es)

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