CZ20023967A3 - Deriváty 3-azabicyklo[3,1,0]hexanu vykazující afinitu k opiátovým receptorům - Google Patents

Deriváty 3-azabicyklo[3,1,0]hexanu vykazující afinitu k opiátovým receptorům Download PDF

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Publication number: CZ20023967A3
Authority: CZ; Czechia
Prior art keywords: alkyl; aryl; heteroaryl; optionally substituted; cycloalkyl
Prior art date: 2000-06-23

Application number

CZ20023967A

Other languages

Czech (cs)

English (en)

Inventor

Bernard Joseph Banks

Douglas James Critcher

Ashley Edward Fenwick

David Morris Gethin

Stephen Paul Gibson

Graham Lunn

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-06-07

Publication date

2004-02-18

2001-06-07 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2004-02-18 Publication of CZ20023967A3 publication Critical patent/CZ20023967A3/cs

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108090000137 Opioid Receptors Proteins 0.000 title claims abstract description 17
102000003840 Opioid Receptors Human genes 0.000 title claims abstract description 16
HGWUUOXXAIISDB-UHFFFAOYSA-N 3-azabicyclo[3.1.0]hexane Chemical class C1NCC2CC21 HGWUUOXXAIISDB-UHFFFAOYSA-N 0.000 title 1
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125000000217 alkyl group Chemical group 0.000 claims description 266
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-1 C 6 alkoxy Chemical group 0.000 claims description 81
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YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 77
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125000001424 substituent group Chemical group 0.000 claims description 57
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Classifications

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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
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Endocrinology (AREA)
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Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Gynecology & Obstetrics (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CZ20023967A 2000-06-23 2001-06-07 Deriváty 3-azabicyklo[3,1,0]hexanu vykazující afinitu k opiátovým receptorům CZ20023967A3 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles

Publications (1)

Publication Number	Publication Date
CZ20023967A3 true CZ20023967A3 (cs)	2004-02-18

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ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ20023967A CZ20023967A3 (cs)	2000-06-23	2001-06-07	Deriváty 3-azabicyklo[3,1,0]hexanu vykazující afinitu k opiátovým receptorům

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (fr)
JP (1)	JP2004512263A (fr)
KR (1)	KR20040002386A (fr)
CN (1)	CN1639121A (fr)
AP (1)	AP2002002698A0 (fr)
AR (1)	AR028969A1 (fr)
AU (1)	AU781837B2 (fr)
BG (1)	BG107329A (fr)
BR (1)	BR0111867A (fr)
CA (1)	CA2412188A1 (fr)
CZ (1)	CZ20023967A3 (fr)
DO (1)	DOP2001000187A (fr)
DZ (1)	DZ3368A1 (fr)
EA (1)	EA005117B1 (fr)
GB (1)	GB0015562D0 (fr)
HR (1)	HRP20020998A2 (fr)
HU (1)	HUP0301228A3 (fr)
IL (1)	IL153427A0 (fr)
IS (1)	IS6637A (fr)
MA (1)	MA26915A1 (fr)
MX (1)	MXPA02012878A (fr)
NO (1)	NO20026168L (fr)
NZ (1)	NZ523141A (fr)
OA (1)	OA12293A (fr)
PA (1)	PA8519401A1 (fr)
PE (1)	PE20020253A1 (fr)
PL (1)	PL365956A1 (fr)
SK (1)	SK17172002A3 (fr)
TN (1)	TNSN01094A1 (fr)
UA (1)	UA73176C2 (fr)
UY (1)	UY26787A1 (fr)
WO (1)	WO2001098267A1 (fr)
YU (1)	YU91802A (fr)
ZA (1)	ZA200210278B (fr)

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US20050176746A1 (en) *	2002-05-17	2005-08-11	Frank Weber	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (de)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivate des Asimadolins mit kovalent gebundenen Säuren
ATE451364T1 (de) *	2004-02-23	2009-12-15	Glaxo Group Ltd	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
JP5068747B2 (ja) *	2005-06-14	2012-11-07	グラクソグループリミテッド	ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体
ATE498619T1 (de) *	2006-04-03	2011-03-15	Glaxo Group Ltd	Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
CN101677997B (zh)	2007-03-30	2012-05-09	泰奥加制药公司	用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
CA2936749C (fr) *	2010-06-11	2019-07-09	Rhodes Technologies	Procedes catalyses par metal de transition pour la preparation de composes de n-allyle et utilisation de ceux-ci
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
DK3072884T3 (da) *	2013-11-20	2020-03-09	Sanwa Kagaku Kenkyusho Co	3-azabicyclo[3.1.0]hexanderivat og anvendelse deraf til medicinske formål
MX388953B (es)	2015-05-20	2025-03-20	Ube Industries	Cristal de sal de derivado de 3-azabiciclo[3.1.0]hexano novedoso y usos medicionales del mismo.
CN110446495B (zh)	2017-02-17	2023-09-05	特维娜有限公司	含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
CN110520129A (zh) *	2017-02-17	2019-11-29	特维娜有限公司	含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
KR20190120212A (ko)	2017-03-02	2019-10-23	가부시키가이샤산와카가쿠켄큐쇼	알코올 사용 장해의 치료약
CN108250088B (zh) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN116406268A (zh)	2020-10-27	2023-07-07	特维娜有限公司	δ-阿片样物质调节剂的结晶和无定形形式
CN115825305B (zh) *	2022-10-21	2024-09-20	昆明理工大学	一种分子印迹固相微萃取纤维及其制备方法与应用

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NZ224236A (en) *	1987-04-16	1990-08-28	Lilly Co Eli	Trans 3,4 pyridine derivatives and pharmaceutical compositions
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
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PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 EP EP01936728A patent/EP1292574A1/fr not_active Withdrawn
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/fr active
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/fr not_active Ceased
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 CA CA002412188A patent/CA2412188A1/fr not_active Abandoned
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
2002
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TNSN01094A1 (fr)	2005-11-10
HUP0301228A2 (hu)	2003-08-28
AU781837B2 (en)	2005-06-16
MXPA02012878A (es)	2003-05-14
UY26787A1 (es)	2002-01-31
NZ523141A (en)	2005-06-24
HRP20020998A2 (en)	2004-02-29
CA2412188A1 (fr)	2001-12-27
PA8519401A1 (es)	2002-12-30
KR20040002386A (ko)	2004-01-07
GB0015562D0 (en)	2000-08-16
SK17172002A3 (sk)	2004-09-08
NO20026168D0 (no)	2002-12-20
PL365956A1 (en)	2005-01-24
AU6259101A (en)	2002-01-02
IL153427A0 (en)	2003-07-06
BG107329A (en)	2003-07-31
ZA200210278B (en)	2003-12-19
BR0111867A (pt)	2003-07-01
AR028969A1 (es)	2003-05-28
OA12293A (en)	2004-03-18
HUP0301228A3 (en)	2005-08-29
CN1639121A (zh)	2005-07-13
EA005117B1 (ru)	2004-10-28
JP2004512263A (ja)	2004-04-22
YU91802A (sh)	2006-05-25
WO2001098267A8 (fr)	2003-02-27
EA200201269A1 (ru)	2003-06-26
UA73176C2 (en)	2005-06-15
NO20026168L (no)	2003-02-18
DZ3368A1 (fr)	2001-12-27
MA26915A1 (fr)	2004-12-20
AP2002002698A0 (en)	2002-12-31
DOP2001000187A (es)	2002-03-30
PE20020253A1 (es)	2002-04-08
WO2001098267A1 (fr)	2001-12-27
EP1292574A1 (fr)	2003-03-19
IS6637A (is)	2002-11-28

Publication	Publication Date	Title
EP1499589B1 (fr)	2007-05-02	Derives de n-¬phenyl(piperidin-2-yl)methyl\|benzamide, leur preparation et leur application en therapeutique
US7723321B2 (en)	2010-05-25	Chromane substituted benzimidazole derivatives
AU781837B2 (en)	2005-06-16	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity
CA2356300C (fr)	2008-12-30	Derives 3-azabicyclo[3.1.0]hexane utiles en therapie
EP1791821B1 (fr)	2013-06-05	Derives d'imidazolidine-2-one en tant que modulateurs selectifs du recepteur androgenique
EP1527048B1 (fr)	2008-01-09	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074A1 (fr)	2005-04-22	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
WO2005037785A2 (fr)	2005-04-28	Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide, et n-[azepan-2-yl) phenylmethyl]benzamide, leur preparation et leur application en therapeutique
JP2005516964A (ja)	2005-06-09	５−ｈｔ２ｃレセプターと関連する疾患における使用のための１ｈ−ピラゾリル誘導体化合物
US20080103178A1 (en)	2008-05-01	N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
EP0480794A1 (fr)	1992-04-15	Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique
US20020025948A1 (en)	2002-02-28	3-azabicyclo[3.1.0]hexane derivatives useful in therapy
RU2536688C2 (ru)	2014-12-27	Новые бензамидные производные
KR101800594B1 (ko)	2017-11-22	미량 아민 결합 수용체(taar) 조절제로서 6-아미노-5,6,7,8-테트라하이드로나프탈렌-2-일 또는 3-아미노크로만-7-일 유도체
EA009059B1 (ru)	2007-10-26	Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
US20030207876A1 (en)	2003-11-06	3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
RS50051B (sr)	2008-11-28	Derivati 3-azabiciklo(3.1.0) heksana kao ligandi opijatskih receptora