YU91802A - Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata - Google Patents

Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata

Info

Publication number: YU91802A
Authority: YU; Yugoslavia
Prior art keywords: azabicyclo; opiate; pharmaceutically; opioid receptor; useful
Prior art date: 2000-06-23

Application number

YU91802A

Other languages

English (en)

Serbo-Croatian (sh)

Inventor

Bernard Joseph Banks

Douglas James Critcher

Ashley Edward Fenwick

David Morris Gethin

Graham Lunn

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-06-07

Publication date

2006-05-25

2001-06-07 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2006-05-25 Publication of YU91802A publication Critical patent/YU91802A/sh

Links

108090000137 Opioid Receptors Proteins 0.000 title abstract 3
102000003840 Opioid Receptors Human genes 0.000 title abstract 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 title 1
208000007848 Alcoholism Diseases 0.000 abstract 1
206010003645 Atopy Diseases 0.000 abstract 1
206010010774 Constipation Diseases 0.000 abstract 1
206010012434 Dermatitis allergic Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
206010019196 Head injury Diseases 0.000 abstract 1
206010028813 Nausea Diseases 0.000 abstract 1
208000012488 Opiate Overdose Diseases 0.000 abstract 1
101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108700023159 delta Opioid Receptors Proteins 0.000 abstract 1
102000048124 delta Opioid Receptors Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
230000008693 nausea Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
230000001823 pruritic effect Effects 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
230000035939 shock Effects 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
230000000391 smoking effect Effects 0.000 abstract 1
230000008673 vomiting Effects 0.000 abstract 1
108020001588 κ-opioid receptors Proteins 0.000 abstract 1
108020001612 μ-opioid receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Addiction (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

YU91802A 2000-06-23 2001-06-07 Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata YU91802A (sh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles

Publications (1)

Publication Number	Publication Date
YU91802A true YU91802A (sh)	2006-05-25

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU91802A YU91802A (sh)	2000-06-23	2001-06-07	Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (fr)
JP (1)	JP2004512263A (fr)
KR (1)	KR20040002386A (fr)
CN (1)	CN1639121A (fr)
AP (1)	AP2002002698A0 (fr)
AR (1)	AR028969A1 (fr)
AU (1)	AU781837B2 (fr)
BG (1)	BG107329A (fr)
BR (1)	BR0111867A (fr)
CA (1)	CA2412188A1 (fr)
CZ (1)	CZ20023967A3 (fr)
DO (1)	DOP2001000187A (fr)
DZ (1)	DZ3368A1 (fr)
EA (1)	EA005117B1 (fr)
GB (1)	GB0015562D0 (fr)
HR (1)	HRP20020998A2 (fr)
HU (1)	HUP0301228A3 (fr)
IL (1)	IL153427A0 (fr)
IS (1)	IS6637A (fr)
MA (1)	MA26915A1 (fr)
MX (1)	MXPA02012878A (fr)
NO (1)	NO20026168L (fr)
NZ (1)	NZ523141A (fr)
OA (1)	OA12293A (fr)
PA (1)	PA8519401A1 (fr)
PE (1)	PE20020253A1 (fr)
PL (1)	PL365956A1 (fr)
SK (1)	SK17172002A3 (fr)
TN (1)	TNSN01094A1 (fr)
UA (1)	UA73176C2 (fr)
UY (1)	UY26787A1 (fr)
WO (1)	WO2001098267A1 (fr)
YU (1)	YU91802A (fr)
ZA (1)	ZA200210278B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL368919A1 (en) *	2001-10-22	2005-04-04	Pfizer Products Inc.	3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
CN101310723A (zh) *	2002-05-17	2008-11-26	迪欧加药品公司	有效的选择性阿片受体调制剂化合物的用途
DE10259245A1 (de)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivate des Asimadolins mit kovalent gebundenen Säuren
TW200538113A (en) *	2004-02-23	2005-12-01	Glaxo Group Ltd	Compounds
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
WO2006133945A1 (fr) *	2005-06-14	2006-12-21	Glaxo Group Limited	Nouveaux composés
DE602007012531D1 (de) *	2006-04-03	2011-03-31	Glaxo Group Ltd	Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
AU2008232954A1 (en)	2007-03-30	2008-10-09	Tioga Pharmaceuticals Inc.	Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
EP2580201B1 (fr)	2010-06-11	2017-08-02	Rhodes Technologies	Procédés catalysés par métal de transition pour la préparation de composés de n-allyle et utilisation de ceux-ci
EP2621902B1 (fr)	2010-09-28	2017-04-12	Panacea Biotec Ltd	Dérivés de 3-azabicyclo[3.1.0]hexane utiles pour le traitement de troubles du snc
KR102305244B1 (ko) *	2013-11-20	2021-09-27	우베 고산 가부시키가이샤	신규 3-아자비사이클로[3.1.0]헥산 유도체 및 그 의약 용도
KR20180004734A (ko)	2015-05-20	2018-01-12	가부시키가이샤산와카가쿠켄큐쇼	신규 3-아자비시클로［3.1.0］헥산 유도체의 염의 결정 및 그의 의약 용도
KR102662065B1 (ko)	2017-02-17	2024-05-07	트레베나, 인코포레이티드.	7-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법
WO2018152293A1 (fr)	2017-02-17	2018-08-23	Trevena, Inc.	Composés modulateurs du récepteur delta des opioïdes contenant des aza-hétérocycles à 5 chaînons, leurs procédés d'utilisation et de fabrication
CA3054122A1 (fr)	2017-03-02	2018-09-07	Ube Industries, Ltd.	Agent therapeutique pour troubles lies a la consommation d'alcool
CN108250088B (zh) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) *	2022-10-21	2024-09-20	昆明理工大学	一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
IL86061A (en) *	1987-04-16	1992-07-15	Lilly Co Eli	Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/fr active
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/fr not_active Ceased
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 EP EP01936728A patent/EP1292574A1/fr not_active Withdrawn
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 CA CA002412188A patent/CA2412188A1/fr not_active Abandoned
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
2002
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ523141A (en)	2005-06-24
DZ3368A1 (fr)	2001-12-27
BG107329A (en)	2003-07-31
EP1292574A1 (fr)	2003-03-19
MA26915A1 (fr)	2004-12-20
CA2412188A1 (fr)	2001-12-27
UY26787A1 (es)	2002-01-31
EA005117B1 (ru)	2004-10-28
PA8519401A1 (es)	2002-12-30
PE20020253A1 (es)	2002-04-08
SK17172002A3 (sk)	2004-09-08
BR0111867A (pt)	2003-07-01
IL153427A0 (en)	2003-07-06
NO20026168L (no)	2003-02-18
AU781837B2 (en)	2005-06-16
HRP20020998A2 (en)	2004-02-29
ZA200210278B (en)	2003-12-19
CN1639121A (zh)	2005-07-13
DOP2001000187A (es)	2002-03-30
HUP0301228A3 (en)	2005-08-29
MXPA02012878A (es)	2003-05-14
NO20026168D0 (no)	2002-12-20
KR20040002386A (ko)	2004-01-07
WO2001098267A8 (fr)	2003-02-27
PL365956A1 (en)	2005-01-24
CZ20023967A3 (cs)	2004-02-18
WO2001098267A1 (fr)	2001-12-27
GB0015562D0 (en)	2000-08-16
OA12293A (en)	2004-03-18
AP2002002698A0 (en)	2002-12-31
JP2004512263A (ja)	2004-04-22
EA200201269A1 (ru)	2003-06-26
AR028969A1 (es)	2003-05-28
HUP0301228A2 (hu)	2003-08-28
AU6259101A (en)	2002-01-02
UA73176C2 (en)	2005-06-15
TNSN01094A1 (fr)	2005-11-10
IS6637A (is)	2002-11-28

Publication	Publication Date	Title
YU91802A (sh)	2006-05-25	Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata
WO2005080343A3 (fr)	2006-01-12	Agents therapeutiques
TW200503713A (en)	2005-02-01	Novel compounds
HK1049333A1 (zh)	2003-05-09	以环状琥珀酸酯代替内酰胺，作为制造Aβ蛋白质的抑制剂
MY138478A (en)	2009-06-30	Benzazepine derivatives for the treatment of neurological disorders
TW200505921A (en)	2005-02-16	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
WO2005028475A3 (fr)	2005-06-09	Compositions utiles pour inhiber des proteines kinases
WO2008094992A3 (fr)	2008-12-04	Inhibiteurs de kinase
UA84930C2 (ru)	2008-12-10	Пиррольные соединения как ингибиторы протеинкиназ erk, их синтез и соответствующие промежуточные соединения
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