DD203720A5 - Verfahren zur herstellung von pyrimidinderivaten - Google Patents

Verfahren zur herstellung von pyrimidinderivaten Download PDF

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Publication number
DD203720A5
DD203720A5 DD82246677A DD24667782A DD203720A5 DD 203720 A5 DD203720 A5 DD 203720A5 DD 82246677 A DD82246677 A DD 82246677A DD 24667782 A DD24667782 A DD 24667782A DD 203720 A5 DD203720 A5 DD 203720A5
Authority
DD
German Democratic Republic
Prior art keywords
methyl
pyridyl
pyrimidone
ethyl
alkyl
Prior art date
Application number
DD82246677A
Other languages
German (de)
English (en)
Inventor
Richard P Pioch
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD203720A5 publication Critical patent/DD203720A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Liquid Crystal Substances (AREA)
DD82246677A 1981-12-28 1982-12-28 Verfahren zur herstellung von pyrimidinderivaten DD203720A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33478481A 1981-12-28 1981-12-28

Publications (1)

Publication Number Publication Date
DD203720A5 true DD203720A5 (de) 1983-11-02

Family

ID=23308823

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82246677A DD203720A5 (de) 1981-12-28 1982-12-28 Verfahren zur herstellung von pyrimidinderivaten

Country Status (23)

Country Link
EP (1) EP0083186B1 (cs)
JP (1) JPS58118585A (cs)
KR (1) KR860000106B1 (cs)
AT (1) ATE34173T1 (cs)
AU (1) AU558153B2 (cs)
CA (1) CA1206151A (cs)
CS (1) CS235976B2 (cs)
DD (1) DD203720A5 (cs)
DE (1) DE3278473D1 (cs)
DK (1) DK574782A (cs)
ES (1) ES8403895A1 (cs)
FI (1) FI824407L (cs)
GB (1) GB2111995B (cs)
GR (1) GR78415B (cs)
HU (1) HU192951B (cs)
IE (1) IE54313B1 (cs)
IL (1) IL67496A (cs)
NZ (1) NZ202797A (cs)
PH (1) PH19797A (cs)
PL (1) PL239796A1 (cs)
PT (1) PT76004B (cs)
SU (1) SU1195906A3 (cs)
ZA (1) ZA829247B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468399A (en) * 1981-12-28 1984-08-28 Eli Lilly And Company 2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
GB8320505D0 (en) * 1983-07-29 1983-09-01 Smith Kline French Lab Chemical compounds
US4772704A (en) * 1983-09-21 1988-09-20 Bristol-Myers Company 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity
GB8421427D0 (en) * 1984-08-23 1984-09-26 Smith Kline French Lab Chemical compounds
TW245716B (cs) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
RU2250767C1 (ru) * 2004-07-12 2005-04-27 Казанский государственный медицинский университет Способ лечения язвенной болезни желудка и двенадцатиперстной кишки
CN102260254A (zh) * 2010-05-31 2011-11-30 中国农业科学院植物保护研究所 新颖2-硝基亚氨基嘧啶衍生物的合成

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
IN146736B (cs) * 1975-10-02 1979-08-25 Smith Kline French Lab
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
AU531142B2 (en) * 1979-04-04 1983-08-11 Smith Kline & French Laboratories Limited 2 amino- pyimindones
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
EP0083186B1 (en) 1988-05-11
EP0083186A3 (en) 1984-05-23
KR840002831A (ko) 1984-07-21
FI824407A7 (fi) 1983-06-29
JPS58118585A (ja) 1983-07-14
IE823031L (en) 1983-06-28
PT76004A (en) 1983-01-01
ATE34173T1 (de) 1988-05-15
PL239796A1 (en) 1984-05-21
GR78415B (cs) 1984-09-27
IL67496A (en) 1986-11-30
EP0083186A2 (en) 1983-07-06
IE54313B1 (en) 1989-08-16
ZA829247B (en) 1984-07-25
PT76004B (en) 1985-12-03
CS235976B2 (en) 1985-05-15
KR860000106B1 (ko) 1986-02-19
AU9153982A (en) 1983-07-07
PH19797A (en) 1986-07-02
GB2111995A (en) 1983-07-13
GB2111995B (en) 1985-07-24
FI824407L (fi) 1983-06-29
HU192951B (en) 1987-08-28
CA1206151A (en) 1986-06-17
NZ202797A (en) 1985-08-30
SU1195906A3 (ru) 1985-11-30
DK574782A (da) 1983-06-29
ES518592A0 (es) 1984-04-01
DE3278473D1 (en) 1988-06-16
AU558153B2 (en) 1987-01-22
FI824407A0 (fi) 1982-12-21
ES8403895A1 (es) 1984-04-01

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