DD209652A5 - Verfahren zur herstellung eines replikablen vektors - Google Patents

Verfahren zur herstellung eines replikablen vektors Download PDF

Info

Publication number
DD209652A5
DD209652A5 DD81249414A DD24941481A DD209652A5 DD 209652 A5 DD209652 A5 DD 209652A5 DD 81249414 A DD81249414 A DD 81249414A DD 24941481 A DD24941481 A DD 24941481A DD 209652 A5 DD209652 A5 DD 209652A5
Authority
DD
German Democratic Republic
Prior art keywords
interferon
plasmid
fragment
sequence
polypeptide
Prior art date
Application number
DD81249414A
Other languages
German (de)
English (en)
Inventor
Roberto Crea
Goeddel David Van Norman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26886463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD209652(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DD209652A5 publication Critical patent/DD209652A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DD81249414A 1980-09-25 1981-09-25 Verfahren zur herstellung eines replikablen vektors DD209652A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19079980A 1980-09-25 1980-09-25
US29189281A 1981-08-11 1981-08-11

Publications (1)

Publication Number Publication Date
DD209652A5 true DD209652A5 (de) 1984-05-16

Family

ID=26886463

Family Applications (3)

Application Number Title Priority Date Filing Date
DD81249414A DD209652A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung eines replikablen vektors
DD81233598A DD202085A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung von human-fibroblasten-interferon
DD81249415A DD209477A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung von mikroorganismen

Family Applications After (2)

Application Number Title Priority Date Filing Date
DD81233598A DD202085A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung von human-fibroblasten-interferon
DD81249415A DD209477A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung von mikroorganismen

Country Status (33)

Country Link
US (1) US5460811A (fr)
EP (1) EP0048970A3 (fr)
AT (1) AT380694B (fr)
AU (1) AU582110B2 (fr)
BR (1) BR8106137A (fr)
CA (1) CA1341569C (fr)
CH (2) CH656388A5 (fr)
DD (3) DD209652A5 (fr)
DE (1) DE3138096A1 (fr)
DK (1) DK423381A (fr)
ES (3) ES505742A0 (fr)
FI (1) FI812993A7 (fr)
FR (1) FR2490675B1 (fr)
GB (1) GB2098996B (fr)
GR (1) GR81946B (fr)
HK (1) HK43686A (fr)
IE (1) IE51679B1 (fr)
IL (1) IL63916A0 (fr)
IT (1) IT1139487B (fr)
KE (1) KE3630A (fr)
LU (1) LU83648A1 (fr)
MC (1) MC1423A1 (fr)
MT (1) MTP900B (fr)
MY (1) MY8600634A (fr)
NL (1) NL8104400A (fr)
NO (1) NO813248L (fr)
NZ (1) NZ198445A (fr)
OA (1) OA06908A (fr)
PL (1) PL233194A1 (fr)
PT (1) PT73728B (fr)
SE (1) SE8105657L (fr)
YU (1) YU44835B (fr)
ZW (1) ZW23981A1 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
DK170476B1 (da) * 1980-04-03 1995-09-11 Biogen Inc Rekombinant DNA-molekyle, uni-cellulær vært transformeret med mindst ét rekombinant DNA-molekyle, fremgangsmåde til transformering af en uni-cellulær vært, samt fremgangsmåder til fremstilling af et polpeptid, der udviser den immunologiske eller biologiske aktivitet af human beta-interferon
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
AU575301B2 (en) * 1982-10-08 1988-07-28 Juridical Foundation, Japanese Foundation For Cancer Research Novel vector
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GR79124B (fr) * 1982-12-22 1984-10-02 Genentech Inc
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US5683688A (en) * 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
GB8414354D0 (en) * 1984-06-05 1984-07-11 Biogen Nv Purifying protein
DE3574145D1 (en) * 1984-08-27 1989-12-14 Genentech Inc Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
US4680262A (en) * 1984-10-05 1987-07-14 Genentech, Inc. Periplasmic protein recovery
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0237019A3 (fr) * 1986-03-14 1988-03-09 Toray Industries, Inc. Interféron conjugué et sa préparation à partir d'un gène recombinant
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US20030026779A1 (en) * 1999-10-15 2003-02-06 Liming Yu Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US6713609B1 (en) 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
JP3576819B2 (ja) 1997-07-30 2004-10-13 キヤノン株式会社 情報処理装置及び印刷制御方法並びに記憶媒体
US20030018174A1 (en) * 1997-10-06 2003-01-23 Genentech, Inc. Monoclonal antibodies to IFNAR2
EP1165835A2 (fr) 1999-03-24 2002-01-02 Serono Genetics Institute S.A. Sequence genomique du gene $i(purh) et des marqueurs bialleliques associes au $i(purh)
US6926898B2 (en) 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
JP4394350B2 (ja) * 2001-01-09 2010-01-06 ベイラー リサーチ インスティテュート 対象における自己免疫疾患の治療法及びｉｎｖｉｔｒｏ診断アッセイ
CA2841097A1 (fr) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumine et proteines hybrides g-csf
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
WO2005003296A2 (fr) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Proteines hybrides d'albumine
RS20050501A (sr) * 2002-12-26 2007-08-03 Mountain View Pharmaceuticals Inc., Polimerni konjugati citokina,hemokina,faktora rasta, polipeptidnih hormona i njihovih antagonista sa očuvanom aktivnošću vezivanja receptora
GEP20084486B (en) 2002-12-26 2008-09-25 Mountain View Pharmaceuticals Polymer conjugates of interferon-beta with enhanced biological potency
BRPI0507169A (pt) 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
JP2008543335A (ja) * 2005-06-22 2008-12-04 ジェネンテック・インコーポレーテッド Ｉｆｎａｒ２を標的とするための方法と組成物
SG188143A1 (en) 2008-02-08 2013-03-28 Ambrx Inc Modified leptin polypeptides and their uses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54163600A (en) * 1977-11-08 1979-12-26 Genentech Inc Microbiological polypeptide expression method and means
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IN150740B (fr) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4332892A (en) * 1979-01-15 1982-06-01 President And Fellows Of Harvard College Protein synthesis
US4262090A (en) * 1979-06-04 1981-04-14 Cetus Corporation Interferon production
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
ZA803943B (en) * 1979-07-31 1981-06-24 Hoffmann La Roche Homogeneous fibroblast interferon and method for manufacture thereof
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4418149A (en) * 1980-01-10 1983-11-29 President And Fellows Of Harvard College Fused hybrid gene
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DK170476B1 (da) * 1980-04-03 1995-09-11 Biogen Inc Rekombinant DNA-molekyle, uni-cellulær vært transformeret med mindst ét rekombinant DNA-molekyle, fremgangsmåde til transformering af en uni-cellulær vært, samt fremgangsmåder til fremstilling af et polpeptid, der udviser den immunologiske eller biologiske aktivitet af human beta-interferon
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes

Also Published As

Publication number Publication date
DK423381A (da) 1982-03-26
FI812993L (fi) 1982-03-26
NL8104400A (nl) 1982-04-16
BR8106137A (pt) 1982-06-15
ZW23981A1 (en) 1982-04-28
NZ198445A (en) 1984-05-31
ATA410381A (de) 1985-11-15
CH656388A5 (de) 1986-06-30
NO813248L (no) 1982-03-26
AT380694B (de) 1986-06-25
FR2490675A1 (fr) 1982-03-26
DD202085A5 (de) 1983-08-24
IE51679B1 (en) 1987-02-04
ES8306324A1 (es) 1983-06-01
US5460811A (en) 1995-10-24
ES515032A0 (es) 1983-06-01
AU7564981A (en) 1982-04-01
LU83648A1 (de) 1983-06-08
ES515033A0 (es) 1983-06-01
IT8124109A0 (it) 1981-09-23
EP0048970A2 (fr) 1982-04-07
ES8306325A1 (es) 1983-06-01
MC1423A1 (fr) 1982-10-18
PT73728B (en) 1984-05-08
AU582110B2 (en) 1989-03-16
OA06908A (fr) 1983-05-31
ES8307297A1 (es) 1983-07-01
GB2098996A (en) 1982-12-01
PT73728A (en) 1981-10-01
KE3630A (en) 1986-05-16
YU229781A (en) 1984-02-29
MY8600634A (en) 1986-12-31
IE812224L (en) 1982-03-25
FI812993A7 (fi) 1982-03-26
CH651309A5 (de) 1985-09-13
ES505742A0 (es) 1983-07-01
EP0048970A3 (fr) 1982-08-18
YU44835B (en) 1991-04-30
GR81946B (fr) 1984-12-12
IL63916A0 (en) 1981-12-31
SE8105657L (sv) 1982-03-26
DE3138096A1 (de) 1982-06-09
GB2098996B (en) 1985-02-06
CA1341569C (fr) 2008-03-25
DD209477A5 (de) 1984-05-09
MTP900B (en) 1985-02-28
IT1139487B (it) 1986-09-24
PL233194A1 (en) 1983-07-18
HK43686A (en) 1986-06-20
FR2490675B1 (fr) 1985-11-15

Similar Documents

Publication Publication Date Title
DD202085A5 (de) Verfahren zur herstellung von human-fibroblasten-interferon
DE3238554C2 (fr)
EP0099084B1 (fr) Procédé de préparation d'interféron et des vecteurs d'expression pour celui-ci
DE3050722C2 (fr)
DE3786767T2 (de) Neues Polypeptid.
DD203330A5 (de) Verfahren zur herstellung hybrider human-leukozyten-interferone
DE3382575T2 (de) Dna-sequenzen, rekombinante dna-molekuele und verfahren zur herstellung von schweinewachstumshormonaehnlichen polypeptiden.
DD159782A5 (de) Verfahren zur herstellung eines eine immunologische oder biologische aktivitaet von humanleukozyten-interferon aufweisendes polypeptids
DD202307A5 (de) Verfahren zur herstellung eines polypeptids
DE2848053A1 (de) Synthetische dna und verfahren zu ihrer herstellung
DE2848052A1 (de) Synthetische dna und verfahren zu ihrer herstellung
DE2848051A1 (de) Synthetische dna und verfahren zu ihrer herstellung
DE3144469A1 (de) Hybride human-leukozyten-interferone
DE3587605T2 (de) Interleukin-1 und dessen Derivat.
DE3752063T2 (de) Funktioneller DNS-Block und für Hirudin kodierendes Plasmid, transformierte Hefe aud Verfahren zur Herstellung von Hirudin.
DD204711A5 (de) Verfahren zur herstellung eines dns-uebertragungsvektors
AT389892B (de) Dna-sequenz mit einem gen, das fuer human-interleukin-2 codiert
DE3688225T2 (de) Herstellung menschlichen somatomedins c.
DE3850410T2 (de) cDNS KODIEREND FÜR SOMATOTROPIN, EXPRESSIONSVEKTOREN UND -WIRTE.
DD218632A5 (de) Verfahren zur herstellung von interleukin-2
EP0198415B1 (fr) Changement de la séquence d'ADN entre la séquence de Shine-Dalgarno et le codon initial de l'opéron trp pour stimuler l'expression de protéines
AT394208B (de) Verfahren zur herstelluung von vektoren
AT394210B (de) Verfahren zur herstellung von doppelstraengiger dna kodierend fuer hybride human-leukozyten-interferone
AT394207B (de) Verfahren zur herstellung von human-leukozyteninterferonen