DE60007324T2 - Verfahren zur herstellung von diazepinderivaten - Google Patents

Verfahren zur herstellung von diazepinderivaten Download PDF

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Publication number
DE60007324T2
DE60007324T2 DE60007324T DE60007324T DE60007324T2 DE 60007324 T2 DE60007324 T2 DE 60007324T2 DE 60007324 T DE60007324 T DE 60007324T DE 60007324 T DE60007324 T DE 60007324T DE 60007324 T2 DE60007324 T2 DE 60007324T2
Authority
DE
Germany
Prior art keywords
diazepine derivatives
lower alkyl
producing
imidazo
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60007324T
Other languages
English (en)
Other versions
DE60007324D1 (de
Inventor
Fabienne Hoffmann-Emery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60007324D1 publication Critical patent/DE60007324D1/de
Application granted granted Critical
Publication of DE60007324T2 publication Critical patent/DE60007324T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60007324T 1999-05-12 2000-05-05 Verfahren zur herstellung von diazepinderivaten Expired - Lifetime DE60007324T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99109514 1999-05-12
PCT/EP2000/004033 WO2000069835A2 (en) 1999-05-12 2000-05-05 Process for manufacturing diazepine derivatives

Publications (2)

Publication Number Publication Date
DE60007324D1 DE60007324D1 (de) 2004-01-29
DE60007324T2 true DE60007324T2 (de) 2004-10-21

Family

ID=8238166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007324T Expired - Lifetime DE60007324T2 (de) 1999-05-12 2000-05-05 Verfahren zur herstellung von diazepinderivaten

Country Status (14)

Country Link
US (1) US6281353B1 (de)
EP (1) EP1202977B1 (de)
JP (1) JP3590590B2 (de)
KR (1) KR100469813B1 (de)
CN (1) CN101426771B (de)
AT (1) ATE256669T1 (de)
AU (1) AU4755500A (de)
CA (1) CA2373506C (de)
DE (1) DE60007324T2 (de)
DK (1) DK1202977T3 (de)
ES (1) ES2209880T3 (de)
JO (1) JO2259B1 (de)
MX (1) MXPA01011445A (de)
WO (1) WO2000069835A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
WO2009024325A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
CN109134471B (zh) * 2017-06-27 2020-05-15 浙江京新药业股份有限公司 一种苯并二氮杂*化合物的固态形式及其制备方法和应用
CN111620834B (zh) * 2019-10-15 2022-05-24 浙江京新药业股份有限公司 一种苯并二氮杂䓬化合物的制备方法和中间体
CN113045574B (zh) * 2019-12-26 2024-06-07 浙江京新药业股份有限公司 二氮杂䓬衍生物的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1184175A (en) 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
CA1185602A (en) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines

Also Published As

Publication number Publication date
DE60007324D1 (de) 2004-01-29
JO2259B1 (en) 2004-10-07
KR20010112485A (ko) 2001-12-20
CA2373506A1 (en) 2000-11-23
ES2209880T3 (es) 2004-07-01
JP3590590B2 (ja) 2004-11-17
CA2373506C (en) 2007-09-11
ATE256669T1 (de) 2004-01-15
WO2000069835A3 (en) 2002-03-07
DK1202977T3 (da) 2004-04-05
KR100469813B1 (ko) 2005-02-02
US6281353B1 (en) 2001-08-28
JP2002544265A (ja) 2002-12-24
EP1202977B1 (de) 2003-12-17
MXPA01011445A (es) 2002-06-04
AU4755500A (en) 2000-12-05
CN101426771A (zh) 2009-05-06
WO2000069835A2 (en) 2000-11-23
CN101426771B (zh) 2011-11-16
EP1202977A2 (de) 2002-05-08

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