ATE256669T1 - Verfahren zur herstellung von diazepinderivaten - Google Patents

Verfahren zur herstellung von diazepinderivaten

Info

Publication number: ATE256669T1
Authority: AT; Austria
Prior art keywords: diazepine derivatives; lower alkyl; producing; imidazo; hydrogen
Prior art date: 1999-05-12

Application number

AT00929501T

Other languages

English (en)

Inventor

Fabienne Hoffmann-Emery

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-12

Filing date

2000-05-05

Publication date

2004-01-15

2000-05-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE256669T1 publication Critical patent/ATE256669T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 3
150000004908 diazepines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
IMXWNWBXKWASOM-UHFFFAOYSA-N 3h-imidazo[1,5-a][1,4]diazepine Chemical class N1=CC=CN2CN=CC2=C1 IMXWNWBXKWASOM-UHFFFAOYSA-N 0.000 abstract 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
JCYLWUVDHLVGER-UHFFFAOYSA-N evt-201 Chemical compound O1C(CN(C)C)=NC(C2=C3N(C4=CC=CC(Cl)=C4C(=O)N(C)C3)C=N2)=N1 JCYLWUVDHLVGER-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001003 psychopharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT00929501T 1999-05-12 2000-05-05 Verfahren zur herstellung von diazepinderivaten ATE256669T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99109514		1999-05-12
PCT/EP2000/004033 WO2000069835A2 (en)	1999-05-12	2000-05-05	Process for manufacturing diazepine derivatives

Publications (1)

Publication Number	Publication Date
ATE256669T1 true ATE256669T1 (de)	2004-01-15

Family

ID=8238166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00929501T ATE256669T1 (de)	1999-05-12	2000-05-05	Verfahren zur herstellung von diazepinderivaten

Country Status (14)

Country	Link
US (1)	US6281353B1 (de)
EP (1)	EP1202977B1 (de)
JP (1)	JP3590590B2 (de)
KR (1)	KR100469813B1 (de)
CN (1)	CN101426771B (de)
AT (1)	ATE256669T1 (de)
AU (1)	AU4755500A (de)
CA (1)	CA2373506C (de)
DE (1)	DE60007324T2 (de)
DK (1)	DK1202977T3 (de)
ES (1)	ES2209880T3 (de)
JO (1)	JO2259B1 (de)
MX (1)	MXPA01011445A (de)
WO (1)	WO2000069835A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
KR101589314B1 (ko)	2007-08-20	2016-01-28	에보텍 인터내셔널 게엠베하	수면 장애의 치료
CN109134471B (zh) *	2017-06-27	2020-05-15	浙江京新药业股份有限公司	一种苯并二氮杂*化合物的固态形式及其制备方法和应用
CN111620834B (zh) *	2019-10-15	2022-05-24	浙江京新药业股份有限公司	一种苯并二氮杂䓬化合物的制备方法和中间体
CN113045574B (zh) *	2019-12-26	2024-06-07	浙江京新药业股份有限公司	二氮杂䓬衍生物的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4352817A (en) *	1981-02-27	1982-10-05	Hoffmann-La Roche Inc.	Imidazo-diazepines and their use
CA1174673A (en) *	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
CA1184175A (en) *	1981-02-27	1985-03-19	Walter Hunkeler	Imidazodiazepines
CA1185602A (en) *	1981-02-27	1985-04-16	Emilio Kyburz	Imidazodiazepines

2000
- 2000-05-04 JO JO200069A patent/JO2259B1/en active
- 2000-05-05 AU AU47555/00A patent/AU4755500A/en not_active Abandoned
- 2000-05-05 ES ES00929501T patent/ES2209880T3/es not_active Expired - Lifetime
- 2000-05-05 CN CN008074224A patent/CN101426771B/zh not_active Expired - Lifetime
- 2000-05-05 CA CA002373506A patent/CA2373506C/en not_active Expired - Lifetime
- 2000-05-05 KR KR10-2001-7014340A patent/KR100469813B1/ko not_active Expired - Lifetime
- 2000-05-05 EP EP00929501A patent/EP1202977B1/de not_active Expired - Lifetime
- 2000-05-05 AT AT00929501T patent/ATE256669T1/de active
- 2000-05-05 DK DK00929501T patent/DK1202977T3/da active
- 2000-05-05 WO PCT/EP2000/004033 patent/WO2000069835A2/en not_active Ceased
- 2000-05-05 DE DE60007324T patent/DE60007324T2/de not_active Expired - Lifetime
- 2000-05-05 JP JP2000618252A patent/JP3590590B2/ja not_active Expired - Lifetime
- 2000-05-05 MX MXPA01011445A patent/MXPA01011445A/es active IP Right Grant
- 2000-05-08 US US09/566,831 patent/US6281353B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60007324T2 (de)	2004-10-21
CN101426771B (zh)	2011-11-16
JP3590590B2 (ja)	2004-11-17
US6281353B1 (en)	2001-08-28
EP1202977B1 (de)	2003-12-17
KR20010112485A (ko)	2001-12-20
DE60007324D1 (de)	2004-01-29
CA2373506A1 (en)	2000-11-23
JO2259B1 (en)	2004-10-07
ES2209880T3 (es)	2004-07-01
DK1202977T3 (da)	2004-04-05
AU4755500A (en)	2000-12-05
JP2002544265A (ja)	2002-12-24
WO2000069835A2 (en)	2000-11-23
MXPA01011445A (es)	2002-06-04
EP1202977A2 (de)	2002-05-08
CN101426771A (zh)	2009-05-06
KR100469813B1 (ko)	2005-02-02
WO2000069835A3 (en)	2002-03-07
CA2373506C (en)	2007-09-11

Similar Documents

Publication	Publication Date	Title
DE60326060D1 (de)	2009-03-19	Nichtvernetzende pyrroloä2,1-cüä1,4übenzodiazepine als potentielle antitumor-agentien und ihre herstellung
ATE513816T1 (de)	2011-07-15	Zwischenprodukte zur herstellung bestimmter triazolopyrimidine als p2t antagonisten
MA29623B1 (fr)	2008-07-01	Derives de pyrazolo [3, 4-d] azepine comme antagonistes d'histamine h3
TNSN05058A1 (en)	2007-05-14	Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl) acetamide and compositions and methods related thereto
EA199900822A2 (ru)	2000-04-24	СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО [4,3-d] ПИРИМИДИН-7-ОНОВ И ИХ ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ
CA2184802A1 (en)	1997-04-11	Process for manufacture of imidazo benzodiazepine derivatives
DE60007324D1 (de)	2004-01-29	Verfahren zur herstellung von diazepinderivaten
MX2007004250A (es)	2007-06-12	Derivados de imidazo[1,5-a]triazolo[1,5-d]benzodiazepina para el tratamiento de trastornos cognitivos.
CA2372040A1 (en)	2000-11-23	Imidazodiazepine derivative
ATE413407T1 (de)	2008-11-15	Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür
ATE35266T1 (de)	1988-07-15	3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6dihydro-5-methyl-6-oxo-4h-imidazo(1,5a)(1,4)benzodiazepin, verfahren zu seiner herstellung und pharmazeutische zubereitungen.
MX2007004640A (es)	2007-06-08	Derivados de benzodiazepina sustituidos con halogeno.
DE602004009962D1 (de)	2007-12-20	Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen
BR0213177A (pt)	2004-09-14	Derivados de 5-metóxi-8-aril-[1,2,4]triazolo[1,5-a]piridina
FI924829A0 (fi)	1992-10-23	Menetelmä uusien terapeuttisesti käyttökelpoisten bentsotieno[2,3-b]pyratsiini-2,3(1H,4H)-dionien valmistamiseksi
AP1631A (en)	2006-07-12	Polymorphs of N-methyl-N- (3- {3- [2-thienylcarbonyl] -pyrazol- [1,5-?] -pyrimidin-7-yl} phenyl) acetamide and compositions and methods related thereto.
DE69529499D1 (de)	2003-03-06	Stereoselektives Verfahren zur Herstellung von Dihydro-2,3-benzodiazepin-Derivaten
AP9801410A0 (en)	1998-12-31	Indoline derivatives useful as 5-HT-2C receptor antagonists.
ATE300534T1 (de)	2005-08-15	Verfahren und zwischenverbindungen zur herstellung von imidazopyridinen
GB2425309A (en)	2006-10-25	C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers
ATE299862T1 (de)	2005-08-15	Verfahren zur herstellung von ketiminen
ATE469904T1 (de)	2010-06-15	Pyren-gebundene pyrrolo(2,1-c)(1,4)benzodiazepin- derivate zur verwendung als antikrebsmittel
ATE51401T1 (de)	1990-04-15	Pyrrolo(1,2-b>(1,2,5>triazepine, verfahren und zwischenprodukte zu ihrer herstellung und ihre anwendung als arzneimittel.
DE60104719D1 (de)	2004-09-09	Verfahren zur herstellung von triphendioxazinpigmenten
US4001261A (en)	1977-01-04	Process for the production of 1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]-benzodiazepine

Legal Events

Date

Code

Title

Description

2004-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1202977

Country of ref document: EP