DE69920669D1 - Quervernetzte stärke mit hohem amyloseanteil und funktionellen gruppen als matrix für langsame freisetzung pharmazeutischer wirkstoffe - Google Patents

Quervernetzte stärke mit hohem amyloseanteil und funktionellen gruppen als matrix für langsame freisetzung pharmazeutischer wirkstoffe

Info

Publication number
DE69920669D1
DE69920669D1 DE69920669T DE69920669T DE69920669D1 DE 69920669 D1 DE69920669 D1 DE 69920669D1 DE 69920669 T DE69920669 T DE 69920669T DE 69920669 T DE69920669 T DE 69920669T DE 69920669 D1 DE69920669 D1 DE 69920669D1
Authority
DE
Germany
Prior art keywords
cross
high amylose
starch
slow release
networked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69920669T
Other languages
English (en)
Other versions
DE69920669T2 (de
Inventor
Vincent Lenaerts
Francois Chouinard
Mircea A Mateescu
Pompilia Ispas-Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69920669D1 publication Critical patent/DE69920669D1/de
Publication of DE69920669T2 publication Critical patent/DE69920669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69920669T 1998-02-24 1999-02-24 Quervernetzte stärke mit hohem amyloseanteil und funktionellen gruppen als matrix für langsame freisetzung pharmazeutischer wirkstoffe Expired - Lifetime DE69920669T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/028,385 US6284273B1 (en) 1998-02-24 1998-02-24 Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
US28385 1998-02-24
PCT/CA1999/000169 WO1999043305A1 (en) 1998-02-24 1999-02-24 Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents

Publications (2)

Publication Number Publication Date
DE69920669D1 true DE69920669D1 (de) 2004-11-04
DE69920669T2 DE69920669T2 (de) 2005-11-03

Family

ID=21843160

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69920669T Expired - Lifetime DE69920669T2 (de) 1998-02-24 1999-02-24 Quervernetzte stärke mit hohem amyloseanteil und funktionellen gruppen als matrix für langsame freisetzung pharmazeutischer wirkstoffe

Country Status (19)

Country Link
US (2) US6284273B1 (de)
EP (1) EP1059915B1 (de)
JP (1) JP2002504508A (de)
KR (1) KR100713702B1 (de)
CN (1) CN1298297A (de)
AT (1) ATE277604T1 (de)
AU (1) AU755069B2 (de)
BR (1) BR9908187A (de)
CA (1) CA2321461C (de)
CZ (1) CZ301010B6 (de)
DE (1) DE69920669T2 (de)
HU (1) HU225045B1 (de)
IL (1) IL137955A (de)
NO (1) NO329257B1 (de)
NZ (1) NZ506437A (de)
PL (1) PL192468B1 (de)
PT (1) PT1059915E (de)
TR (1) TR200003014T2 (de)
WO (1) WO1999043305A1 (de)

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US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
DE19927688A1 (de) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
WO2002088331A1 (en) * 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
PT1558935E (pt) * 2002-10-25 2008-10-16 Labopharm Inc Composições de libertação controlada
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
CA2547843A1 (en) * 2004-02-09 2005-08-18 Transfert Plus Societe En Commandite Composition comprising polymeric material and uses thereof
CA2491665A1 (fr) * 2004-12-24 2006-06-24 Louis Cartilier Formulation de comprime pour liberation soutenue de principe actif
ES2620293T3 (es) * 2005-09-09 2017-06-28 Paladin Labs Inc. Composición de liberación sostenida de fármacos
CN101252932B (zh) 2005-09-09 2012-10-03 安吉利尼莱博法姆有限责任公司 用于一天给药一次的曲唑酮组合物
ATE543522T1 (de) * 2005-09-21 2012-02-15 Surmodics Inc In vivo geformte matrizen mit natürlichen biologisch abbaubaren polysacchariden und ihre ophthalmischen verwendungen
CN101309709A (zh) * 2005-09-21 2008-11-19 苏尔莫迪克斯公司 包含天然生物可降解的多糖的涂层和物品
WO2007105719A1 (ja) * 2006-03-14 2007-09-20 National University Corporation NARA Institute of Science and Technology 新規なヘパリン代替材料およびその製造方法
CA2590821A1 (en) * 2007-06-07 2008-12-07 Universite De Montreal High-amylose sodium carboxymethyl starch sustained release excipient and process for preparing the same
CA2678092C (en) * 2007-10-16 2013-07-30 Labopharm Inc. Bilayer composition for the sustained release of acetaminophen and tramadol
CN101161684B (zh) * 2007-11-23 2010-05-19 华南理工大学 交联羧甲基淀粉的红外线合成方法
CA2707980C (en) * 2007-12-17 2015-05-12 Labopharm Inc. Misuse preventative, controlled release formulation
RU2491301C2 (ru) * 2007-12-21 2013-08-27 Акцо Нобель Н.В. Термореактивные полимеры
JP5763525B2 (ja) 2008-05-07 2015-08-12 サーモディクス，インコーポレイティド 粒子からの核酸複合体の送達
EP2331629B1 (de) * 2008-09-15 2016-06-22 Paladin Labs Inc. Auf stärke basierende mikropartikel zur freisetzung von darin enthaltenen wirkstoffen
EP2367541B1 (de) 2008-12-16 2014-07-16 Paladin Labs Inc. Formulierung mit gesteuerter freisetzung und missbrauchsschutz
EP2590636A1 (de) 2010-07-06 2013-05-15 Grünenthal GmbH Neue gastroretentive dosierungsformen mit einem gaba-analog und einem opioid
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
WO2012116434A1 (en) * 2011-03-01 2012-09-07 4413261 Canada Inc. (Spencer Canada) Two speed monolithic system for controlled release of drugs
JP6605508B2 (ja) * 2014-02-27 2019-11-13 ビー‐オーガニック フィルムス コーポレイション 一重らせんｖ構造を有する官能化デンプン中に含まれる生物活性剤
KR20170093243A (ko) 2014-12-19 2017-08-14 백스터 인터내셔널 인코포레이티드 유동성 지혈 조성물
CN104784738B (zh) * 2015-04-03 2016-12-07 四川大学 一种天然缓释多效医用海绵
CN106279453B (zh) * 2015-05-28 2019-12-10 易媛 交联的高分子化合物及其制备方法、水凝胶、水基压裂液和用途
CN105536058A (zh) * 2016-01-22 2016-05-04 青岛中腾生物技术有限公司 一种医用淀粉海绵及其制备方法和用途
GB2567493B (en) 2017-10-13 2019-12-18 Altus Formulation Inc Starch-based release modifying excipients and pharmaceutical compositions derived therefrom
CN111072791A (zh) * 2019-12-27 2020-04-28 河南新孚望新材料科技有限公司 一种包膜剂用高直链淀粉的制备方法
JP7125216B1 (ja) 2021-03-31 2022-08-24 長瀬産業株式会社 水溶性ポリマーの製造方法、および吸水性樹脂の製造方法
AU2022251740B2 (en) * 2021-03-31 2026-02-26 Nagase & Co., Ltd. Method for producing water-soluble polymer and method for producing water-absorbing resin
WO2025194276A1 (en) * 2024-03-21 2025-09-25 Eric Therasse Pharmaceutical composition comprising microparticles for high drug loading
CN119264282A (zh) * 2024-10-18 2025-01-07 华南理工大学 一种高空腔纳米淀粉及基于其的高耐老化橡胶材料与制备

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US4072535A (en) * 1970-12-28 1978-02-07 A. E. Staley Manufacturing Company Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules
US4369308A (en) * 1981-07-24 1983-01-18 National Starch And Chemical Corporation Low swelling starches as tablet disintegrants
JPH0791240B2 (ja) * 1987-04-01 1995-10-04 株式会社日本触媒 ２−ハロエチルアミンハロゲン化水素酸塩の製造方法
CA2041774C (en) * 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
JPH06271704A (ja) * 1993-03-22 1994-09-27 Asahi Chem Ind Co Ltd 水性易燃性組成物
US5616343A (en) * 1993-03-25 1997-04-01 Labopharm, Inc. Cross-linked amylose as a binder/disintegrant in tablets
CN1150218C (zh) * 1994-04-11 2004-05-19 赫希斯特人造丝公司 超吸收性聚合物及其制品
US5830884A (en) * 1995-01-18 1998-11-03 National Starch And Chemical Investment Holding Corporation Pharmaceutical products containing thermally-inhibited starches
US5593503A (en) * 1995-06-07 1997-01-14 National Starch And Chemical Investment Holding Corporation Process for producing amylase resistant granular starch
US5667637A (en) * 1995-11-03 1997-09-16 Weyerhaeuser Company Paper and paper-like products including water insoluble fibrous carboxyalkyl cellulose
CA2173818A1 (fr) * 1996-04-10 1997-10-11 Francois Chouinard Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
US5879707A (en) * 1996-10-30 1999-03-09 Universite De Montreal Substituted amylose as a matrix for sustained drug release
US5807575A (en) * 1997-02-14 1998-09-15 Rougier Inc. Manufacture of cross-linked amylose useful as a excipient for control release of active compounds

Also Published As

Publication number Publication date
NZ506437A (en) 2003-03-28
KR100713702B1 (ko) 2007-05-02
HUP0100818A2 (hu) 2001-08-28
KR20010034531A (ko) 2001-04-25
US6419957B1 (en) 2002-07-16
HUP0100818A3 (en) 2001-12-28
PL192468B1 (pl) 2006-10-31
EP1059915A1 (de) 2000-12-20
JP2002504508A (ja) 2002-02-12
US6284273B1 (en) 2001-09-04
DE69920669T2 (de) 2005-11-03
CN1298297A (zh) 2001-06-06
HU225045B1 (en) 2006-05-29
CZ20003097A3 (en) 2001-06-13
CA2321461C (en) 2008-04-29
WO1999043305A1 (en) 1999-09-02
CZ301010B6 (cs) 2009-10-14
TR200003014T2 (tr) 2001-02-21
AU755069B2 (en) 2002-12-05
NO20004208D0 (no) 2000-08-23
ATE277604T1 (de) 2004-10-15
NO20004208L (no) 2000-08-23
PT1059915E (pt) 2005-02-28
EP1059915B1 (de) 2004-09-29
BR9908187A (pt) 2000-10-31
PL342596A1 (en) 2001-06-18
CA2321461A1 (en) 1999-09-02
AU3242099A (en) 1999-09-15
IL137955A (en) 2005-12-18
IL137955A0 (en) 2001-10-31
NO329257B1 (no) 2010-09-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KOENIG, B., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 80